ZA200908753B - Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents - Google Patents
Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agentsInfo
- Publication number
- ZA200908753B ZA200908753B ZA200908753A ZA200908753A ZA200908753B ZA 200908753 B ZA200908753 B ZA 200908753B ZA 200908753 A ZA200908753 A ZA 200908753A ZA 200908753 A ZA200908753 A ZA 200908753A ZA 200908753 B ZA200908753 B ZA 200908753B
- Authority
- ZA
- South Africa
- Prior art keywords
- synthesis
- compositions
- methods
- atypical antipsychotic
- antipsychotic agents
- Prior art date
Links
- 239000003693 atypical antipsychotic agent Substances 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
- 229930185107 quinolinone Natural products 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93926207P | 2007-05-21 | 2007-05-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200908753B true ZA200908753B (en) | 2010-07-28 |
Family
ID=40072982
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200908753A ZA200908753B (en) | 2007-05-21 | 2009-01-01 | Compositions, synthesis, and methods of using quinolinone based atypical antipsychotic agents |
Country Status (13)
Country | Link |
---|---|
US (1) | US8247420B2 (xx) |
EP (1) | EP2162135A4 (xx) |
JP (1) | JP5466147B2 (xx) |
CN (1) | CN101754761B (xx) |
AU (1) | AU2008254585B2 (xx) |
BR (1) | BRPI0811844A2 (xx) |
CA (1) | CA2688784A1 (xx) |
IL (1) | IL202003A (xx) |
MX (1) | MX2009012506A (xx) |
NZ (1) | NZ582124A (xx) |
RU (1) | RU2497819C2 (xx) |
WO (1) | WO2008144764A1 (xx) |
ZA (1) | ZA200908753B (xx) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010217772B2 (en) * | 2009-02-26 | 2014-10-23 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of utilizing arylpiperazine derivatives |
EP3309151A1 (en) | 2009-06-25 | 2018-04-18 | Alkermes Pharma Ireland Limited | Heterocyclic compounds for the treatment of neurological and psychological disorders |
PL395469A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Pochodne indoloamin do leczenia chorób osrodkowego ukladu nerwowego |
JP6787926B2 (ja) | 2015-01-12 | 2020-11-18 | レビバ ファーマシューティカルズ,インコーポレイティド | 肺高血圧症の治療方法 |
CN106749219A (zh) * | 2015-11-20 | 2017-05-31 | 江苏恩华药业股份有限公司 | 一种内酰胺类衍生物及其应用 |
RU2667954C2 (ru) * | 2016-03-04 | 2018-09-25 | Общество С Ограниченной Ответственностью "Валентек" | Фармацевтическая композиция для лечения функциональных психических расстройств |
KR102444803B1 (ko) * | 2017-05-04 | 2022-09-19 | 익스시바 게엠베하 | 신규 조성물, 조합 및 그의 방법을 갖는 표적 약물 구제 |
WO2018234805A1 (en) * | 2017-06-22 | 2018-12-27 | Curadev Pharma Limited | SMALL MOLECULAR MODULATORS OF HUMAN STING |
UA125730C2 (uk) | 2017-06-22 | 2022-05-25 | Курадев Фарма Лімітед | Низькомолекулярні модулятори sting людини |
AU2019230014A1 (en) | 2018-03-05 | 2020-09-17 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
CN115784983A (zh) * | 2022-12-05 | 2023-03-14 | 井冈山大学 | 6-胺烷氧基-3,4-二氢喹啉酮衍生物及制备方法和应用 |
CN116496234A (zh) * | 2023-02-09 | 2023-07-28 | 江苏润安制药有限公司 | 一种盐酸乌拉地尔关键中间体的制备方法 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
JPS54130587A (en) * | 1978-03-30 | 1979-10-09 | Otsuka Pharmaceut Co Ltd | Carbostyryl derivative |
JPS5649364A (en) * | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
JPS5649361A (en) * | 1979-09-28 | 1981-05-02 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
DE3442570A1 (de) * | 1984-11-22 | 1986-05-22 | Hoechst Ag, 6230 Frankfurt | Neue substituierte phenylpiperazinderivate, verfahren zu deren herstellung und die verwendung substituierter phenylpiperazinderivate als aggressionshemmer fuer tiere |
DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
JP2608788B2 (ja) * | 1988-10-31 | 1997-05-14 | 大塚製薬 株式会社 | 精神分裂病治療剤 |
