ZA200800228B - Nucleotide analogue prodrug and the preparation thereof - Google Patents

Nucleotide analogue prodrug and the preparation thereof

Info

Publication number
ZA200800228B
ZA200800228B ZA200800228A ZA200800228A ZA200800228B ZA 200800228 B ZA200800228 B ZA 200800228B ZA 200800228 A ZA200800228 A ZA 200800228A ZA 200800228 A ZA200800228 A ZA 200800228A ZA 200800228 B ZA200800228 B ZA 200800228B
Authority
ZA
South Africa
Prior art keywords
preparation
nucleotide analogue
analogue prodrug
prodrug
nucleotide
Prior art date
Application number
ZA200800228A
Other languages
English (en)
Inventor
Yuan Jiandong
Original Assignee
Brightgene Bio Medical Technol
Jiangsu Chia Tai Tianqing Phar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brightgene Bio Medical Technol, Jiangsu Chia Tai Tianqing Phar filed Critical Brightgene Bio Medical Technol
Publication of ZA200800228B publication Critical patent/ZA200800228B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ZA200800228A 2005-06-13 2008-01-09 Nucleotide analogue prodrug and the preparation thereof ZA200800228B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN200510040480 2005-06-13

Publications (1)

Publication Number Publication Date
ZA200800228B true ZA200800228B (en) 2008-09-25

Family

ID=37531955

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200800228A ZA200800228B (en) 2005-06-13 2008-01-09 Nucleotide analogue prodrug and the preparation thereof

Country Status (5)

Country Link
US (1) US20100216822A1 (zh)
JP (1) JP5323476B2 (zh)
CN (5) CN102240295B (zh)
WO (1) WO2006133632A1 (zh)
ZA (1) ZA200800228B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011111074A2 (en) * 2010-03-11 2011-09-15 Matrix Laboratories Ltd An improved process for the preparation of tenofovir disoproxil fumarate
US9187508B2 (en) 2010-08-01 2015-11-17 Jiangsu Chiatai Tianqing Pharmaceutical Co., Ltd. Crystalline forms of tenofovir dipivoxil fumarate
CN102453055B (zh) * 2010-10-29 2015-04-01 上海迪赛诺医药发展有限公司 制备(r)-9-(2-膦酰甲氧基丙基)腺嘌呤双(异丙氧羰基氧甲基)酯的方法
EP2697238B1 (en) * 2011-04-08 2019-03-20 Laurus Labs Limited Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof
CN103374038B (zh) * 2012-04-11 2016-04-13 广州白云山医药集团股份有限公司白云山制药总厂 一种抗病毒药物的制备方法
CN103626803B (zh) * 2012-08-23 2017-12-15 四川海思科制药有限公司 替诺福韦二吡呋酯的固体及其制备方法和用途
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
WO2014068265A1 (en) * 2012-10-29 2014-05-08 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
CN104725423A (zh) * 2013-12-18 2015-06-24 山东新时代药业有限公司 一种富马酸替诺福韦二吡呋酯的合成方法
KR101548724B1 (ko) * 2014-04-25 2015-09-02 주식회사 휴온스 고체 형태의 항바이러스제 및 이의 제조방법
CN105399771B (zh) * 2014-07-21 2020-11-24 江苏豪森药业集团有限公司 替诺福韦前药晶型及其制备方法和用途
CN107334772B (zh) * 2016-07-15 2020-02-14 安徽贝克生物制药有限公司 一种抗逆转录病毒药物组合物
CN107266500B (zh) * 2017-08-10 2019-04-12 黄哲敏 一种泰诺福韦生产线的晶体析出反应系统
CN110577555A (zh) * 2018-06-08 2019-12-17 欣凯医药化工中间体（上海）有限公司 一种无定形的替诺福韦十八烷氧乙酯的制备方法及其应用
WO2024033632A1 (en) * 2022-08-08 2024-02-15 Cipla Limited An improved process for preparing antiviral phosphonate analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2261619C (en) * 1996-07-26 2006-05-23 Gilead Sciences, Inc. Nucleotide analogs
PT1256585E (pt) * 1997-07-25 2005-01-31 Gilead Sciences Inc Processo para a preparacao de 9-(2-(dietilfosfonometoxi)-etil)-adenina
ZA986614B (en) * 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
CN1374314A (zh) * 2002-03-13 2002-10-16 上海仲夏化学有限公司 阿德福韦酯无定形固化物及制备方法
CN1465582A (zh) * 2002-07-01 2004-01-07 中国人民解放军军事医学科学院放射医 核苷酸类似物、含它的药物组合物及其用途
CN100488970C (zh) * 2002-07-08 2009-05-20 江苏正大天晴药业股份有限公司 匹伏阿德福韦的晶型
CN100384426C (zh) * 2003-12-05 2008-04-30 天津药物研究院 一种含活性成分阿德福韦或其盐的固体分散物及其制备方法
CN1679596B (zh) * 2005-01-18 2010-12-08 美德（江西）生物科技有限公司 无结晶型态的阿地福韦酯与辅料的分散组合物及其制备方法

Also Published As

Publication number Publication date
CN102240295A (zh) 2011-11-16
CN102240297B (zh) 2013-04-03
CN102240295B (zh) 2013-04-03
JP2008545802A (ja) 2008-12-18
CN102228464B (zh) 2013-06-05
WO2006133632A1 (fr) 2006-12-21
US20100216822A1 (en) 2010-08-26
CN102240297A (zh) 2011-11-16
CN102228463B (zh) 2012-12-19
JP5323476B2 (ja) 2013-10-23
CN102228464A (zh) 2011-11-02
CN102228463A (zh) 2011-11-02
CN102240296A (zh) 2011-11-16
CN102240296B (zh) 2013-04-03

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