ZA200707238B - Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein - Google Patents

Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein

Info

Publication number
ZA200707238B
ZA200707238B ZA200707238A ZA200707238A ZA200707238B ZA 200707238 B ZA200707238 B ZA 200707238B ZA 200707238 A ZA200707238 A ZA 200707238A ZA 200707238 A ZA200707238 A ZA 200707238A ZA 200707238 B ZA200707238 B ZA 200707238B
Authority
ZA
South Africa
Prior art keywords
affinity
alpha
preparation
amino acids
optically pure
Prior art date
Application number
ZA200707238A
Other languages
English (en)
Inventor
Franczyk Thaddeus Stephan Li
Perrault William Roland
Herrinton Paul Matthew
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of ZA200707238B publication Critical patent/ZA200707238B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA200707238A 2005-03-24 2007-08-27 Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein ZA200707238B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US66550205P 2005-03-24 2005-03-24

Publications (1)

Publication Number Publication Date
ZA200707238B true ZA200707238B (en) 2008-10-29

Family

ID=36480947

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200707238A ZA200707238B (en) 2005-03-24 2007-08-27 Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein

Country Status (14)

Country Link
US (1) US20080194841A1 (fr)
EP (1) EP1863780A1 (fr)
JP (1) JP2006265251A (fr)
KR (1) KR20070107147A (fr)
CN (1) CN101389616A (fr)
AR (1) AR056952A1 (fr)
AU (1) AU2006226046A1 (fr)
BR (1) BRPI0609435A2 (fr)
CA (1) CA2602418A1 (fr)
IL (1) IL185332A0 (fr)
MX (1) MX2007011778A (fr)
TW (1) TW200700400A (fr)
WO (1) WO2006100568A1 (fr)
ZA (1) ZA200707238B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108752232B (zh) * 2018-05-14 2021-03-19 四川大学 一种α-季碳氨基酸的合成方法
CN112812029B (zh) * 2021-01-23 2023-08-15 台州臻挚生物科技有限公司 苯巴豆酸酯类化合物的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3798949B2 (ja) * 2001-03-06 2006-07-19 エヌ・イーケムキャット株式会社 水素化分解用触媒
NI200300043A (es) * 2002-03-28 2003-11-05 Warner Lambert Co AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA.
CA2540208A1 (fr) * 2003-09-25 2005-04-07 Warner-Lambert Company Llc Acides amines a affinite pour la proteine a2d

Also Published As

Publication number Publication date
IL185332A0 (en) 2008-02-09
AR056952A1 (es) 2007-11-07
TW200700400A (en) 2007-01-01
EP1863780A1 (fr) 2007-12-12
CN101389616A (zh) 2009-03-18
WO2006100568A1 (fr) 2006-09-28
AU2006226046A1 (en) 2006-09-28
CA2602418A1 (fr) 2006-09-28
MX2007011778A (es) 2007-10-18
BRPI0609435A2 (pt) 2010-04-06
KR20070107147A (ko) 2007-11-06
US20080194841A1 (en) 2008-08-14
JP2006265251A (ja) 2006-10-05

Similar Documents

Publication Publication Date Title
IL187191A0 (en) Incorporation of non-naturally encoded amino acids into proteins
ZA200902008B (en) Dextran functionalized with hydrophobic amino acids
IL182495A0 (en) Orthogonal translation components for the in vivo incorporation of unnatural amino acids
PL1999259T3 (pl) Specyficzne miejscowo wprowadzanie aminokwasów do cząsteczek
IL197681A0 (en) Dextran functionalized with hydrophobic amino acids
EP2102355A4 (fr) Protéines et peptides à action prolongée et procédés de production et d'utilisation de ces derniers
DK1983849T3 (da) Fødevaresammensætning omfattende aminosyrer
ZA200803448B (en) Preparation of canola protein isolate involving isoelectric precipitation
IL193722A0 (en) Genetically programmed expression of proteins containing the unnatural amino acid phenylselenocysteine
IL190748A0 (en) Methods and compositions comprising non-natural amino acids
IL222924A0 (en) Albumin fusion proteins
ZA200804611B (en) Methods for the use of branched chain amino acids
IL205238A0 (en) Directed evolution using proteins comprising unnatural amino acids
IL197580A0 (en) Albumin fusion proteins
ZA200804780B (en) Preparation of gamma-amino acids having affinity for the alpha-2-delta protein
ZA200710330B (en) Methods of purifying FC region containing proteins
ZA200900836B (en) Process for the purification of FC-fusion proteins
EP1968635A4 (fr) Compositions contenant des acides amines et polypeptides non naturels, procedes mettant en jeu ceux-ci et utilisations de ceux-ci
GB0626021D0 (en) The stabilisation of proteins
PL1890994T3 (pl) Stabilny kompleks substancji czynnej soli kwasu O-acetylosalicylowego z aminokwasami zasadowymi i glicyną
IL173764A0 (en) Amino acids with affinity for the alpha2delta-protein
PL1998790T3 (pl) Kompozycje zawierające peptydy z aminokwasami niewystępującymi w przyrodzie i sposoby stosowania
ZA200700675B (en) Process for the preparation of amino acids useful in the preparation of peptide receptor modulators
ZA200707238B (en) Preparation of optically pure beta-amino acids having affinity for the alpha-2-delta protein
IL179851A0 (en) Preparation of beta-amino acids having affinity for the alpha-2-delta protein