ZA200604094B - Use of hydroxylated amino acids for treating diabetes - Google Patents

Use of hydroxylated amino acids for treating diabetes Download PDF

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Publication number
ZA200604094B
ZA200604094B ZA200604094A ZA200604094A ZA200604094B ZA 200604094 B ZA200604094 B ZA 200604094B ZA 200604094 A ZA200604094 A ZA 200604094A ZA 200604094 A ZA200604094 A ZA 200604094A ZA 200604094 B ZA200604094 B ZA 200604094B
Authority
ZA
South Africa
Prior art keywords
insulin
pharmaceutical kit
agents
antidiabetic agent
additional
Prior art date
Application number
ZA200604094A
Other languages
English (en)
Inventor
Bellini Francesco
Vezeau Claude
Ribes Gerard
Chapal Nicolas
Prentki Marc
Original Assignee
Innodia Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innodia Inc filed Critical Innodia Inc
Publication of ZA200604094B publication Critical patent/ZA200604094B/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/64Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2278Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200604094A 2003-10-27 2006-05-22 Use of hydroxylated amino acids for treating diabetes ZA200604094B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51473803P 2003-10-27 2003-10-27

Publications (1)

Publication Number Publication Date
ZA200604094B true ZA200604094B (en) 2007-09-26

Family

ID=34520228

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200604094A ZA200604094B (en) 2003-10-27 2006-05-22 Use of hydroxylated amino acids for treating diabetes

Country Status (10)

Country Link
US (1) US20070004623A1 (fr)
EP (1) EP1701735A4 (fr)
JP (1) JP2008500955A (fr)
CN (1) CN1921881A (fr)
AU (1) AU2004282999A1 (fr)
BR (1) BRPI0415781A (fr)
CA (1) CA2543498A1 (fr)
MX (1) MXPA06004698A (fr)
WO (1) WO2005039626A2 (fr)
ZA (1) ZA200604094B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2598491A1 (fr) * 2005-02-18 2006-11-09 Innodia Inc. Diastereoisomeres de of 4-hydroxyisoleucine et utilisations associees
JP2008530197A (ja) * 2005-02-18 2008-08-07 イノディア インク. 4−ヒドロキシイソロイシンの類似体及びその使用
CN101252926A (zh) * 2005-03-22 2008-08-27 因诺迪亚有限公司 用于预防和治疗肥胖症及相关综合征的化合物与组合物
FR2887773B1 (fr) * 2005-07-01 2008-05-30 Soc Extraction Principes Actif Utilisation d'un acide amine en tant qu'agent actif inducteur de la synthese des proteines sirt dans les cellules de la peau.
WO2007107008A1 (fr) * 2006-03-22 2007-09-27 Innodia Inc. Composés et compositions utilisables pour la prévention et le traitement de troubles du métabolisme lipidique et de l'obésité
WO2008044770A1 (fr) * 2006-10-13 2008-04-17 Ajinomoto Co., Inc. Agent comprenant de la 4-hydroxyisoleucine et destiné à la suppression de la vidange gastrique
CA2678990A1 (fr) 2007-02-22 2008-08-28 Ajinomoto Co., Inc. Procede de purification de 4-hydroxy-isoleucine
CN102014880A (zh) * 2008-05-01 2011-04-13 Nod药物公司 治疗性磷酸钙颗粒及其制备和使用方法
CN104244958B (zh) * 2011-11-23 2017-11-17 澳星医疗私人有限公司 改进的协同抗糖尿病组合物
TW201513857A (zh) * 2013-07-05 2015-04-16 Cadila Healthcare Ltd 協同性組成物
CN104803864B (zh) * 2014-01-29 2017-01-11 华东师范大学 β-羟基-α-氨基酸衍生物及其合成方法和应用
US9795676B2 (en) 2014-03-03 2017-10-24 Shayne Kenneth Morris Chromium 4-hydroxyisoleucinate compound methods for prepartion and use
WO2015161448A1 (fr) * 2014-04-22 2015-10-29 Wuhan Ll Science And Technology Development Co., Ltd. Compositions contenant de l'ornithine ou de l'aspartate et leurs utilisations
EP3206710B1 (fr) * 2014-09-24 2020-05-06 Indiana University Research & Technology Corporation Conjugués d'insuline-incrétines
AU2018258250A1 (en) 2017-04-25 2019-12-12 Almeda Labs Llc Amino acid formulations for pancreatic viability
CN108371326B (zh) * 2017-12-14 2021-08-20 天津科技大学 一种降血糖的功能性组合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545618A (en) * 1990-01-24 1996-08-13 Buckley; Douglas I. GLP-1 analogs useful for diabetes treatment
FR2695317B1 (fr) * 1992-09-07 1995-03-10 Monal Lab Composition apte à stimuler la sécrétion d'insuline destinée au traitement du diabète non insulino-dépendant.
TWI238064B (en) * 1995-06-20 2005-08-21 Takeda Chemical Industries Ltd A pharmaceutical composition for prophylaxis and treatment of diabetes
WO1999007404A1 (fr) * 1997-08-08 1999-02-18 Amylin Pharmaceuticals, Inc. Nouveaux composes agonistes de l'exendine
WO1999025370A1 (fr) * 1997-11-18 1999-05-27 Nutricept, Inc. Procede permettant de reduire l'absorption intestinale d'un compose calorifique chez les diabetiques
FR2797767B1 (fr) * 1999-08-27 2002-06-14 Centre Nat Rech Scient Utilisation d'acides amines pour la fabrication de medicaments destines au traitement des insulino-resistances
JP2001316292A (ja) * 1999-09-03 2001-11-13 Takeda Chem Ind Ltd 医 薬
US20050176827A1 (en) * 2002-05-10 2005-08-11 Lee Steve S. Compositions and methods for glycogen synthesis
US20060159746A1 (en) * 2003-03-18 2006-07-20 Troup John P Compositions comprising fatty acids and amino acids

Also Published As

Publication number Publication date
AU2004282999A1 (en) 2005-05-06
MXPA06004698A (es) 2006-07-05
WO2005039626A3 (fr) 2005-06-16
JP2008500955A (ja) 2008-01-17
BRPI0415781A (pt) 2006-12-26
US20070004623A1 (en) 2007-01-04
WO2005039626A2 (fr) 2005-05-06
CA2543498A1 (fr) 2005-05-06
CN1921881A (zh) 2007-02-28
EP1701735A4 (fr) 2009-12-09
EP1701735A2 (fr) 2006-09-20

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