ZA737317B - Process for the preparation of tetracyclines derivatives in the 7 position and products obtained - Google Patents

Process for the preparation of tetracyclines derivatives in the 7 position and products obtained

Info

Publication number
ZA737317B
ZA737317B ZA737317A ZA737317A ZA737317B ZA 737317 B ZA737317 B ZA 737317B ZA 737317 A ZA737317 A ZA 737317A ZA 737317 A ZA737317 A ZA 737317A ZA 737317 B ZA737317 B ZA 737317B
Authority
ZA
South Africa
Prior art keywords
tetracyclines
derivatives
preparation
products obtained
products
Prior art date
Application number
ZA737317A
Other languages
English (en)
Inventor
Luigi Bernardi
Vincenzo Colonna
Roberto De Castiglione
Paolo Masi
Original Assignee
Farmaceutici Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia filed Critical Farmaceutici Italia
Publication of ZA737317B publication Critical patent/ZA737317B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
ZA737317A 1972-09-18 1973-09-14 Process for the preparation of tetracyclines derivatives in the 7 position and products obtained ZA737317B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2932872 1972-09-18

Publications (1)

Publication Number Publication Date
ZA737317B true ZA737317B (en) 1974-09-25

Family

ID=11226772

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA737317A ZA737317B (en) 1972-09-18 1973-09-14 Process for the preparation of tetracyclines derivatives in the 7 position and products obtained

Country Status (14)

Country Link
US (1) US3901942A (fr)
JP (1) JPS5741458B2 (fr)
AT (1) AT328613B (fr)
BE (1) BE804913A (fr)
CA (1) CA999855A (fr)
DE (1) DE2346535C3 (fr)
ES (1) ES418809A1 (fr)
FR (1) FR2208885B1 (fr)
GB (1) GB1413347A (fr)
HU (1) HU167850B (fr)
IE (1) IE38820B1 (fr)
NL (1) NL158172B (fr)
SU (1) SU574145A3 (fr)
ZA (1) ZA737317B (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2437487A1 (de) * 1974-08-03 1976-02-19 Merck Patent Gmbh 7-methoxy-6-thia-tetracycline und verfahren zu ihrer herstellung
AU578068B2 (en) * 1984-03-08 1988-10-13 Nippon Zoki Pharmaceutical Co., Ltd. Hydantoin derivatives and pharmaceutical compositions containing them
JPH0737433B2 (ja) * 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds
JPH01116549U (fr) * 1988-01-29 1989-08-07
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
CA2318580A1 (fr) * 1998-01-23 1999-07-29 Mark L. Nelson Composes pharmaceutiquement actifs et procedes d'utilisation correspondants
EP2327686A3 (fr) * 1999-09-14 2012-08-22 Trustees Of Tufts College Procédé de préparation de tétracyclines substituées avec chimies à base de métaux
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US20040224927A1 (en) 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
WO2001098236A2 (fr) * 2000-06-16 2001-12-27 Trustees Of Tufts College Composes de tetracycline 7-phenyl-substituee
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001271642B2 (en) 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
US7094806B2 (en) 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
MXPA03000055A (es) * 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
US7553828B2 (en) 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
WO2002072506A2 (fr) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. Composes de 7-pyrollyl tetracycline et procedes d'utilisation associes
JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
US20040092490A1 (en) * 2001-04-24 2004-05-13 Michael Draper Substituted tetracycline compounds for the treatment of malaria
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
EP2311799A1 (fr) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. Composés de tétracycline 4-dedimethylamino
IL163931A0 (en) 2002-03-08 2005-12-18 Paratek Pharm Innc Amino-methyl substituted tetracyline compounds
CN1653037A (zh) * 2002-03-21 2005-08-10 帕拉特克药品公司 取代的四环素化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
AU2004259659B2 (en) 2003-07-09 2011-11-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
SI2109602T1 (sl) * 2006-12-21 2014-06-30 Paratek Pharmaceuticals, Inc. Derivati tetraciklina za zdravljenje bakterijskih, virusnih in parazitskih infekcij
DK2120963T3 (en) 2006-12-21 2019-01-14 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS
PT103661B (pt) * 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
EP2144614A1 (fr) 2007-04-12 2010-01-20 Paratek Pharmaceuticals, Inc. Procédés pour le traitement de l'amyotrophie spinale à l'aide de composés tétracyclines.
KR20100126469A (ko) 2008-03-05 2010-12-01 파라테크 파마슈티컬스, 인크. 미노사이클린 화합물 및 이들의 사용 방법
TWI680117B (zh) * 2008-05-23 2019-12-21 派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
EP3534908A4 (fr) 2016-11-01 2020-05-27 Paratek Pharmaceuticals, Inc. Composés de 9-aminométhylminocycline et leur utilisation dans le traitement de la pneumonie bactérienne d'acquisition communautaire (cabp)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2895993A (en) * 1957-05-16 1959-07-21 Pfizer & Co C Alkyl substituted anhydrotetracycline compounds and process of preparing the same
US2997471A (en) * 1958-08-18 1961-08-22 Bristol Myers Co Tetracycline derivatives
US3029284A (en) * 1960-09-14 1962-04-10 Pfizer & Co C Nu-dealkylation of carboxamido-nu-alkyltetracycline and its analogs
US3239499A (en) * 1961-05-19 1966-03-08 Pfizer & Co C Tetracycline derivative
US3165551A (en) * 1961-06-26 1965-01-12 Pfizer & Co C New antibacterial agents
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3388162A (en) * 1966-03-14 1968-06-11 American Cyanamid Co 7-and/or 9-nitro or amino tetracyclines
US3403179A (en) * 1967-01-10 1968-09-24 American Cyanamid Co Novel 7-(1, 2-bis-substituted-hydrazino)-tetracyclines and methods of preparing same
US3483251A (en) * 1967-03-03 1969-12-09 American Cyanamid Co Reductive alkylation process
US3373196A (en) * 1967-03-21 1968-03-12 American Cyanamid Co 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines

Also Published As

Publication number Publication date
GB1413347A (en) 1975-11-12
AT328613B (de) 1976-03-25
HU167850B (fr) 1975-12-25
DE2346535A1 (de) 1974-04-11
ATA799673A (de) 1975-06-15
DE2346535B2 (de) 1980-09-11
NL7312648A (fr) 1974-03-20
IE38820B1 (en) 1978-06-07
FR2208885B1 (fr) 1977-05-20
ES418809A1 (es) 1976-03-16
JPS5741458B2 (fr) 1982-09-03
NL158172B (nl) 1978-10-16
AU6033373A (en) 1975-03-20
CA999855A (en) 1976-11-16
US3901942A (en) 1975-08-26
DE2346535C3 (de) 1981-05-21
IE38820L (en) 1974-03-18
FR2208885A1 (fr) 1974-06-28
JPS4969653A (fr) 1974-07-05
SU574145A3 (ru) 1977-09-25
BE804913A (fr) 1974-03-18

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