ZA200808556B - Solid dispersions of poorly soluble drugs in graft copolymers - Google Patents

Solid dispersions of poorly soluble drugs in graft copolymers

Info

Publication number
ZA200808556B
ZA200808556B ZA200808556A ZA200808556A ZA200808556B ZA 200808556 B ZA200808556 B ZA 200808556B ZA 200808556 A ZA200808556 A ZA 200808556A ZA 200808556 A ZA200808556 A ZA 200808556A ZA 200808556 B ZA200808556 B ZA 200808556B
Authority
ZA
South Africa
Prior art keywords
poorly soluble
graft copolymers
solid dispersions
soluble drugs
drugs
Prior art date
Application number
ZA200808556A
Other languages
English (en)
Inventor
Janssens Sandrien
Van Den Mooter Guy
Original Assignee
Leuven K U Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leuven K U Res & Dev filed Critical Leuven K U Res & Dev
Publication of ZA200808556B publication Critical patent/ZA200808556B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200808556A 2006-04-10 2008-01-01 Solid dispersions of poorly soluble drugs in graft copolymers ZA200808556B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0607105.4A GB0607105D0 (en) 2006-04-10 2006-04-10 Enhancing solubility and dissolution rate of poorly soluble drugs

Publications (1)

Publication Number Publication Date
ZA200808556B true ZA200808556B (en) 2009-11-25

Family

ID=36539598

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200808556A ZA200808556B (en) 2006-04-10 2008-01-01 Solid dispersions of poorly soluble drugs in graft copolymers

Country Status (9)

Country Link
US (1) US20110059175A9 (zh)
EP (1) EP2004142A2 (zh)
JP (1) JP2009533357A (zh)
CN (1) CN101460148B (zh)
CA (1) CA2642757A1 (zh)
GB (1) GB0607105D0 (zh)
IL (1) IL194635A0 (zh)
WO (1) WO2007115381A2 (zh)
ZA (1) ZA200808556B (zh)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009042114A2 (en) 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
MX2010008945A (es) * 2008-02-13 2010-09-07 Bayer Schering Pharma Ag Sistema de administracion de drogas con efecto estabilizante.
ES2382618T3 (es) * 2008-03-25 2012-06-11 Formac Pharmaceuticals N.V. Método de preparación para dispersiones sólidas
US20120121703A1 (en) * 2010-07-20 2012-05-17 Japan Tobacco Inc. Tablet containing ferric citrate
US10463739B2 (en) 2010-12-23 2019-11-05 AbbVie Deutschland GmbH & Co. KG Solid retard formulations based on solid dispersions
CN102144982B (zh) * 2011-03-30 2012-12-12 江苏神龙药业有限公司 一种米诺膦酸片及其制备方法
US20140178479A1 (en) * 2011-08-12 2014-06-26 Perosphere, Inc. Concentrated Felbamate Formulations for Parenteral Administration
US9044734B2 (en) 2011-09-23 2015-06-02 Basf Se Diesel oxidation catalyst with layered structure containing ceria composition as palladium support material for enhanced HC and CO gas conversion
EP2649989B1 (en) 2012-04-13 2017-10-18 King Saud University Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof
CN104379174B (zh) * 2012-06-22 2018-01-26 巴斯夫欧洲公司 基于甲基丙烯酸二乙基氨基乙酯共聚物的含活性成分固体分散体
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
EP2919903B1 (en) 2012-11-14 2020-07-22 W.R. Grace & CO. - CONN. Compositions containing a biologically active material and a non-ordered inorganic oxide
US20160074396A1 (en) * 2013-04-11 2016-03-17 Ctc Bio, Inc. Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer
US11116769B2 (en) 2013-04-11 2021-09-14 Ctc Bio, Inc. Tadalafil free base-containing film dosage form containing polyethylene glycol-based polymer and/or vinyl pyrrolidone-based polymer as dispersion stabilizer
CN103330685B (zh) * 2013-07-08 2014-11-26 浙江昂利康制药有限公司 一种头孢克洛颗粒剂及其制备方法
CN103446075B (zh) * 2013-09-04 2016-05-18 回音必集团浙江亚东制药有限公司 一种头孢克洛胶囊及其制备方法
US20150231081A1 (en) * 2014-02-20 2015-08-20 Cadila Healthcare Limited Delayed release posaconazole tablets
TWI525110B (zh) * 2014-12-24 2016-03-11 財團法人工業技術研究院 聚合物、及包含其之醫藥組合物
US20180355165A1 (en) * 2015-12-02 2018-12-13 Nippon Shokubai Co., Ltd. Water-soluble film and manufacturing method therefor
WO2017115746A1 (ja) * 2015-12-28 2017-07-06 沢井製薬株式会社 ゲフィチニブ含有錠剤
CN105832680B (zh) * 2016-05-12 2018-12-25 沈阳药科大学 一种改善螺内酯体外溶出及流动性的药物组合物
MX2019002880A (es) * 2016-09-13 2019-07-04 Procter & Gamble Proceso para elaborar una composicion que comprende particulas de suministro de agente benefico.
CN108261401B (zh) * 2018-01-31 2021-01-08 佛山市南海东方澳龙制药有限公司 伊维菌素固体分散体及伊维菌素片剂
CN117835971A (zh) * 2021-08-25 2024-04-05 巴斯夫欧洲公司 直接压片用辅料组合物
CN114736263B (zh) * 2022-03-08 2023-12-26 天津大学 一种二元共无定形物及其应用
WO2023187599A1 (en) * 2022-03-27 2023-10-05 Didenko Kirill Methods and bioavailable highly permeable compounds for the treatment of viral diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5633A (en) 1848-06-13 Improvement in water-wheels
US15A (en) 1836-08-31 Cotton-planter
DE1077430B (de) 1958-04-15 1960-03-10 Hoechst Ag Verfahren zur Herstellung von Pfropfpolymerisaten von Polyvinylestern
DE3536530A1 (de) 1985-10-12 1987-04-23 Basf Ag Verwendung von pfropfcopolymerisaten aus polyalkylenoxiden und vinylacetat als vergrauungsinhibitoren beim waschen und nachbehandeln von synthesefasern enthaltendem textilgut
US4957974A (en) * 1988-03-29 1990-09-18 Rohm And Haas Company Graft copolymers and blends thereof with polyolefins
DE4317172A1 (de) 1993-05-22 1995-01-05 Rhone Poulenc Rorer Gmbh Geschmacksneutrale und schnellfreisetzende Buflomedil-Hydrochlorid-Arzneiform und Herstellungsverfahren desselben
CA2240161C (en) * 1996-05-20 2005-05-24 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
AU1511399A (en) * 1997-12-31 1999-07-19 Choongwae Pharma Corporation Method and composition of an oral preparation of itraconazole
US6630170B2 (en) * 2001-04-26 2003-10-07 Board Of Regents The University Of Texas System Mesoporous compositions and method of preparation
US20040208931A1 (en) * 2002-12-30 2004-10-21 Friend David R Fast dissolving films for oral administration of drugs
US20040242770A1 (en) * 2003-04-16 2004-12-02 Feldstein Mikhail M. Covalent and non-covalent crosslinking of hydrophilic polymers and adhesive compositions prepared therewith
US20050013863A1 (en) * 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
CA2531564C (en) * 2003-07-18 2016-01-19 Santarus, Inc. Pharmaceutical composition for inhibiting acid secretion
US7914971B2 (en) * 2005-08-12 2011-03-29 Semiconductor Energy Laboratory Co., Ltd. Light exposure mask and method for manufacturing semiconductor device using the same
PL1978936T3 (pl) * 2006-02-03 2013-11-29 Evonik Roehm Gmbh Kompozycje farmaceutyczne zawierające mieszaniny polimerów i trudno rozpuszczalnych w wodzie substancji czynnych

