CA2711424A1 - Nouveaux derives de lupane - Google Patents
Nouveaux derives de lupane Download PDFInfo
- Publication number
- CA2711424A1 CA2711424A1 CA2711424A CA2711424A CA2711424A1 CA 2711424 A1 CA2711424 A1 CA 2711424A1 CA 2711424 A CA2711424 A CA 2711424A CA 2711424 A CA2711424 A CA 2711424A CA 2711424 A1 CA2711424 A1 CA 2711424A1
- Authority
- CA
- Canada
- Prior art keywords
- beta
- alkyl
- ene
- oxolup
- dimethylsuccinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 0 CC(C)C(C(*1)=O)=C(C2CC3)[C@@]1(*)CCC2[C@](C)(CC1)C3[C@@](C)(CC2)C1[C@](C)[C@]2O* Chemical compound CC(C)C(C(*1)=O)=C(C2CC3)[C@@]1(*)CCC2[C@](C)(CC1)C3[C@@](C)(CC2)C1[C@](C)[C@]2O* 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1875908P | 2008-01-03 | 2008-01-03 | |
US61/018,759 | 2008-01-03 | ||
US3966008P | 2008-03-26 | 2008-03-26 | |
US61/039,660 | 2008-03-26 | ||
PCT/CA2008/002291 WO2009082819A1 (fr) | 2008-01-03 | 2008-12-23 | Nouveaux dérivés de lupane |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2711424A1 true CA2711424A1 (fr) | 2009-07-09 |
Family
ID=40823729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2711424A Abandoned CA2711424A1 (fr) | 2008-01-03 | 2008-12-23 | Nouveaux derives de lupane |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP2250185A4 (fr) |
JP (1) | JP2011508748A (fr) |
CN (1) | CN101981047A (fr) |
AU (1) | AU2008342537A1 (fr) |
CA (1) | CA2711424A1 (fr) |
MX (1) | MX2010007375A (fr) |
WO (1) | WO2009082819A1 (fr) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2713105C (fr) | 2008-01-25 | 2016-06-07 | Chimerix, Inc. | Methodes de traitement d'infections virales |
ES2641765T3 (es) * | 2008-12-11 | 2017-11-13 | Shionogi & Co., Ltd. | Síntesis de inhibidores de integrasa de VIH carbamoilpiridona y productos intermedios |
US8802727B2 (en) | 2009-07-14 | 2014-08-12 | Hetero Research Foundation, Hetero Drugs Limited | Pharmaceutically acceptable salts of betulinic acid derivatives |
US9067966B2 (en) | 2009-07-14 | 2015-06-30 | Hetero Research Foundation, Hetero Drugs Ltd. | Lupeol-type triterpene derivatives as antivirals |
MX356891B (es) * | 2010-01-27 | 2018-06-19 | Viiv Healthcare Co | Combinaciones de compuestos que comprenden inhibidores de la integrasa de vih y otros agentes terapéuticos. |
EP2533643A4 (fr) * | 2010-02-11 | 2013-07-10 | Glaxosmithkline Llc | Dérivés de bétuline |
PL2534150T3 (pl) | 2010-02-12 | 2017-09-29 | Chimerix, Inc. | Sposoby leczenia infekcji wirusowej |
CA2797601A1 (fr) | 2010-04-26 | 2011-11-10 | Chimerix, Inc. | Methodes de traitement d'infections retrovirales et regimes posologiques associes |
CN104271550B (zh) * | 2011-12-14 | 2016-09-07 | 葛兰素史克有限责任公司 | 白桦脂醇的丙烯酸酯衍生物 |
JO3387B1 (ar) | 2011-12-16 | 2019-03-13 | Glaxosmithkline Llc | مشتقات بيتولين |
CN103242413B (zh) * | 2012-02-08 | 2015-08-26 | 江西青峰药业有限公司 | Lupane三萜系衍生物及其药学用途 |
US8906889B2 (en) * | 2012-02-15 | 2014-12-09 | Bristol-Myers Squibb Company | C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity |
JP2016503030A (ja) | 2012-12-14 | 2016-02-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 医薬組成物 |
US9637516B2 (en) | 2012-12-31 | 2017-05-02 | Hetero Research Foundation | Betulinic acid proline derivatives as HIV inhibitors |
