ZA200800729B - A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it - Google Patents

A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it

Info

Publication number
ZA200800729B
ZA200800729B ZA200800729A ZA200800729A ZA200800729B ZA 200800729 B ZA200800729 B ZA 200800729B ZA 200800729 A ZA200800729 A ZA 200800729A ZA 200800729 A ZA200800729 A ZA 200800729A ZA 200800729 B ZA200800729 B ZA 200800729B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical composition
crystalline form
zoledronic acid
zoledronic
acid
Prior art date
Application number
ZA200800729A
Other languages
English (en)
Inventor
Labriola Rafael Alberto
Tombari Dora Graciela
Vecchioli Adriana
Original Assignee
Gador Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gador Sa filed Critical Gador Sa
Publication of ZA200800729B publication Critical patent/ZA200800729B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200800729A 2005-07-28 2006-05-12 A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it ZA200800729B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP050103131A AR054673A1 (es) 2005-07-28 2005-07-28 Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende

Publications (1)

Publication Number Publication Date
ZA200800729B true ZA200800729B (en) 2009-08-26

Family

ID=36659934

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800729A ZA200800729B (en) 2005-07-28 2006-05-12 A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it

Country Status (10)

Country Link
US (3) US20080090784A1 (ko)
EP (1) EP1924587B1 (ko)
KR (2) KR20080031475A (ko)
AR (1) AR054673A1 (ko)
AU (1) AU2006278951B2 (ko)
BR (1) BRPI0613924A2 (ko)
CA (1) CA2615418C (ko)
NZ (1) NZ565356A (ko)
WO (1) WO2007016982A1 (ko)
ZA (1) ZA200800729B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071574B2 (en) 2005-02-22 2011-12-06 John Dennis Bobyn Implant improving local bone formation
CN101262856A (zh) * 2005-09-12 2008-09-10 雷迪博士实验室有限公司 唑来膦酸的结晶三水合物
WO2007125521A2 (en) * 2006-05-02 2007-11-08 Ranbaxy Laboratories Limited Polymorphic form of zoledronic acid and processes for their preparation
EP1925621A1 (en) * 2006-11-27 2008-05-28 Novartis AG Crystalline forms of zoledronic acid
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US9169279B2 (en) 2009-07-31 2015-10-27 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
LT2459176T (lt) 2009-07-31 2017-12-11 Grünenthal GmbH Kristalizacijos būdas ir bioprieinamumas
WO2011023280A1 (en) * 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US8882740B2 (en) 2009-12-23 2014-11-11 Stryker Trauma Gmbh Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
US9340565B2 (en) 2010-11-24 2016-05-17 Thar Pharmaceuticals, Inc. Crystalline forms
HU230718B1 (hu) 2011-02-08 2017-11-28 Richter Gedeon Nyrt. Új eljárás dronsavak gyógyszeripari előállítására
CN102690288B (zh) * 2012-06-07 2015-06-17 吉林大学 一种双膦酸类化合物的制备方法
US10195218B2 (en) 2016-05-31 2019-02-05 Grunenthal Gmbh Crystallization method and bioavailability
CN110551152A (zh) * 2018-05-31 2019-12-10 四川科伦药物研究院有限公司 唑来膦酸一水合物及无水物晶型制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3626058A1 (de) 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
ES2038692T4 (es) 1986-11-21 2012-02-10 Novartis Ag Procedimiento para la obtencion de acidos alcanodifosfonicos substituidos.
US4922007A (en) 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
WO2004075860A2 (en) * 2003-02-27 2004-09-10 Teva Pharmaceutical Industries Ltd. Process for purification of zoledronic acid
WO2005005447A2 (en) 2003-07-03 2005-01-20 Teva Pharmaceutical Industries Ltd. Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation
WO2005066188A1 (en) * 2003-10-17 2005-07-21 Sun Pharmaceutical Industries Limited A process for the preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1, 1-diphosphonic acid
US7723542B2 (en) * 2003-12-23 2010-05-25 Trifarma S.P.A. Process for the preparation of alkyl- and aryl-diphosphonic acids and salts thereof
WO2005063717A1 (en) * 2003-12-26 2005-07-14 Natco Pharma Limited An improved process for the preparation of zoledronic acid
US20060178439A1 (en) * 2005-01-04 2006-08-10 Mohakhud Pradeep K Crystalline form of zoledronic acid

