ZA200604409B - Enoxaparin for the treatment of cancer - Google Patents
Enoxaparin for the treatment of cancer Download PDFInfo
- Publication number
- ZA200604409B ZA200604409B ZA200604409A ZA200604409A ZA200604409B ZA 200604409 B ZA200604409 B ZA 200604409B ZA 200604409 A ZA200604409 A ZA 200604409A ZA 200604409 A ZA200604409 A ZA 200604409A ZA 200604409 B ZA200604409 B ZA 200604409B
- Authority
- ZA
- South Africa
- Prior art keywords
- disease
- enoxaparin
- cancer
- heparanase
- treatment
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims description 75
- 229960000610 enoxaparin Drugs 0.000 title claims description 55
- 206010028980 Neoplasm Diseases 0.000 title claims description 24
- 201000011510 cancer Diseases 0.000 title claims description 23
- 238000011282 treatment Methods 0.000 title claims description 19
- 102100024025 Heparanase Human genes 0.000 claims description 44
- 108010037536 heparanase Proteins 0.000 claims description 44
- 201000010099 disease Diseases 0.000 claims description 42
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 42
- 230000000694 effects Effects 0.000 claims description 31
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 18
- 230000000973 chemotherapeutic effect Effects 0.000 claims description 17
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims description 14
- 229960003668 docetaxel Drugs 0.000 claims description 14
- 230000005764 inhibitory process Effects 0.000 claims description 14
- 201000011486 lichen planus Diseases 0.000 claims description 10
- 206010027476 Metastases Diseases 0.000 claims description 9
- 229960004679 doxorubicin Drugs 0.000 claims description 9
- 230000009401 metastasis Effects 0.000 claims description 9
- 208000023275 Autoimmune disease Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 6
- 206010006187 Breast cancer Diseases 0.000 claims description 5
- 208000026310 Breast neoplasm Diseases 0.000 claims description 5
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims description 5
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 229930012538 Paclitaxel Natural products 0.000 claims description 4
- 229960004397 cyclophosphamide Drugs 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 229960001592 paclitaxel Drugs 0.000 claims description 4
- 230000007170 pathology Effects 0.000 claims description 4
- 208000024891 symptom Diseases 0.000 claims description 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims description 3
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
- 206010060862 Prostate cancer Diseases 0.000 claims description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 229960001904 epirubicin Drugs 0.000 claims description 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
- 201000002528 pancreatic cancer Diseases 0.000 claims description 3
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 2
- 229920002971 Heparan sulfate Polymers 0.000 description 20
- 229920000669 heparin Polymers 0.000 description 20
- 230000015556 catabolic process Effects 0.000 description 13
- 238000006731 degradation reaction Methods 0.000 description 12
- 238000000034 method Methods 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 210000004027 cell Anatomy 0.000 description 10
- 239000003055 low molecular weight heparin Substances 0.000 description 8
- 229940127215 low-molecular weight heparin Drugs 0.000 description 8
- 102000008055 Heparan Sulfate Proteoglycans Human genes 0.000 description 7
- 108090000054 Syndecan-2 Proteins 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 229940045799 anthracyclines and related substance Drugs 0.000 description 6
- 229960002897 heparin Drugs 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 206010047249 Venous thrombosis Diseases 0.000 description 4
- 238000009472 formulation Methods 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 208000010378 Pulmonary Embolism Diseases 0.000 description 3
- 238000005227 gel permeation chromatography Methods 0.000 description 3
- 239000003112 inhibitor Substances 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 208000004043 venous thromboembolism Diseases 0.000 description 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 description 2
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- 206010014522 Embolism venous Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 102000005262 Sulfatase Human genes 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 229940059329 chondroitin sulfate Drugs 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000013068 control sample Substances 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 description 2
- 238000005567 liquid scintillation counting Methods 0.000 description 2