US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
US5776959A (en) | 1995-06-05 | 1998-07-07 | Washington University | Anticonvulsant and anxiolytic lactam and thiolactam derivatives |
EP0900792B1 (en) * | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
US6174882B1 (en) * | 1998-11-23 | 2001-01-16 | Sepracor Inc. | 2-hydroxymethylolanzapine compositions and methods |
US6432985B2 (en) | 2000-04-25 | 2002-08-13 | Hoffmann-La Roche Inc. | Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists |
US6521623B1 (en) | 2000-09-19 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
SE0200301D0 (sv) | 2002-02-01 | 2002-02-01 | Axon Biochemicals Bv | Thio-carbostyril derivative |
PL218788B1 (pl) * | 2002-03-29 | 2015-01-30 | Janssen Pharmaceutica Nv | Znakowane radioaktywnie pochodne chinoliny i jej zastosowanie |
TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
BR0314393A (pt) * | 2002-09-17 | 2005-07-19 | Warner Lambert Co | Piperazinas heterocìclicas substituìdas para o tratamento de esquizofrenia |
EP1480953B2 (en) | 2003-01-09 | 2010-08-18 | Otsuka Pharmaceutical Co., Ltd. | Process for preparing aripiprazole |
TWI289141B (en) * | 2003-03-11 | 2007-11-01 | Hoffmann La Roche F. Ag. | Quinolinone derivatives and uses thereof |
CA2428237C (en) | 2003-05-08 | 2010-07-20 | Delmar Chemicals Inc. | Process for the preparation of carbostyril derivatives |
PL1626721T3 (pl) * | 2003-05-23 | 2017-05-31 | Otsuka Pharmaceutical Co., Ltd. | Pochodne karbostyrylu i stabilizatory nastroju do leczenia zaburzeń nastroju |
US7160888B2 (en) * | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
EP1797039A1 (en) | 2004-09-13 | 2007-06-20 | Matrix Laboratories Ltd | Process for the preparation of polymorphs, solvates of aripiprazole using aripiprazole acid salts |
US7872132B2 (en) | 2004-10-08 | 2011-01-18 | Suven Life Sciences Limited | Intermediates useful for the preparation of aripiprazole and methods for the preparation of the novel intermediates and aripiprazole |
-
2008
- 2008-05-21 EP EP20080756096 patent/EP2162135A4/en not_active Withdrawn
- 2008-05-21 RU RU2009147268/04A patent/RU2497819C2/ru not_active IP Right Cessation
- 2008-05-21 US US12/124,985 patent/US8247420B2/en active Active
- 2008-05-21 WO PCT/US2008/064433 patent/WO2008144764A1/en active Application Filing
- 2008-05-21 BR BRPI0811844-2A2A patent/BRPI0811844A2/pt not_active IP Right Cessation
- 2008-05-21 MX MX2009012506A patent/MX2009012506A/es active IP Right Grant
- 2008-05-21 AU AU2008254585A patent/AU2008254585B2/en not_active Ceased
- 2008-05-21 NZ NZ582124A patent/NZ582124A/en not_active IP Right Cessation
- 2008-05-21 CN CN200880025022.6A patent/CN101754761B/zh not_active Expired - Fee Related
- 2008-05-21 JP JP2010509539A patent/JP5466147B2/ja not_active Expired - Fee Related
- 2008-05-21 CA CA2688784A patent/CA2688784A1/en not_active Abandoned
-
2009
- 2009-01-01 ZA ZA200908753A patent/ZA200908753B/xx unknown
- 2009-11-09 IL IL202003A patent/IL202003A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ582124A (en) | 2012-07-27 |
JP2010528042A (ja) | 2010-08-19 |
EP2162135A1 (en) | 2010-03-17 |
BRPI0811844A2 (pt) | 2014-11-18 |
RU2009147268A (ru) | 2011-06-27 |
RU2497819C2 (ru) | 2013-11-10 |
US8247420B2 (en) | 2012-08-21 |
CN101754761B (zh) | 2014-06-18 |
CA2688784A1 (en) | 2008-11-27 |
EP2162135A4 (en) | 2012-02-22 |
US20080293736A1 (en) | 2008-11-27 |
AU2008254585A1 (en) | 2008-11-27 |
CN101754761A (zh) | 2010-06-23 |
AU2008254585B2 (en) | 2013-09-26 |
IL202003A0 (en) | 2010-06-16 |
WO2008144764A1 (en) | 2008-11-27 |
MX2009012506A (es) | 2009-12-09 |
IL202003A (en) | 2013-11-28 |
JP5466147B2 (ja) | 2014-04-09 |
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