ZA200905990B - Recombinant antibodies for treatment of respriratory syncytial virus infections - Google Patents
Recombinant antibodies for treatment of respriratory syncytial virus infectionsInfo
- Publication number
- ZA200905990B ZA200905990B ZA200905990A ZA200905990A ZA200905990B ZA 200905990 B ZA200905990 B ZA 200905990B ZA 200905990 A ZA200905990 A ZA 200905990A ZA 200905990 A ZA200905990 A ZA 200905990A ZA 200905990 B ZA200905990 B ZA 200905990B
- Authority
- ZA
- South Africa
- Prior art keywords
- respriratory
- treatment
- syncytial virus
- recombinant antibodies
- virus infections
- Prior art date
Links
- 230000009385 viral infection Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1027—Paramyxoviridae, e.g. respiratory syncytial virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK2007/000113 WO2007101441A1 (en) | 2006-03-06 | 2007-03-06 | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
DKPA200701291 | 2007-09-07 | ||
US97138707P | 2007-09-11 | 2007-09-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200905990B true ZA200905990B (en) | 2010-05-26 |
Family
ID=39687110
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200905990A ZA200905990B (en) | 2007-03-06 | 2009-08-28 | Recombinant antibodies for treatment of respriratory syncytial virus infections |
Country Status (13)
Country | Link |
---|---|
US (2) | US7879329B2 (xx) |
EP (1) | EP2134747A2 (xx) |
JP (1) | JP2010534057A (xx) |
KR (1) | KR20090127341A (xx) |
CN (1) | CN101679513A (xx) |
AU (1) | AU2008224259A1 (xx) |
BR (1) | BRPI0808673A2 (xx) |
CA (1) | CA2678628A1 (xx) |
IL (1) | IL200330A0 (xx) |
MX (1) | MX2009009226A (xx) |
RU (1) | RU2009136677A (xx) |
WO (1) | WO2008106980A2 (xx) |
ZA (1) | ZA200905990B (xx) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
ATE521704T1 (de) * | 2007-03-01 | 2011-09-15 | Symphogen As | Verfahren zur klonierung verwandter antikörper |
CN101679513A (zh) * | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
JP2008289483A (ja) * | 2007-05-25 | 2008-12-04 | Symphogen As | 真核生物系において発現可能な形質転換体のスクリーニング |
MX2010002044A (es) * | 2007-09-07 | 2010-03-18 | Symphogen As | Metodos para produccion recombinante de anticuerpos anti-virus sincitial respiratorio (anti-rsv). |
CA2735020A1 (en) * | 2008-08-29 | 2010-03-04 | Symphogen A/S | Method for cloning avian-derived antibodies |
CA2761310C (en) * | 2009-05-07 | 2017-02-28 | Charles S. Craik | Antibodies and methods of use thereof |
JP5762408B2 (ja) * | 2009-08-13 | 2015-08-12 | クルセル ホランド ベー ヴェー | ヒト呼吸器合胞体ウイルス(rsv)に対する抗体および使用方法 |
KR20120100982A (ko) | 2009-10-09 | 2012-09-12 | 심포젠 에이/에스 | 시그너처 펩티드 및 질량 분광법에 의해 혼합물에서 개별적인 재조합 단백질의 다중 정량 |
CN103097412B (zh) * | 2010-07-09 | 2016-08-10 | 克鲁塞尔荷兰公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
US10392726B2 (en) | 2010-10-08 | 2019-08-27 | President And Fellows Of Harvard College | High-throughput immune sequencing |
GB201019240D0 (en) | 2010-11-15 | 2010-12-29 | Vib Vzw | Respiratory syncytical virus vaccine |
KR101938343B1 (ko) * | 2011-03-09 | 2019-01-14 | 셀 시그널링 테크놀러지, 인크. | 모노클로날 항체를 생성하는 방법 및 시약 |
WO2013095091A2 (en) * | 2011-11-17 | 2013-06-27 | Aimm Therapeutics B.V. | Rsv g protein specific antibodies |
WO2013078223A1 (en) * | 2011-11-23 | 2013-05-30 | Children's Hospital & Research Center Oakland | Anti-factor h binding protein antibodies and methods of use thereof |
US9546219B2 (en) * | 2012-02-08 | 2017-01-17 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
