BRPI0810613A2 - derivados de tetra-hidrocarbazol como ligantes de receptores acoplados à proteína g - Google Patents

derivados de tetra-hidrocarbazol como ligantes de receptores acoplados à proteína g

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Publication number
BRPI0810613A2
BRPI0810613A2 BRPI0810613A BRPI0810613A BRPI0810613A2 BR PI0810613 A2 BRPI0810613 A2 BR PI0810613A2 BR PI0810613 A BRPI0810613 A BR PI0810613A BR PI0810613 A BRPI0810613 A BR PI0810613A BR PI0810613 A2 BRPI0810613 A2 BR PI0810613A2
Authority
BR
Brazil
Prior art keywords
coupled receptor
protein coupled
receptor ligands
tetrahydrocarbazole derivatives
tetrahydrocarbazole
Prior art date
Application number
BRPI0810613A
Other languages
English (en)
Inventor
Günther Eckhard
Polymeropoulos Emmanuel
Paulini Klaus
Teifel Michael
Schmidt Peter
Baasner Silke
Schuster Tlmamm
Original Assignee
Aeterna Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Publication of BRPI0810613A2 publication Critical patent/BRPI0810613A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
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  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
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BRPI0810613A 2007-04-27 2008-04-25 derivados de tetra-hidrocarbazol como ligantes de receptores acoplados à proteína g BRPI0810613A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91442407P 2007-04-27 2007-04-27
EP07107094A EP1988098A1 (en) 2007-04-27 2007-04-27 Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
PCT/EP2008/055039 WO2008132153A1 (en) 2007-04-27 2008-04-25 Novel tetrahydrocarbazole derivatives as ligands of g-protein coupled receptors

Publications (1)

Publication Number Publication Date
BRPI0810613A2 true BRPI0810613A2 (pt) 2017-05-09

Family

ID=38529386

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0810613A BRPI0810613A2 (pt) 2007-04-27 2008-04-25 derivados de tetra-hidrocarbazol como ligantes de receptores acoplados à proteína g

Country Status (18)

Country Link
US (2) US8148546B2 (pt)
EP (2) EP1988098A1 (pt)
JP (1) JP5371956B2 (pt)
KR (1) KR20100015967A (pt)
CN (1) CN101668769B (pt)
AR (1) AR066145A1 (pt)
AU (1) AU2008244305B2 (pt)
BR (1) BRPI0810613A2 (pt)
CA (1) CA2685428A1 (pt)
HK (1) HK1138601A1 (pt)
IL (1) IL200851A0 (pt)
MX (1) MX2009011348A (pt)
NZ (1) NZ579671A (pt)
RU (1) RU2497806C9 (pt)
TW (1) TWI432454B (pt)
UA (1) UA99618C2 (pt)
WO (1) WO2008132153A1 (pt)
ZA (1) ZA200906241B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2095818A1 (en) 2008-02-29 2009-09-02 AEterna Zentaris GmbH Use of LHRH antagonists at non-castrating doses
CN103402996B (zh) 2011-01-04 2015-02-11 诺瓦提斯公司 可用于治疗年龄相关性黄斑变性(amd)的吲哚化合物或其类似物
US8748470B2 (en) * 2011-03-17 2014-06-10 The University Of Chicago Methods for treating ovarian cancer by inhibiting fatty acid binding proteins
CN103142593B (zh) * 2011-03-23 2014-07-16 浙江理工大学 神经激肽受体2的拮抗剂在白血病治疗中的用途
CN102139107B (zh) * 2011-03-23 2012-10-03 浙江理工大学 神经激肽受体拮抗剂在制备抗癌药物中的用途
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CA2856520C (en) 2011-11-23 2021-04-06 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2644700T3 (es) 2012-06-28 2017-11-30 Novartis Ag Derivados de pirrolidina y su uso como moduladores de la ruta del complemento
WO2014002051A2 (en) 2012-06-28 2014-01-03 Novartis Ag Complement pathway modulators and uses thereof
WO2014002052A1 (en) 2012-06-28 2014-01-03 Novartis Ag Pyrrolidine derivatives and their use as complement pathway modulators
ES2647124T3 (es) 2012-06-28 2017-12-19 Novartis Ag Derivados de pirrolidina y su uso como moduladores de la ruta del complemento
CN104640855B (zh) 2012-06-28 2017-08-29 诺华股份有限公司 补体途经调节剂及其用途
CN104684910B (zh) 2012-07-12 2016-10-12 诺华股份有限公司 补体途经调节剂及其用途
CN103864754B (zh) * 2012-12-10 2016-12-21 中国科学院上海药物研究所 五元唑类杂环化合物及其制备方法、药物组合物和用途
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
EP2959013A2 (en) * 2013-02-25 2015-12-30 Novartis AG Novel androgen receptor mutation
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN106794175B (zh) 2014-06-12 2020-06-09 西达-赛奈医疗中心 用于治疗癌症的组合物
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
CA3020153A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
EP3463419A4 (en) 2016-05-27 2020-03-25 Forsyth Dental Infirmary for Children COMPOSITIONS AND METHODS FOR TREATING CANCER USING LIPIDAGONISTS AND RECEPTORS THEREOF
CN109369510A (zh) * 2018-10-31 2019-02-22 云南大学 具有抗hiv活性的双甲氧基取代咔唑类化合物制备及用途
TR201819936A2 (pt) * 2018-12-20 2020-07-21 Hacettepe Ueniversitesi
WO2021067600A1 (en) * 2019-10-03 2021-04-08 Caren Pharmaceuticals, Inc. Combination hormone formulations and therapies
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations
CN114790166B (zh) * 2022-04-28 2023-06-23 周口市公共检验检测中心 四氢咔唑类衍生物及其在制备抗肿瘤药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
RU2207340C2 (ru) * 2001-08-10 2003-06-27 Ципла Лтд. Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
WO2003051837A2 (de) * 2001-12-14 2003-06-26 Zentaris Gmbh Tetrahydrocarbazolderivate als liganden für g-protein gekoppelte rezeptoren (gpcr)
DE102004033902A1 (de) * 2004-07-14 2006-02-16 Zentaris Gmbh Neue Tetrahydrocarbazolderivate mit verbesserter biologischer Wirkung und verbesserter Löslichkeit als Liganden für G-Protein gekoppelte Rezeptoren (GPCR's)

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