MX2010007375A - Novel lupane derivatives. - Google Patents

Novel lupane derivatives.

Info

Publication number
MX2010007375A
MX2010007375A MX2010007375A MX2010007375A MX2010007375A MX 2010007375 A MX2010007375 A MX 2010007375A MX 2010007375 A MX2010007375 A MX 2010007375A MX 2010007375 A MX2010007375 A MX 2010007375A MX 2010007375 A MX2010007375 A MX 2010007375A
Authority
MX
Mexico
Prior art keywords
sup
lt
gt
formula
treatment
Prior art date
Application number
MX2010007375A
Other languages
Spanish (es)
Inventor
Christophe Moinet
Oswy Z Pereira
Laval Chan Chun Kong
Liliane Halab
Carl Poisson
Monica Bubenik
Marc Courchesne
Nathalie Chauret
Caroline Cadilhac
Bingcan Liu
Paul Nguyen-Ba
Nathalie Turcotte
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US1875908P priority Critical
Priority to US3966008P priority
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Priority to PCT/CA2008/002291 priority patent/WO2009082819A1/en
Publication of MX2010007375A publication Critical patent/MX2010007375A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55Protease inhibitors

Abstract

The invention relates to 21-keto triterpene compounds of formula (I): wherein R<sup>1</sup>, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
MX2010007375A 2008-01-03 2008-12-23 Novel lupane derivatives. MX2010007375A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US1875908P true 2008-01-03 2008-01-03
US3966008P true 2008-03-26 2008-03-26
PCT/CA2008/002291 WO2009082819A1 (en) 2008-01-03 2008-12-23 Novel lupane derivatives

Publications (1)

Publication Number Publication Date
MX2010007375A true MX2010007375A (en) 2010-09-30

Family

ID=40823729

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010007375A MX2010007375A (en) 2008-01-03 2008-12-23 Novel lupane derivatives.

Country Status (7)

Country Link
EP (1) EP2250185A4 (en)
JP (1) JP2011508748A (en)
CN (1) CN101981047A (en)
AU (1) AU2008342537A1 (en)
CA (1) CA2711424A1 (en)
MX (1) MX2010007375A (en)
WO (1) WO2009082819A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8993542B2 (en) 2008-01-25 2015-03-31 Chimerix Inc. Methods of treating viral infections
KR101733625B1 (en) * 2008-12-11 2017-05-10 시오노기세야쿠 가부시키가이샤 Synthesis of carbamoylpyridone hiv integrase inhibitors and intermediates
US8802727B2 (en) 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
US9067966B2 (en) * 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
ES2670811T3 (en) * 2010-01-27 2018-06-01 Viiv Healthcare Company antiviral therapy
AU2011215986A1 (en) * 2010-02-11 2012-08-30 Glaxosmithkline Llc Derivatives of betulin
DK2534150T3 (en) 2010-02-12 2017-06-12 Chimerix Inc Methods of treating virus infection
AU2011248620B2 (en) 2010-04-26 2015-11-26 Chimerix, Inc. Methods of treating retroviral infections and related dosage regimes
US9340513B2 (en) * 2011-12-14 2016-05-17 Glaxosmithkline Llc Propenoate derivatives of betulin
JO3387B1 (en) 2011-12-16 2019-03-13 Glaxosmithkline Llc Derivatives of betulin
CN103242413B (en) * 2012-02-08 2015-08-26 江西青峰药业有限公司 Lupane triterpenoid derivatives and pharmaceutical use
US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US9795619B2 (en) 2012-12-14 2017-10-24 Glaxosmithkline Llc Pharmaceutical compositions
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
AU2015323321A1 (en) 2014-09-26 2017-04-13 Glaxosmithkline Intellectual Property (No.2) Limited Long acting pharmaceutical compositions
JP2018505216A (en) 2015-02-09 2018-02-22 ヘテロ ラブズ リミテッドHetero Labs Limited C-3 novel triterpenone with C-17 reverse amide derivatives as HIV inhibitors
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
BR112018014622A2 (en) * 2016-01-20 2018-12-11 Glaxosmithkline Ip No 2 Ltd a compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, methods for treating an HIV infection and for preventing an HIV infection, and use of a compound or salt;
WO2018025247A1 (en) * 2016-08-05 2018-02-08 Hetero Labs Limited C-3 novel triterpenone with c-28 diamide derivatives as hiv inhibitors
WO2018029604A1 (en) * 2016-08-08 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018029610A1 (en) * 2016-08-09 2018-02-15 Hetero Labs Limited C-3 novel triterpenone with c-17 n-amide derivatives as hiv inhibitors
WO2018065930A1 (en) * 2016-10-05 2018-04-12 Hetero Labs Limited C-3 triterpenone with c-17 reverse amide derivatives as hiv inhibitors
WO2018069857A1 (en) * 2016-10-12 2018-04-19 Hetero Labs Limited C-3 novel triterpenone with c-17 reverse amide heterocycle derivatives as hiv inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1292562A1 (en) * 2000-05-23 2003-03-19 Univerzita Karlova Praha Triterpenoid derivatives
GB0012528D0 (en) * 2000-05-23 2000-07-12 Univ Palackeho Triterpenoid derivatives
WO2005112929A2 (en) * 2004-05-20 2005-12-01 Cornell Research Foundation, Inc. Anti-hiv-1 activity of betulinol derivatives
TW200628161A (en) * 2004-11-12 2006-08-16 Panacos Pharmaceuticals Inc Novel betulin derivatives, preparation thereof and use thereof

Also Published As

Publication number Publication date
WO2009082819A1 (en) 2009-07-09
JP2011508748A (en) 2011-03-17
CA2711424A1 (en) 2009-07-09
EP2250185A4 (en) 2011-11-16
CN101981047A (en) 2011-02-23
EP2250185A1 (en) 2010-11-17
AU2008342537A1 (en) 2009-07-09
WO2009082819A8 (en) 2009-10-22

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Legal Events

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