ZA200701666B - Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors - Google Patents
Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors Download PDFInfo
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- ZA200701666B ZA200701666B ZA200701666A ZA200701666A ZA200701666B ZA 200701666 B ZA200701666 B ZA 200701666B ZA 200701666 A ZA200701666 A ZA 200701666A ZA 200701666 A ZA200701666 A ZA 200701666A ZA 200701666 B ZA200701666 B ZA 200701666B
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- South Africa
- Prior art keywords
- pyridine
- derivative according
- imidazo
- alkyl
- diseases
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 title claims description 10
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- HAIALLMLSNZDAL-UHFFFAOYSA-N 3-methylidenepyrrolidin-2-one;pyridine Chemical class C1=CC=NC=C1.C=C1CCNC1=O HAIALLMLSNZDAL-UHFFFAOYSA-N 0.000 claims abstract description 27
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60737404P | 2004-09-03 | 2004-09-03 | |
| EP04104259 | 2004-09-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701666B true ZA200701666B (en) | 2008-07-30 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701666A ZA200701666B (en) | 2004-09-03 | 2005-09-02 | Pyridine méthylène azolidinones and use thereof phospho-inositide inhibitors |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US7842698B2 (no) |
| EP (1) | EP1786812B1 (no) |
| JP (1) | JP5209311B2 (no) |
| KR (1) | KR101229647B1 (no) |
| CN (1) | CN101052640B (no) |
| AT (1) | ATE532783T1 (no) |
| AU (1) | AU2005279156B2 (no) |
| BR (1) | BRPI0515627A (no) |
| CA (1) | CA2576765C (no) |
| CY (1) | CY1112316T1 (no) |
| EA (1) | EA012178B1 (no) |
| HK (1) | HK1106773A1 (no) |
| HR (1) | HRP20110834T1 (no) |
| IL (1) | IL181415A (no) |
| MX (1) | MX2007002604A (no) |
| NO (1) | NO20071605L (no) |
| PL (1) | PL1786812T3 (no) |
| SI (1) | SI1786812T1 (no) |
| WO (1) | WO2006024666A1 (no) |
| ZA (1) | ZA200701666B (no) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602004022170D1 (de) | 2003-07-28 | 2009-09-03 | Merck Serono Sa Coinsins | 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| WO2008014219A2 (en) * | 2006-07-24 | 2008-01-31 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as p13 kinase inhibitors |
| WO2009133070A1 (en) * | 2008-04-29 | 2009-11-05 | Novartis Ag | Imidazo-pyridine derivatives as activin-like receptor kinase (alk4 or alk5) inhibitors |
| US20100061982A1 (en) * | 2008-09-10 | 2010-03-11 | Wyeth | 3-substituted-1h-indole, 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
| AU2010213014B2 (en) * | 2009-02-12 | 2016-02-25 | Merck Serono S.A. | 2-morpholino-pyrido[3,2-d]pyrimidines |
| AU2010326268B2 (en) * | 2009-12-04 | 2016-11-03 | Senhwa Biosciences, Inc. | Pyrazolopyrimidines and related heterocycles as CK2 inhibitors |
| CA2783575C (en) * | 2009-12-23 | 2018-06-05 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| US8901145B2 (en) | 2011-04-22 | 2014-12-02 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| CA2848877A1 (en) * | 2011-09-15 | 2013-03-21 | Taipei Medical University | Use of indolyl and indolinvl hvdroxamates for treating heart failure or neuronal injury |
| JP6057907B2 (ja) * | 2011-10-04 | 2017-01-11 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とする医薬品 |
| ES2629690T3 (es) | 2011-11-04 | 2017-08-14 | Jasco Pharmaceuticals, LLC | Inhibidores de aminopirimidina quinasa |
| KR101684950B1 (ko) | 2012-07-23 | 2016-12-12 | 주식회사유한양행 | 퓨란-함유 융합 고리 화합물 또는 그의 염 및 이를 포함하는 약학 조성물 |
| JP6434416B2 (ja) | 2012-11-08 | 2018-12-05 | ライゼン・ファーマシューティカルズ・エスアー | ＰＤＥ４阻害剤とＰＩ３δ阻害剤または二重ＰＩ３δ−γキナーゼ阻害剤とを含有する薬学的組成物 |
| SG11201708190UA (en) * | 2015-04-29 | 2017-11-29 | Janssen Pharmaceutica Nv | Azabenzimidazoles and their use as ampa receptor modulators |
| EP3288936B1 (en) | 2015-04-29 | 2020-05-06 | Janssen Pharmaceutica NV | Benzimidazolone and benzothiazolone compounds and their use as ampa receptor modulators |
| BR112017023038A2 (pt) | 2015-04-29 | 2018-07-03 | Janssen Pharmaceutica Nv | imidazopirazinas e pirazolopirimidinas e seu uso como moduladores do receptor ampa |
| ES2767707T3 (es) | 2015-04-29 | 2020-06-18 | Janssen Pharmaceutica Nv | Compuestos de indolona y su uso como moduladores de receptor AMPA |
| US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
| CN106588909B (zh) * | 2017-01-06 | 2019-08-27 | 广东工业大学 | 一种喹啉类衍生物的制备及其在抗炎中的应用 |