- 210000002540 macrophage Anatomy 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 208000035736 spondylodysplastic type Ehlers-Danlos syndrome Diseases 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 108060007951 sulfatase Proteins 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
- 206010002388 Angina unstable Diseases 0.000 description 1
- 102000008076 Angiogenic Proteins Human genes 0.000 description 1
- 108010074415 Angiogenic Proteins Proteins 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 201000006474 Brain Ischemia Diseases 0.000 description 1
- 206010048962 Brain oedema Diseases 0.000 description 1
- 108091016585 CD44 antigen Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010008120 Cerebral ischaemia Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 208000001382 Experimental Melanoma Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 206010015866 Extravasation Diseases 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000010956 Glypican Human genes 0.000 description 1
- 108050001154 Glypican Proteins 0.000 description 1
- 229940122588 Heparanase inhibitor Drugs 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 206010027458 Metastases to lung Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000005662 Paraffin oil Substances 0.000 description 1
- 208000037273 Pathologic Processes Diseases 0.000 description 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
- 102000019361 Syndecan Human genes 0.000 description 1
- 108050006774 Syndecan Proteins 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 238000005571 anion exchange chromatography Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 210000002469 basement membrane Anatomy 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 208000006752 brain edema Diseases 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000009702 cancer cell proliferation Effects 0.000 description 1
- 230000004709 cell invasion Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- -1 cyclophasphamide Chemical compound 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 201000002491 encephalomyelitis Diseases 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000007515 enzymatic degradation Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 230000036251 extravasation Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 108010083213 heparitinsulfate lyase Proteins 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 239000003701 inert diluent Substances 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 210000002161 motor neuron Anatomy 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000009054 pathological process Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000003206 sterilizing agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 229960005062 tinzaparin Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000003104 tissue culture media Substances 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03293028A EP1537871A1 (en) | 2003-12-04 | 2003-12-04 | Enoxaparin for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200604409B true ZA200604409B (en) | 2007-09-26 |
Family
ID=34443115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200604409A ZA200604409B (en) | 2003-12-04 | 2004-12-01 | Enoxaparin for the treatment of cancer |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20050164985A1 (no) |
| EP (2) | EP1537871A1 (no) |
| JP (1) | JP2007513123A (no) |
| KR (1) | KR20060109929A (no) |
| AU (1) | AU2004294730A1 (no) |
| BR (1) | BRPI0417371A (no) |
| CA (1) | CA2546292A1 (no) |
| IL (1) | IL175689A0 (no) |
| MX (1) | MXPA06006275A (no) |
| NO (1) | NO20063114L (no) |
| WO (1) | WO2005053713A1 (no) |
| ZA (1) | ZA200604409B (no) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7381410B2 (en) * | 2003-03-12 | 2008-06-03 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| WO2010013231A2 (en) * | 2008-07-29 | 2010-02-04 | Yeda Research And Development Co. Ltd. | Modulation of coagulation factors and effectors of same for control of transplant organ size |
| US8999906B2 (en) | 2008-12-19 | 2015-04-07 | Aktiebolaget Skf | Machine part comprising a physical component coated with a polyelectrolyte layer |
| US20160129112A1 (en) * | 2013-05-28 | 2016-05-12 | Momenta Pharmaceuticals, Inc. | Pharmaceutical Compositions Comprising Pyrophosphate |
| CA2958568A1 (en) * | 2014-08-20 | 2016-02-25 | Health Research, Inc. | Methods for prophylaxis and/or treatment of erbb1 positive cancers |
| CN110548045A (zh) * | 2018-05-30 | 2019-12-10 | 北京大学 | 低分子肝素-抗肿瘤药物静电复合物纳米系统的制备方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6492332B1 (en) * | 1995-12-12 | 2002-12-10 | Omeros Corporation | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation |
| DK0935667T3 (da) * | 1996-07-23 | 2007-04-10 | Nagase Chemtex Corp | Fremgangsmåde til fremstilling af docosahexaensyre og docosapentaensyre |
