ZA200906241B - Novel tetrahydrocarbazole derivatives as ligands of G-protein coupled receptors - Google Patents
Novel tetrahydrocarbazole derivatives as ligands of G-protein coupled receptorsInfo
- Publication number
- ZA200906241B ZA200906241B ZA200906241A ZA200906241A ZA200906241B ZA 200906241 B ZA200906241 B ZA 200906241B ZA 200906241 A ZA200906241 A ZA 200906241A ZA 200906241 A ZA200906241 A ZA 200906241A ZA 200906241 B ZA200906241 B ZA 200906241B
- Authority
- ZA
- South Africa
- Prior art keywords
- ligands
- protein coupled
- coupled receptors
- tetrahydrocarbazole derivatives
- novel tetrahydrocarbazole
- Prior art date
Links
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- Health & Medical Sciences (AREA)
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- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07107094A EP1988098A1 (en) | 2007-04-27 | 2007-04-27 | Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200906241B true ZA200906241B (en) | 2010-04-28 |
Family
ID=38529386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200906241A ZA200906241B (en) | 2007-04-27 | 2009-09-09 | Novel tetrahydrocarbazole derivatives as ligands of G-protein coupled receptors |
Country Status (18)
Country | Link |
---|---|
US (2) | US8148546B2 (uk) |
EP (2) | EP1988098A1 (uk) |
JP (1) | JP5371956B2 (uk) |
KR (1) | KR20100015967A (uk) |
CN (1) | CN101668769B (uk) |
AR (1) | AR066145A1 (uk) |
AU (1) | AU2008244305B2 (uk) |
BR (1) | BRPI0810613A2 (uk) |
CA (1) | CA2685428A1 (uk) |
HK (1) | HK1138601A1 (uk) |
IL (1) | IL200851A0 (uk) |
MX (1) | MX2009011348A (uk) |
NZ (1) | NZ579671A (uk) |
RU (1) | RU2497806C9 (uk) |
TW (1) | TWI432454B (uk) |
UA (1) | UA99618C2 (uk) |
WO (1) | WO2008132153A1 (uk) |
ZA (1) | ZA200906241B (uk) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2095818A1 (en) * | 2008-02-29 | 2009-09-02 | AEterna Zentaris GmbH | Use of LHRH antagonists at non-castrating doses |
EA023259B1 (ru) | 2011-01-04 | 2016-05-31 | Новартис Аг | Индольные соединения или их аналоги, полезные для лечения возрастной макулярной дегенерации (amd) |
US8748470B2 (en) * | 2011-03-17 | 2014-06-10 | The University Of Chicago | Methods for treating ovarian cancer by inhibiting fatty acid binding proteins |
CN102139107B (zh) * | 2011-03-23 | 2012-10-03 | 浙江理工大学 | 神经激肽受体拮抗剂在制备抗癌药物中的用途 |
CN103142593B (zh) * | 2011-03-23 | 2014-07-16 | 浙江理工大学 | 神经激肽受体2的拮抗剂在白血病治疗中的用途 |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
LT2782584T (lt) | 2011-11-23 | 2021-09-10 | Therapeuticsmd, Inc. | Natūralios kombinuotos pakaitinės hormonų terapijos kompozicijos ir gydymas |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
EP2867224B1 (en) | 2012-06-28 | 2017-07-26 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
EP2867227B1 (en) | 2012-06-28 | 2018-11-21 | Novartis AG | Complement pathway modulators and uses thereof |
JP6273274B2 (ja) | 2012-06-28 | 2018-01-31 | ノバルティス アーゲー | 補体経路モジュレーターおよびその使用 |
ES2648962T3 (es) | 2012-06-28 | 2018-01-09 | Novartis Ag | Derivados de pirrolidina y su uso como moduladores de la vía del complemento |
CN104619698B (zh) | 2012-06-28 | 2016-08-31 | 诺华股份有限公司 | 吡咯烷衍生物及其作为补体途径调节剂的用途 |
EA201590200A1 (ru) | 2012-07-12 | 2015-08-31 | Новартис Аг | Модуляторы пути активации комплемента и их применение |
CN103864754B (zh) * | 2012-12-10 | 2016-12-21 | 中国科学院上海药物研究所 | 五元唑类杂环化合物及其制备方法、药物组合物和用途 |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
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DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
RU2207340C2 (ru) * | 2001-08-10 | 2003-06-27 | Ципла Лтд. | Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей |
JP2005518375A (ja) * | 2001-12-14 | 2005-06-23 | ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング | Gタンパク質結合受容体(gpcr)のためのリガンドとしてのテトラヒドロカルバゾール誘導体 |
DE102004033902A1 (de) * | 2004-07-14 | 2006-02-16 | Zentaris Gmbh | Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's) |
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2007
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2008
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- 2008-04-25 CN CN200880013673.3A patent/CN101668769B/zh not_active Expired - Fee Related
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- 2008-04-25 BR BRPI0810613A patent/BRPI0810613A2/pt not_active IP Right Cessation
- 2008-04-25 EP EP08749717A patent/EP2150558A1/en not_active Withdrawn
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- 2008-04-25 AR ARP080101755A patent/AR066145A1/es unknown
- 2008-04-25 WO PCT/EP2008/055039 patent/WO2008132153A1/en active Application Filing
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- 2008-04-25 CA CA002685428A patent/CA2685428A1/en not_active Abandoned
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KR20100015967A (ko) | 2010-02-12 |
JP5371956B2 (ja) | 2013-12-18 |
US8541462B2 (en) | 2013-09-24 |
AU2008244305B2 (en) | 2013-08-01 |
CA2685428A1 (en) | 2008-11-06 |
UA99618C2 (uk) | 2012-09-10 |
MX2009011348A (es) | 2009-11-05 |
RU2009143990A (ru) | 2011-06-10 |
US20120122763A1 (en) | 2012-05-17 |
CN101668769B (zh) | 2014-07-02 |
AU2008244305A1 (en) | 2008-11-06 |
TWI432454B (zh) | 2014-04-01 |
EP1988098A1 (en) | 2008-11-05 |
BRPI0810613A2 (pt) | 2017-05-09 |
CN101668769A (zh) | 2010-03-10 |
JP2010525028A (ja) | 2010-07-22 |
RU2497806C2 (ru) | 2013-11-10 |
WO2008132153A1 (en) | 2008-11-06 |
EP2150558A1 (en) | 2010-02-10 |
NZ579671A (en) | 2011-06-30 |
TW200909448A (en) | 2009-03-01 |
IL200851A0 (en) | 2010-05-17 |
RU2497806C9 (ru) | 2014-01-20 |
US8148546B2 (en) | 2012-04-03 |
HK1138601A1 (en) | 2010-08-27 |
AR066145A1 (es) | 2009-07-29 |
US20090170783A1 (en) | 2009-07-02 |
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