ZA200908886B - Brassica plant comprising of mutant fatty acyl-thioesterase alleles - Google Patents
Brassica plant comprising of mutant fatty acyl-thioesterase allelesInfo
- Publication number
- ZA200908886B ZA200908886B ZA2009/08886A ZA200908886A ZA200908886B ZA 200908886 B ZA200908886 B ZA 200908886B ZA 2009/08886 A ZA2009/08886 A ZA 2009/08886A ZA 200908886 A ZA200908886 A ZA 200908886A ZA 200908886 B ZA200908886 B ZA 200908886B
- Authority
- ZA
- South Africa
- Prior art keywords
- fatty acyl
- brassica plant
- mutant fatty
- thioesterase
- alleles
- Prior art date
Links
- 108700028369 Alleles Proteins 0.000 title 1
- 241000219198 Brassica Species 0.000 title 1
- 102000008172 Palmitoyl-CoA Hydrolase Human genes 0.000 title 1
- 108010035473 Palmitoyl-CoA Hydrolase Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6895—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for plants, fungi or algae
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A01H1/04—Processes of selection involving genotypic or phenotypic markers; Methods of using phenotypic markers for selection
- A01H1/045—Processes of selection involving genotypic or phenotypic markers; Methods of using phenotypic markers for selection using molecular markers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/10—Seeds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H6/00—Angiosperms, i.e. flowering plants, characterised by their botanic taxonomy
- A01H6/20—Brassicaceae, e.g. canola, broccoli or rucola
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/172—Haplotypes
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Plant Pathology (AREA)
- Cell Biology (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07075568 | 2007-07-09 | ||
| US95894507P | 2007-07-10 | 2007-07-10 | |
| PCT/EP2008/005551 WO2009007091A2 (en) | 2007-07-09 | 2008-07-07 | Brassica plant comprising mutant fatty acyl-acp thioesterase alleles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200908886B true ZA200908886B (en) | 2011-02-23 |
Family
ID=40076671
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2009/08886A ZA200908886B (en) | 2007-07-09 | 2009-12-14 | Brassica plant comprising of mutant fatty acyl-thioesterase alleles |
| ZA2010/09002A ZA201009002B (en) | 2007-07-09 | 2010-12-14 | Brassica plant comprising mutant fatty acyl-acp thioesterase alleles |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2010/09002A ZA201009002B (en) | 2007-07-09 | 2010-12-14 | Brassica plant comprising mutant fatty acyl-acp thioesterase alleles |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8981180B2 (https=) |
| EP (1) | EP2167667B1 (https=) |
| JP (1) | JP5677839B2 (https=) |
| CN (1) | CN101688220B (https=) |
| AR (1) | AR067480A1 (https=) |
| AU (1) | AU2008274551B2 (https=) |
| CA (2) | CA3128584A1 (https=) |
| DK (1) | DK2167667T3 (https=) |
| EA (1) | EA030862B1 (https=) |
| ES (1) | ES2545083T3 (https=) |
| PL (1) | PL2167667T3 (https=) |
| SI (1) | SI2167667T1 (https=) |
| UA (1) | UA99471C2 (https=) |
| WO (1) | WO2009007091A2 (https=) |
| ZA (2) | ZA200908886B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1685093T6 (pl) | 2003-11-21 | 2012-10-31 | Givaudan Sa | N-podstawiony p-mentanokarboksamid i zastosowanie N-podstawionych p-mentanokarboksamidów |