| DK0946185T4 (da) * | 1996-11-27 | 2010-08-30 | Aventis Pharma Inc | Farmaceutisk præparat, som omfatter en forbindelse med anti-Xa-aktivitet og en blodpladeaggregations antagonistforbindelse |
| US6541036B1 (en) * | 1997-05-29 | 2003-04-01 | Thomas Jefferson University | Treatment of tumors with oligonucleotides directed to insulin-like growth factor-I receptors (IGF-IR) |
| US6690976B2 (en) * | 2000-04-13 | 2004-02-10 | Celsion Corporation | Thermotherapy method for treatment and prevention of breast cancer and cancer in other organs |
| DE10026699A1 (de) * | 2000-05-30 | 2001-12-06 | Basf Ag | Formulierung auf Heparin-, Glycosaminoglycan- oder Heparinoidbasis und Verwendung der Formulierung sowie der Formulierungsgrundlage |
| DE10141106A1 (de) * | 2001-08-22 | 2003-03-13 | Aventis Pharma Gmbh | Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen |
| AU2003225724A1 (en) * | 2002-03-11 | 2003-09-29 | Momenta Pharmaceuticals, Inc. | Analysis of sulfated polysaccharides |
| US6908907B2 (en) * | 2002-04-22 | 2005-06-21 | El-Naggar Mawaheb M. | Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients |
-
2003
- 2003-12-04 EP EP03293028A patent/EP1537871A1/en not_active Withdrawn
-
2004
- 2004-12-01 MX MXPA06006275A patent/MXPA06006275A/es not_active Application Discontinuation
- 2004-12-01 KR KR1020067010855A patent/KR20060109929A/ko not_active Application Discontinuation
- 2004-12-01 JP JP2006541926A patent/JP2007513123A/ja not_active Withdrawn
- 2004-12-01 CA CA002546292A patent/CA2546292A1/en not_active Abandoned
- 2004-12-01 WO PCT/EP2004/014807 patent/WO2005053713A1/en not_active Application Discontinuation
- 2004-12-01 AU AU2004294730A patent/AU2004294730A1/en not_active Abandoned
- 2004-12-01 EP EP04804393A patent/EP1694340A1/en not_active Ceased
- 2004-12-01 BR BRPI0417371-6A patent/BRPI0417371A/pt not_active IP Right Cessation
- 2004-12-01 ZA ZA200604409A patent/ZA200604409B/en unknown
- 2004-12-03 US US11/003,270 patent/US20050164985A1/en not_active Abandoned
-
2006
- 2006-05-16 IL IL175689A patent/IL175689A0/en unknown
- 2006-07-04 NO NO20063114A patent/NO20063114L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20060109929A (ko) | 2006-10-23 |
| AU2004294730A1 (en) | 2005-06-16 |
| EP1694340A1 (en) | 2006-08-30 |
| WO2005053713A1 (en) | 2005-06-16 |
| JP2007513123A (ja) | 2007-05-24 |
| MXPA06006275A (es) | 2006-08-23 |
| BRPI0417371A (pt) | 2007-04-10 |
| NO20063114L (no) | 2006-08-29 |
| US20050164985A1 (en) | 2005-07-28 |
| CA2546292A1 (en) | 2005-06-16 |
| EP1537871A1 (en) | 2005-06-08 |
| IL175689A0 (en) | 2008-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Ciccone et al. | Bemiparin, an effective and safe low molecular weight heparin: a review | |
| AU1669592A (en) | New non-anticoagulant heparin derivatives | |
| JP2005521629A (ja) | 関節炎の関節を治療するためのグリコサミノグリカンとヒアルロニダーゼ阻害剤を含んで成る組成物 | |
| US8293722B2 (en) | Inhibition of cathepsin K activity and the treatment and prevention of disease | |
| Middeldorp | Heparin: from animal organ extract to designer drug | |
| Jorpes | Heparin, its chemistry, pharmacology and clinical use | |
| Lu et al. | Different molecular weights of hyaluronan research in knee osteoarthritis: A state-of-the-art review | |
| EP1537871A1 (en) | Enoxaparin for the treatment of cancer | |
| Dang et al. | Developments of anticoagulants and new agents with anti-coagulant effects in deep vein thrombosis | |
| US7763594B2 (en) | Compositions for the treatment of osteoarthritis and to nourish the synovial fluid | |
| Harenberg et al. | Pharmacology and special clinical applications of low‐molecular‐weight heparins | |
| Kakkar | Low-molecular-weight heparin and survival in patients with malignant disease | |
| US20210032376A1 (en) | Glycosaminoglycan derivative and preparation method therefor and use thereof | |
| Poggi et al. | Inhibition of B16-BL6 melanoma lung colonies by semisynthetic sulfaminoheparosan sulfates from E. coli K5 polysaccharide | |
| Martin et al. | Pharmacologic and biochemical profiles of new venous antithrombotic β-d-xyloside derivatives: potential antiathero/thrombotic drugs | |
| US20020009782A1 (en) | Heparin and heparan sulfate derived oligosaccharides and a method for their manufacture | |
| Pecly et al. | Effects of molecular size and chemical structure on renal and hepatic removal of exogenously administered chondroitin sulfate in rats | |
| Van Doormaal et al. | Development in anticoagulant therapy | |
| KR100630479B1 (ko) | 아카란 황산을 유효성분으로 함유하는 헬리코박터 파일로리감염 억제용 조성물 | |
| KR100658154B1 (ko) | 정향으로부터 얻은 암 전이 억제 활성분획물 | |
| KR100477896B1 (ko) | 상백피로부터 얻은 헤파리나제 효소 활성 및 암전이활성을 저해하는 활성분획물 | |
| Hoppensteadt et al. | Low molecular weight heparins: an objective overview | |
| KR20020046293A (ko) | 글리코사미노글리칸을 분해하는 인간 장내 미생물 유래신규 헤파리네이즈, 그의 제조 방법 및 용도 | |
| CA2306766A1 (en) | Use of sulfated oligosaccharides in lowering blood triglyceride levels | |
| JP2004238294A (ja) | Ｃｄ４４切断誘導剤 |