ZA735660B - Process for preparing 2-amino and 4-amino-quinazolines - Google Patents
Process for preparing 2-amino and 4-amino-quinazolinesInfo
- Publication number
- ZA735660B ZA735660B ZA735660A ZA735660A ZA735660B ZA 735660 B ZA735660 B ZA 735660B ZA 735660 A ZA735660 A ZA 735660A ZA 735660 A ZA735660 A ZA 735660A ZA 735660 B ZA735660 B ZA 735660B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- quinazolines
- preparing
- Prior art date
Links
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- DRYRBWIFRVMRPV-UHFFFAOYSA-N quinazolin-4-amine Chemical class C1=CC=C2C(N)=NC=NC2=C1 DRYRBWIFRVMRPV-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4199272A GB1383409A (en) | 1972-09-09 | 1972-09-09 | Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA735660B true ZA735660B (en) | 1974-07-31 |
Family
ID=10422335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA735660A ZA735660B (en) | 1972-09-09 | 1973-08-20 | Process for preparing 2-amino and 4-amino-quinazolines |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3960861A (fa) |
| JP (1) | JPS4985078A (fa) |
| AR (1) | AR203373A1 (fa) |
| AT (1) | AT330785B (fa) |
| BE (1) | BE804558A (fa) |
| CA (1) | CA995673A (fa) |
| DE (2) | DE2345064C3 (fa) |
| DK (1) | DK131725C (fa) |
| ES (1) | ES418612A1 (fa) |
| FR (1) | FR2198751B1 (fa) |
| GB (1) | GB1383409A (fa) |
| IE (1) | IE38318B1 (fa) |
| IN (2) | IN139088B (fa) |
| LU (1) | LU68373A1 (fa) |
| NL (1) | NL161152C (fa) |
| SU (1) | SU555850A3 (fa) |
| ZA (1) | ZA735660B (fa) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4044136A (en) * | 1972-09-09 | 1977-08-23 | Pfizer Inc. | Aminoquinazoline therapeutic agents |
| GR79603B (fa) * | 1982-07-24 | 1984-10-31 | Pfizer | |
| DE3464247D1 (de) * | 1983-06-28 | 1987-07-23 | Ciba Geigy Ag | Chromogenic quinazoline compounds |
| JPH05507290A (ja) * | 1990-11-06 | 1993-10-21 | フアイザー・インコーポレイテツド | 抗腫瘍活性を強化するためのキナゾリン誘導体 |
| KR0144833B1 (ko) * | 1992-12-28 | 1998-07-15 | 김태훈 | 신규의 퀴나졸린 유도체 및 그의 제조방법 |
| DE4338396A1 (de) * | 1993-11-10 | 1995-05-11 | Basf Ag | N-Substituierte Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| IT1286302B1 (it) * | 1996-04-10 | 1998-07-08 | Rotta Research Lab | Chinazoline-4-amino-2-(piperidino-1-il-4-sostituite) ad attivita' anti-ipertensiva, procedimento per la loro preparazione e loro uso |
| IN188411B (fa) | 1997-03-27 | 2002-09-21 | Yuhan Corp | |
| KR100272471B1 (ko) | 1998-11-17 | 2000-11-15 | 김선진 | 신규의 피리미딘 유도체 및 그의 제조방법 |
| US6900220B2 (en) | 2001-01-02 | 2005-05-31 | Syntex (U.S.A.) Llc | Quinazolone derivatives as alpha 1A/B adrenergic receptor antagonists |
| KR100647932B1 (ko) * | 2002-07-05 | 2006-11-23 | 에프. 호프만-라 로슈 아게 | 퀴나졸린 유도체 |
| DE602007011773D1 (de) * | 2006-08-04 | 2011-02-17 | Merz Pharma Gmbh & Co Kgaa | Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin |
| US8871756B2 (en) * | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| WO2015018797A2 (en) * | 2013-08-05 | 2015-02-12 | Haplogen Gmbh | Antiviral compounds |
| AR099134A1 (es) * | 2014-01-24 | 2016-06-29 | Hoffmann La Roche | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina |
| CN107635999B (zh) | 2015-05-20 | 2020-09-25 | 豪夫迈·罗氏有限公司 | 用于治疗脊髓性肌萎缩的化合物 |
| JP6779972B2 (ja) | 2015-07-16 | 2020-11-04 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 呼吸器合胞体ウイルス（ｒｓｖ）感染症の処置のためのｎ−［（３−アミノ−３−オキセタニル）メチル］−２−（２，３−ジヒドロ−１，１−ジオキシド−１，４−ベンゾチアゼピン−４（５ｈ）−イル）−６−メチル−４−キナゾリンアミンの結晶形 |
| JP6659841B2 (ja) | 2015-11-12 | 2020-03-04 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 脊髄性筋萎縮症を処置するための組成物 |
| EP3386978B1 (en) | 2015-12-10 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bridged piperidine derivatives |
| MX391850B (es) | 2015-12-10 | 2025-03-19 | Ptc Therapeutics Inc | Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington |
