EP2250185A4 - Novel lupane derivatives - Google Patents

Novel lupane derivatives

Info

Publication number
EP2250185A4
EP2250185A4 EP08869088A EP08869088A EP2250185A4 EP 2250185 A4 EP2250185 A4 EP 2250185A4 EP 08869088 A EP08869088 A EP 08869088A EP 08869088 A EP08869088 A EP 08869088A EP 2250185 A4 EP2250185 A4 EP 2250185A4
Authority
EP
European Patent Office
Prior art keywords
novel
lupane derivatives
derivatives
novel lupane
lupane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08869088A
Other languages
German (de)
French (fr)
Other versions
EP2250185A1 (en
Inventor
Christophe Moinet
Liliane Halab
Nathalie Turcotte
Monica Bubenik
Marc Courchesne
Carl Poisson
Oswy Z Pereira
Paul Nguyen-Ba
Bingcan Liu
Nathalie Chauret
Caroline Cadilhac
Chun Kong Laval Chan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Virochem Pharma Inc
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of EP2250185A1 publication Critical patent/EP2250185A1/en
Publication of EP2250185A4 publication Critical patent/EP2250185A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP08869088A 2008-01-03 2008-12-23 Novel lupane derivatives Withdrawn EP2250185A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1875908P 2008-01-03 2008-01-03
US3966008P 2008-03-26 2008-03-26
PCT/CA2008/002291 WO2009082819A1 (en) 2008-01-03 2008-12-23 Novel lupane derivatives

Publications (2)

Publication Number Publication Date
EP2250185A1 EP2250185A1 (en) 2010-11-17
EP2250185A4 true EP2250185A4 (en) 2011-11-16

Family

ID=40823729

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08869088A Withdrawn EP2250185A4 (en) 2008-01-03 2008-12-23 Novel lupane derivatives

Country Status (7)

Country Link
EP (1) EP2250185A4 (en)
JP (1) JP2011508748A (en)
CN (1) CN101981047A (en)
AU (1) AU2008342537A1 (en)
CA (1) CA2711424A1 (en)
MX (1) MX2010007375A (en)
WO (1) WO2009082819A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993542B2 (en) 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
CN102245182B (en) * 2008-12-11 2014-07-23 盐野义制药株式会社 Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates
US9067966B2 (en) 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
ES2670811T3 (en) 2010-01-27 2018-06-01 Viiv Healthcare Company Antiviral therapy
KR20120138761A (en) * 2010-02-11 2012-12-26 글락소스미스클라인 엘엘씨 Derivatives of betulin
AU2011216243B2 (en) 2010-02-12 2015-07-09 Chimerix, Inc. Nucleoside phosphonate salts
CA2797601A1 (en) 2010-04-26 2011-11-10 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
US9340513B2 (en) * 2011-12-14 2016-05-17 Glaxosmithkline Llc Propenoate derivatives of betulin
JO3387B1 (en) 2011-12-16 2019-03-13 Glaxosmithkline Llc Derivatives of betulin
CN103242413B (en) 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane triterpene system's derivative and pharmaceutical use thereof
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
CA2893959A1 (en) 2012-12-14 2014-06-19 Shenshen Cai Pharmaceutical compositions
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
KR20170056702A (en) 2014-09-26 2017-05-23 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Long acting pharmaceutical compositions
JP2017533937A (en) * 2014-11-14 2017-11-16 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド Oxolpen derivatives
MA40886B1 (en) 2015-02-09 2020-03-31 Hetero Research Foundation Novel c-3 triterpenone with c-28 reverse amide derivatives as hiv inhibitors
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017064628A1 (en) * 2015-10-13 2017-04-20 Hetero Research Foundation C-3 novel triterpenone with c-28 urea derivatives as hiv inhibitors
US20190023733A1 (en) * 2016-01-20 2019-01-24 Glaxosmithkline Intellectual Property (No.2) Limited Amine derivatives of lupanes with hiv maturation inhibitory activity
WO2018025247A1 (en) * 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029610A1 (en) * 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
WO2018065930A1 (en) * 2016-10-05 2018-04-12 Hetero Labs Limited C-3 triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018069857A1 (en) * 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090046A1 (en) * 2000-05-23 2001-11-29 Univerzita Palackeho V Olomouci Triterpenoid derivatives
US20060205697A1 (en) * 2004-11-12 2006-09-14 Robinson Gary N Novel betulin derivatives, preparation thereof and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
WO2005112929A2 (en) * 2004-05-20 2005-12-01 Cornell Research Foundation, Inc. Anti-hiv-1 activity of betulinol derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090046A1 (en) * 2000-05-23 2001-11-29 Univerzita Palackeho V Olomouci Triterpenoid derivatives
US20060205697A1 (en) * 2004-11-12 2006-09-14 Robinson Gary N Novel betulin derivatives, preparation thereof and use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2009082819A1 *

Also Published As

Publication number Publication date
AU2008342537A1 (en) 2009-07-09
MX2010007375A (en) 2010-09-30
CA2711424A1 (en) 2009-07-09
WO2009082819A8 (en) 2009-10-22
WO2009082819A1 (en) 2009-07-09
CN101981047A (en) 2011-02-23
JP2011508748A (en) 2011-03-17
EP2250185A1 (en) 2010-11-17

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Legal Events

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DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111017

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 45/06 20060101ALI20111011BHEP

Ipc: A61K 38/55 20060101ALI20111011BHEP

Ipc: C07J 53/00 20060101ALI20111011BHEP

Ipc: C07J 43/00 20060101ALI20111011BHEP

Ipc: C07J 41/00 20060101ALI20111011BHEP

Ipc: A61P 31/18 20060101ALI20111011BHEP

Ipc: A61P 31/12 20060101ALI20111011BHEP

Ipc: A61K 45/00 20060101ALI20111011BHEP

Ipc: A61K 31/58 20060101ALI20111011BHEP

Ipc: A61K 31/575 20060101ALI20111011BHEP

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