ZA200702792B - Improved adenoviral vectors and uses thereof - Google Patents
Improved adenoviral vectors and uses thereof Download PDFInfo
- Publication number
- ZA200702792B ZA200702792B ZA200702792A ZA200702792A ZA200702792B ZA 200702792 B ZA200702792 B ZA 200702792B ZA 200702792 A ZA200702792 A ZA 200702792A ZA 200702792 A ZA200702792 A ZA 200702792A ZA 200702792 B ZA200702792 B ZA 200702792B
- Authority
- ZA
- South Africa
- Prior art keywords
- vectors
- seq
- serotype
- vector
- adenovirus
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract description 276
- 241000701161 unidentified adenovirus Species 0.000 claims abstract description 86
- 101710094396 Hexon protein Proteins 0.000 claims abstract description 56
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims description 111
- 101000666856 Homo sapiens Vasoactive intestinal polypeptide receptor 1 Proteins 0.000 claims description 26
- 102100038388 Vasoactive intestinal polypeptide receptor 1 Human genes 0.000 claims description 26
- 241001217856 Chimpanzee adenovirus Species 0.000 claims description 4
- 230000036039 immunity Effects 0.000 abstract description 60
- 101710145505 Fiber protein Proteins 0.000 abstract description 34
- 102100025278 Coxsackievirus and adenovirus receptor Human genes 0.000 abstract description 27
- 101710176411 Coxsackievirus and adenovirus receptor Proteins 0.000 abstract description 27
- 241000598171 Human adenovirus sp. Species 0.000 abstract description 23
- 210000000234 capsid Anatomy 0.000 abstract description 21
- 239000000835 fiber Substances 0.000 description 85
- 241000700605 Viruses Species 0.000 description 64
- 241000699670 Mus sp. Species 0.000 description 53
- 108090000623 proteins and genes Proteins 0.000 description 50
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 44
- 102000004169 proteins and genes Human genes 0.000 description 40
- 210000004027 cell Anatomy 0.000 description 37
- 230000028993 immune response Effects 0.000 description 33
- 230000005847 immunogenicity Effects 0.000 description 29
- 230000004044 response Effects 0.000 description 27
- 230000003053 immunization Effects 0.000 description 26
- 238000002649 immunization Methods 0.000 description 26
- 150000007523 nucleic acids Chemical class 0.000 description 26
- 229960005486 vaccine Drugs 0.000 description 25
- 108020004707 nucleic acids Proteins 0.000 description 22
- 102000039446 nucleic acids Human genes 0.000 description 22
- 230000003472 neutralizing effect Effects 0.000 description 21
- 230000002163 immunogen Effects 0.000 description 19
- 230000001225 therapeutic effect Effects 0.000 description 18
- 210000001744 T-lymphocyte Anatomy 0.000 description 17
- 238000002255 vaccination Methods 0.000 description 17
- 101100348738 Mus musculus Noc3l gene Proteins 0.000 description 16
- 125000003275 alpha amino acid group Chemical group 0.000 description 15
- 239000000427 antigen Substances 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 102000036639 antigens Human genes 0.000 description 15
- 102000005962 receptors Human genes 0.000 description 15
- 108020003175 receptors Proteins 0.000 description 15
- 239000012634 fragment Substances 0.000 description 14
- 238000004806 packaging method and process Methods 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- 230000000890 antigenic effect Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 description 10
- 108060001084 Luciferase Proteins 0.000 description 10
- 239000005089 Luciferase Substances 0.000 description 10
- 238000003556 assay Methods 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 208000015181 infectious disease Diseases 0.000 description 10
- 239000013612 plasmid Substances 0.000 description 10
- 238000002347 injection Methods 0.000 description 9
- 239000007924 injection Substances 0.000 description 9
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 230000003612 virological effect Effects 0.000 description 9
- 241000282693 Cercopithecidae Species 0.000 description 8
- 238000011510 Elispot assay Methods 0.000 description 8
- 241000282560 Macaca mulatta Species 0.000 description 8
- 241000713311 Simian immunodeficiency virus Species 0.000 description 8
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 8
- 241000282412 Homo Species 0.000 description 7
- 230000010530 Virus Neutralization Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 7
- 238000012217 deletion Methods 0.000 description 7
- 230000037430 deletion Effects 0.000 description 7
- 210000004443 dendritic cell Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000001415 gene therapy Methods 0.000 description 7
- 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 6
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 6
