ZA201700488B - Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same - Google Patents
Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for sameInfo
- Publication number
- ZA201700488B ZA201700488B ZA2017/00488A ZA201700488A ZA201700488B ZA 201700488 B ZA201700488 B ZA 201700488B ZA 2017/00488 A ZA2017/00488 A ZA 2017/00488A ZA 201700488 A ZA201700488 A ZA 201700488A ZA 201700488 B ZA201700488 B ZA 201700488B
- Authority
- ZA
- South Africa
- Prior art keywords
- antibody
- cytoplasm
- positioning
- same
- cell membrane
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/80—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
- C07K2317/82—Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies functional in the cytoplasm, the inner aspect of the cell membrane, the nucleus or the mitochondria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20140092673 | 2014-07-22 | ||
| KR1020150103163A KR101602870B1 (ko) | 2014-07-22 | 2015-07-21 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| PCT/KR2015/007626 WO2016013870A1 (ko) | 2014-07-22 | 2015-07-22 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201700488B true ZA201700488B (en) | 2018-12-19 |
Family
ID=55354088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2017/00488A ZA201700488B (en) | 2014-07-22 | 2017-01-20 | Method for positioning, in cytoplasm, antibody having complete immunoglobulin form by penetrating antibody through cell membrane, and use for same |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10844136B2 (enExample) |
| EP (1) | EP3173428B1 (enExample) |
| JP (1) | JP6595592B2 (enExample) |
| KR (1) | KR101602870B1 (enExample) |
| CN (1) | CN107001481A (enExample) |
| AU (1) | AU2015292955B2 (enExample) |
| BR (1) | BR112017001304A2 (enExample) |
| CA (1) | CA2955272A1 (enExample) |
| IL (1) | IL250203B (enExample) |
| RU (1) | RU2017103675A (enExample) |
| ZA (1) | ZA201700488B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6178785B2 (ja) | 2011-04-01 | 2017-08-09 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ | 細胞浸透性抗ｄｎａ抗体およびｄｎａ修復を阻害するためのその使用 |
| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| JP2019520086A (ja) | 2016-05-27 | 2019-07-18 | オラム・セラピューティクス・インコーポレイテッド | 細胞質浸透抗体およびその用途 |
| KR102000000B1 (ko) * | 2016-05-27 | 2019-07-12 | 오름테라퓨틱 주식회사 | 항체에 엔도좀 탈출능을 부여하는 엔도좀 탈출 구조 모티프 및 이의 활용 |
| EP3471777A1 (en) | 2016-06-15 | 2019-04-24 | Yale University | Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors |
| US12486318B2 (en) | 2016-06-15 | 2025-12-02 | Yale University | Anti-guanosine antibody as a molecular delivery vehicle |
| KR102163305B1 (ko) | 2017-11-16 | 2020-10-08 | 오름테라퓨틱 주식회사 | 세포의 세포질에 침투하여 세포내 활성화된 Ras를 억제하는 항체 및 이의 용도 |
| US12304970B2 (en) | 2018-02-01 | 2025-05-20 | Yale University | Nuclear localization signals, compositions formed therefrom, and methods of use thereof for delivery of cargo to the nucleus |
| WO2019199941A1 (en) * | 2018-04-10 | 2019-10-17 | Northwestern University | Extracellular vesicles comprising targeting affinity domain-based membrane proteins |
| KR20190143826A (ko) | 2018-06-21 | 2019-12-31 | 오름테라퓨틱 주식회사 | 세포/조직 특이적 세포 침투 항체 |
| US20210292409A1 (en) * | 2018-07-23 | 2021-09-23 | Chugai Seiyaku Kabushiki Kaisha | Target cell specific cytosol-penetrating antigen-binding molecules |
| CN110759996B (zh) * | 2018-07-27 | 2022-09-06 | 深圳康体生命科技有限公司 | 一种gfp抗体 |
| CN108949565B (zh) * | 2018-09-26 | 2024-09-06 | 中国科学技术大学 | 用于红细胞负载冻干保护剂的装置及方法 |
| EP3962491B1 (en) * | 2019-05-01 | 2025-08-06 | Universidade De Santiago De Compostela | Intracellular delivery of anti-kras antibodies formulated into nanocapsules |