| RU2568056C2 (ru) | 2009-10-22 | 2015-11-10 | ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи | Конструируемые белки с цинковыми пальцами, направленные на гены растений, вовлеченные в биосинтез жирных кислот |
| DK2501804T3 (en) | 2009-11-20 | 2016-07-18 | Bayer Cropscience Nv | Brassica plants, WHICH INCLUDES mutated FAD3 alleles |
| JP5882225B2 (ja) * | 2009-12-18 | 2016-03-09 | カーギル・インコーポレイテッド | 低総飽和脂肪酸含有率を有するオイルを産するアブラナ属植物 |
| EP2525658B1 (de) | 2010-01-22 | 2017-03-01 | Bayer Intellectual Property GmbH | Akarizide und/oder insektizide wirkstoffkombinationen |
| HUE032218T2 (en) * | 2010-05-12 | 2017-09-28 | Agrigenetics Inc | Properties-introgressive use of 'Brown midrib-3' gene specific markers in maize |
| WO2011150028A2 (en) * | 2010-05-25 | 2011-12-01 | Cargill, Incorporated | Brassica plants yielding oils with a low alpha linolenic acid content |
| US9695434B2 (en) * | 2010-05-25 | 2017-07-04 | Cargill, Incorporated | Brassica plants yielding oils with a low alpha linolenic acid content |
| CN108823254A (zh) * | 2010-11-03 | 2018-11-16 | 柯碧恩生物技术公司 | 具有降低倾点的微生物油、从其中产生的介电流体、以及相关方法 |
| EP2640706B1 (en) | 2010-11-15 | 2017-03-01 | Bayer Intellectual Property GmbH | N-aryl pyrazole(thio)carboxamides |
| US9265252B2 (en) | 2011-08-10 | 2016-02-23 | Bayer Intellectual Property Gmbh | Active compound combinations comprising specific tetramic acid derivatives |
| US9968041B2 (en) | 2012-07-06 | 2018-05-15 | Bayer Cropscience Nv | Soybean ROD1 gene sequences and uses thereof |
| EA201590164A1 (ru) | 2012-07-06 | 2015-05-29 | Байер Кропсайенс Нв | Растения brassica с модифицированным составом масла семян |
| CA2878286C (en) | 2012-07-06 | 2023-06-13 | Bayer Cropscience Nv | Brassica rod1 gene sequences and uses thereof |
| BR112015014307A2 (pt) | 2012-12-19 | 2017-07-11 | Bayer Cropscience Ag | difluorometil-nicotínico- tetrahidronaftil carboxamidas |
| US9816079B2 (en) | 2013-01-29 | 2017-11-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| US9567615B2 (en) | 2013-01-29 | 2017-02-14 | Terravia Holdings, Inc. | Variant thioesterases and methods of use |
| KR20150128770A (ko) * | 2013-03-15 | 2015-11-18 | 솔라짐, 인코포레이티드 | 티오에스테라아제 및 맞춤형 오일 생산용 세포 |
| US9290749B2 (en) | 2013-03-15 | 2016-03-22 | Solazyme, Inc. | Thioesterases and cells for production of tailored oils |
| US9783836B2 (en) | 2013-03-15 | 2017-10-10 | Terravia Holdings, Inc. | Thioesterases and cells for production of tailored oils |
| EP3172320B1 (en) | 2014-07-24 | 2019-11-20 | Corbion Biotech, Inc. | Variant thioesterases and methods of use |
| CN107208103A (zh) | 2014-09-18 | 2017-09-26 | 泰拉瑞亚控股公司 | 酰基‑acp硫酯酶及其突变体 |
| WO2016174119A1 (en) | 2015-04-28 | 2016-11-03 | Bayer Cropscience Nv | Brassica plants with modified seed oil composition |
| CA3021682A1 (en) * | 2016-05-25 | 2017-11-30 | Cargill Incorporated | Engineered nucleases to generate deletion mutants in plants |
| US11517025B2 (en) | 2016-08-12 | 2022-12-06 | Cargill, Incorporated | Speciality low saturates canola oil |
| US10440915B2 (en) | 2016-09-01 | 2019-10-15 | Cargill, Incorporated | Canola cultivar 15RH0611 |
