ZA200900959B - Benzofuro-and benzothienopyrylmidine modulators of the histamine H4 receptor - Google Patents

Benzofuro-and benzothienopyrylmidine modulators of the histamine H4 receptor

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Publication number
ZA200900959B
ZA200900959B ZA200900959A ZA200900959A ZA200900959B ZA 200900959 B ZA200900959 B ZA 200900959B ZA 200900959 A ZA200900959 A ZA 200900959A ZA 200900959 A ZA200900959 A ZA 200900959A ZA 200900959 B ZA200900959 B ZA 200900959B
Authority
ZA
South Africa
Prior art keywords
benzothienopyrylmidine
benzofuro
histamine
modulators
receptor
Prior art date
Application number
ZA200900959A
Other languages
English (en)
Inventor
Frank Chavez
Michael P Curtis
James P Edwards
Laurent Gomez
Cheryl A Grice
Aaron M Kearney
Brad M Savall
Anne E Fitzgerald
Jing Lui
Neelakandha S Mani
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of ZA200900959B publication Critical patent/ZA200900959B/xx

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Rheumatology (AREA)
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  • Urology & Nephrology (AREA)
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  • Hematology (AREA)
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  • Transplantation (AREA)
  • Agronomy & Crop Science (AREA)
  • Neurosurgery (AREA)
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ZA200900959A 2006-07-11 2009-02-10 Benzofuro-and benzothienopyrylmidine modulators of the histamine H4 receptor ZA200900959B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83019206P 2006-07-11 2006-07-11

Publications (1)

Publication Number Publication Date
ZA200900959B true ZA200900959B (en) 2010-04-28

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ZA200900959A ZA200900959B (en) 2006-07-11 2009-02-10 Benzofuro-and benzothienopyrylmidine modulators of the histamine H4 receptor

Country Status (24)

Country Link
US (2) US7576092B2 (xx)
EP (1) EP2040549B1 (xx)
JP (1) JP5352458B2 (xx)
KR (1) KR20090028819A (xx)
CN (1) CN101511190A (xx)
AR (1) AR061891A1 (xx)
AU (1) AU2007272956B2 (xx)
BR (1) BRPI0715452A2 (xx)
CA (1) CA2657908A1 (xx)
CL (1) CL2007002007A1 (xx)
CO (1) CO6150182A2 (xx)
CR (1) CR10609A (xx)
EA (1) EA015344B1 (xx)
EC (1) ECSP099061A (xx)
ES (1) ES2441958T3 (xx)
IL (1) IL196448A0 (xx)
MX (1) MX2009000457A (xx)
MY (1) MY145349A (xx)
NO (1) NO20090268L (xx)
PE (1) PE20080520A1 (xx)
TW (1) TW200821315A (xx)
UY (1) UY30479A1 (xx)
WO (1) WO2008008359A2 (xx)
ZA (1) ZA200900959B (xx)

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CL2008000467A1 (es) 2007-02-14 2008-08-22 Janssen Pharmaceutica Nv Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma
WO2009081222A1 (en) * 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
JP5658661B2 (ja) * 2008-06-12 2015-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ 手術後癒着の治療のためのヒスタミンｈ４拮抗物質の使用
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
WO2010064705A1 (ja) * 2008-12-05 2010-06-10 大日本住友製薬株式会社 Ｈ４受容体アンタゴニスト作用を有する新規７位置換ジヒドロピラノピリミジン誘導体
WO2010075270A1 (en) 2008-12-22 2010-07-01 Incyte Corporation 4, 6-disubstituted 2-amino-pyrimidines as histamine h4 receptor modulators
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
IT1393337B1 (it) 2009-03-06 2012-04-20 Italiana Sint Spa Sintesi di (4as, 7as)-ottaidro-1h-pirrolo[3,4-b]piridina
WO2010108059A1 (en) 2009-03-20 2010-09-23 Incyte Corporation Substituted pyrimidine derivatives as antagonists of the histamine h4 receptor
EP2671883A1 (en) * 2012-06-05 2013-12-11 Bioprojet New 6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepines derivatives as histamine H4 receptor ligands
EP2858647B1 (en) 2012-06-08 2018-05-23 Sensorion H4 receptor inhibitors for treating tinnitus
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
UY35370A (es) 2013-03-06 2014-09-30 Janssen Pharmaceutica Nv Moduladores benzoimidazol-2-il pirimidina del receptor de histamina h4
CN108602780A (zh) * 2016-01-29 2018-09-28 明治制果药业株式会社 新的化合物及其药理学上可接受的盐
EP3906241A4 (en) * 2019-01-04 2022-11-02 Bellbrook Labs, Llc INHIBITORS OF CGAS ACTIVITY AS THERAPEUTIC AGENT
KR20230144550A (ko) * 2021-02-11 2023-10-16 벨부르크 랩스, 엘엘씨 치료제로서의 cGAS 활성의 저해제
CN116589472A (zh) * 2023-05-22 2023-08-15 郑州大学 一种苯并呋喃[3,2-d]并嘧啶-2-胺类化合物及其制备方法和应用

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IL196448A0 (en) 2009-11-18
US20090325927A1 (en) 2009-12-31
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US7576092B2 (en) 2009-08-18
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