ZA200804110B - An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds - Google Patents
An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compoundsInfo
- Publication number
- ZA200804110B ZA200804110B ZA200804110A ZA200804110A ZA200804110B ZA 200804110 B ZA200804110 B ZA 200804110B ZA 200804110 A ZA200804110 A ZA 200804110A ZA 200804110 A ZA200804110 A ZA 200804110A ZA 200804110 B ZA200804110 B ZA 200804110B
- Authority
- ZA
- South Africa
- Prior art keywords
- azabicy
- dioxopropyl
- lamino
- valyl
- buty
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73654205P | 2005-11-14 | 2005-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200804110B true ZA200804110B (en) | 2009-03-25 |
Family
ID=37963789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200804110A ZA200804110B (en) | 2005-11-14 | 2008-05-13 | An oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3- dioxopropyl]-3-{N-[(tert-buty-lamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicy-clo[3.1.0]hexane-2-carboxamide and related compounds |
Country Status (8)
Country | Link |
---|---|
US (1) | US7528263B2 (ja) |
EP (1) | EP1966233B1 (ja) |
JP (2) | JP5215863B2 (ja) |
CN (1) | CN101356187A (ja) |
AR (1) | AR056805A1 (ja) |
CA (1) | CA2628738A1 (ja) |
WO (1) | WO2008010831A1 (ja) |
ZA (1) | ZA200804110B (ja) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2634397A1 (en) * | 2005-12-22 | 2007-07-05 | Schering Corporation | Process for the preparation of 6,6-dimethyl-3-azabicyclo[3.1.0|-hexane compounds and enantiomeric salts thereof |
US8188137B2 (en) | 2008-08-15 | 2012-05-29 | Avila Therapeutics, Inc. | HCV protease inhibitors and uses thereof |
WO2012151271A1 (en) * | 2011-05-04 | 2012-11-08 | Merck Sharp & Dohme Corp. | Processes for preparing inhibitors of the hepatitis c virus |
WO2014061034A1 (en) * | 2012-10-18 | 2014-04-24 | Msn Laboratories Limited | Process for preparation of boceprevir and intermediates thereof |
US20240043417A1 (en) * | 2020-12-01 | 2024-02-08 | Purdue Research Foundation | Compounds for the treatment of sars |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5238602A (en) | 1984-07-16 | 1993-08-24 | Hoffmann La Roche Inc. | Liquid crystals |
US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
IL153670A0 (en) | 2000-07-21 | 2003-07-06 | Schering Corp | Novel peptides as ns3-serine protease inhibitors of hepatitis c virus |
US6587902B1 (en) | 2001-12-27 | 2003-07-01 | Inventec Corporation | I/O port assembly of notebook computer connectable to monitor or TV as needed |
US20050059684A1 (en) | 2002-10-16 | 2005-03-17 | Ben-Zion Dolitzky | Method for reducing residual alcohols in crystalline valacyclovir hydrochloride |
AR044694A1 (es) | 2003-06-17 | 2005-09-21 | Schering Corp | Proceso y compuestos intermedios para la preparacion de (1r, 2s,5s) - 3 azabiciclo [3,1,0] hexano-2- carboxamida, n- [3- amino-1- (ciclobutilmetil) - 2, 3 - dioxopropil] -3- [ (2s) - 2 - [[ [ 1,1- dimetiletil] amino] carbonilamino] -3,3-dimetil -1- oxobutil]-6,6 dimetilo |
US7309717B2 (en) | 2003-06-17 | 2007-12-18 | Schering Corporation | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof |
EP1633698A1 (en) | 2003-06-17 | 2006-03-15 | Schering Corporation | Process and intermediates for the preparation of 3-(amino)-3-cyclobutylmethyl-2-hydroxy-propionamide or salts thereof |
US7205330B2 (en) | 2004-02-27 | 2007-04-17 | Schering Corporation | Inhibitors of hepatitis C virus NS3 protease |
AR049635A1 (es) * | 2004-05-06 | 2006-08-23 | Schering Corp | (1r,2s,5s)-n-((1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil)-3-((2s)-2-((((1,1-dimetiletil)amino)carbonil)amino)-3,3-dimetil-1-oxobutil)-6,6-dimetil-3-azabiciclo(3.1.0)hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de la hepatitis c |
-
2006
- 2006-11-10 AR ARP060104941A patent/AR056805A1/es active IP Right Grant
- 2006-11-13 WO PCT/US2006/043950 patent/WO2008010831A1/en active Application Filing
- 2006-11-13 US US11/598,528 patent/US7528263B2/en not_active Expired - Fee Related
- 2006-11-13 JP JP2008540241A patent/JP5215863B2/ja not_active Expired - Fee Related
- 2006-11-13 EP EP06851460.3A patent/EP1966233B1/en active Active
- 2006-11-13 CA CA002628738A patent/CA2628738A1/en not_active Abandoned
- 2006-11-13 CN CNA2006800507113A patent/CN101356187A/zh active Pending
-
2008
- 2008-05-13 ZA ZA200804110A patent/ZA200804110B/xx unknown
-
2012
- 2012-09-28 JP JP2012217154A patent/JP2013032370A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2008010831A1 (en) | 2008-01-24 |
CN101356187A (zh) | 2009-01-28 |
US20070149459A1 (en) | 2007-06-28 |
AR056805A1 (es) | 2007-10-24 |
EP1966233A1 (en) | 2008-09-10 |
JP2009515894A (ja) | 2009-04-16 |
JP5215863B2 (ja) | 2013-06-19 |
EP1966233B1 (en) | 2014-08-13 |
US7528263B2 (en) | 2009-05-05 |
CA2628738A1 (en) | 2008-01-24 |
JP2013032370A (ja) | 2013-02-14 |
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