ZA200804780B - Preparation of gamma-amino acids having affinity for the alpha-2-delta protein - Google Patents

Preparation of gamma-amino acids having affinity for the alpha-2-delta protein

Info

Publication number
ZA200804780B
ZA200804780B ZA200804780A ZA200804780A ZA200804780B ZA 200804780 B ZA200804780 B ZA 200804780B ZA 200804780 A ZA200804780 A ZA 200804780A ZA 200804780 A ZA200804780 A ZA 200804780A ZA 200804780 B ZA200804780 B ZA 200804780B
Authority
ZA
South Africa
Prior art keywords
gamma
affinity
alpha
preparation
amino acids
Prior art date
Application number
ZA200804780A
Other languages
English (en)
Inventor
Margaret Claire Evans
Lloyd Charles Franklin
Lorraine Michelle Murtagh
Thomas Norman Nanninga
Bruce Allen Pearlman
James Edward Saenz
Niamh Josephine Willis
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA200804780B publication Critical patent/ZA200804780B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/005—Amino acids other than alpha- or beta amino acids, e.g. gamma amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200804780A 2005-12-21 2008-06-02 Preparation of gamma-amino acids having affinity for the alpha-2-delta protein ZA200804780B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75283905P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
ZA200804780B true ZA200804780B (en) 2009-05-27

Family

ID=37903526

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804780A ZA200804780B (en) 2005-12-21 2008-06-02 Preparation of gamma-amino acids having affinity for the alpha-2-delta protein

Country Status (28)

Country Link
US (2) US20070141684A1 (zh)
EP (2) EP2017259A3 (zh)
JP (1) JP2009520492A (zh)
KR (1) KR20080068932A (zh)
CN (1) CN101341117A (zh)
AP (1) AP2008004485A0 (zh)
AR (1) AR058559A1 (zh)
AU (1) AU2006327872A1 (zh)
BR (1) BRPI0620467A2 (zh)
CA (1) CA2633358A1 (zh)
CR (1) CR10080A (zh)
DO (1) DOP2006000286A (zh)
EA (1) EA200801393A1 (zh)
EC (1) ECSP088551A (zh)
GT (1) GT200600524A (zh)
IL (1) IL191840A0 (zh)
MA (1) MA30139B1 (zh)
ME (1) ME00005B (zh)
NL (1) NL2000374C2 (zh)
NO (1) NO20082989L (zh)
NZ (1) NZ568971A (zh)
PE (1) PE20071169A1 (zh)
RS (1) RS20080279A (zh)
TN (1) TNSN08272A1 (zh)
TW (1) TW200736201A (zh)
UY (1) UY30031A1 (zh)
WO (1) WO2007072159A1 (zh)
ZA (1) ZA200804780B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724828C (en) * 2008-05-21 2016-01-12 Sandoz Ag Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
CN103003264B (zh) 2010-05-21 2014-08-06 切米利亚股份公司 嘧啶衍生物
FR2966734B1 (fr) * 2010-10-29 2014-07-18 Max Rombi Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides
EP2688883B1 (en) 2011-03-24 2016-05-18 Noviga Research AB Pyrimidine derivatives
CN102249833B (zh) * 2011-05-27 2013-12-11 中国科学院化学研究所 一种制备手性γ-氨基酸及其衍生物的方法
WO2017155025A1 (ja) * 2016-03-10 2017-09-14 第一三共株式会社 酵素による光学分割を用いた光学活性吉草酸誘導体の製造方法
CN108192932B (zh) * 2017-12-26 2020-09-29 上海皓元生物医药科技有限公司 一种手性醇的酶催化制备方法
CN112877219A (zh) * 2021-01-29 2021-06-01 江西科技师范大学 一种高浓度胆固醇培养基及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5618710A (en) 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
GEP20074142B (en) 1999-06-10 2007-07-10 Warner Lambert Co Mono- and Disubstituted 3-Propyl Gamma-Aminobutyric Acids
US6642398B2 (en) * 1999-06-10 2003-11-04 Warner-Lambert Company Mono-and disubstituted 3-propyl gamma-aminobutyric acids
JP2006513257A (ja) 2002-12-13 2006-04-20 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 線維筋痛症および他の障害を処置するためのプレガバリン誘導体
UA82292C2 (uk) * 2004-04-14 2008-03-25 Пфайзер Продактс Инк. Спосіб стереоселективного біоперетворення аліфатичних динітрилів в ціанокарбонові кислоти (варіанти)

Also Published As

Publication number Publication date
RS20080279A (en) 2009-07-15
NO20082989L (no) 2008-09-19
MEP0708A (xx) 2010-02-10
NL2000374A1 (nl) 2007-06-25
CN101341117A (zh) 2009-01-07
EP2017259A2 (en) 2009-01-21
BRPI0620467A2 (pt) 2011-11-16
US20070141684A1 (en) 2007-06-21
TW200736201A (en) 2007-10-01
AU2006327872A1 (en) 2007-06-28
NL2000374C2 (nl) 2010-02-09
WO2007072159A1 (en) 2007-06-28
MA30139B1 (fr) 2009-01-02
IL191840A0 (en) 2008-12-29
CA2633358A1 (en) 2007-06-28
GT200600524A (es) 2007-12-03
KR20080068932A (ko) 2008-07-24
PE20071169A1 (es) 2007-11-30
AP2008004485A0 (en) 2008-06-30
EP2017259A3 (en) 2011-04-13
EA200801393A1 (ru) 2009-12-30
ME00005B (me) 2010-06-10
TNSN08272A1 (fr) 2009-10-30
UY30031A1 (es) 2007-07-31
CR10080A (es) 2008-07-10
WO2007072159B1 (en) 2008-08-21
DOP2006000286A (es) 2007-07-31
JP2009520492A (ja) 2009-05-28
ECSP088551A (es) 2008-07-30
EP1973867A1 (en) 2008-10-01
NZ568971A (en) 2010-04-30
AR058559A1 (es) 2008-02-13
US20090299093A1 (en) 2009-12-03

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