ZA200603824B - Moderating the effect of endotoxins - Google Patents
Moderating the effect of endotoxins Download PDFInfo
- Publication number
- ZA200603824B ZA200603824B ZA200603824A ZA200603824A ZA200603824B ZA 200603824 B ZA200603824 B ZA 200603824B ZA 200603824 A ZA200603824 A ZA 200603824A ZA 200603824 A ZA200603824 A ZA 200603824A ZA 200603824 B ZA200603824 B ZA 200603824B
- Authority
- ZA
- South Africa
- Prior art keywords
- toxin
- oral composition
- peptones
- extract
- intestinal
- Prior art date
Links
- 230000000694 effects Effects 0.000 title claims description 25
- 239000002158 endotoxin Substances 0.000 title description 2
- 239000000203 mixture Substances 0.000 claims description 42
- 239000001888 Peptone Substances 0.000 claims description 28
- 108010080698 Peptones Proteins 0.000 claims description 28
- 235000019319 peptone Nutrition 0.000 claims description 28
- 239000000284 extract Substances 0.000 claims description 26
- 108050003267 Prostaglandin G/H synthase 2 Proteins 0.000 claims description 21
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims description 21
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 claims description 21
- 229940066779 peptones Drugs 0.000 claims description 21
- 229940041514 candida albicans extract Drugs 0.000 claims description 19
- 239000012138 yeast extract Substances 0.000 claims description 19
- 235000013372 meat Nutrition 0.000 claims description 17
- 241000193163 Clostridioides difficile Species 0.000 claims description 15
- 239000000147 enterotoxin Substances 0.000 claims description 13
- 231100000655 enterotoxin Toxicity 0.000 claims description 13
- 238000011282 treatment Methods 0.000 claims description 13
- 206010012735 Diarrhoea Diseases 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 244000052769 pathogen Species 0.000 claims description 9
- 108010046377 Whey Proteins Proteins 0.000 claims description 7
- 230000001404 mediated effect Effects 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 102000007544 Whey Proteins Human genes 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 235000013350 formula milk Nutrition 0.000 claims description 4
- 235000021119 whey protein Nutrition 0.000 claims description 4
- 101710146739 Enterotoxin Proteins 0.000 claims description 3
- 241000607528 Aeromonas hydrophila Species 0.000 claims description 2
- 241000606124 Bacteroides fragilis Species 0.000 claims description 2
- 241000193468 Clostridium perfringens Species 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000222727 Leishmania donovani Species 0.000 claims description 2
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims description 2
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000000688 enterotoxigenic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000001717 pathogenic effect Effects 0.000 claims description 2
- 241000607598 Vibrio Species 0.000 claims 1
- 101710084578 Short neurotoxin 1 Proteins 0.000 description 55
- 101710182532 Toxin a Proteins 0.000 description 55
- 239000000243 solution Substances 0.000 description 25
- 230000000968 intestinal effect Effects 0.000 description 19
- 210000004027 cell Anatomy 0.000 description 18
- 241000699670 Mus sp. Species 0.000 description 16
- 230000028327 secretion Effects 0.000 description 16
- 102000007469 Actins Human genes 0.000 description 15
- 108010085238 Actins Proteins 0.000 description 15
- 239000012530 fluid Substances 0.000 description 15
- 235000015278 beef Nutrition 0.000 description 13
- 230000014509 gene expression Effects 0.000 description 12
- 239000003053 toxin Substances 0.000 description 11
- 231100000765 toxin Toxicity 0.000 description 11
- 108700012359 toxins Proteins 0.000 description 11
- 210000001035 gastrointestinal tract Anatomy 0.000 description 10
- 206010061218 Inflammation Diseases 0.000 description 9
- 230000004054 inflammatory process Effects 0.000 description 9
- 210000002919 epithelial cell Anatomy 0.000 description 8
- 210000001578 tight junction Anatomy 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000004913 activation Effects 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 6
- 229940088710 antibiotic agent Drugs 0.000 description 6
- 206010009887 colitis Diseases 0.000 description 6
- 244000005709 gut microbiome Species 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000001681 protective effect Effects 0.000 description 6
- 230000001953 sensory effect Effects 0.000 description 6
- 239000002356 single layer Substances 0.000 description 6
- 241000282412 Homo Species 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 210000002950 fibroblast Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 102100027609 Rho-related GTP-binding protein RhoD Human genes 0.000 description 4