| EP4101866A4 (en) | 2020-02-06 | 2024-04-24 | Ajou University Industry-Academic Cooperation Foundation | FUSION ANTIBODIES FOR PRESENTING AN ANTIGEN-DERIVED T-CELL ANTIGEN EPITOPE OR A PEPTIDE CONTAINING THE SAME ON THE CELL SURFACE AND COMPOSITION THEREOF |
| AU2021227406A1 (en) * | 2020-02-24 | 2022-09-29 | Oblique Therapeutics Ab | Kras epitopes and antibodies |
| MX2022012278A (es) * | 2020-03-30 | 2022-10-27 | Ablynx Nv | Metodo para la produccion y purificacion de dominios variables unicos de inmunoglobulina multivalentes. |
| CR20220598A (es) | 2020-04-30 | 2023-01-17 | Genentech Inc | Anticuerpos específicos para kras y sus usos |
| WO2023003339A1 (ko) | 2021-07-20 | 2023-01-26 | 아주대학교산학협력단 | 세포 내부에 침투하여 표적단백질을 분해하여 제거하는 세포침투 분해항체 및 이의 용도 |
| WO2025127633A1 (ko) | 2023-12-14 | 2025-06-19 | 아주대학교산학협력단 | 고효율 세포질 침투 능을 갖는 세포질 침투 항체 및 이의 용도 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2706486B1 (fr) | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
| CN1241574A (zh) * | 1998-07-02 | 2000-01-19 | 中国人民解放军第四军医大学 | 抗肝癌单克隆抗体HAb25及其单链抗体和双功能抗体 |
| GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
| AU2003219277A1 (en) | 2002-03-14 | 2003-09-29 | Medical Research Council | Intracellular antibodies |
| EP1565495A2 (en) | 2002-11-15 | 2005-08-24 | Medical Research Council | Anti-activated ras antibodies |
| TW200806789A (en) | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
| EA021967B1 (ru) | 2008-01-03 | 2015-10-30 | Дзе Скриппс Рисерч Инститьют | Доставка антител посредством модульного домена распознавания |
| KR100849941B1 (ko) | 2008-04-29 | 2008-08-01 | 원우이에프엔지니어링주식회사 | 열 및 연기 화재감지장치 복합시험기 |
| EP2279002B1 (en) | 2008-04-30 | 2013-08-14 | Ajou University Industry-Academic Cooperation Foundation | Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same |
| KR101075123B1 (ko) * | 2008-10-24 | 2011-10-19 | 아주대학교산학협력단 | 핵산가수분해 능 및 암세포내 침투능력을 갖는 인간화된 항체 및 그 용도 |
| CN102209726A (zh) * | 2008-11-11 | 2011-10-05 | 亚州大学校产学协力团 | 具有细胞穿透性、序列特异性和核酸水解性的抗体、其制备方法及包含所述抗体的药物组合物 |
| CN101402675B (zh) | 2008-11-28 | 2012-05-30 | 中国人民解放军第三军医大学第三附属医院 | 一种靶向抑制ανβ3阳性细胞增殖的环肽 |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| GB201103631D0 (en) | 2011-03-03 | 2011-04-13 | Univ Leeds | Identification of candidate therapeutics |
| JP6178785B2 (ja) | 2011-04-01 | 2017-08-09 | イェール ユニバーシティーＹａｌｅ Ｕｎｉｖｅｒｓｉｔｙ | 細胞浸透性抗ｄｎａ抗体およびｄｎａ修復を阻害するためのその使用 |
| US9283272B2 (en) | 2012-03-30 | 2016-03-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
| JP6246128B2 (ja) | 2012-09-14 | 2017-12-13 | 公益財団法人がん研究会 | ＥｐＣＡＭに結合するペプチド |
| WO2015048477A1 (en) | 2013-09-27 | 2015-04-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
| WO2016013871A1 (ko) | 2014-07-22 | 2016-01-28 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| CN114456272A (zh) | 2015-04-03 | 2022-05-10 | 优瑞科生物技术公司 | 靶向afp肽/mhc复合体的构建体及其用途 |
| KR101790669B1 (ko) | 2015-10-14 | 2017-10-26 | 아주대학교산학협력단 | 개선된 분할 녹색 형광 단백질 상보 시스템 및 이의 용도 |
| JP2019520086A (ja) | 2016-05-27 | 2019-07-18 | オラム・セラピューティクス・インコーポレイテッド | 細胞質浸透抗体およびその用途 |
| KR101836392B1 (ko) | 2016-08-17 | 2018-03-08 | 한림대학교 산학협력단 | 사이클릭 펩타이드를 포함하는 백신 조성물, 사이클릭 펩타이드에 대한 항체 또는 이를 포함하는 항암 조성물 |
| KR102163305B1 (ko) | 2017-11-16 | 2020-10-08 | 오름테라퓨틱 주식회사 | 세포의 세포질에 침투하여 세포내 활성화된 Ras를 억제하는 항체 및 이의 용도 |
| KR20190143826A (ko) | 2018-06-21 | 2019-12-31 | 오름테라퓨틱 주식회사 | 세포/조직 특이적 세포 침투 항체 |
-
2015
- 2015-07-21 KR KR1020150103163A patent/KR101602870B1/ko not_active Expired - Fee Related
- 2015-07-22 CA CA2955272A patent/CA2955272A1/en not_active Abandoned
- 2015-07-22 AU AU2015292955A patent/AU2015292955B2/en not_active Ceased
- 2015-07-22 JP JP2017525495A patent/JP6595592B2/ja not_active Expired - Fee Related