| US10440916B2 (en) | 2016-09-06 | 2019-10-15 | Cargill, Incorporated | Canola cultivar 15RH0612 |
| US10440909B2 (en) | 2016-09-06 | 2019-10-15 | Cargill, Incorporated | Canola cultivar 15RH0613 |
| TWI873082B (zh) * | 2017-08-17 | 2025-02-21 | 日商莎卡達種子股份有限公司 | 甘藍（Ｂｒａｓｓｉｃａ ｏｌｅｒａｃｅａ）植物之異型檢出法 |
| EP3850087A4 (en) * | 2018-09-14 | 2022-08-03 | Chuanxin Sun | RICE PLANT MATTER RESISTANT TO BIOTIC STRESS |
| US12173299B2 (en) | 2019-01-04 | 2024-12-24 | Pioneer Hi-Bred International, Inc. | Engineered nucleases to generate mutations in plants |
| CA3047768A1 (en) | 2019-06-21 | 2020-12-21 | BASF Agricultural Solutions Seed US LLC | Canola hybrid variety 7cn0425 |
| US20230062896A1 (en) * | 2020-01-31 | 2023-03-02 | Calyxt, Inc. | Increase of saturated fat in soybean |
| US11997965B2 (en) | 2020-04-24 | 2024-06-04 | BASF Agricultural Solutions Seed US LLC | Canola hybrid variety 8CN0001 |
| US11672218B2 (en) | 2020-04-24 | 2023-06-13 | BASF Agricultural Solutions Seed US LLC | Canola hybrid variety 7CN0065 |
| US11997966B2 (en) | 2020-04-24 | 2024-06-04 | BASF Agricultural Solutions Seed US LLC | Canola hybrid variety 7CN0020 |
| WO2022140762A1 (en) | 2020-12-21 | 2022-06-30 | BASF Agricultural Solutions Seed US LLC | Brassica napus plants comprising an improved fertility restorer |
| TW202342744A (zh) | 2022-03-01 | 2023-11-01 | 美商巴斯夫農業解決方案種子美國有限責任公司 | Ｃａｓ１２ａ切口酶 |
| CN114958880B (zh) * | 2022-04-06 | 2023-08-29 | 吉林大学 | 大豆脂酰-酰基载体蛋白硫酯酶GmFATA2基因及应用 |
| IL326806A (en) | 2023-08-31 | 2026-04-01 | Basf Agricultural Solutions Us Llc | CRISPR-CAS type V primer editing, class 2 |
| WO2025083165A1 (en) | 2023-10-19 | 2025-04-24 | Basf Agricultural Solutions Us Llc | Brassica napus plants having enhanced blackleg resistance |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU639319B2 (en) * | 1990-04-04 | 1993-07-22 | Pioneer Hi-Bred International, Inc. | Production of improved rapeseed exhibiting a reduced saturated fatty acid content |
| US5344771A (en) | 1990-04-26 | 1994-09-06 | Calgene, Inc. | Plant thiosterases |
| US5512482A (en) | 1990-04-26 | 1996-04-30 | Calgene, Inc. | Plant thioesterases |
| EP0563191B2 (en) | 1990-12-20 | 2000-01-19 | E.I. Du Pont De Nemours And Company | Nucleotide sequences of soybean acyl-acp thioesterase genes |
| US5945585A (en) | 1990-12-20 | 1999-08-31 | E. I. Du Pont De Nemours And Company | Specific for palmitoyl, stearoyl and oleoyl-alp thioesters nucleic acid fragments encoding acyl-acp thiosesterase enzymes and the use of these fragments in altering plant oil composition |
| US5455167A (en) | 1991-05-21 | 1995-10-03 | Calgene Inc. | Medium-chain thioesterases in plants |
| IL103267A (en) | 1991-09-24 | 2004-07-25 | Keygene Nv | Process and kit for amplification of restriction fragment obtained from starting dna |
| US5850022A (en) | 1992-10-30 | 1998-12-15 | Calgene, Inc. | Production of myristate in plant cells |
| CA2176137A1 (en) | 1993-11-10 | 1995-05-18 | Alois Toni Voelker | Plant acyl acp thioesterase sequences |
| EP2311959B1 (en) * | 1994-08-31 | 2015-08-12 | E. I. du Pont de Nemours and Company | Nucleotide sequences of canola palmitoyl-ACP thioesterase genes and their use in the regulation of fatty acid content of the oils of soybean and canola plants |