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 4
- 230000027455 binding Effects 0.000 description 4
- 230000003436 cytoskeletal effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 210000000936 intestine Anatomy 0.000 description 4
- 244000005700 microbiome Species 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 208000018522 Gastrointestinal disease Diseases 0.000 description 3
- 108010070551 Meat Proteins Proteins 0.000 description 3
- 108090000189 Neuropeptides Proteins 0.000 description 3
- 239000005862 Whey Substances 0.000 description 3
- 244000052616 bacterial pathogen Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 210000001842 enterocyte Anatomy 0.000 description 3
- 239000012909 foetal bovine serum Substances 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 210000003632 microfilament Anatomy 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 210000000440 neutrophil Anatomy 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 235000018102 proteins Nutrition 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 235000009854 Cucurbita moschata Nutrition 0.000 description 2
- 240000001980 Cucurbita pepo Species 0.000 description 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 208000004232 Enteritis Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 2
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000003833 cell viability Effects 0.000 description 2
- 230000000112 colonic effect Effects 0.000 description 2
- 210000004292 cytoskeleton Anatomy 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 235000021004 dietary regimen Nutrition 0.000 description 2
- 230000003292 diminished effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000001650 focal adhesion Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000002779 inactivation Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000005706 microflora Species 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 235000015277 pork Nutrition 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000003757 reverse transcription PCR Methods 0.000 description 2
- 230000019491 signal transduction Effects 0.000 description 2
- 210000001626 skin fibroblast Anatomy 0.000 description 2
- 229960005322 streptomycin Drugs 0.000 description 2
- 210000003518 stress fiber Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- LSQZJLSUYDQPKJ-BBGACYKPSA-N (2S,5R,6R)-6-[[(2S)-2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound C1([C@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-BBGACYKPSA-N 0.000 description 1
- HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229930183010 Amphotericin Natural products 0.000 description 1
- QGGFZZLFKABGNL-UHFFFAOYSA-N Amphotericin A Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCCC=CC=CC(C)C(O)C(C)C(C)OC(=O)CC(O)CC(O)CCC(O)C(O)CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 QGGFZZLFKABGNL-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 235000000832 Ayote Nutrition 0.000 description 1
- 108010023063 Bacto-peptone Proteins 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101100273751 Caenorhabditis elegans cdc-42 gene Proteins 0.000 description 1
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 description 1
- 102000004414 Calcitonin Gene-Related Peptide Human genes 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 208000037384 Clostridium Infections Diseases 0.000 description 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 1
- 206010054236 Clostridium difficile infection Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 235000009804 Cucurbita pepo subsp pepo Nutrition 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010012741 Diarrhoea haemorrhagic Diseases 0.000 description 1
- 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- 101000605127 Homo sapiens Prostaglandin G/H synthase 2 Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 241000736262 Microbiota Species 0.000 description 1
- 206010028124 Mucosal ulceration Diseases 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 101000605126 Mus musculus Prostaglandin G/H synthase 2 Proteins 0.000 description 1
- 108010057466 NF-kappa B Proteins 0.000 description 1
- 102000003945 NF-kappa B Human genes 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 206010036772 Proctalgia Diseases 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 239000013614 RNA sample Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 102000042463 Rho family Human genes 0.000 description 1
- 108091078243 Rho family Proteins 0.000 description 1
- 102100037346 Substance-P receptor Human genes 0.000 description 1