| CN109575435A (zh) | 2017-09-14 | 2019-04-05 | 株式会社日化精密科技 | 聚丙烯树脂组合物、聚丙烯树脂成形体以及聚丙烯树脂成形体的制造方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003255528B2 (en) * | 2002-07-10 | 2009-07-16 | Merck Serono Sa | Azolidinone-vinyl fused-benzene derivatives |
| EP1569653A1 (en) * | 2002-12-06 | 2005-09-07 | Warner-Lambert Company LLC | Benzoxazin-3-ones and derivatives thereof as inhibitors of pi3k |
| CA2510851A1 (en) | 2002-12-20 | 2004-07-08 | Warner-Lambert Company Llc | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| DE602004022170D1 (de) * | 2003-07-28 | 2009-09-03 | Merck Serono Sa Coinsins | 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren |
| US7696210B2 (en) * | 2004-06-17 | 2010-04-13 | Wyeth | Gonadotropin releasing hormone receptor antagonists |
| JP2008515955A (ja) | 2004-10-12 | 2008-05-15 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 貧血の治療のためのＰＩ３キナーゼγ阻害剤 |
| EP1931424A2 (en) | 2005-09-07 | 2008-06-18 | Laboratoires Serono S.A. | P13k inhibitors for the treatment of endometriosis |
| TW200808793A (en) * | 2006-03-07 | 2008-02-16 | Smithkline Beecham Corp | Prolyl hydroxylase inhibitors |
| WO2008028141A2 (en) * | 2006-08-31 | 2008-03-06 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
| MX2010000474A (es) * | 2007-07-12 | 2010-06-23 | Univ South Florida | Inhibidores de proteina serina/treonina quinasa a/proteina quinasa b con actividad antitumoral. |
| US7932251B2 (en) * | 2007-07-16 | 2011-04-26 | N.V. Organon | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives |
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2005
- 2005-09-02 AT AT05797231T patent/ATE532783T1/de active
- 2005-09-02 US US11/574,613 patent/US7842698B2/en not_active Expired - Fee Related
- 2005-09-02 MX MX2007002604A patent/MX2007002604A/es active IP Right Grant
- 2005-09-02 KR KR1020077007588A patent/KR101229647B1/ko not_active IP Right Cessation
- 2005-09-02 EP EP05797231A patent/EP1786812B1/en active Active
- 2005-09-02 BR BRPI0515627-0A patent/BRPI0515627A/pt not_active IP Right Cessation
- 2005-09-02 SI SI200531418T patent/SI1786812T1/sl unknown
- 2005-09-02 CA CA2576765A patent/CA2576765C/en not_active Expired - Fee Related
- 2005-09-02 ZA ZA200701666A patent/ZA200701666B/en unknown
- 2005-09-02 EA EA200700541A patent/EA012178B1/ru not_active IP Right Cessation
- 2005-09-02 WO PCT/EP2005/054339 patent/WO2006024666A1/en active Application Filing
- 2005-09-02 PL PL05797231T patent/PL1786812T3/pl unknown
- 2005-09-02 AU AU2005279156A patent/AU2005279156B2/en not_active Ceased
- 2005-09-02 JP JP2007528883A patent/JP5209311B2/ja not_active Expired - Fee Related
- 2005-09-02 CN CN200580037159XA patent/CN101052640B/zh not_active Expired - Fee Related
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2007
- 2007-02-19 IL IL181415A patent/IL181415A/en not_active IP Right Cessation
- 2007-03-27 NO NO20071605A patent/NO20071605L/no not_active Application Discontinuation
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2008
- 2008-01-16 HK HK08100536.3A patent/HK1106773A1/xx not_active IP Right Cessation
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2010
- 2010-10-18 US US12/906,729 patent/US8058289B2/en not_active Expired - Fee Related
-
2011
- 2011-11-11 HR HR20110834T patent/HRP20110834T1/hr unknown
-
2012
- 2012-02-02 CY CY20121100119T patent/CY1112316T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20110834T1 (hr) | 2011-12-31 |
| KR20070053315A (ko) | 2007-05-23 |
| SI1786812T1 (sl) | 2011-12-30 |
| JP5209311B2 (ja) | 2013-06-12 |
| US20110034458A1 (en) | 2011-02-10 |
| EP1786812A1 (en) | 2007-05-23 |
| CN101052640B (zh) | 2011-05-11 |
| MX2007002604A (es) | 2007-04-25 |
| US7842698B2 (en) | 2010-11-30 |
| EA200700541A1 (ru) | 2007-08-31 |
| CN101052640A (zh) | 2007-10-10 |
| NO20071605L (no) | 2007-05-31 |
| JP2008511589A (ja) | 2008-04-17 |
| IL181415A (en) | 2012-09-24 |
| BRPI0515627A (pt) | 2008-07-29 |
| AU2005279156A1 (en) | 2006-03-09 |
| HK1106773A1 (en) | 2008-03-20 |
| CA2576765C (en) | 2013-05-28 |
| ATE532783T1 (de) | 2011-11-15 |
| KR101229647B1 (ko) | 2013-02-05 |
| US8058289B2 (en) | 2011-11-15 |
| AU2005279156B2 (en) | 2011-06-02 |
| PL1786812T3 (pl) | 2012-04-30 |
| WO2006024666A1 (en) | 2006-03-09 |
| US20080269227A1 (en) | 2008-10-30 |
| CY1112316T1 (el) | 2015-12-09 |
| IL181415A0 (en) | 2007-07-04 |
| EP1786812B1 (en) | 2011-11-09 |
| CA2576765A1 (en) | 2006-03-09 |
| EA012178B1 (ru) | 2009-08-28 |
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