ZA200705216B - Novel process for the preparation of substituted indoles - Google Patents

Novel process for the preparation of substituted indoles

Info

Publication number
ZA200705216B
ZA200705216B ZA200705216A ZA200705216A ZA200705216B ZA 200705216 B ZA200705216 B ZA 200705216B ZA 200705216 A ZA200705216 A ZA 200705216A ZA 200705216 A ZA200705216 A ZA 200705216A ZA 200705216 B ZA200705216 B ZA 200705216B
Authority
ZA
South Africa
Prior art keywords
preparation
novel process
substituted indoles
indoles
substituted
Prior art date
Application number
ZA200705216A
Other languages
English (en)
Inventor
Keegan Philip
Gill Duncan
Merifield Eric
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of ZA200705216B publication Critical patent/ZA200705216B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200705216A 2005-01-13 2007-06-29 Novel process for the preparation of substituted indoles ZA200705216B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0500604.4A GB0500604D0 (en) 2005-01-13 2005-01-13 Novel process

Publications (1)

Publication Number Publication Date
ZA200705216B true ZA200705216B (en) 2008-09-25

Family

ID=34203986

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200705216A ZA200705216B (en) 2005-01-13 2007-06-29 Novel process for the preparation of substituted indoles

Country Status (15)

Country Link
US (1) US7781598B2 (fr)
EP (1) EP1844012A2 (fr)
JP (1) JP2008526936A (fr)
KR (1) KR20070104350A (fr)
CN (1) CN101102999B (fr)
AU (1) AU2006205697B2 (fr)
BR (1) BRPI0606639A2 (fr)
CA (1) CA2594391A1 (fr)
GB (1) GB0500604D0 (fr)
IL (1) IL183965A0 (fr)
MX (1) MX2007008348A (fr)
NO (1) NO20074047L (fr)
NZ (1) NZ556147A (fr)
WO (1) WO2006075139A2 (fr)
ZA (1) ZA200705216B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200307542A (en) * 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) * 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301569D0 (sv) * 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) * 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SE0303180D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
EP2125722A2 (fr) * 2006-05-26 2009-12-02 AstraZeneca AB Indoles substitues par biaryl ou aryl-heteroaryl
TW201118067A (en) * 2009-07-06 2011-06-01 Astrazeneca Ab Pharmaceutical process and intermediates
SG11201402796SA (en) 2011-12-16 2014-06-27 Atopix Therapeutics Ltd Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
CN103288707B (zh) * 2013-05-28 2015-12-23 浙江大学 一种3-苯巯基吲哚衍生物的制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
JPH0615542B2 (ja) 1986-07-22 1994-03-02 吉富製薬株式会社 ピラゾロピリジン化合物
US5095031A (en) 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
WO1993005020A1 (fr) 1991-09-06 1993-03-18 Merck & Co., Inc. Indoles utilises comme inhibiteurs de la transcriptase inverse du vih
FR2692574B1 (fr) 1992-06-23 1995-06-23 Sanofi Elf Derives hydroxy-4 benzenethio, leur preparation ainsi que leur utilisation pour la preparation de derives aminoalkoxybenzenesulfonyles.
CA2156420A1 (fr) 1993-02-24 1994-09-01 Theresa M. Williams Inhibiteurs de la transcriptase inverse du vih
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
US5567711A (en) 1995-04-19 1996-10-22 Abbott Laboratories Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
TW472045B (en) 1996-09-25 2002-01-11 Astra Ab Protein kinase C inhibitor compounds, method for their preparation, pharmaceutical composition thereof and intermediate used for their preparation
ZA987554B (en) 1997-08-21 2000-02-21 American Home Prod Methods for the solid phase synthesis of substituted indole compounds.
AU2201699A (en) 1997-12-19 1999-07-12 Eli Lilly And Company Hypoglycemic imidazoline compounds
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
WO2000078761A1 (fr) 1999-06-23 2000-12-28 Sepracor, Inc. Antibacteriens indolyl-benzimidazole et procedes d'utilisation
AU7962200A (en) 1999-10-29 2001-05-14 Wakunaga Pharmaceutical Co., Ltd Novel indole derivatives and drugs containing the same as the active ingredient
OA12514A (en) 1999-12-24 2006-05-29 Aventis Pharma Ltd Azaindoles.
IL152682A0 (en) 2000-05-31 2003-06-24 Astrazeneca Ab Indole derivatives with vascular damaging activity
US6878522B2 (en) 2000-07-07 2005-04-12 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states mediated by prostaglandin D2
WO2003013510A1 (fr) * 2001-08-07 2003-02-20 Smithkline Beecham P.L.C. 3-arylsulfonyl-7-piperazinyl- indols, -benzofurans et benzothiophenes a affinite avec les recepteurs 5-ht6 pour le traitement de troubles du snc
TWI317634B (en) 2001-12-13 2009-12-01 Nat Health Research Institutes Aroyl indoles compounds
BR0307406A (pt) 2002-02-01 2004-12-28 Hoffmann La Roche Indóis substituìdos como agonistas alfa-1
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
AU2003231509A1 (en) 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0202463D0 (sv) 2002-08-14 2002-08-14 Astrazeneca Ab Novel compounds
ATE479686T1 (de) * 2002-10-30 2010-09-15 Merck Frosst Canada Ltd Pyridopyrrolizin- und pyridoindolizinderivate
DE60316180T2 (de) * 2002-12-03 2008-05-29 F. Hoffmann-La Roche Ag Aminoalkoxyindol-derivate als 5-ht6-rezeptorliganden zur bekämpfung von zns-krankheiten
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
AU2004283139A1 (en) 2003-10-14 2005-05-06 Oxagen Limited Compounds having CRTH2 antagonist activity
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
GB2422831A (en) 2005-02-04 2006-08-09 Oxagen Ltd Pyrrolopyridines and their use in the treatment of diseases mediated by PGD2 at the CRTH2 receptor
EP2125722A2 (fr) 2006-05-26 2009-12-02 AstraZeneca AB Indoles substitues par biaryl ou aryl-heteroaryl
BRPI0712139A2 (pt) 2006-06-08 2012-01-10 Neurokey As uso de agonistas receptores de canabinóide como fármacos indutores de hipotermia para o tratamento da isquemia
KR20090023645A (ko) 2006-06-28 2009-03-05 사노피-아벤티스 신규한 ｃｘｃｒ2 억제제

Also Published As

Publication number Publication date
CA2594391A1 (fr) 2006-07-20
US20080051586A1 (en) 2008-02-28
IL183965A0 (en) 2007-10-31
MX2007008348A (es) 2007-08-03
WO2006075139A2 (fr) 2006-07-20
GB0500604D0 (en) 2005-02-16
CN101102999B (zh) 2010-12-29
NO20074047L (no) 2007-08-06
AU2006205697B2 (en) 2009-01-22
JP2008526936A (ja) 2008-07-24
NZ556147A (en) 2010-01-29
US7781598B2 (en) 2010-08-24
KR20070104350A (ko) 2007-10-25
WO2006075139A3 (fr) 2006-10-19
AU2006205697A1 (en) 2006-07-20
CN101102999A (zh) 2008-01-09
BRPI0606639A2 (pt) 2009-07-07
EP1844012A2 (fr) 2007-10-17

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