US20170129916A1 (en) | 2014-06-26 | 2017-05-11 | Hetero Research Foundation | Novel betulinic proline imidazole derivatives as hiv inhibitors |
CA2961528A1 (fr) | 2014-09-26 | 2016-03-31 | Glaxosmithkline Intellectual Property (No.2) Limited | Compositions pharmaceutiques a action prolongee |
RU2017118489A (ru) * | 2014-11-14 | 2018-12-14 | ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД | Оксолупеновые производные |
MA40886B1 (fr) * | 2015-02-09 | 2020-03-31 | Hetero Research Foundation | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih |
WO2016147099A2 (fr) * | 2015-03-16 | 2016-09-22 | Hetero Research Foundation | Nouveaux triterpénone c-3 avec des dérivés amide c-28 servant d'inhibiteurs de vih |
US10669305B2 (en) * | 2015-10-13 | 2020-06-02 | Hetero Labs Limited | C-3 novel triterpenone with C-28 urea derivatives as HIV inhibitors |
JP2019502728A (ja) * | 2016-01-20 | 2019-01-31 | グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited | Hiv成熟阻害活性を有するルパンのアミン誘導体 |
WO2018025247A1 (fr) * | 2016-08-05 | 2018-02-08 | Hetero Labs Limited | Nouvelle triterpénone en c-3 avec des dérivés de diamide en c-28 en tant qu'inhibiteurs du vih |
WO2018029604A1 (fr) * | 2016-08-08 | 2018-02-15 | Hetero Labs Limited | Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-17 en tant qu'inhibiteurs du vih |
WO2018029610A1 (fr) * | 2016-08-09 | 2018-02-15 | Hetero Labs Limited | Nouvelle triterpénone en c-3 avec des dérivés de n-amide en c-17 en tant qu'inhibiteurs du vih |
WO2018065930A1 (fr) * | 2016-10-05 | 2018-04-12 | Hetero Labs Limited | Triterpénone en c-3 avec des dérivés amides inversés en c-17 en tant qu'inhibiteurs du vih |
WO2018069857A1 (fr) * | 2016-10-12 | 2018-04-19 | Hetero Labs Limited | Nouvelle triterpénone en c-3 à dérivés hétérocycliques d'amide inverse en c-17 utilisés comme inhibiteurs du vih |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0012528D0 (en) * | 2000-05-23 | 2000-07-12 | Univ Palackeho | Triterpenoid derivatives |
EP1292562A1 (fr) * | 2000-05-23 | 2003-03-19 | Univerzita palackeho V Olomouci | Derives triterpenoides |
US20060019934A1 (en) * | 2004-05-20 | 2006-01-26 | Saxena Brij B | Anti-HIV-1 activity of betulinol derivatives |
TW200628161A (en) * | 2004-11-12 | 2006-08-16 | Panacos Pharmaceuticals Inc | Novel betulin derivatives, preparation thereof and use thereof |
-
2008
- 2008-12-23 CA CA2711424A patent/CA2711424A1/fr not_active Abandoned
- 2008-12-23 JP JP2010540997A patent/JP2011508748A/ja not_active Withdrawn
- 2008-12-23 WO PCT/CA2008/002291 patent/WO2009082819A1/fr active Application Filing
- 2008-12-23 AU AU2008342537A patent/AU2008342537A1/en not_active Abandoned
- 2008-12-23 EP EP08869088A patent/EP2250185A4/fr not_active Withdrawn
- 2008-12-23 CN CN2008801275273A patent/CN101981047A/zh active Pending
- 2008-12-23 MX MX2010007375A patent/MX2010007375A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2008342537A1 (en) | 2009-07-09 |
CN101981047A (zh) | 2011-02-23 |
EP2250185A4 (fr) | 2011-11-16 |
EP2250185A1 (fr) | 2010-11-17 |
WO2009082819A8 (fr) | 2009-10-22 |
JP2011508748A (ja) | 2011-03-17 |
MX2010007375A (es) | 2010-09-30 |
WO2009082819A1 (fr) | 2009-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |
Effective date: 20121224 |