ZA200606730B - Method for quantitatively determining specific constituting heparins or low molecular weight heparins using HPLC - Google Patents

Method for quantitatively determining specific constituting heparins or low molecular weight heparins using HPLC

Info

Publication number
ZA200606730B
ZA200606730B ZA200606730A ZA200606730A ZA200606730B ZA 200606730 B ZA200606730 B ZA 200606730B ZA 200606730 A ZA200606730 A ZA 200606730A ZA 200606730 A ZA200606730 A ZA 200606730A ZA 200606730 B ZA200606730 B ZA 200606730B
Authority
ZA
South Africa
Prior art keywords
heparins
hplc
molecular weight
low molecular
quantitatively determining
Prior art date
Application number
ZA200606730A
Other languages
English (en)
Inventor
Mourier Pierre
Viskov Christian
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of ZA200606730B publication Critical patent/ZA200606730B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
ZA200606730A 2004-03-24 2005-03-22 Method for quantitatively determining specific constituting heparins or low molecular weight heparins using HPLC ZA200606730B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04290790A EP1580197A1 (en) 2004-03-24 2004-03-24 Method for quantitatively determining specific groups constituting heparins or low molecular wieght heparins using HPLC

Publications (1)

Publication Number Publication Date
ZA200606730B true ZA200606730B (en) 2008-01-30

Family

ID=34854727

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200606730A ZA200606730B (en) 2004-03-24 2005-03-22 Method for quantitatively determining specific constituting heparins or low molecular weight heparins using HPLC

Country Status (14)

Country Link
EP (2) EP1580197A1 (ja)
JP (1) JP2007530932A (ja)
KR (1) KR20060132741A (ja)
CN (1) CN1934135A (ja)
AR (1) AR048113A1 (ja)
AU (1) AU2005223360A1 (ja)
BR (1) BRPI0509068B1 (ja)
CA (1) CA2558563A1 (ja)
IL (1) IL177604A0 (ja)
MA (1) MA28483B1 (ja)
NO (1) NO20064809L (ja)
RU (1) RU2006137370A (ja)
WO (1) WO2005090409A1 (ja)
ZA (1) ZA200606730B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003225724A1 (en) 2002-03-11 2003-09-29 Momenta Pharmaceuticals, Inc. Analysis of sulfated polysaccharides
US8101733B1 (en) 2006-06-27 2012-01-24 Momenta Pharmaceuticals, Inc. Methods of evaluating mixtures of polysaccharides
US7790466B1 (en) 2007-01-26 2010-09-07 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by chain profiles or chain mapping
US7968082B1 (en) 2007-01-26 2011-06-28 Momenta Pharmaceuticals, Inc. Evaluating mixtures of low molecular weight heparins by NMR
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
EP2256137A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel sulfated octasaccharide and its use as antithrombotic agent
EP2256139A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel sulfated heptasaccharide and its use as antithrombotic agent
EP2256136A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel acylated decasaccharides and their use as antithrombotic agents
EP2256138A1 (en) 2009-05-05 2010-12-01 Sanofi-Aventis Novel acylated 1,6-anhhydro decasaccharide and its use as antithrombotic agent
ES2817779T3 (es) 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
WO2012100733A1 (zh) * 2011-01-28 2012-08-02 杭州九源基因工程有限公司 一种基于毛细管电泳的依诺肝素钠精细结构测定方法
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102206690A (zh) * 2011-03-13 2011-10-05 广元市海鹏生物科技有限公司 一种肝素寡糖的制备方法
CN102323355B (zh) * 2011-08-22 2013-10-16 深圳市天道医药有限公司 一种酶解-hplc法检测依诺肝素的方法
CN102533906B (zh) * 2012-03-12 2013-11-13 南京健友生化制药股份有限公司 一种依诺肝素钠酶解方法
CN103149198B (zh) * 2013-02-08 2015-04-22 浙江工业大学 一种酶法快速定量检测heparosan的方法
CN103755823B (zh) * 2013-12-12 2016-09-28 中国海洋大学 一种硫酸软骨素中硫酸角质素的纯化与检测方法
CN104193849B (zh) * 2014-08-13 2016-08-17 南京健友生化制药股份有限公司 一种依诺肝素钠的生产方法
CN105891343B (zh) * 2014-12-06 2019-01-08 烟台东诚药业集团股份有限公司 一种舒洛地特组分精细结构分析检测方法
CN104483418B (zh) * 2014-12-30 2016-09-14 深圳市天道医药有限公司 一种rp-ip-hplc法收集依诺肝素寡糖的方法
CN104792896A (zh) * 2015-04-23 2015-07-22 苏州融析生物科技有限公司 一种可彻底特异性酶解依诺肝素钠的肝素酶组合物及其应用
CN112005110B (zh) * 2018-07-24 2022-11-29 深圳市海普瑞药业集团股份有限公司 一种达肝素钠亚硝酸降解产物的分析方法及其应用
CN112626058B (zh) * 2020-12-22 2022-09-27 山东大学 一种外切型肝素酶及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033468A1 (en) * 1994-06-06 1995-12-14 Oestergaard Per Bjoern A pharmaceutical composition comprising oligosaccharides binding to lipoprotein lipase
FR2800074B1 (fr) * 1999-10-22 2001-12-21 Aventis Pharma Sa Nouveaux oligosaccharides, leur preparation et les compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
IL177604A0 (en) 2006-12-10
MA28483B1 (fr) 2007-03-01
KR20060132741A (ko) 2006-12-21
EP1730200A1 (en) 2006-12-13
NO20064809L (no) 2006-10-23
RU2006137370A (ru) 2008-04-27
BRPI0509068A (pt) 2007-08-21
EP1580197A1 (en) 2005-09-28
CA2558563A1 (en) 2005-09-29
JP2007530932A (ja) 2007-11-01
AU2005223360A1 (en) 2005-09-29
AR048113A1 (es) 2006-03-29
CN1934135A (zh) 2007-03-21
BRPI0509068B1 (pt) 2015-11-03
WO2005090409A1 (en) 2005-09-29
EP1730200B1 (en) 2014-04-23