- 101710097909 Substance-P receptor Proteins 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 101710182223 Toxin B Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- 229940009444 amphotericin Drugs 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000001949 anaesthesia Methods 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 230000003816 axenic effect Effects 0.000 description 1
- 235000021336 beef liver Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000021196 dietary intervention Nutrition 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 description 1
- XEYBRNLFEZDVAW-ARSRFYASSA-N dinoprostone Chemical compound CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O XEYBRNLFEZDVAW-ARSRFYASSA-N 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000002095 exotoxin Substances 0.000 description 1
- 231100000776 exotoxin Toxicity 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000005417 food ingredient Substances 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000003365 immunocytochemistry Methods 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 230000006662 intracellular pathway Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 210000001630 jejunum Anatomy 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 244000039328 opportunistic pathogen Species 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 108010045867 phallotoxin Proteins 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002181 saccharomyces boulardii Drugs 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 235000020354 squash Nutrition 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 201000009032 substance abuse Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000024033 toxin binding Effects 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Alternative & Traditional Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03023016 | 2003-10-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200603824B true ZA200603824B (en) | 2007-07-25 |
Family
ID=34354433
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200603824A ZA200603824B (en) | 2003-10-13 | 2006-05-12 | Moderating the effect of endotoxins |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8216605B2 (de) |
| EP (1) | EP1675601B2 (de) |
| JP (1) | JP4918361B2 (de) |
| CN (2) | CN1886144A (de) |
| AR (1) | AR047763A1 (de) |
| AT (1) | ATE435022T1 (de) |
| BR (1) | BRPI0415385A (de) |
| CA (1) | CA2542448A1 (de) |
| DE (1) | DE602004021831D1 (de) |
| DK (1) | DK1675601T4 (de) |
| ES (1) | ES2328149T5 (de) |
| IL (1) | IL174978A0 (de) |
| MY (1) | MY140220A (de) |
| PT (1) | PT1675601E (de) |
| TW (1) | TW200520696A (de) |
| WO (1) | WO2005039606A2 (de) |
| ZA (1) | ZA200603824B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007508342A (ja) * | 2003-10-13 | 2007-04-05 | ネステク ソシエテ アノニム | エンドトキシンの作用の緩和 |
| CN113729228A (zh) * | 2020-05-29 | 2021-12-03 | 安琪纽特股份有限公司 | 用于预防或改善腹泻的组合物及其制备方法和应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US177534A (en) | 1876-05-16 | Improvement in meat-extracts | ||
| US4595590A (en) | 1984-01-17 | 1986-06-17 | Laboratoires Biocodex | Method for preventing or treating pseudo-membranous colitis |
| JPS61236727A (ja) | 1985-04-12 | 1986-10-22 | Advance Res & Dev Co Ltd | 抗う蝕乃至抗菌周症剤 |
| JP2805490B2 (ja) | 1989-02-07 | 1998-09-30 | 雪印乳業株式会社 | 細菌毒素中和剤 |
| CN1056750C (zh) * | 1993-12-10 | 2000-09-27 | 济南三株药业有限公司 | 一种营养保健口服液及其制法 |
| US5550106A (en) | 1994-03-04 | 1996-08-27 | Bristol-Myers Squibb Company | Low buffer nutritional composition |
| RU2168915C2 (ru) * | 1996-03-19 | 2001-06-20 | Алтайский научно-исследовательский проектно-технологический институт животноводства | Мясной продукт для детского питания |
| US7374753B1 (en) * | 1997-06-03 | 2008-05-20 | Ganeden Biotech, Inc. | Probiotic lactic acid bacterium to treat bacterial infections associated with SIDS |
| US6368591B2 (en) * | 1998-05-15 | 2002-04-09 | Shanghai Sine Pharmaceutical Corporation Ltd. | Beneficial microbe composition, new protective materials for the microbes, method to prepare the same and uses thereof |
| JP2001008636A (ja) | 1999-06-30 | 2001-01-16 | Tanabe Seiyaku Co Ltd | 感染症防止用飼料組成物 |
| JP2001055338A (ja) | 1999-08-13 | 2001-02-27 | Kirin Brewery Co Ltd | 酵母細胞壁画分からなる薬理用組成物 |
| JP3307627B2 (ja) | 2000-02-09 | 2002-07-24 | オク タイン | 酵母ジゴサッカロマイシスロキシイ（Ｚｙｇｏｓａｃｃｈａｒｏｍｙｃｅｓｒｏｕｘｉｉ）からサイトカラシン（Ｃｙｔｏｃｈａｌａｓｉｎ）様物質群を製造する方法。 |
| NL1014380C2 (nl) † | 2000-02-14 | 2001-08-15 | Friesland Brands Bv | Darmwandversterkend voedingsmiddel. |
| JP2002080351A (ja) | 2000-09-07 | 2002-03-19 | Natl Fedelation Of Agricult Coop Assoc | 免疫増強剤 |
| SE0003958D0 (sv) * | 2000-10-31 | 2000-10-31 | Biogaia Fermentation Ab | Method for growth of microorganisms |
| FI114895B (fi) * | 2001-05-14 | 2005-01-31 | Suomen Rehu Oy | Ravinnon lisäaine |