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 6
- 238000010367 cloning Methods 0.000 description 6
- 238000003114 enzyme-linked immunosorbent spot assay Methods 0.000 description 6
- 238000000338 in vitro Methods 0.000 description 6
- 238000006386 neutralization reaction Methods 0.000 description 6
- 230000003389 potentiating effect Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 238000002965 ELISA Methods 0.000 description 5
- 102100039373 Membrane cofactor protein Human genes 0.000 description 5
- 101710173835 Penton protein Proteins 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 238000010348 incorporation Methods 0.000 description 5
- 244000045947 parasite Species 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 230000037452 priming Effects 0.000 description 5
- 238000000159 protein binding assay Methods 0.000 description 5
- 230000010076 replication Effects 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000010186 staining Methods 0.000 description 5
- 238000010361 transduction Methods 0.000 description 5
- 230000026683 transduction Effects 0.000 description 5
- 241000990167 unclassified Simian adenoviruses Species 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 108090000565 Capsid Proteins Proteins 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 230000024932 T cell mediated immunity Effects 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 230000002950 deficient Effects 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 230000003993 interaction Effects 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 108700026758 Adenovirus hexon capsid Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 102100023321 Ceruloplasmin Human genes 0.000 description 3
- 101710177291 Gag polyprotein Proteins 0.000 description 3
- 241000701124 Human adenovirus 35 Species 0.000 description 3
- 206010061598 Immunodeficiency Diseases 0.000 description 3
- 208000029462 Immunodeficiency disease Diseases 0.000 description 3
- 101710125418 Major capsid protein Proteins 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 241001503524 Ovine adenovirus Species 0.000 description 3
- 108700019146 Transgenes Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000007813 immunodeficiency Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 201000004792 malaria Diseases 0.000 description 3
- 238000011321 prophylaxis Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- 241001430294 unidentified retrovirus Species 0.000 description 3
- 241000701157 Canine mastadenovirus A Species 0.000 description 2
- 101710114676 E1B 55 kDa protein Proteins 0.000 description 2
- 241001115402 Ebolavirus Species 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000223960 Plasmodium falciparum Species 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 230000005867 T cell response Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 210000001163 endosome Anatomy 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000006801 homologous recombination Effects 0.000 description 2
- 238000002744 homologous recombination Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000010189 intracellular transport Effects 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- YRNWIFYIFSBPAU-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline Chemical compound C1=CC(N(C)C)=CC=C1C1=CC=C(N(C)C)C=C1 YRNWIFYIFSBPAU-UHFFFAOYSA-N 0.000 description 1
- -1 Ad2 Proteins 0.000 description 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
- 101710117490 Circumsporozoite protein Proteins 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 101100290057 Drosophila virilis Mal-B1 gene Proteins 0.000 description 1
- 101150075174 E1B gene Proteins 0.000 description 1
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000224016 Plasmodium Species 0.000 description 1
- 241000188845 Porcine adenovirus Species 0.000 description 1
- 108091034057 RNA (poly(A)) Proteins 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 230000010799 Receptor Interactions Effects 0.000 description 1
- 241000700584 Simplexvirus Species 0.000 description 1
- 238000000540 analysis of variance Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 210000000172 cytosol Anatomy 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001943 fluorescence-activated cell sorting Methods 0.000 description 1
- 108020001507 fusion proteins Proteins 0.000 description 1
- 102000037865 fusion proteins Human genes 0.000 description 1
- 108700004026 gag Genes Proteins 0.000 description 1
- 101150098622 gag gene Proteins 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 238000012239 gene modification Methods 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 238000010212 intracellular staining Methods 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 201000005296 lung carcinoma Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 101150088856 pix gene Proteins 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000007501 viral attachment Effects 0.000 description 1