| FR3061494B1 (fr) | 2016-12-29 | 2020-07-03 | Arkema France | Procede de synthese de dithiocarbamates cycliques fonctionnalises |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| US11382918B2 (en) | 2017-06-28 | 2022-07-12 | Ptc Therapeutics, Inc. | Methods for treating Huntington's Disease |
| EP3645121B8 (en) | 2017-06-28 | 2025-06-18 | PTC Therapeutics, Inc. | Methods for treating huntington's disease |
| MX2020009957A (es) | 2018-03-27 | 2021-01-15 | Ptc Therapeutics Inc | Compuestos para el tratamiento de enfermedad de hungtinton. |
| EA202092899A1 (ru) | 2018-06-27 | 2021-05-14 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Гетероарильные соединения для лечения болезни гентингтона |
| PL3814357T3 (pl) | 2018-06-27 | 2024-09-16 | Ptc Therapeutics, Inc. | Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| KR20220022114A (ko) | 2019-05-13 | 2022-02-24 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 화합물 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2945859A (en) * | 1960-07-19 | Diaminoquinazolines and method of | ||
| BE501634A (fa) * | 1950-03-02 | |||
| US3155572A (en) * | 1959-04-13 | 1964-11-03 | Merck & Co Inc | Compositions and methods for treating coccidiosis |
| GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
| GB1131126A (en) * | 1966-03-10 | 1968-10-23 | Pfizer Ltd | 2-vinyl-1,4-dihydroquinazoline derivatives |
| US3511836A (en) * | 1967-12-13 | 1970-05-12 | Pfizer & Co C | 2,4,6,7-tetra substituted quinazolines |
| US3637701A (en) * | 1969-03-03 | 1972-01-25 | Sandoz Ag | Certain nitrate derivatives of 4-aminoquinazolines |
| US3663706A (en) * | 1969-09-29 | 1972-05-16 | Pfizer | Use of 2,4-diaminoquinazolines as hypotensive agents |
| US3669968A (en) * | 1970-05-21 | 1972-06-13 | Pfizer | Trialkoxy quinazolines |
-
1972
- 1972-09-09 GB GB4199272A patent/GB1383409A/en not_active Expired
-
1973
- 1973-08-20 ZA ZA735660A patent/ZA735660B/xx unknown
- 1973-08-21 IN IN1920/CAL/73A patent/IN139088B/en unknown
- 1973-08-30 DK DK478273*A patent/DK131725C/da active
- 1973-08-31 CA CA180,089A patent/CA995673A/en not_active Expired
- 1973-09-03 IE IE1560/73A patent/IE38318B1/xx unknown
- 1973-09-03 AR AR249880A patent/AR203373A1/es active
- 1973-09-04 JP JP48098934A patent/JPS4985078A/ja active Pending
- 1973-09-05 US US05/394,491 patent/US3960861A/en not_active Expired - Lifetime
- 1973-09-06 BE BE135402A patent/BE804558A/xx unknown
- 1973-09-06 DE DE2345064A patent/DE2345064C3/de not_active Expired
- 1973-09-06 DE DE2366106A patent/DE2366106C2/de not_active Expired
- 1973-09-06 AT AT774573A patent/AT330785B/de active
- 1973-09-07 FR FR7332315A patent/FR2198751B1/fr not_active Expired
- 1973-09-07 LU LU68373A patent/LU68373A1/xx unknown
- 1973-09-07 NL NL7312350.A patent/NL161152C/xx not_active IP Right Cessation
- 1973-09-08 ES ES418612A patent/ES418612A1/es not_active Expired
-
1975
- 1975-01-08 SU SU2095549A patent/SU555850A3/ru active
- 1975-07-11 IN IN1357/CAL/75A patent/IN141109B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE804558A (fr) | 1974-03-06 |
| DE2345064B2 (de) | 1979-03-08 |
| IE38318B1 (en) | 1978-02-15 |
| NL161152B (nl) | 1979-08-15 |
| DE2345064C3 (de) | 1979-10-25 |
| DE2366106B1 (de) | 1979-06-21 |
| DE2366106C2 (de) | 1980-02-14 |
| ATA774573A (de) | 1975-10-15 |
| GB1383409A (en) | 1974-02-12 |
| JPS4985078A (fa) | 1974-08-15 |
| AR203373A1 (es) | 1975-09-08 |
| DK131725B (da) | 1975-08-25 |
| SU555850A3 (ru) | 1977-04-25 |
| CA995673A (en) | 1976-08-24 |
| DK131725C (da) | 1976-01-26 |
| AU5960673A (en) | 1975-02-27 |
| FR2198751A1 (fa) | 1974-04-05 |
| ES418612A1 (es) | 1976-07-16 |
| NL161152C (nl) | 1980-01-15 |
| IE38318L (en) | 1974-03-09 |
| IN141109B (fa) | 1977-01-22 |
| FR2198751B1 (fa) | 1977-01-28 |
| NL7312350A (fa) | 1974-03-12 |
| AT330785B (de) | 1976-07-26 |
| IN139088B (fa) | 1976-05-08 |
| US3960861A (en) | 1976-06-01 |
| DE2345064A1 (de) | 1974-04-11 |
| LU68373A1 (fa) | 1975-05-21 |
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