| US20040176320A1 (en) † | 2001-06-29 | 2004-09-09 | Jari Natunen | Use of at least one glycoinhibitor substance |
| ATE428430T1 (de) † | 2002-06-28 | 2009-05-15 | Glykos Finland Oy | Therapeutische zusammensetzungen zur verwendung bei der prophylaxe oder behandlung von durchfall |
| PT1565547E (pt) * | 2002-06-28 | 2008-11-03 | Puleva Biotech Sa | Estirpes probióticas, processo para a sua selecção, suas composições e sua utilização |
| ATE339114T1 (de) * | 2002-07-23 | 2006-10-15 | Wrigley W M Jun Co | Verkapselte aromastoffe und kaugummi damit |
| JP2007508342A (ja) | 2003-10-13 | 2007-04-05 | ネステク ソシエテ アノニム | エンドトキシンの作用の緩和 |
-
2004
- 2004-10-12 AT AT04790307T patent/ATE435022T1/de active
- 2004-10-12 PT PT04790307T patent/PT1675601E/pt unknown
- 2004-10-12 EP EP04790307.5A patent/EP1675601B2/de not_active Not-in-force
- 2004-10-12 DK DK04790307.5T patent/DK1675601T4/da active
- 2004-10-12 ES ES04790307T patent/ES2328149T5/es active Active
- 2004-10-12 JP JP2006534666A patent/JP4918361B2/ja not_active Expired - Fee Related
- 2004-10-12 CN CNA200480035018XA patent/CN1886144A/zh active Pending
- 2004-10-12 WO PCT/EP2004/011416 patent/WO2005039606A2/en active Application Filing
- 2004-10-12 BR BRPI0415385-5A patent/BRPI0415385A/pt not_active IP Right Cessation
- 2004-10-12 CA CA002542448A patent/CA2542448A1/en not_active Abandoned
- 2004-10-12 DE DE602004021831T patent/DE602004021831D1/de active Active
- 2004-10-12 CN CN201110206882.3A patent/CN102319417B/zh not_active Expired - Fee Related
- 2004-10-12 US US10/595,397 patent/US8216605B2/en not_active Expired - Fee Related
- 2004-10-13 TW TW093131102A patent/TW200520696A/zh unknown
- 2004-10-13 AR ARP040103711A patent/AR047763A1/es not_active Application Discontinuation
- 2004-10-13 MY MYPI20044204A patent/MY140220A/en unknown
-
2006
- 2006-04-11 IL IL174978A patent/IL174978A0/en unknown
- 2006-05-12 ZA ZA200603824A patent/ZA200603824B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20070122453A1 (en) | 2007-05-31 |
| ES2328149T3 (es) | 2009-11-10 |
| JP4918361B2 (ja) | 2012-04-18 |
| CA2542448A1 (en) | 2005-05-06 |
| CN1886144A (zh) | 2006-12-27 |
| MY140220A (en) | 2009-12-31 |
| AR047763A1 (es) | 2006-02-22 |
| IL174978A0 (en) | 2006-08-20 |
| JP2007527410A (ja) | 2007-09-27 |
| EP1675601B2 (de) | 2013-04-10 |
| DK1675601T3 (da) | 2009-11-09 |
| ES2328149T5 (es) | 2013-07-12 |
| WO2005039606A3 (en) | 2005-09-15 |
| BRPI0415385A (pt) | 2006-12-12 |
| DK1675601T4 (da) | 2013-05-06 |
| TW200520696A (en) | 2005-07-01 |
| CN102319417B (zh) | 2014-08-13 |
| US8216605B2 (en) | 2012-07-10 |
| ATE435022T1 (de) | 2009-07-15 |
| WO2005039606A2 (en) | 2005-05-06 |
| PT1675601E (pt) | 2009-08-31 |
| CN102319417A (zh) | 2012-01-18 |
| EP1675601B1 (de) | 2009-07-01 |
| DE602004021831D1 (de) | 2009-08-13 |
| EP1675601A2 (de) | 2006-07-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI463986B (zh) | 胚芽乳酸桿菌ｃｍｕ９９５菌株之新用途 | |
| CA2748200C (en) | Compositions comprising probiotic and prebiotic components and mineral salts, with lactoferrin | |
| Batiha et al. | Dairy-derived and egg white proteins in enhancing immune system against COVID-19 | |
| BRPI0417793B1 (pt) | composição compreendendo bifidobactéria globosum probiótica canina | |
| KR20080003859A (ko) | 세균의 성장을 억제하기 위한 의약의 제조에 있어서 소락토페린의 용도 | |
| KR20200054796A (ko) | 간 기능 개선용 유산균 및 이의 용도 | |
| Yu et al. | Casein-fed mice showed faster recovery from DSS-induced colitis than chicken-protein-fed mice | |
| US20100028316A1 (en) | Moderating the effect of endotoxins | |
| US8216605B2 (en) | Moderating the effect of endotoxins | |
| US10849941B2 (en) | Method for preventing or treating colitis disease comprising Lactobacillus sakei K040706 as an active ingredient | |
| AU2013205352A1 (en) | Compositions comprising probiotic and prebiotic components and mineral salts, with lactoferrin | |
| AU2016203744A1 (en) | Compositions comprising probiotic and prebiotic components and mineral salts, with lactoferrin | |
| US20240082324A1 (en) | Method for promoting antimicrobial peptide production | |
| Cootes | Dietary regulation of the host response to viral infection | |
| Pearlin | Evaluation of Postbiotics on Production Performance and Endotoxin Challenge in Broiler Chicken as an Alternative to Antibiotic Growth Promoter (AGP) | |
| KR20200099311A (ko) | 글루텐 분해능을 가지는 락토바실러스 파라카제이 glu70 균주를 유효성분으로 함유하는 글리아딘으로 야기된 염증성 장 질환의 예방, 개선 또는 치료용 조성물 | |
| Wang | Probiotic-derived factors as potential chemopreventive agents for intestinal mucositis and colon cancer | |
| BG2482U1 (bg) | Биологично активна хранителна добавка | |
| Moughan et al. | Diet, immunity and inflammation: 12. Food bioactive proteins and peptides: antimicrobial, immunomodulatory and anti-inflammatory effects |