ZA200604888B - Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection - Google Patents
Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection Download PDFInfo
- Publication number
- ZA200604888B ZA200604888B ZA200604888A ZA200604888A ZA200604888B ZA 200604888 B ZA200604888 B ZA 200604888B ZA 200604888 A ZA200604888 A ZA 200604888A ZA 200604888 A ZA200604888 A ZA 200604888A ZA 200604888 B ZA200604888 B ZA 200604888B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- amino
- alkoxy
- alkylamino
- cyano
- Prior art date
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- 206010052779 Transplant rejections Diseases 0.000 title claims description 16
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 1242
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 213
- -1 hydroxy, amino Chemical group 0.000 claims description 205
- 125000002252 acyl group Chemical group 0.000 claims description 196
- 229910052684 Cerium Inorganic materials 0.000 claims description 187
- 125000004442 acylamino group Chemical group 0.000 claims description 187
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 184
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 164
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 127
- 229910052805 deuterium Inorganic materials 0.000 claims description 127
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- 239000001257 hydrogen Substances 0.000 claims description 107
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53118003P | 2003-12-17 | 2003-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200604888B true ZA200604888B (en) | 2007-11-28 |
Family
ID=34710208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200604888A ZA200604888B (en) | 2003-12-17 | 2006-06-13 | Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20050159433A1 (fr) |
| EP (1) | EP1734967A2 (fr) |
| JP (1) | JP2007514729A (fr) |
| KR (1) | KR20060096153A (fr) |
| CN (1) | CN1893952A (fr) |
| AU (1) | AU2004305317A1 (fr) |
| BR (1) | BRPI0417803A (fr) |
| CA (1) | CA2549485A1 (fr) |
| CO (1) | CO5700767A2 (fr) |
| IL (1) | IL175812A0 (fr) |
| MX (1) | MXPA06007002A (fr) |
| NO (1) | NO20062292L (fr) |
| RU (1) | RU2006120956A (fr) |
| SG (1) | SG133602A1 (fr) |
| TW (1) | TW200529853A (fr) |
| WO (1) | WO2005060972A2 (fr) |
| ZA (1) | ZA200604888B (fr) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200400105T4 (tr) | 1999-12-10 | 2004-02-23 | Prizer Products Inc. | Pirrolo [2,3-d] pirimidin bileşikleri |
| PL378246A1 (pl) | 2002-11-26 | 2006-03-20 | Pfizer Products Inc. | Sposób leczenia odrzucania przeszczepu |
| AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
| CA2615291A1 (fr) | 2005-07-14 | 2007-01-18 | Astellas Pharma Inc. | Inibiteurs heterocycliques de la janus kinase 3 |
| EP2251341A1 (fr) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Hétérocycles inhibiteurs de Janus kinase-3 |
| WO2007038215A1 (fr) | 2005-09-22 | 2007-04-05 | Incyte Corporation | Inhibiteurs tetracycliques de janus kinases |
| ES2611588T3 (es) | 2005-12-13 | 2017-05-09 | Incyte Holdings Corporation | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas Janus |
| GB0605691D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic Compounds |
| US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
| LT3070090T (lt) | 2007-06-13 | 2019-06-25 | Incyte Holdings Corporation | Janus kinazės inhibitoriaus (r)-3-(4-(7h-pirol[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciklopentilpropannitrilo druskų panaudojimas |
| CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
| SG191660A1 (en) | 2008-03-11 | 2013-07-31 | Incyte Corp | Azetidine and cyclobutane derivatives as jak inhibitors |
| PL2384326T3 (pl) | 2008-08-20 | 2014-09-30 | Zoetis Services Llc | Związki pirolo[2,3-d]pirymidyonowe |
| KR20130009577A (ko) | 2009-04-20 | 2013-01-23 | 오스펙스 파마슈티컬즈 엘엘씨 | 야누스 키나아제 3의 피페리딘 억제제 |
| EA020494B1 (ru) | 2009-05-22 | 2014-11-28 | Инсайт Корпорейшн | 3-[4-(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)-1H-ПИРАЗОЛ-1-ИЛ]ОКТАН- ИЛИ ГЕПТАННИТРИЛ КАК JAK-ИНГИБИТОРЫ |
| EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
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| EP2338888A1 (fr) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Dérivés d'imidazopyridine en tant qu'inhibiteurs JAK |
| NZ602313A (en) | 2010-03-10 | 2014-08-29 | Incyte Corp | Piperidin-4-yl azetidine derivatives as jak1 inhibitors |
| ME02445B (fr) | 2010-05-21 | 2016-09-20 | Incyte Holdings Corp | Formulation topique pour inhibiteur de jak |
| WO2012068440A1 (fr) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Pyrrolopyridines et pyrrolopyrimidines à substitution hétérocyclique utilisées en tant qu'inhibiteurs des jak |
