ZA200601803B - FSH glycosylation mutant - Google Patents
FSH glycosylation mutant Download PDFInfo
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- ZA200601803B ZA200601803B ZA200601803A ZA200601803A ZA200601803B ZA 200601803 B ZA200601803 B ZA 200601803B ZA 200601803 A ZA200601803 A ZA 200601803A ZA 200601803 A ZA200601803 A ZA 200601803A ZA 200601803 B ZA200601803 B ZA 200601803B
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- fsh
- mutant
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- 230000002209 hydrophobic effect Effects 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 229940065638 intron a Drugs 0.000 description 1
- 238000001155 isoelectric focusing Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001592 luteinising effect Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000001254 matrix assisted laser desorption--ionisation time-of-flight mass spectrum Methods 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229960004927 neomycin Drugs 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- 210000000287 oocyte Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000002731 protein assay Methods 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002287 radioligand Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000004017 serum-free culture medium Substances 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 238000010563 solid-state fermentation Methods 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
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- 238000012533 structure-function relationship study Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000001447 template-directed synthesis Methods 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 230000009261 transgenic effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
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- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
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- 239000013603 viral vector Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 108010055450 with HCG C-terminal peptide human follicle stimulating hormone Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Reproductive Health (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49980203P | 2003-09-02 | 2003-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200601803B true ZA200601803B (en) | 2007-05-30 |
Family
ID=34272871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200601803A ZA200601803B (en) | 2003-09-02 | 2004-09-02 | FSH glycosylation mutant |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7700112B2 (zh) |
| EP (1) | EP1694271B1 (zh) |
| JP (1) | JP4653090B2 (zh) |
| KR (1) | KR101099809B1 (zh) |
| CN (1) | CN1984926B (zh) |
| AT (1) | ATE511829T1 (zh) |
| AU (1) | AU2004268683B2 (zh) |
| BR (1) | BRPI0413206A (zh) |
| CA (1) | CA2535522A1 (zh) |
| CY (1) | CY1112439T1 (zh) |
| DK (1) | DK1694271T3 (zh) |
| EA (1) | EA012175B1 (zh) |
| ES (1) | ES2367784T3 (zh) |
| HK (1) | HK1101315A1 (zh) |
| HR (1) | HRP20110430T1 (zh) |
| IL (1) | IL174037A0 (zh) |
| MX (1) | MXPA06002119A (zh) |
| NO (1) | NO20061446L (zh) |
| PL (1) | PL1694271T3 (zh) |
| PT (1) | PT1694271E (zh) |
| SI (1) | SI1694271T1 (zh) |
| UA (1) | UA88879C2 (zh) |
| WO (1) | WO2005020934A2 (zh) |
| ZA (1) | ZA200601803B (zh) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE038947T2 (hu) | 2005-08-26 | 2018-12-28 | Ares Trading Sa | Eljárás glikozilált béta-interferon elõállítására |
| WO2007065918A2 (en) * | 2005-12-09 | 2007-06-14 | Ares Trading S.A. | Method for purifying fsh or a fsh mutant |
| BRPI0620223A2 (pt) * | 2005-12-22 | 2011-11-01 | Serono Lab | mutantes de fsh |