WO2014120555A1 (en) | 2013-01-31 | 2014-08-07 | The Regents Of The University Of California | Antibodies specific for urokinase-type plasminogen activator and methods of use thereof |
CN111303278B (zh) * | 2013-04-15 | 2022-09-06 | 扬森疫苗与预防公司 | 结合到rsv g蛋白的人类抗体 |
KR102201555B1 (ko) * | 2013-04-15 | 2021-01-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Rsv g 단백질에 결합하는 인간 항체 |
US20160340414A1 (en) | 2014-01-15 | 2016-11-24 | Medimmune, Llc | Rsv-specific antibodies and functional parts thereof |
CN105542003B (zh) * | 2016-03-01 | 2019-12-06 | 苏州博泰神州生物技术有限公司 | 一种针对rsv粘附g蛋白表面抗原的全人源单克隆抗体 |
WO2018075954A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
WO2018075974A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
US11312761B2 (en) * | 2016-10-21 | 2022-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
CA3041717A1 (en) | 2016-11-09 | 2018-05-17 | North Carolina State University | Treatment of allergic diseases with chimeric protein |
WO2018140242A1 (en) * | 2017-01-27 | 2018-08-02 | Vanderbilt University | Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus |
DK3872091T3 (da) | 2020-02-26 | 2023-09-11 | Vir Biotechnology Inc | Antistoffer mod sars-cov-2 |
WO2021202463A1 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Anti-rsv antibodies |
CN112225803B (zh) * | 2020-10-20 | 2022-08-05 | 长春百克生物科技股份公司 | 纳米抗体及其应用 |
CN113249333B (zh) * | 2021-03-16 | 2023-06-02 | 贵州省人民医院 | 一种分泌抗呼吸道合胞病毒单克隆抗体的杂交瘤细胞株rsvn4c3 |
CN114134118B (zh) * | 2021-11-22 | 2023-05-09 | 南方医科大学南方医院 | 一种永生化人喉环后区细胞及其构建方法 |
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US607751A (en) * | 1898-07-19 | Wire-stretcher | ||
US5639853A (en) | 1987-09-29 | 1997-06-17 | Praxis Biologics, Inc. | Respiratory syncytial virus vaccines |
ATE175123T1 (de) | 1990-07-19 | 1999-01-15 | Us Commerce | Verbesserte immunotherapeutische methode zur verhinderung oder behandlung viraler krankheiten der atemwege |
US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
CA2144043C (en) | 1992-09-16 | 2005-01-18 | Dennis R. Burton | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
JPH10512846A (ja) | 1994-08-25 | 1998-12-08 | インスティテゥート ヴォー ディールホウデレイ エン ディーゲゾントヘイド (イーデー−デーエルオー) | 呼吸器系合胞体ウィルス(rsv)感染の型または亜型−特異的診断のためのrsvのgタンパク質に由来する抗原ペプチド |
US5922344A (en) | 1995-02-10 | 1999-07-13 | Abbott Laboratories | Product for prevention of respiratory virus infection and method of use |
US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
AU7075496A (en) | 1995-09-18 | 1997-04-09 | Intracel Corporation | Neutralizing monoclonal antibodies to respiratory syncytial virus |
AUPO026596A0 (en) | 1996-06-05 | 1996-06-27 | Biomolecular Research Institute Limited | Viral peptide |
US20020141990A1 (en) | 1996-11-01 | 2002-10-03 | Smithkline Beecham Corporation | Anti-RSV human monoclonal antibodies |
US6699478B1 (en) | 1997-09-19 | 2004-03-02 | Wyeth Holdings Corporation | Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus |
WO2001055217A1 (en) | 2000-01-27 | 2001-08-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
JP2003525061A (ja) | 2000-03-01 | 2003-08-26 | メディミューン,インコーポレイテッド | 高効力組換え抗体およびその産生法 |
US20050175986A1 (en) | 2000-05-09 | 2005-08-11 | Smit Kline Beecham Corporation | Human monoclonal antibody |
ES2316487T5 (es) | 2000-10-18 | 2019-05-13 | The Government Of The Us Secretary Department Of Health And Human Services | Composiciones y métodos para modular la inmunidad e infección de RSV |
US20040161846A1 (en) | 2000-11-22 | 2004-08-19 | Mason Anthony John | Method of expression and agents identified thereby |