| CA2818542A1 (fr) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Derives pyrrolopyridine et pyrrolopyrimidine a substitution cyclobutyle utilises comme inhibiteurs des jak |
| AU2012204843A1 (en) | 2011-01-07 | 2013-05-02 | Leo Pharma A/S | Novel sulfamide piperazine derivatives as protein tyrosine kinase inhibitors and pharmaceutical use thereof |
| CN103732226B (zh) | 2011-02-18 | 2016-01-06 | 诺瓦提斯药物公司 | mTOR/JAK抑制剂组合疗法 |
| CA2830882C (fr) | 2011-03-22 | 2021-03-16 | Dinesh Barawkar | Composes tricycliques substitues; compositions et applications medicinales correspondantes |
| WO2012177606A1 (fr) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Dérivés d'azétidinyl-phényl-, de pyridyl- ou de pyrazinyl-carboxamide en tant qu'inhibiteurs des jak |
| JP2014521725A (ja) | 2011-08-10 | 2014-08-28 | ノバルティス・ファルマ・アクチェンゲゼルシャフト | ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 |
| TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物 |
| UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
| US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
| EP2897962A1 (fr) | 2012-09-21 | 2015-07-29 | Advinus Therapeutics Limited | Composés tricycliques condensés substitués, compositions et applications médicales correspondantes |
| LT2919766T (lt) | 2012-11-15 | 2021-09-27 | Incyte Holdings Corporation | Ruksolitinibo pailginto atpalaidavimo vaisto formos |
| CN103896826B (zh) * | 2012-12-26 | 2016-08-03 | 上海朴颐化学科技有限公司 | 氮保护的(3r,4r)-3-甲氨基-4-甲基哌啶的不对称合成方法、相关中间体及原料制备方法 |
| EP2938616A4 (fr) | 2012-12-28 | 2016-06-15 | Glenmark Pharmaceuticals Ltd | Procédé de préparation de tofacitinib et d'intermédiaires |
| SG10201707259PA (en) | 2013-03-06 | 2017-10-30 | Incyte Corp | Processes and intermediates for making a jak inhibitor |
| ES2792549T3 (es) | 2013-08-07 | 2020-11-11 | Incyte Corp | Formas de dosificación de liberación sostenida para un inhibidor de JAK1 |
| US9498467B2 (en) | 2014-05-30 | 2016-11-22 | Incyte Corporation | Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1 |
| CN104059016A (zh) * | 2014-06-20 | 2014-09-24 | 湖南天地恒一制药有限公司 | 制备托法替布的中间体及所述中间体的制备方法 |
| WO2019113487A1 (fr) | 2017-12-08 | 2019-06-13 | Incyte Corporation | Polythérapie à faible dose pour le traitement de néoplasmes myéloprolifératifs |
| AR114810A1 (es) | 2018-01-30 | 2020-10-21 | Incyte Corp | Procesos e intermedios para elaborar un inhibidor de jak |
| AU2019245420A1 (en) | 2018-03-30 | 2020-11-12 | Incyte Corporation | Treatment of hidradenitis suppurativa using JAK inhibitors |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US53782A (en) * | 1866-04-10 | Improvement in nut-machines | ||
| TR200400105T4 (tr) * | 1999-12-10 | 2004-02-23 | Prizer Products Inc. | Pirrolo [2,3-d] pirimidin bileşikleri |
| PL378246A1 (pl) * | 2002-11-26 | 2006-03-20 | Pfizer Products Inc. | Sposób leczenia odrzucania przeszczepu |
-
2004
- 2004-12-06 KR KR1020067011842A patent/KR20060096153A/ko not_active Application Discontinuation
- 2004-12-06 CN CNA2004800377587A patent/CN1893952A/zh active Pending
- 2004-12-06 MX MXPA06007002A patent/MXPA06007002A/es unknown
- 2004-12-06 CA CA002549485A patent/CA2549485A1/fr not_active Abandoned
- 2004-12-06 WO PCT/IB2004/004034 patent/WO2005060972A2/fr active Application Filing
- 2004-12-06 BR BRPI0417803-3A patent/BRPI0417803A/pt not_active IP Right Cessation
- 2004-12-06 AU AU2004305317A patent/AU2004305317A1/en not_active Abandoned
- 2004-12-06 SG SG200704529-7A patent/SG133602A1/en unknown
- 2004-12-06 JP JP2006544578A patent/JP2007514729A/ja active Pending
- 2004-12-06 RU RU2006120956/04A patent/RU2006120956A/ru not_active Application Discontinuation
- 2004-12-06 EP EP04801340A patent/EP1734967A2/fr not_active Withdrawn
- 2004-12-13 US US11/011,474 patent/US20050159433A1/en not_active Abandoned
- 2004-12-16 TW TW093139167A patent/TW200529853A/zh unknown
-
2006
- 2006-05-19 NO NO20062292A patent/NO20062292L/no not_active Application Discontinuation
- 2006-05-22 IL IL175812A patent/IL175812A0/en unknown
- 2006-06-09 CO CO06056308A patent/CO5700767A2/es not_active Application Discontinuation
- 2006-06-13 ZA ZA200604888A patent/ZA200604888B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA06007002A (es) | 2006-08-31 |
| WO2005060972A2 (fr) | 2005-07-07 |
| CN1893952A (zh) | 2007-01-10 |
| AU2004305317A1 (en) | 2005-07-07 |
| CO5700767A2 (es) | 2006-11-30 |
| IL175812A0 (en) | 2008-04-13 |
| JP2007514729A (ja) | 2007-06-07 |
| EP1734967A2 (fr) | 2006-12-27 |
| RU2006120956A (ru) | 2008-01-27 |
| BRPI0417803A (pt) | 2007-04-10 |
| KR20060096153A (ko) | 2006-09-07 |
| US20050159433A1 (en) | 2005-07-21 |
| CA2549485A1 (fr) | 2005-07-07 |
| TW200529853A (en) | 2005-09-16 |
| NO20062292L (no) | 2006-06-14 |
| SG133602A1 (en) | 2007-07-30 |
| WO2005060972A3 (fr) | 2005-10-20 |
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