Also Published As

Publication number Publication date
CA2642757A1 (en) 2007-10-18
CN101460148B (zh) 2012-11-14
US20110059175A9 (en) 2011-03-10
US20090311325A1 (en) 2009-12-17
JP2009533357A (ja) 2009-09-17
WO2007115381B1 (en) 2008-02-14
CN101460148A (zh) 2009-06-17
WO2007115381A2 (en) 2007-10-18
GB0607105D0 (en) 2006-05-17
EP2004142A2 (en) 2008-12-24
WO2007115381A3 (en) 2007-12-06
IL194635A0 (en) 2009-08-03

Similar Documents

Publication Publication Date Title
ZA200808556B (en) Solid dispersions of poorly soluble drugs in graft copolymers
EP1863859A4 (en) GRAFT COPOLYMERS OF PEG-POLYACETAL AND PEG-POLYACETAL-POE AND PHARMACEUTICAL COMPOSITIONS
EP2010584A4 (en) GRAFT POLYMERS AND USES THEREOF
EP2068776A4 (en) VASCULAR STENT AND ITS PLACEMENT DEVICE
IL194751A0 (en) Drugs and uses
EP1915449A4 (en) SIRNA-HYDROPHILES POLYMERIC CONJUGATES FOR INTRA-CELLULAR INTRODUCTION OF SIRNA AND METHOD THEREFOR
EP1922019A4 (en) TRI-BLOCK COPOLYMERS FOR MEDICINAL DISPENSING ON NANO BEADS BASE
PT1988910T (pt) Acriloiloxietilfosforilcolina contendo conjugados de polímeros e sua preparação
EP1933881A4 (en) SOLID POLYMER DISPENSING COMPOSITIONS AND APPLICATION METHOD THEREFOR
EP2162493A4 (en) STABLE AND COMPATIBLE POLYMER MIXTURES
EP2119734A4 (en) COPOLYMER AND ITS USE
PL2027208T3 (pl) Amfifilowe kopolimery blokowe
EP2042138A4 (en) PLASTER AND PAVER PREPARATION
GB2440619B (en) Alkylacrylate copolymer dispersants and uses thereof
IL196861A0 (en) Antibodies against ccr5 and uses thereof
EP2119442A4 (en) PHARMACEUTICAL COMPOSITION WITH TACROLIMUS MAINTAINED RELEASE
EP2044980A4 (en) SHEET TYPE OBJECT FOR A BALL, AND BALL
EP1976490A4 (en) EXTENDED RELEASE TABLET CONTAINING ZALTOPROFEN AND PROCESS FOR PREPARING SAID TABLET
EP2053069A4 (en) HYDROPHILIC POLYMER
IL193541A0 (en) Polymer dispersions comprising effect substances and use thereof
EP2127677A4 (en) AMINO ALKYL METHACRYLATE COPOLYMER FOR MAINTAINING THE SOLUBILITY OF A HEAVY WATER-SOLUBLE MEDICAMENT
IL199991A0 (en) Soluble fcgammaria and related methods
GB0610090D0 (en) Particulate drug compositions and their uses
EP1988082A4 (en) MULTICOLORED COMPLEX AND POLYMER THEREOF
GB0611422D0 (en) Polymeric particles and their preparation