Similar Documents

Publication Publication Date Title
ZA200606730B (en) Method for quantitatively determining specific constituting heparins or low molecular weight heparins using HPLC
EP1745150A4 (en) METHOD FOR DETECTING NCRNA
GB2437144B (en) Formation evaluation system and method
IL181842A0 (en) Multi-threat detection system
HK1123916A1 (en) Methods and apparatus determining, communicating, and/or using delay information
EP1936528A4 (en) SITE DETERMINATION METHOD
EP1934701A4 (en) SEARCH SYSTEM AND METHOD
EP1772823A4 (en) SYSTEM AND METHOD OF SEARCH
EP1866614A4 (en) SYSTEM AND METHOD FOR DETECTION OF CONCEALED OBJECTS
EP1775575A4 (en) FLUORESCENCE DETECTION METHOD
EP1926066A4 (en) METHOD FOR DETECTING MOBILITY OF CONDUCTIVE CONDUCTIVE OBJECTS
EP1771736A4 (en) SYSTEM FOR DETECTING MOLECULAR INTERACTIONS
EP1952138A4 (en) METHOD FOR DETECTION OF INFLAMMATORY DISEASE OR CANCER DISEASE
EP1865067A4 (en) METHOD OF STUDY, MEASUREMENT OR EVALUATION
EP1862547A4 (en) METHOD FOR DETECTING MYCOPLASM
HUP0401134A2 (en) Method for processing of polymer wasts like matrixmatherial
GB0523239D0 (en) Quantification method
EP1861001A4 (en) SYSTEM AND METHOD FOR DETERMINING HEART RATE
GB0416372D0 (en) Methods and apparatus for target sensing using profiles
GB0414233D0 (en) Analysis method
GB0419628D0 (en) Method for determining protein solubility
GB0509497D0 (en) Detection system
GB2450436B (en) Formation evaluation system and method
GB2410872B (en) Signal processing method
GB0305589D0 (en) Method for detection