ZA201406078B - Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhibitors - Google Patents
Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhibitorsInfo
- Publication number
- ZA201406078B ZA201406078B ZA2014/06078A ZA201406078A ZA201406078B ZA 201406078 B ZA201406078 B ZA 201406078B ZA 2014/06078 A ZA2014/06078 A ZA 2014/06078A ZA 201406078 A ZA201406078 A ZA 201406078A ZA 201406078 B ZA201406078 B ZA 201406078B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrazolo
- kinase inhibitors
- dependent kinase
- triazine derivatives
- selective cyclin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12157751.4A EP2634190A1 (en) | 2012-03-01 | 2012-03-01 | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| PCT/EP2013/054224 WO2013128028A1 (en) | 2012-03-01 | 2013-03-01 | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201406078B true ZA201406078B (en) | 2016-08-31 |
Family
ID=47757629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2014/06078A ZA201406078B (en) | 2012-03-01 | 2014-08-19 | Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9567345B2 (show.php) |
| EP (2) | EP2634190A1 (show.php) |
| JP (1) | JP6182549B2 (show.php) |
| KR (1) | KR101821452B1 (show.php) |
| CN (1) | CN104350054B (show.php) |
| AU (1) | AU2013224848B2 (show.php) |
| BR (1) | BR112014021189B1 (show.php) |
| CA (1) | CA2865946C (show.php) |
| DK (1) | DK2820020T3 (show.php) |
| ES (1) | ES2583231T3 (show.php) |
| HU (1) | HUE029264T2 (show.php) |
| IL (1) | IL234183A (show.php) |
| MX (1) | MX347359B (show.php) |
| RU (1) | RU2645347C2 (show.php) |
| SG (1) | SG11201405129RA (show.php) |
| WO (1) | WO2013128028A1 (show.php) |
| ZA (1) | ZA201406078B (show.php) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA119247C2 (uk) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Спіроциклічні сполуки як інгібітори триптофангідроксилази |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| KR20170003553A (ko) | 2014-04-04 | 2017-01-09 | 사이로스 파마수티컬스, 인크. | 사이클린-의존성 키나제 7(cdk7)의 저해제 |
| EP3805218A1 (en) * | 2014-04-05 | 2021-04-14 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| KR102575327B1 (ko) | 2014-10-31 | 2023-09-07 | 유비이 가부시키가이샤 | 치환 디히드로피롤로피라졸 화합물 |
| US11186576B2 (en) | 2015-03-09 | 2021-11-30 | Aurigene Discovery Technologies Limited | Pyrazolo[1,5-A][1,3,5]triazine and pyrazolo[1,5-A]pyrimidine derivatives as CDK inhibitors |
| JP6787314B2 (ja) | 2015-06-15 | 2020-11-18 | 宇部興産株式会社 | 置換ジヒドロピロロピラゾール誘導体 |
| CA2989722C (en) * | 2015-06-24 | 2023-09-19 | Jacob Westman | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
| SI3432916T1 (sl) | 2016-09-13 | 2020-01-31 | Allergan, Inc. | Stabilizirani ne-protein klostridijski toksin sestavki |
| CN106432249B (zh) * | 2016-09-30 | 2018-12-04 | 陕西科技大学 | 一类吡咯并[2，1-f][1，2，4]三嗪母核化合物的合成及其医药用途 |
| EP3664806B1 (en) | 2017-08-09 | 2025-04-30 | Sanford Burnham Prebys Medical Discovery Institute | 3-PHENYL-PYRAZOLO[1,5-A]PYRIMIDINE-5-CARBOXILIC ACID DERIVATIVES AS APELIN (APJ) RECEPTOR AGONISTS FOR THE TREATMENT OF CARDIOVASCULAR, METABOLIC, CNS, OR INFECTIOUS DISEASES OR DISORDERS |
