EP2250185A4 - Nouveaux dérivés de lupane - Google Patents
Nouveaux dérivés de lupaneInfo
- Publication number
- EP2250185A4 EP2250185A4 EP08869088A EP08869088A EP2250185A4 EP 2250185 A4 EP2250185 A4 EP 2250185A4 EP 08869088 A EP08869088 A EP 08869088A EP 08869088 A EP08869088 A EP 08869088A EP 2250185 A4 EP2250185 A4 EP 2250185A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- novel
- lupane derivatives
- derivatives
- novel lupane
- lupane
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1875908P | 2008-01-03 | 2008-01-03 | |
US3966008P | 2008-03-26 | 2008-03-26 | |
PCT/CA2008/002291 WO2009082819A1 (fr) | 2008-01-03 | 2008-12-23 | Nouveaux dérivés de lupane |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2250185A1 EP2250185A1 (fr) | 2010-11-17 |
EP2250185A4 true EP2250185A4 (fr) | 2011-11-16 |
Family
ID=40823729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08869088A Withdrawn EP2250185A4 (fr) | 2008-01-03 | 2008-12-23 | Nouveaux dérivés de lupane |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2250185A4 (fr) |
JP (1) | JP2011508748A (fr) |
CN (1) | CN101981047A (fr) |
AU (1) | AU2008342537A1 (fr) |
CA (1) | CA2711424A1 (fr) |
MX (1) | MX2010007375A (fr) |
WO (1) | WO2009082819A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102670628B (zh) | 2008-01-25 | 2015-11-25 | 奇默里克斯公司 | 治疗病毒感染的方法 |
US8624023B2 (en) * | 2008-12-11 | 2014-01-07 | Shionogi & Co., Ltd. | Synthesis of carbamoylpyridone HIV integrase inhibitors and intermediates |
US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
TR201807704T4 (tr) | 2010-01-27 | 2018-06-21 | Viiv Healthcare Co | Anti-viral tedavi. |
BR112012019762A2 (pt) * | 2010-02-11 | 2016-02-23 | Glaxosmithkline Llc | composto, composição, e, método para tratar uma doença. |
DK2534150T3 (en) | 2010-02-12 | 2017-06-12 | Chimerix Inc | METHODS OF TREATING VIRUS INFECTION |
WO2011139709A2 (fr) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Méthodes de traitement d'infections rétrovirales et régimes posologiques associés |
AU2012352129B2 (en) * | 2011-12-14 | 2016-02-04 | Glaxosmithkline Llc | Propenoate derivatives of betulin |
JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
CN103242413B (zh) | 2012-02-08 | 2015-08-26 | 江西青峰药业有限公司 | Lupane三萜系衍生物及其药学用途 |
US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
MX2015007563A (es) | 2012-12-14 | 2015-10-14 | Glaxosmithkline Llc | Composiciones farmaceuticas. |
US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
AU2015323321A1 (en) | 2014-09-26 | 2017-04-13 | Glaxosmithkline Intellectual Property (No.2) Limited | Long acting pharmaceutical compositions |
US9969767B2 (en) * | 2014-11-14 | 2018-05-15 | VIIV Healthcare UK (No.5) Limited | Oxolupene derivatives |
MA40886B1 (fr) * | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
WO2016147099A2 (fr) * | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | Nouveaux triterpénone c-3 avec des dérivés amide c-28 servant d'inhibiteurs de vih |
US10669305B2 (en) * | 2015-10-13 | 2020-06-02 | Hetero Labs Limited | C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors |
EP3405474A1 (fr) * | 2016-01-20 | 2018-11-28 | Glaxosmithkline Intellectual Property (No. 2) Limited | Dérivés amine de lupanes ayant une activité inhibitrice de la maturation du vih |
WO2018025247A1 (fr) * | 2016-08-05 | 2018-02-08 | Hetero Labs Limited | Nouvelle triterpénone en c-3 avec des dérivés de diamide en c-28 en tant qu'inhibiteurs du vih |
WO2018029604A1 (fr) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-17 en tant qu'inhibiteurs du vih |
WO2018029610A1 (fr) * | 2016-08-09 | 2018-02-15 | Hetero Labs Limited | Nouvelle triterpénone en c-3 avec des dérivés de n-amide en c-17 en tant qu'inhibiteurs du vih |
WO2018065930A1 (fr) * | 2016-10-05 | 2018-04-12 | Hetero Labs Limited | Triterpénone en c-3 avec des dérivés amides inversés en c-17 en tant qu'inhibiteurs du vih |
WO2018069857A1 (fr) * | 2016-10-12 | 2018-04-19 | Hetero Labs Limited | Nouvelle triterpénone en c-3 à dérivés hétérocycliques d'amide inverse en c-17 utilisés comme inhibiteurs du vih |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001090046A1 (fr) * | 2000-05-23 | 2001-11-29 | Univerzita Palackeho V Olomouci | Derives triterpenoides |
US20060205697A1 (en) * | 2004-11-12 | 2006-09-14 | Robinson Gary N | Novel betulin derivatives, preparation thereof and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
US20060019934A1 (en) * | 2004-05-20 | 2006-01-26 | Saxena Brij B | Anti-HIV-1 activity of betulinol derivatives |
-
2008
- 2008-12-23 CA CA2711424A patent/CA2711424A1/fr not_active Abandoned
- 2008-12-23 MX MX2010007375A patent/MX2010007375A/es not_active Application Discontinuation
- 2008-12-23 WO PCT/CA2008/002291 patent/WO2009082819A1/fr active Application Filing
- 2008-12-23 JP JP2010540997A patent/JP2011508748A/ja not_active Withdrawn
- 2008-12-23 EP EP08869088A patent/EP2250185A4/fr not_active Withdrawn
- 2008-12-23 CN CN2008801275273A patent/CN101981047A/zh active Pending
- 2008-12-23 AU AU2008342537A patent/AU2008342537A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001090046A1 (fr) * | 2000-05-23 | 2001-11-29 | Univerzita Palackeho V Olomouci | Derives triterpenoides |
US20060205697A1 (en) * | 2004-11-12 | 2006-09-14 | Robinson Gary N | Novel betulin derivatives, preparation thereof and use thereof |
Non-Patent Citations (1)
Title |
---|
See also references of WO2009082819A1 * |
Also Published As
Publication number | Publication date |
---|---|
MX2010007375A (es) | 2010-09-30 |
EP2250185A1 (fr) | 2010-11-17 |
JP2011508748A (ja) | 2011-03-17 |
CA2711424A1 (fr) | 2009-07-09 |
AU2008342537A1 (en) | 2009-07-09 |
WO2009082819A1 (fr) | 2009-07-09 |
CN101981047A (zh) | 2011-02-23 |
WO2009082819A8 (fr) | 2009-10-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20100729 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA MK RS |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20111017 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 45/06 20060101ALI20111011BHEP Ipc: A61K 38/55 20060101ALI20111011BHEP Ipc: C07J 53/00 20060101ALI20111011BHEP Ipc: C07J 43/00 20060101ALI20111011BHEP Ipc: C07J 41/00 20060101ALI20111011BHEP Ipc: A61P 31/18 20060101ALI20111011BHEP Ipc: A61P 31/12 20060101ALI20111011BHEP Ipc: A61K 45/00 20060101ALI20111011BHEP Ipc: A61K 31/58 20060101ALI20111011BHEP Ipc: A61K 31/575 20060101ALI20111011BHEP Ipc: C07J 63/00 20060101AFI20111011BHEP |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20120515 |