- 230000007502 viral entry Effects 0.000 description 1
- 230000007482 viral spreading Effects 0.000 description 1
- 230000009614 wildtype growth Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10344—Chimeric viral vector comprising heterologous viral elements for production of another viral vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04105005 | 2004-10-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200702792B true ZA200702792B (en) | 2007-12-27 |
Family
ID=34929696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200702792A ZA200702792B (en) | 2004-10-13 | 2007-04-03 | Improved adenoviral vectors and uses thereof |
Country Status (6)
Country | Link |
---|---|
JP (1) | JP4843613B2 (pt) |
CN (1) | CN101072879B (pt) |
AT (1) | ATE492643T1 (pt) |
DE (1) | DE602005025512D1 (pt) |
ES (1) | ES2358523T3 (pt) |
ZA (1) | ZA200702792B (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010085984A1 (en) * | 2009-02-02 | 2010-08-05 | Okairos Ag | Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
WO2011022002A1 (en) * | 2009-08-18 | 2011-02-24 | The Rockefeller University | Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes |
WO2011129468A1 (en) * | 2010-04-14 | 2011-10-20 | Mogam Biotechnology Research Institute | Hexon isolated from simian adenovirus serotype 19, hypervariable region thereof and chimeric adenovirus using the same |
PL2655604T3 (pl) * | 2010-12-14 | 2019-02-28 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Szczepionki adenowirusowe serotyp 26 i serotyp 35 przeciwko filowirusom |
CN102199616B (zh) * | 2011-03-07 | 2013-04-24 | 首都医科大学附属北京佑安医院 | Hiv-1表型耐药检测载体及其构建方法 |
US9629906B2 (en) * | 2011-10-05 | 2017-04-25 | Genvec, Inc. | Affenadenovirus (gorilla) or adenoviral vectors and methods of use |
CN105431169B (zh) * | 2012-03-22 | 2019-04-02 | 扬森疫苗与预防公司 | 抗rsv疫苗 |
MX2018001182A (es) | 2015-07-28 | 2018-04-20 | Univ Pennsylvania | Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos. |
WO2018111767A1 (en) * | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
CN106868047B (zh) * | 2017-03-07 | 2020-04-28 | 南方医科大学 | 一种重组腺病毒载体及其构建方法和用途 |
AU2018295421B2 (en) * | 2017-07-05 | 2024-01-25 | Nouscom Ag | Non human great apes adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof |
CN107267469B (zh) * | 2017-08-22 | 2020-06-16 | 广州医科大学附属第一医院 | 纤毛蛋白嵌合型重组人b型腺病毒及其制备方法 |
CA3077630A1 (en) * | 2017-10-31 | 2019-05-09 | Janssen Vaccines & Prevention B.V. | Adenovirus vectors and uses thereof |
KR20200074987A (ko) * | 2017-10-31 | 2020-06-25 | 얀센 백신스 앤드 프리벤션 비.브이. | 아데노바이러스 및 이의 용도 |
WO2019195444A1 (en) | 2018-04-03 | 2019-10-10 | Stridebio, Inc. | Antibody-evading virus vectors |
CN113227361A (zh) * | 2018-11-21 | 2021-08-06 | 梅奥医学教育及研究基金会 | 腺病毒和使用腺病毒的方法 |
EP3927833A4 (en) * | 2019-02-21 | 2022-11-30 | Unleash Immuno Oncolytics, Inc. | ONCOLYTIC ADENOVIRAL VECTOR AND METHODS OF USE |
JP2023529841A (ja) | 2020-06-04 | 2023-07-12 | カリスマ セラピューティクス インコーポレイテッド | キメラ抗原受容体のための新規コンストラクト |
CN114262692A (zh) * | 2021-11-30 | 2022-04-01 | 华中科技大学同济医学院附属同济医院 | 一种携带tmvp1和hsv-tk的溶瘤腺病毒重组体,其构建方法及应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US5922315A (en) * | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
AU2002322285A1 (en) * | 2001-06-22 | 2003-01-08 | The Trustees Of The University Of Pennsylvania | Method for rapid screening of bacterial transformants and novel simian adenovirus proteins |
-
2005
- 2005-10-12 AT AT05815456T patent/ATE492643T1/de active
- 2005-10-12 CN CN2005800351365A patent/CN101072879B/zh not_active Expired - Fee Related
- 2005-10-12 JP JP2007536171A patent/JP4843613B2/ja not_active Expired - Fee Related
- 2005-10-12 ES ES05815456T patent/ES2358523T3/es active Active
- 2005-10-12 DE DE602005025512T patent/DE602005025512D1/de active Active
-
2007
- 2007-04-03 ZA ZA200702792A patent/ZA200702792B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101072879B (zh) | 2011-05-11 |
CN101072879A (zh) | 2007-11-14 |
ATE492643T1 (de) | 2011-01-15 |
JP4843613B2 (ja) | 2011-12-21 |
DE602005025512D1 (de) | 2011-02-03 |
ES2358523T3 (es) | 2011-05-11 |
JP2009523007A (ja) | 2009-06-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2005293568B2 (en) | Improved adenoviral vectors and uses thereof | |
JP4843613B2 (ja) | 改良されたアデノウイルスベクターおよびその使用方法 | |
US11214599B2 (en) | Recombinant simian adenoviral vectors encoding a heterologous fiber protein and uses thereof | |
CA2880060C (en) | Chimpanzee adenovirus vaccine carriers | |
US7968286B2 (en) | Settings for recombinant adenoviral-based vaccines |