ZA200800729B - A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it - Google Patents
A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising itInfo
- Publication number
- ZA200800729B ZA200800729B ZA200800729A ZA200800729A ZA200800729B ZA 200800729 B ZA200800729 B ZA 200800729B ZA 200800729 A ZA200800729 A ZA 200800729A ZA 200800729 A ZA200800729 A ZA 200800729A ZA 200800729 B ZA200800729 B ZA 200800729B
- Authority
- ZA
- South Africa
- Prior art keywords
- pharmaceutical composition
- crystalline form
- zoledronic acid
- zoledronic
- acid
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 title 1
- 229960004276 zoledronic acid Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP050103131A AR054673A1 (es) | 2005-07-28 | 2005-07-28 | Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200800729B true ZA200800729B (en) | 2009-08-26 |
Family
ID=36659934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200800729A ZA200800729B (en) | 2005-07-28 | 2006-05-12 | A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20080090784A1 (xx) |
| EP (1) | EP1924587B1 (xx) |
| KR (2) | KR20140023949A (xx) |
| AR (1) | AR054673A1 (xx) |
| AU (1) | AU2006278951B2 (xx) |
| BR (1) | BRPI0613924A2 (xx) |
| CA (1) | CA2615418C (xx) |
| NZ (1) | NZ565356A (xx) |
| WO (1) | WO2007016982A1 (xx) |
| ZA (1) | ZA200800729B (xx) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| WO2007032808A1 (en) * | 2005-09-12 | 2007-03-22 | Dr. Reddy's Laboratories Ltd. | Crystalline trihydrate of zoledronic acid |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| EP1925621A1 (en) * | 2006-11-27 | 2008-05-28 | Novartis AG | Crystalline forms of zoledronic acid |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| CA2769633C (en) | 2009-07-31 | 2017-06-06 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EA201270328A1 (ru) * | 2009-08-28 | 2012-09-28 | Синтон Б. В. | Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот |
| US8882740B2 (en) | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| HU230718B1 (hu) | 2011-02-08 | 2017-11-28 | Richter Gedeon Nyrt. | Új eljárás dronsavak gyógyszeripari előállítására |
| CN102690288B (zh) * | 2012-06-07 | 2015-06-17 | 吉林大学 | 一种双膦酸类化合物的制备方法 |
| US10195218B2 (en) | 2016-05-31 | 2019-02-05 | Grunenthal Gmbh | Crystallization method and bioavailability |
| CN110551152A (zh) * | 2018-05-31 | 2019-12-10 | 四川科伦药物研究院有限公司 | 唑来膦酸一水合物及无水物晶型制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3626058A1 (de) | 1986-08-01 | 1988-02-11 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL84497A (en) | 1986-11-21 | 1994-10-21 | Ciba Geigy Ag | History 2-) Imidazol-1-yl (ethane-1,1-diphosphonic acid, their preparation and pharmaceutical preparations containing them |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| PE20011061A1 (es) * | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| ITMI20020908A1 (it) * | 2002-04-29 | 2003-10-29 | Chemi Spa | Processo di preparazione di sodio alendronato |
| EP1525207A2 (en) * | 2003-02-27 | 2005-04-27 | Teva Pharmaceutical Industries Limited | Process for purification of zoledronic acid |
| WO2005005447A2 (en) | 2003-07-03 | 2005-01-20 | Teva Pharmaceutical Industries Ltd. | Zoledronic acid crystal forms, zoledronate sodium salt crystal forms, amorphous zoledronate sodium salt, and processes for their preparation |
| WO2005066188A1 (en) * | 2003-10-17 | 2005-07-21 | Sun Pharmaceutical Industries Limited | A process for the preparation of 2-(imidazol-1-yl)-1-hydroxyethane-1, 1-diphosphonic acid |
| ATE508134T1 (de) * | 2003-12-23 | 2011-05-15 | Alchymars S P A | Amorphe form das natriumsalzes der ibandronsäure |
| WO2005063717A1 (en) * | 2003-12-26 | 2005-07-14 | Natco Pharma Limited | An improved process for the preparation of zoledronic acid |
| US20060178439A1 (en) * | 2005-01-04 | 2006-08-10 | Mohakhud Pradeep K | Crystalline form of zoledronic acid |
-
2005
- 2005-07-28 AR ARP050103131A patent/AR054673A1/es unknown
-
2006
- 2006-05-12 NZ NZ565356A patent/NZ565356A/en not_active IP Right Cessation
- 2006-05-12 KR KR1020137028232A patent/KR20140023949A/ko not_active Application Discontinuation
- 2006-05-12 ZA ZA200800729A patent/ZA200800729B/xx unknown
- 2006-05-12 EP EP06753582.3A patent/EP1924587B1/en active Active
- 2006-05-12 KR KR1020087004752A patent/KR20080031475A/ko active Search and Examination
- 2006-05-12 WO PCT/EP2006/004473 patent/WO2007016982A1/en active Application Filing
- 2006-05-12 AU AU2006278951A patent/AU2006278951B2/en not_active Ceased
- 2006-05-12 CA CA2615418A patent/CA2615418C/en not_active Expired - Fee Related
- 2006-05-12 BR BRPI0613924-8A patent/BRPI0613924A2/pt not_active IP Right Cessation
-
2007
- 2007-08-10 US US11/837,277 patent/US20080090784A1/en not_active Abandoned
-
2010
- 2010-02-04 US US12/700,082 patent/US8952172B2/en active Active
- 2010-02-04 US US12/700,067 patent/US8338619B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100197935A1 (en) | 2010-08-05 |
| EP1924587B1 (en) | 2014-03-05 |
| US8338619B2 (en) | 2012-12-25 |
| AR054673A1 (es) | 2007-07-11 |
| AU2006278951B2 (en) | 2012-01-12 |
| NZ565356A (en) | 2010-01-29 |
| EP1924587A1 (en) | 2008-05-28 |
| US20080090784A1 (en) | 2008-04-17 |
| WO2007016982A1 (en) | 2007-02-15 |
| CA2615418C (en) | 2011-04-26 |
| CA2615418A1 (en) | 2007-02-15 |
| AU2006278951A1 (en) | 2007-02-15 |
| US8952172B2 (en) | 2015-02-10 |
| KR20080031475A (ko) | 2008-04-08 |
| BRPI0613924A2 (pt) | 2012-03-20 |
| US20100197931A1 (en) | 2010-08-05 |
| KR20140023949A (ko) | 2014-02-27 |
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