- 2015-07-22 BR BR112017001304-5A patent/BR112017001304A2/pt not_active Application Discontinuation
- 2015-07-22 EP EP15825418.5A patent/EP3173428B1/en active Active
- 2015-07-22 RU RU2017103675A patent/RU2017103675A/ru not_active Application Discontinuation
- 2015-07-22 CN CN201580045139.0A patent/CN107001481A/zh active Pending
- 2015-07-22 US US15/327,369 patent/US10844136B2/en not_active Expired - Fee Related
-
2017
- 2017-01-19 IL IL250203A patent/IL250203B/en not_active IP Right Cessation
- 2017-01-20 ZA ZA2017/00488A patent/ZA201700488B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017529097A (ja) | 2017-10-05 |
| AU2015292955B2 (en) | 2020-08-13 |
| US20170218084A1 (en) | 2017-08-03 |
| US10844136B2 (en) | 2020-11-24 |
| BR112017001304A2 (pt) | 2018-01-30 |
| IL250203A0 (en) | 2017-03-30 |
| EP3173428B1 (en) | 2020-02-19 |
| CN107001481A (zh) | 2017-08-01 |
| AU2015292955A1 (en) | 2017-02-09 |
| RU2017103675A (ru) | 2018-08-06 |
| JP6595592B2 (ja) | 2019-10-23 |
| EP3173428A4 (en) | 2018-01-24 |
| IL250203B (en) | 2020-09-30 |
| KR20160011598A (ko) | 2016-02-01 |
| KR101602870B1 (ko) | 2016-03-21 |
| EP3173428A1 (en) | 2017-05-31 |
| CA2955272A1 (en) | 2016-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL250203A0 (en) | A method for positioning, in the cytoplasm, an antibody with a complete immunoglobulic form using an antibody that penetrates the cell membrane, and its use | |
| IL320713A (en) | Antibodies, uses and methods | |
| ZA202105220B (en) | Cell penetrating antibodies | |
| SG11201706826VA (en) | Method for separating cells, and device therefor | |
| EP3130604A4 (en) | Anti-il-17 antibodies, method for producing same and method for using same | |
| EP3150692A4 (en) | Cell evaluation device, method, and program | |
| EP3133865A4 (en) | Method, device and system for cell reselection | |
| EP3176277A4 (en) | Ferritic stainless steel material for fuel cell, and method for producing same | |
| EP3173099A4 (en) | Method for suppressing ras activated in cell by using antibody having cytoplasm penetration capacity and complete immunoglobulin form, and use for same | |
| EP3091786A4 (en) | Apparatus, method and system for cell selection | |
| EP3150693A4 (en) | Cell determination device, method, and program | |
| EP3239691A4 (en) | Cell imaging device, cell imaging method, and sample cell | |
| EP3118750A4 (en) | Factor analysis device, factor analysis method, and factor analysis program | |
| IL252430B1 (en) | Antibodies, uses and methods | |
| SG11201701562WA (en) | Cell trapping method, method for producing specific cell-trapping device, and method for producing specific cell-containing solution | |
| EP3150694A4 (en) | Cell evaluation device, method, and program | |
| EP3220464A4 (en) | Cell structure, method for producing same, and fuel cell | |
| EP3107141A4 (en) | Microbial fuel cell, microbial fuel cell system, and method for using microbial fuel cell | |
| EP3226607A4 (en) | Method and apparatus for transmitting information in cell | |
| KR101687291B9 (ko) | 3차원 세포배양 시스템 및 이를 이용한 세포 배양 방법 | |
| EP3216801A4 (en) | Soluble heterodimeric t cell receptor, and preparation method and use thereof | |
| BR112016030851A2 (pt) | recipiente de separação de células, sistema de separação de células e método de separação de células | |
| EP3275993B8 (en) | Device for producing information for cell analysis, method for producing information for cell analysis, and program | |
| SG11201700557RA (en) | Lipid membrane structure, lipid-membrane-structure-immobilization carrier, and method for fusing cells | |
| HUE051941T2 (hu) | Biológiai élesztõ, eljárás elõállítására és alkalmazásai |