| GB201715194D0 (en) | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| KR102523513B1 (ko) * | 2018-01-17 | 2023-04-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Pi4kiii베타 억제제 |
| CN112313235A (zh) * | 2018-04-11 | 2021-02-02 | 奎利恩特有限公司 | 作为周期蛋白依赖性激酶的选择性抑制剂的吡唑并-三嗪和/或吡唑并-嘧啶衍生物 |
| AU2019250504B2 (en) | 2018-04-11 | 2023-05-18 | Lead Discovery Center Gmbh | Pharmaceutically active pyrazolo-triazine and/or pyrazolo-pyrimidine derivatives |
| US12022832B2 (en) | 2018-09-12 | 2024-07-02 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| US11517568B2 (en) | 2018-09-12 | 2022-12-06 | The Governing Council Of The University Of Toronto | Compounds and methods for treating nematode infections |
| SG11202104438VA (en) | 2018-11-01 | 2021-05-28 | Syros Pharmaceuticals Inc | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| JP7530297B2 (ja) | 2018-11-14 | 2024-08-07 | Ｕｂｅ株式会社 | ジヒドロピロロピラゾール誘導体 |
| CN110101703B (zh) * | 2019-05-06 | 2021-06-11 | 暨南大学 | Cdk7抑制剂在制备溃疡性结肠炎或结肠癌药物的应用 |
| RU2713152C1 (ru) * | 2019-08-30 | 2020-02-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ лечения хронической аллергической крапивницы на фоне описторхоза |
| TW202146416A (zh) * | 2019-12-11 | 2021-12-16 | 德商拜耳廠股份有限公司 | 吡唑并三𠯤 |
| GB201918541D0 (en) | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| CN110950871B (zh) * | 2019-12-25 | 2022-05-17 | 陕西师范大学 | 2-取代-4-芳氨基吡唑并三嗪衍生物及制备抗肿瘤药物的应用 |
| CN116964061A (zh) * | 2020-12-21 | 2023-10-27 | 詹森药业有限公司 | 作为细胞周期蛋白依赖性激酶7（cdk7）抑制剂的三环嘧啶 |
| US20250281495A1 (en) * | 2021-02-25 | 2025-09-11 | Icahn School Of Medicine At Mount Sinai | Methods for inhibiting inflammation and progression of atherosclerotic plaques and cardiovascular events in patients with cerebro- and cardio-vascular disease |
| JP2024509864A (ja) * | 2021-03-09 | 2024-03-05 | ヤンセン ファーマシューティカ エヌ．ベー． | サイクリン依存性キナーゼ７（ｃｄｋ７）阻害剤としての三環式ピリジン |
| WO2022266418A1 (en) * | 2021-06-17 | 2022-12-22 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Triazine inhibitors of cyclin-dependent kinases |
| WO2023001061A1 (en) * | 2021-07-17 | 2023-01-26 | Jingrui Biopharma Co., Ltd. | Cdk7 selective inhibitors as anticancer agents |
| EP4377312A1 (en) | 2021-07-29 | 2024-06-05 | Syngenta Crop Protection AG | Pesticidally active fused bicyclic heteroaromatic compounds |
| KR20240115270A (ko) * | 2021-11-23 | 2024-07-25 | 오리제니스 게엠베하 | 사이클린 의존성 키나아제의 새로운 억제제 |
| CN114181217B (zh) * | 2022-01-10 | 2022-12-27 | 陕西师范大学 | 吡唑并[1,5-a][1,3,5]三嗪衍生物及其盐和在制备抗癌药物中的应用 |
| AU2023235439A1 (en) * | 2022-03-18 | 2024-09-19 | Lead Discovery Center Gmbh | Cdk7 inhibitors for antiviral treatment |
| CN120712267A (zh) * | 2023-02-21 | 2025-09-26 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US615968A (en) | 1898-12-13 | Apparatus for treating ores | ||
| DE60023268T2 (de) * | 1999-02-01 | 2006-06-01 | CV Therapeutics, Inc., Palo Alto | INHIBITEURS PURIQUES DE KINASE 2 DEPENDANTE DES CYCLINES et IkB-alpha |
| US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| TW200536536A (en) * | 2004-02-25 | 2005-11-16 | Schering Corp | Pyrazolotriazines as kinase inhibitors |