| US5625130A (en) * | 1995-03-07 | 1997-04-29 | Pioneer Hi-Bred International, Inc. | Oilseed Brassica bearing an endogenous oil wherein the levels of oleic, alpha-linolenic, and saturated fatty acids are simultaneously provided in an atypical highly beneficial distribution via genetic control |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US7067722B2 (en) * | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| WO2002008403A2 (en) | 2000-07-25 | 2002-01-31 | Calgene Llc | Nucleic acid sequences encoding beta-ketoacyl-acp synthase and uses thereof |
| BR0312162A (pt) * | 2002-06-21 | 2007-05-29 | Monsanto Technology Llc | seqüências de ácido nucléico relacionadas com a tioesterase e processos de uso para a produção de plantas com composição modificada de ácidos graxos |
| EP3318121A1 (en) * | 2004-10-08 | 2018-05-09 | Dow AgroSciences LLC | Certain plants with "no saturate" or reduced saturate levels of fatty acids in seeds, and oil derived from the seeds |
-
2008
- 2008-07-07 AU AU2008274551A patent/AU2008274551B2/en active Active
- 2008-07-07 EA EA201070114A patent/EA030862B1/ru not_active IP Right Cessation
- 2008-07-07 CN CN200880024009.9A patent/CN101688220B/zh active Active
- 2008-07-07 JP JP2010515401A patent/JP5677839B2/ja not_active Expired - Fee Related
- 2008-07-07 SI SI200831474T patent/SI2167667T1/sl unknown
- 2008-07-07 UA UAA201001364A patent/UA99471C2/ru unknown
- 2008-07-07 PL PL08773917T patent/PL2167667T3/pl unknown
- 2008-07-07 US US12/668,303 patent/US8981180B2/en active Active
- 2008-07-07 ES ES08773917.3T patent/ES2545083T3/es active Active
- 2008-07-07 EP EP20080773917 patent/EP2167667B1/en active Active
- 2008-07-07 DK DK08773917.3T patent/DK2167667T3/en active
- 2008-07-07 WO PCT/EP2008/005551 patent/WO2009007091A2/en not_active Ceased
- 2008-07-07 CA CA3128584A patent/CA3128584A1/en active Pending
- 2008-07-07 CA CA2692687A patent/CA2692687C/en active Active
- 2008-07-08 AR ARP080102946A patent/AR067480A1/es active IP Right Grant
-
2009
- 2009-12-14 ZA ZA2009/08886A patent/ZA200908886B/en unknown
-
2010
- 2010-12-14 ZA ZA2010/09002A patent/ZA201009002B/en unknown
-
2015
- 2015-01-05 US US14/589,178 patent/US10837066B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN101688220A (zh) | 2010-03-31 |
| WO2009007091A2 (en) | 2009-01-15 |
| ZA201009002B (en) | 2011-07-27 |
| EP2167667B1 (en) | 2015-05-20 |
| US20150232951A1 (en) | 2015-08-20 |
| CA2692687A1 (en) | 2009-01-15 |
| EA030862B1 (ru) | 2018-10-31 |
| SI2167667T1 (sl) | 2016-03-31 |
| US20110145944A1 (en) | 2011-06-16 |
| US10837066B2 (en) | 2020-11-17 |
| CN101688220B (zh) | 2017-04-05 |
| CA3128584A1 (en) | 2009-01-15 |
| JP2010532667A (ja) | 2010-10-14 |
| EA201070114A1 (ru) | 2010-08-30 |
| AR067480A1 (es) | 2009-10-14 |
| AU2008274551B2 (en) | 2014-05-29 |
| EP2167667A2 (en) | 2010-03-31 |
| PL2167667T3 (pl) | 2015-10-30 |
| WO2009007091A3 (en) | 2009-07-23 |
| ES2545083T3 (es) | 2015-09-08 |
| AU2008274551A1 (en) | 2009-01-15 |
| DK2167667T3 (en) | 2015-07-27 |
| UA99471C2 (ru) | 2012-08-27 |
| CA2692687C (en) | 2021-10-26 |
| US8981180B2 (en) | 2015-03-17 |
| JP5677839B2 (ja) | 2015-02-25 |
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