ZA200806366B - Novel 11 beta-hydroxyandrosta-4-ene-3-ones - Google Patents

Novel 11 beta-hydroxyandrosta-4-ene-3-ones

Info

Publication number
ZA200806366B
ZA200806366B ZA200806366A ZA200806366A ZA200806366B ZA 200806366 B ZA200806366 B ZA 200806366B ZA 200806366 A ZA200806366 A ZA 200806366A ZA 200806366 A ZA200806366 A ZA 200806366A ZA 200806366 B ZA200806366 B ZA 200806366B
Authority
ZA
South Africa
Prior art keywords
hydroxyandrosta
ene
beta
ones
novel
Prior art date
Application number
ZA200806366A
Other languages
English (en)
Inventor
Patel Jiten Ranchhodbhai
Patel Gopalkumar Chimanlal
Sheth Gaurav Sanjivkumar
Shah Samir Rameshchandra
Mandhane Sanjar Nandlal
Chitturi Trinadha Rao
Thennati Rajamannar
Original Assignee
Sun Pharma Advanced Res Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharma Advanced Res Co Ltd filed Critical Sun Pharma Advanced Res Co Ltd
Publication of ZA200806366B publication Critical patent/ZA200806366B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
ZA200806366A 2006-01-27 2008-07-22 Novel 11 beta-hydroxyandrosta-4-ene-3-ones ZA200806366B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN131MU2006 2006-01-27

Publications (1)

Publication Number Publication Date
ZA200806366B true ZA200806366B (en) 2009-08-26

Family

ID=38459436

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200806366A ZA200806366B (en) 2006-01-27 2008-07-22 Novel 11 beta-hydroxyandrosta-4-ene-3-ones

Country Status (21)