| CZ302122B6 (cs) * | 2009-01-28 | 2010-10-20 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-aminobenzylamino)purinu, jejich použití jako léciva a prípravky tyto slouceniny obsahující |
| FR2943058B1 (fr) * | 2009-03-11 | 2011-06-03 | Centre Nat Rech Scient | Derives de pyrazolo°1,5-a!-1,3,5-triazines, leur preparation et leur application en therapeutique. |
| CZ302711B6 (cs) * | 2009-06-03 | 2011-09-14 | Univerzita Palackého v Olomouci | Substituované deriváty 6-(2-hydroxybenzylamino)purinu, jejich použití jako léciva a farmaceutické prípravky tyto slouceniny obsahující |
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2012
- 2012-03-01 EP EP12157751.4A patent/EP2634190A1/en not_active Withdrawn
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2013
- 2013-03-01 KR KR1020147027812A patent/KR101821452B1/ko active Active
- 2013-03-01 AU AU2013224848A patent/AU2013224848B2/en active Active
- 2013-03-01 CN CN201380011917.5A patent/CN104350054B/zh active Active
- 2013-03-01 HU HUE13707008A patent/HUE029264T2/en unknown
- 2013-03-01 WO PCT/EP2013/054224 patent/WO2013128028A1/en not_active Ceased
- 2013-03-01 MX MX2014010494A patent/MX347359B/es active IP Right Grant
- 2013-03-01 DK DK13707008.2T patent/DK2820020T3/en active
- 2013-03-01 EP EP13707008.2A patent/EP2820020B1/en active Active
- 2013-03-01 JP JP2014559259A patent/JP6182549B2/ja active Active
- 2013-03-01 RU RU2014139705A patent/RU2645347C2/ru active
- 2013-03-01 US US14/381,146 patent/US9567345B2/en active Active
- 2013-03-01 SG SG11201405129RA patent/SG11201405129RA/en unknown
- 2013-03-01 ES ES13707008.2T patent/ES2583231T3/es active Active
- 2013-03-01 BR BR112014021189-2A patent/BR112014021189B1/pt active IP Right Grant
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2014
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- 2014-08-19 IL IL234183A patent/IL234183A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DK2820020T3 (en) | 2016-07-04 |
| MX347359B (es) | 2017-04-06 |
| MX2014010494A (es) | 2015-04-08 |
| HK1206014A1 (en) | 2015-12-31 |
| CN104350054A (zh) | 2015-02-11 |
| WO2013128028A8 (en) | 2014-10-02 |
| BR112014021189B1 (pt) | 2022-08-16 |
| WO2013128028A1 (en) | 2013-09-06 |
| JP6182549B2 (ja) | 2017-08-16 |
| KR20140131994A (ko) | 2014-11-14 |
| CN104350054B (zh) | 2017-06-13 |
| KR101821452B1 (ko) | 2018-01-23 |
| US9567345B2 (en) | 2017-02-14 |
| RU2645347C2 (ru) | 2018-02-21 |
| AU2013224848B2 (en) | 2017-06-29 |
| BR112014021189A2 (show.php) | 2017-06-20 |
| CA2865946A1 (en) | 2013-09-06 |
| EP2820020A1 (en) | 2015-01-07 |
| SG11201405129RA (en) | 2014-09-26 |
| JP2015511952A (ja) | 2015-04-23 |
| HUE029264T2 (en) | 2017-02-28 |
| US20150018329A1 (en) | 2015-01-15 |
| IL234183A (en) | 2016-11-30 |
| EP2634190A1 (en) | 2013-09-04 |
| CA2865946C (en) | 2020-01-21 |
| AU2013224848A1 (en) | 2014-08-28 |
| ES2583231T3 (es) | 2016-09-19 |
| EP2820020B1 (en) | 2016-04-06 |
| RU2014139705A (ru) | 2016-04-20 |
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