US6818216B2 (en) | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
AU2003256823B9 (en) | 2002-07-25 | 2009-01-08 | Medimmune, Llc | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
US20060275766A1 (en) | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
EP1762617A1 (en) * | 2003-01-07 | 2007-03-14 | Symphogen A/S | Method for manufacturing recombinant polyclonal proteins |
US6821450B2 (en) | 2003-01-21 | 2004-11-23 | Hewlett-Packard Development Company, L.P. | Substrate and method of forming substrate for fluid ejection device |
GB0306618D0 (en) | 2003-03-22 | 2003-04-30 | Univ Newcastle | Antibody |
JP4783726B2 (ja) | 2003-03-28 | 2011-09-28 | メディミューン,エルエルシー | 呼吸器合胞体ウイルスサブグループb株9320に関連する組成物および方法 |
WO2004092207A2 (en) | 2003-04-16 | 2004-10-28 | Algonomics N.V. | Respiratory syncytial virus (rsv) peptides |
US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
EP1768993A4 (en) | 2004-06-16 | 2008-07-23 | Univ Johns Hopkins | CYSTEINE-RICH REGION OF SYNCYTIAL RESPIRATORY VIRUS AND METHODS OF USE THEREOF |
BRPI0513706A (pt) | 2004-07-20 | 2008-05-13 | Symphogen As | anticorpo policlonal recombinante anti-rhesus d e métodos de produção |
WO2006007853A2 (en) | 2004-07-20 | 2006-01-26 | Symphogen A/S | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
WO2006034292A2 (en) | 2004-09-21 | 2006-03-30 | Medimmune, Inc. | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
JP2009518320A (ja) | 2005-12-05 | 2009-05-07 | シュムフォウエン アクティーゼルスカブ | 抗オルトポックスウイルス組換えポリクローナル抗体 |
KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
TW200846362A (en) | 2007-02-09 | 2008-12-01 | Symphogen As | A polyclonal antibody product |
CN101679513A (zh) * | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
-
2008
- 2008-03-05 CN CN200880015046A patent/CN101679513A/zh active Pending
- 2008-03-05 KR KR1020097020758A patent/KR20090127341A/ko not_active Application Discontinuation
- 2008-03-05 RU RU2009136677/10A patent/RU2009136677A/ru not_active Application Discontinuation
- 2008-03-05 EP EP08715607A patent/EP2134747A2/en not_active Withdrawn
- 2008-03-05 MX MX2009009226A patent/MX2009009226A/es active IP Right Grant
- 2008-03-05 AU AU2008224259A patent/AU2008224259A1/en not_active Abandoned
- 2008-03-05 WO PCT/DK2008/050053 patent/WO2008106980A2/en active Application Filing
- 2008-03-05 JP JP2009552068A patent/JP2010534057A/ja active Pending
- 2008-03-05 CA CA002678628A patent/CA2678628A1/en not_active Abandoned
- 2008-03-05 BR BRPI0808673-7A2A patent/BRPI0808673A2/pt not_active IP Right Cessation
- 2008-03-06 US US12/073,538 patent/US7879329B2/en not_active Expired - Fee Related
-
2009
- 2009-08-11 IL IL200330A patent/IL200330A0/en unknown
- 2009-08-28 ZA ZA200905990A patent/ZA200905990B/xx unknown
-
2010
- 2010-12-21 US US12/974,585 patent/US20110189171A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101679513A (zh) | 2010-03-24 |
JP2010534057A (ja) | 2010-11-04 |
WO2008106980A2 (en) | 2008-09-12 |
EP2134747A2 (en) | 2009-12-23 |
WO2008106980A3 (en) | 2008-10-30 |
IL200330A0 (en) | 2010-04-29 |
BRPI0808673A2 (pt) | 2014-08-12 |
US20110189171A1 (en) | 2011-08-04 |
AU2008224259A1 (en) | 2008-09-12 |
KR20090127341A (ko) | 2009-12-10 |
CA2678628A1 (en) | 2008-09-12 |
MX2009009226A (es) | 2009-10-28 |
US7879329B2 (en) | 2011-02-01 |
US20080226630A1 (en) | 2008-09-18 |
RU2009136677A (ru) | 2011-04-20 |
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