ZA200604888B - Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection - Google Patents
Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection Download PDFInfo
- Publication number
- ZA200604888B ZA200604888B ZA200604888A ZA200604888A ZA200604888B ZA 200604888 B ZA200604888 B ZA 200604888B ZA 200604888 A ZA200604888 A ZA 200604888A ZA 200604888 A ZA200604888 A ZA 200604888A ZA 200604888 B ZA200604888 B ZA 200604888B
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- ZA
- South Africa
- Prior art keywords
- alkyl
- amino
- alkoxy
- alkylamino
- cyano
- Prior art date
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- 206010052779 Transplant rejections Diseases 0.000 title claims description 16
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims description 1242
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 213
- -1 hydroxy, amino Chemical group 0.000 claims description 205
- 125000002252 acyl group Chemical group 0.000 claims description 196
- 229910052684 Cerium Inorganic materials 0.000 claims description 187
- 125000004442 acylamino group Chemical group 0.000 claims description 187
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 184
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 164
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 127
- 229910052805 deuterium Inorganic materials 0.000 claims description 127
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- 239000001257 hydrogen Substances 0.000 claims description 107
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US53118003P | 2003-12-17 | 2003-12-17 |
Publications (1)
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ZA200604888B true ZA200604888B (en) | 2007-11-28 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200604888A ZA200604888B (en) | 2003-12-17 | 2006-06-13 | Pyrrolo (2,3-D) pyrimidine compounds for treating transplant rejection |
Country Status (17)
Country | Link |
---|---|
US (1) | US20050159433A1 (fr) |
EP (1) | EP1734967A2 (fr) |
JP (1) | JP2007514729A (fr) |
KR (1) | KR20060096153A (fr) |
CN (1) | CN1893952A (fr) |
AU (1) | AU2004305317A1 (fr) |
BR (1) | BRPI0417803A (fr) |
CA (1) | CA2549485A1 (fr) |
CO (1) | CO5700767A2 (fr) |
IL (1) | IL175812A0 (fr) |
MX (1) | MXPA06007002A (fr) |
NO (1) | NO20062292L (fr) |
RU (1) | RU2006120956A (fr) |
SG (1) | SG133602A1 (fr) |
TW (1) | TW200529853A (fr) |
WO (1) | WO2005060972A2 (fr) |
ZA (1) | ZA200604888B (fr) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4078074B2 (ja) | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
KR20050086784A (ko) | 2002-11-26 | 2005-08-30 | 화이자 프로덕츠 인크. | 이식 거부반응의 치료 방법 |
AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
KR20080026654A (ko) | 2005-07-14 | 2008-03-25 | 아스텔라스세이야쿠 가부시키가이샤 | 헤테로시클릭 야누스 키나제 3 억제제 |
CN102127078A (zh) | 2005-07-14 | 2011-07-20 | 安斯泰来制药株式会社 | Janus激酶3的杂环类抑制剂 |
US20070149506A1 (en) | 2005-09-22 | 2007-06-28 | Arvanitis Argyrios G | Azepine inhibitors of Janus kinases |
HUE030235T2 (en) | 2005-12-13 | 2017-04-28 | Incyte Holdings Corp | Heteroaryl-substituted pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] pyrimidines as Janus kinase inhibitors |
GB0605691D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic Compounds |
WO2008079965A1 (fr) | 2006-12-22 | 2008-07-03 | Incyte Corporation | Hétérocycles substitués servant d'inhibiteurs de janus kinases |
EP3070090B1 (fr) | 2007-06-13 | 2018-12-12 | Incyte Holdings Corporation | Utilisation des sels de l'inhibiteur de janus kinase (r)-3-(4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl)-1h-pyrazol-1-yl) -3-cyclopentylpropanenitrile |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
ES2602577T3 (es) | 2008-03-11 | 2017-02-21 | Incyte Holdings Corporation | Derivados de azetidina y ciclobutano como inhibidores de JAK |
CA2733359C (fr) | 2008-08-20 | 2014-08-05 | Pfizer Inc. | Composes pyrrolo[2,3-d]pyrimidines |
BRPI1007737A2 (pt) | 2009-04-20 | 2015-09-01 | Auspex Pharmaceuticals Llc | "composto da fórmula estrutural i, composição farmacêutica, método de tratamento de um distúbio mediano por janus quinase 3, método de preparação de um composto da fórmula estrutural ii, e método de preparação de um composto da fórmula estrutural xii" |
AR076794A1 (es) | 2009-05-22 | 2011-07-06 | Incyte Corp | Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen |
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US53782A (en) * | 1866-04-10 | Improvement in nut-machines | ||
JP4078074B2 (ja) * | 1999-12-10 | 2008-04-23 | ファイザー・プロダクツ・インク | ピロロ[2,3−d]ピリミジン化合物 |
KR20050086784A (ko) * | 2002-11-26 | 2005-08-30 | 화이자 프로덕츠 인크. | 이식 거부반응의 치료 방법 |
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2004
- 2004-12-06 AU AU2004305317A patent/AU2004305317A1/en not_active Abandoned
- 2004-12-06 CA CA002549485A patent/CA2549485A1/fr not_active Abandoned
- 2004-12-06 BR BRPI0417803-3A patent/BRPI0417803A/pt not_active IP Right Cessation
- 2004-12-06 WO PCT/IB2004/004034 patent/WO2005060972A2/fr active Application Filing
- 2004-12-06 SG SG200704529-7A patent/SG133602A1/en unknown
- 2004-12-06 KR KR1020067011842A patent/KR20060096153A/ko not_active Application Discontinuation
- 2004-12-06 MX MXPA06007002A patent/MXPA06007002A/es unknown
- 2004-12-06 RU RU2006120956/04A patent/RU2006120956A/ru not_active Application Discontinuation
- 2004-12-06 CN CNA2004800377587A patent/CN1893952A/zh active Pending
- 2004-12-06 JP JP2006544578A patent/JP2007514729A/ja active Pending
- 2004-12-06 EP EP04801340A patent/EP1734967A2/fr not_active Withdrawn
- 2004-12-13 US US11/011,474 patent/US20050159433A1/en not_active Abandoned
- 2004-12-16 TW TW093139167A patent/TW200529853A/zh unknown
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- 2006-05-22 IL IL175812A patent/IL175812A0/en unknown
- 2006-06-09 CO CO06056308A patent/CO5700767A2/es not_active Application Discontinuation
- 2006-06-13 ZA ZA200604888A patent/ZA200604888B/en unknown
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SG133602A1 (en) | 2007-07-30 |
MXPA06007002A (es) | 2006-08-31 |
AU2004305317A1 (en) | 2005-07-07 |
CO5700767A2 (es) | 2006-11-30 |
EP1734967A2 (fr) | 2006-12-27 |
BRPI0417803A (pt) | 2007-04-10 |
NO20062292L (no) | 2006-06-14 |
JP2007514729A (ja) | 2007-06-07 |
WO2005060972A2 (fr) | 2005-07-07 |
WO2005060972A3 (fr) | 2005-10-20 |
US20050159433A1 (en) | 2005-07-21 |
IL175812A0 (en) | 2008-04-13 |
TW200529853A (en) | 2005-09-16 |
CA2549485A1 (fr) | 2005-07-07 |
KR20060096153A (ko) | 2006-09-07 |
RU2006120956A (ru) | 2008-01-27 |
CN1893952A (zh) | 2007-01-10 |
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