Also Published As

Publication number Publication date
US8952172B2 (en) 2015-02-10
WO2007016982A1 (en) 2007-02-15
CA2615418C (en) 2011-04-26
AR054673A1 (es) 2007-07-11
EP1924587B1 (en) 2014-03-05
NZ565356A (en) 2010-01-29
AU2006278951B2 (en) 2012-01-12
BRPI0613924A2 (pt) 2012-03-20
EP1924587A1 (en) 2008-05-28
US20080090784A1 (en) 2008-04-17
US20100197931A1 (en) 2010-08-05
KR20140023949A (ko) 2014-02-27
US20100197935A1 (en) 2010-08-05
CA2615418A1 (en) 2007-02-15
AU2006278951A1 (en) 2007-02-15
KR20080031475A (ko) 2008-04-08
US8338619B2 (en) 2012-12-25

Similar Documents

Publication Publication Date Title
ZA200800729B (en) A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it
PL1752443T3 (pl) Nowa postać krystaliczna V agomelatyny, sposób jej wytwarzania i kompozycje farmaceutyczne, które ją zawierają
PT2210872T (pt) Nova forma cristalina iii de agomelatina, processo para a sua preparação e composições farmacêuticas que a contêm
ZA200606455B (en) Crystalline form IV of agomelatine, a process for its preparation and pharmaceutical compositions containing it
SI1695709T1 (sl) Gama-d kristalna oblika hidroklorida ivabradina, postopek za njegovo pripravo in farmacevtski sestavki, ki ga vsebujejo
EP1970076A4 (en) PHARMACEUTICAL COMPOSITION FOR APPLYING TO A NAIL
GB0507165D0 (en) Novel crystalline pharmaceutical product
EP1931326A4 (en) CRYSTALLINE TRIHYDRATE OF ZOLEDONIC ACID
EP1919688A4 (en) PROCESS FOR THE APPLICATION OF INGREDIENTS WITHIN A STRAW
IL184562A (en) Polymorph ivandront a, a process for its preparation and pharmaceutical preparations containing it
IL190880A (en) Crystalline posidic acid, a method of preparation and a pharmaceutical composition comprising it
IL182238A0 (en) Agrochemical composition containing phosphoric acid esters
PL2137206T3 (pl) Sposób wytwarzania kwasu tauroursodeoksycholowego
ME02456B (me) Kristalni oblik argininske soli perindoprila, postupak njene proizvodnje i farmaceutske smeše koje je sadrže
IL180311A0 (en) Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters
IL177561A0 (en) Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
EP2212325A4 (en) 2-ARYLMETHYLAZETIDINCARBAPENEM-3-CARBOXYLENE DERTERIVATE OR SALT, METHOD FOR THE PRODUCTION THEREOF AND THEREOF COMPRISING PHARMACEUTICAL COMPOSITION
WO2007125521A3 (en) Polymorphic form of zoledronic acid and processes for their preparation
WO2007013043A3 (en) Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid
EP2077822A4 (en) ORAL FORMULATION CONTAINING OXCARBAZEPINE AND METHOD FOR PRODUCING THE SAME
EP2046342A4 (en) CRYSTALLINE FORM WITH IBANDRONIC ACID AND PROCESS FOR PREPARING THE SAME
IL190743A0 (en) Improved method for the production of betulinic acid
IL189177A0 (en) Process for producing carcosporamide and pharmaceutical compositions containing cercosporamide
HK1129687A1 (en) A process for the preparation of poly-alfa-glutamic acid and derivatives thereof
HK1115578A1 (en) Process for the preparation of enantiomerically pure 1-substituted-3- aminoalcohols