Country Link
US (1) US8785425B2 (fr)
EP (1) EP2004667B1 (fr)
JP (1) JP5097129B2 (fr)
KR (1) KR101390272B1 (fr)
CN (1) CN101384610B (fr)
AP (1) AP2642A (fr)
AR (1) AR059216A1 (fr)
AU (1) AU2007220114B2 (fr)
BR (1) BRPI0706767A2 (fr)
CA (1) CA2637548C (fr)
EA (1) EA017490B9 (fr)
EC (1) ECSP088689A (fr)
ES (1) ES2428066T3 (fr)
IL (1) IL192983A (fr)
MX (1) MX2008009173A (fr)
NZ (1) NZ569867A (fr)
SG (1) SG170049A1 (fr)
TW (1) TWI374147B (fr)
UA (1) UA95095C2 (fr)
WO (1) WO2007099548A2 (fr)
ZA (1) ZA200806366B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI374147B (en) 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
AU2013202843B2 (en) * 2006-06-14 2015-11-12 Generics [Uk] Limited Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1, 4-diene-17-carbothioate and intermediates
WO2007144668A2 (fr) * 2006-06-14 2007-12-21 Generics [Uk] Limited Nouveau procédé et nouveaux intermédiaires
WO2010136940A1 (fr) 2009-05-29 2010-12-02 Pfizer Limited Nouveaux agonistes du récepteur des glucocorticoïdes
WO2011132171A1 (fr) 2010-04-23 2011-10-27 Piramal Life Sciences Limited Promédicaments d'agents thérapeutiques libérant de l'oxyde nitrique
KR101103943B1 (ko) * 2011-12-12 2012-01-12 오수련 무료이용쿠폰을 활용한 제휴사 및 리셀러의 온라인 제휴마케팅 운영방법
WO2013133980A1 (fr) * 2012-03-05 2013-09-12 Bausch & Lomb Incorporated Dérivés nitroxy de stéroïdes doux
WO2014111957A1 (fr) 2013-01-21 2014-07-24 Apparao Satyam Promédicaments d'agents thérapeutiques libérant de l'oxyde nitrique
BR112015029530A8 (pt) 2013-05-28 2019-12-17 Sun Pharma Advanced Res Co Ltd métodos para tratamento de condições inflamatórias utilizando s-[4-(3-fluoro-3-metilbutiriloxi)but-2-inil] 6\alpha, 9\alpha-difluoro-17\alpha-(furan-2-il)carboniloxi-11\beta-hidroxi-16\alpha-metil-3-oxoandrosta-1, 4-dieno-17\beta-carbotioato.
CN106279341A (zh) * 2015-05-11 2017-01-04 正大天晴药业集团股份有限公司 一种糠酸氟替卡松的制备方法
CN109438543B (zh) * 2018-11-28 2020-09-15 广州健康元呼吸药物工程技术有限公司 一种高纯度糠酸氟替卡松的制备方法
CN111662353A (zh) * 2019-03-05 2020-09-15 上海谷森医药有限公司 一种糠酸氟替卡松晶型1的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US300792A (en) * 1884-06-24 John asbeeey nicholson
US392976A (en) * 1888-11-13 Support for spinning-spindles
US3007923A (en) 1959-01-22 1961-11-07 Lab Francais Chimiotherapie Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids
SE378109B (fr) 1972-05-19 1975-08-18 Bofors Ab
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
BE887518A (fr) 1980-02-15 1981-08-13 Glaxo Group Ltd Cartothioates d'androstanes
ZA814440B (en) * 1980-07-10 1982-10-27 Otsuka Pharma Co Ltd Soft steroids having anti-inflammatory activity
US6610675B1 (en) * 1980-07-10 2003-08-26 Nicholas S. Bodor Inactive metabolite approach to soft drug design
SE449106B (sv) * 1980-07-10 1987-04-06 Otsuka Pharma Co Ltd Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US4996335A (en) * 1980-07-10 1991-02-26 Nicholas S. Bodor Soft steroids having anti-inflammatory activity
DE3260474D1 (en) 1981-02-02 1984-09-06 Schering Corp Aromatic heterocyclic esters of steroids, their preparation and pharmaceutical compositions containing them
CA2241728A1 (fr) * 1995-12-29 1997-07-10 Panayiotis Alexandrou Procopiou Derives de lactone de derives de 17-beta-carboxy, carbothio et amide androstane
US5981517A (en) * 1996-05-09 1999-11-09 Soft Drugs, Inc. Androstene derivatives
WO1999001467A2 (fr) 1997-06-30 1999-01-14 Glaxo Group Limited Composes
GB0125259D0 (en) * 2001-10-20 2001-12-12 Glaxo Group Ltd Novel compounds
AU2003263575A1 (en) * 2002-06-20 2004-01-06 Sun Pharmaceutical Industries Limited Convenient synthesis of s-fluoromethyl 6alpha, 9alpha-difluoro-11beta-hydroxy-16alpha- methyl-17alpha-propionyloxy-3-oxoandrosta-1, 4-diene-17beta-carbothioate
GB0225287D0 (en) 2002-10-30 2002-12-11 Glaxo Group Ltd Novel compounds
TWI374147B (en) 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones

Also Published As

Publication number Publication date
SG170049A1 (en) 2011-04-29
AU2007220114A1 (en) 2007-09-07
CN101384610A (zh) 2009-03-11
CN101384610B (zh) 2013-07-17
AR059216A1 (es) 2008-03-19
EA200801596A1 (ru) 2009-04-28
TW200804407A (en) 2008-01-16
US20090054388A1 (en) 2009-02-26
US8785425B2 (en) 2014-07-22
UA95095C2 (en) 2011-07-11
KR20080091813A (ko) 2008-10-14
CA2637548C (fr) 2014-09-23
EP2004667A4 (fr) 2012-07-18
ES2428066T3 (es) 2013-11-05
AP2008004558A0 (en) 2008-08-31
TWI374147B (en) 2012-10-11
JP5097129B2 (ja) 2012-12-12
EA017490B9 (ru) 2013-04-30
WO2007099548A3 (fr) 2008-10-09
AP2642A (en) 2013-04-15
CA2637548A1 (fr) 2007-09-07
AU2007220114B2 (en) 2011-11-10
EP2004667A2 (fr) 2008-12-24
IL192983A0 (en) 2009-02-11
EA017490B1 (ru) 2012-12-28
NZ569867A (en) 2011-06-30
IL192983A (en) 2014-06-30
ECSP088689A (es) 2008-11-27
MX2008009173A (es) 2009-01-15
BRPI0706767A2 (pt) 2011-06-28
WO2007099548A2 (fr) 2007-09-07
EP2004667B1 (fr) 2013-09-04
JP2009524649A (ja) 2009-07-02
KR101390272B1 (ko) 2014-05-19

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