ZA200902362B - Bicyclic and tricyclic derivatives as thrombin receptor antagonists - Google Patents

Bicyclic and tricyclic derivatives as thrombin receptor antagonists

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Publication number
ZA200902362B
ZA200902362B ZA200902362A ZA200902362A ZA200902362B ZA 200902362 B ZA200902362 B ZA 200902362B ZA 200902362 A ZA200902362 A ZA 200902362A ZA 200902362 A ZA200902362 A ZA 200902362A ZA 200902362 B ZA200902362 B ZA 200902362B
Authority
ZA
South Africa
Prior art keywords
bicyclic
receptor antagonists
thrombin receptor
tricyclic derivatives
tricyclic
Prior art date
Application number
ZA200902362A
Other languages
English (en)
Inventor
Samuel Chackalamannil
Yuguang Wang
Mariappan V Chelliah
Yan Xia
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200902362B publication Critical patent/ZA200902362B/xx

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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ZA200902362A 2006-10-04 2009-04-03 Bicyclic and tricyclic derivatives as thrombin receptor antagonists ZA200902362B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84935406P 2006-10-04 2006-10-04

Publications (1)

Publication Number Publication Date
ZA200902362B true ZA200902362B (en) 2010-10-27

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ID=39269039

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Application Number Title Priority Date Filing Date
ZA200902362A ZA200902362B (en) 2006-10-04 2009-04-03 Bicyclic and tricyclic derivatives as thrombin receptor antagonists

Country Status (13)

Country Link
US (2) US8153664B2 (ko)
EP (1) EP2069326B1 (ko)
JP (1) JP2010505842A (ko)
KR (1) KR20090074219A (ko)
CN (1) CN101541782A (ko)
AR (1) AR063123A1 (ko)
AU (1) AU2007305269A1 (ko)
CA (1) CA2667082A1 (ko)
IL (1) IL198009A0 (ko)
MX (1) MX2009003761A (ko)
TW (1) TW200823205A (ko)
WO (1) WO2008042422A2 (ko)
ZA (1) ZA200902362B (ko)

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KR20190065246A (ko) 2016-07-29 2019-06-11 선오비온 파마슈티컬스 인코포레이티드 화합물 및 조성물 및 이들의 용도
JP7146782B2 (ja) 2017-02-16 2022-10-04 サノビオン ファーマシューティカルズ インク 統合失調症を処置する方法
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EA202091945A1 (ru) 2018-02-16 2021-01-18 Суновион Фармасьютикалз Инк. Соли, кристаллические формы и способы их получения
CN110559294A (zh) * 2018-06-06 2019-12-13 杨仑 脂肪性肝病及其相关疾病的预防和治疗性药物
MX2021010880A (es) 2019-03-14 2022-01-18 Sunovion Pharmaceuticals Inc Sales de un compuesto de isocromanilo y formas cristalinas, procesos de preparacion, usos terapeuticos y composiciones farmaceuticas de las mismas.
CN110627710B (zh) * 2019-09-29 2020-06-05 山东大学 一种新型par-1抑制剂及其制备方法和在预防和/或治疗血栓性疾病中的用途
EP4135690A1 (en) 2020-04-14 2023-02-22 Sunovion Pharmaceuticals Inc. (s)-(4,5-dihydro-7h-thieno[2,3-c]pyran-7-yl)-n-methylmethanamine for treating neurological and psychiatric disorders
CN112759548B (zh) * 2020-12-31 2021-11-02 山东大学 一种par-1抑制剂及其制备方法
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WO2008042422A2 (en) 2008-04-10
US8153664B2 (en) 2012-04-10
US20080090830A1 (en) 2008-04-17
KR20090074219A (ko) 2009-07-06
IL198009A0 (en) 2009-12-24
WO2008042422A3 (en) 2009-03-26
JP2010505842A (ja) 2010-02-25
AU2007305269A1 (en) 2008-04-10
US20120157403A1 (en) 2012-06-21
CN101541782A (zh) 2009-09-23

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