ZA200807459B - Pyrrolotriazine aniline prodrugs compounds useful as kinase inhibitors - Google Patents

Pyrrolotriazine aniline prodrugs compounds useful as kinase inhibitors

Info

Publication number
ZA200807459B
ZA200807459B ZA200807459A ZA200807459A ZA200807459B ZA 200807459 B ZA200807459 B ZA 200807459B ZA 200807459 A ZA200807459 A ZA 200807459A ZA 200807459 A ZA200807459 A ZA 200807459A ZA 200807459 B ZA200807459 B ZA 200807459B
Authority
ZA
South Africa
Prior art keywords
kinase inhibitors
compounds useful
prodrugs compounds
pyrrolotriazine
aniline
Prior art date
Application number
ZA200807459A
Other languages
English (en)
Inventor
Liu Chunjian
Leftheris Katerina
Vivekananda M Vrudkhula
Lin James
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of ZA200807459B publication Critical patent/ZA200807459B/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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ZA200807459A 2006-03-07 2008-08-29 Pyrrolotriazine aniline prodrugs compounds useful as kinase inhibitors ZA200807459B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07

Publications (1)

Publication Number Publication Date
ZA200807459B true ZA200807459B (en) 2009-11-25

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ID=38475749

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Application Number Title Priority Date Filing Date
ZA200807459A ZA200807459B (en) 2006-03-07 2008-08-29 Pyrrolotriazine aniline prodrugs compounds useful as kinase inhibitors

Country Status (17)

Country Link
US (2) US7572795B2 (fr)
EP (1) EP2001886A2 (fr)
JP (1) JP2009535295A (fr)
KR (1) KR20080107408A (fr)
CN (1) CN101395158A (fr)
AR (1) AR059778A1 (fr)
AU (1) AU2007223342A1 (fr)
BR (1) BRPI0708644A2 (fr)
CA (1) CA2645031A1 (fr)
EA (1) EA200801945A1 (fr)
IL (1) IL193653A0 (fr)
MX (1) MX2008011136A (fr)
NO (1) NO20083717L (fr)
PE (1) PE20080139A1 (fr)
TW (1) TW200804390A (fr)
WO (1) WO2007103839A2 (fr)
ZA (1) ZA200807459B (fr)

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CN101395158A (zh) * 2006-03-07 2009-03-25 百时美施贵宝公司 可作为激酶抑制剂的吡咯并三嗪苯胺前体药物化合物
WO2009158450A1 (fr) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Formes cristallines de ((((4-((5-(cyclopropylcarbamoyl)-2-méthylphényl)- amino)-5-méthylpyrrolo-[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)- carbamoyl)oxy)méthyl-(4-(phosphonooxy)phényl)acétate, leur préparation et utilisation
WO2009158446A2 (fr) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Formes cristallines de ((((4-((5-(cyclopropylcarbamoyl)-2-méthylphényl)amino)-5-méthylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)méthyl (4-(phosphonooxy)phényl)acétate, procédé d'élaboration et d'utilisation
DK2334378T3 (da) 2008-08-19 2014-07-07 Xenoport Inc Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
AU2010266040B2 (en) 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
ES2512727T3 (es) * 2009-09-29 2014-10-24 Glaxo Group Limited Nuevos compuestos
CN102596921B (zh) * 2009-09-29 2015-04-29 葛兰素集团有限公司 新化合物
JP5752232B2 (ja) 2010-03-31 2015-07-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ プロテインキナーゼ阻害剤としての置換ピロロトリアジン化合物
WO2012031057A1 (fr) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms-582949 pour le traitement d'une maladie rhumatismale résistante
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
US8901305B2 (en) * 2012-07-31 2014-12-02 Bristol-Myers Squibb Company Aryl lactam kinase inhibitors
WO2014031892A1 (fr) 2012-08-22 2014-02-27 Xenoport, Inc. Formes pharmaceutiques orales de fumarate de méthyle-hydrogène et leurs promédicaments
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014160633A1 (fr) 2013-03-24 2014-10-02 Xenoport, Inc. Compositions pharmaceutiques de fumarate de diméthyle
WO2014197860A1 (fr) 2013-06-07 2014-12-11 Xenoport, Inc. Procédé de production de monométhylfumarate
US9421182B2 (en) 2013-06-21 2016-08-23 Xenoport, Inc. Cocrystals of dimethyl fumarate
EP3041467A1 (fr) 2013-09-06 2016-07-13 XenoPort, Inc. Formes cristallines de méthyl(2e)but-2-ène-1,4-dioate de (n,n-diéthylcarbamoyl)méthyle, procédés de synthèse et d'utilisation
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
MA41136A (fr) * 2014-12-09 2017-10-17 Bayer Pharma AG Composés pour le traitement d'un cancer
WO2017070135A1 (fr) * 2015-10-20 2017-04-27 Bristol-Myers Squibb Company Promédicaments de dérivés 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phényl)pipérazin-1-yl)propanamide utilisés comme inhibiteurs de ck2 pour le traitement du cancer
RU2748260C2 (ru) * 2016-04-04 2021-05-21 Кемосентрикс, Инк. РАСТВОРИМЫЕ С5аR АНТАГОНИСТЫ
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 réduisant l'expression du gène dux4 et des gènes aval pour le traitement de la fshd
AU2019230014A1 (en) 2018-03-05 2020-09-17 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
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WO2007103839A2 (fr) 2007-09-13
IL193653A0 (en) 2009-08-03
CA2645031A1 (fr) 2007-09-13
WO2007103839A3 (fr) 2008-06-05
EA200801945A1 (ru) 2009-02-27
MX2008011136A (es) 2008-09-08
PE20080139A1 (es) 2008-03-10
TW200804390A (en) 2008-01-16
JP2009535295A (ja) 2009-10-01
US7572795B2 (en) 2009-08-11
US20090156555A1 (en) 2009-06-18
AU2007223342A1 (en) 2007-09-13
US20070213300A1 (en) 2007-09-13
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CN101395158A (zh) 2009-03-25
EP2001886A2 (fr) 2008-12-17

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