ZA200804110B - An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds - Google Patents

An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds

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Publication number
ZA200804110B
ZA200804110B ZA200804110A ZA200804110A ZA200804110B ZA 200804110 B ZA200804110 B ZA 200804110B ZA 200804110 A ZA200804110 A ZA 200804110A ZA 200804110 A ZA200804110 A ZA 200804110A ZA 200804110 B ZA200804110 B ZA 200804110B
Authority
ZA
South Africa
Prior art keywords
azabicy
dioxopropyl
lamino
valyl
buty
Prior art date
Application number
ZA200804110A
Other languages
English (en)
Inventor
George G Wu
Rashatasakhon Paitoon
Poirier Marc
Xie Ji
Chen Frank Xing
Victoria M Sprague
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA200804110B publication Critical patent/ZA200804110B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200804110A 2005-11-14 2008-05-13 An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds ZA200804110B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US73654205P 2005-11-14 2005-11-14

Publications (1)

Publication Number Publication Date
ZA200804110B true ZA200804110B (en) 2009-03-25

Family

ID=37963789

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200804110A ZA200804110B (en) 2005-11-14 2008-05-13 An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds

Country Status (8)

Country Link
US (1) US7528263B2 (ja)
EP (1) EP1966233B1 (ja)
JP (2) JP5215863B2 (ja)
CN (1) CN101356187A (ja)
AR (1) AR056805A1 (ja)
CA (1) CA2628738A1 (ja)
WO (1) WO2008010831A1 (ja)
ZA (1) ZA200804110B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2634397A1 (en) * 2005-12-22 2007-07-05 Schering Corporation Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof
US8188137B2 (en) 2008-08-15 2012-05-29 Avila Therapeutics, Inc. HCV protease inhibitors and uses thereof
WO2012151271A1 (en) * 2011-05-04 2012-11-08 Merck Sharp & Dohme Corp. Processes for preparing inhibitors of the hepatitis c virus
WO2014061034A1 (en) * 2012-10-18 2014-04-24 Msn Laboratories Limited Process for preparation of boceprevir and intermediates thereof
US20240043417A1 (en) * 2020-12-01 2024-02-08 Purdue Research Foundation Compounds for the treatment of sars

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5238602A (en) 1984-07-16 1993-08-24 Hoffmann La Roche Inc. Liquid crystals
US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
IL153670A0 (en) 2000-07-21 2003-07-06 Schering Corp Novel peptides as ns3-serine protease inhibitors of hepatitis c virus
US6587902B1 (en) 2001-12-27 2003-07-01 Inventec Corporation I/O port assembly of notebook computer connectable to monitor or TV as needed
US20050059684A1 (en) 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
AR044694A1 (es) 2003-06-17 2005-09-21 Schering Corp Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo
US7309717B2 (en) 2003-06-17 2007-12-18 Schering Corporation Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof
EP1633698A1 (en) 2003-06-17 2006-03-15 Schering Corporation Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof
US7205330B2 (en) 2004-02-27 2007-04-17 Schering Corporation Inhibitors of hepatitis C virus NS3 protease
AR049635A1 (es) * 2004-05-06 2006-08-23 Schering Corp (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c

Also Published As

Publication number Publication date
WO2008010831A1 (en) 2008-01-24
CN101356187A (zh) 2009-01-28
US20070149459A1 (en) 2007-06-28
AR056805A1 (es) 2007-10-24
EP1966233A1 (en) 2008-09-10
JP2009515894A (ja) 2009-04-16
JP5215863B2 (ja) 2013-06-19
EP1966233B1 (en) 2014-08-13
US7528263B2 (en) 2009-05-05
CA2628738A1 (en) 2008-01-24
JP2013032370A (ja) 2013-02-14

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