| RS51792B (en) * | 2006-01-17 | 2011-12-31 | Merck Serono Sa. | NEW FSH WITH GLYCOSILATION OPTION D3N |
| WO2008116867A1 (en) * | 2007-03-26 | 2008-10-02 | Novartis Ag | Predictive renal safety biomarkers and biomarker signatures to monitor kidney function |
| AR081755A1 (es) | 2010-04-02 | 2012-10-17 | Hanmi Holdings Co Ltd | Formulacion de accion prolongada de la hormona estimuladora de los foliculos donde se usa un fragmento de inmunoglobulina, metodo de preparacion y metodo para tratar a un sujeto que sufre un trastorno reproductivo |
| CN108676096B (zh) * | 2018-05-22 | 2022-03-29 | 北京伟杰信生物科技有限公司 | 重组猪fsh-ctp融合蛋白及其制备方法与应用 |
| EP4055038A4 (en) * | 2019-11-06 | 2023-11-15 | The Regents of the University of Colorado, a body corporate | MODIFIED FOLLICLE-STIMULATING HORMONE AND METHOD OF USE THEREOF |
| CN114213523B (zh) * | 2021-11-15 | 2024-07-09 | 广州源博医药科技有限公司 | 一种用于重组蛋白的高糖基化修饰序列及其重组猪促卵泡激素和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4840896A (en) | 1983-11-02 | 1989-06-20 | Integrated Genetics, Inc. | Heteropolymeric protein |
| US5639639A (en) | 1983-11-02 | 1997-06-17 | Genzyme Corporation | Recombinant heterodimeric human fertility hormones, and methods, cells, vectors and DNA for the production thereof |
| US4923805A (en) | 1983-11-02 | 1990-05-08 | Integrated Genetics, Inc. | Fsh |
| US5156957A (en) | 1983-11-02 | 1992-10-20 | Genzyme Corporation | Follicle stimulating hormone |
| US4845077A (en) | 1984-04-03 | 1989-07-04 | Serono Laboratories, Inc. | Method of inducing ovulation |
| US4589402A (en) | 1984-07-26 | 1986-05-20 | Serono Laboratories, Inc. | Method of in vitro fertilization |
| US5338835A (en) | 1989-02-21 | 1994-08-16 | Washington University | CTP-extended form of FSH |
| ATE148171T1 (de) | 1989-02-21 | 1997-02-15 | Univ Washington | Modifizierte formen von fortpflanzungshormonen |
| US5508261A (en) | 1991-06-18 | 1996-04-16 | University Of Medicine & Dentistry Of New Jersey | Analogs of glycoprotein hormones having altered receptor binding specificity and activity and methods for preparing and using same |
| US6407205B1 (en) * | 1997-06-04 | 2002-06-18 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | FSH-releasing peptides |
| ES2247710T3 (es) * | 1997-06-20 | 2006-03-01 | Akzo Nobel N.V. | Antagonista de gonadotropina. |
| US6235755B1 (en) * | 1998-08-07 | 2001-05-22 | Applied Research Systems Ars Holding N.A. | FSH mimetics for the treatment of infertility |
| EP1442748A1 (en) * | 2000-01-27 | 2004-08-04 | Applied Research Systems ARS Holding N.V. | Use of FSH for treating infertility |
| US20020127652A1 (en) * | 2000-02-11 | 2002-09-12 | Schambye Hans Thalsgard | Follicle stimulating hormones |
| WO2001058493A1 (en) | 2000-02-11 | 2001-08-16 | Maxygen Aps | Conjugates of follicle stimulating hormones |
| AU2002368265B2 (en) | 2001-10-22 | 2007-06-07 | Merck Serono Sa | Mutant glycoproteins |
-
2004
- 2004-02-09 UA UAA200603350A patent/UA88879C2/ru unknown
- 2004-09-02 SI SI200431701T patent/SI1694271T1/sl unknown
- 2004-09-02 KR KR1020067004084A patent/KR101099809B1/ko not_active IP Right Cessation
- 2004-09-02 ZA ZA200601803A patent/ZA200601803B/en unknown
- 2004-09-02 WO PCT/US2004/029042 patent/WO2005020934A2/en active Application Filing
- 2004-09-02 DK DK04783331.4T patent/DK1694271T3/da active
- 2004-09-02 JP JP2006525513A patent/JP4653090B2/ja not_active Expired - Fee Related
- 2004-09-02 CA CA002535522A patent/CA2535522A1/en not_active Abandoned
- 2004-09-02 EP EP04783331A patent/EP1694271B1/en not_active Expired - Lifetime
- 2004-09-02 AU AU2004268683A patent/AU2004268683B2/en not_active Ceased
- 2004-09-02 BR BRPI0413206-8A patent/BRPI0413206A/pt not_active IP Right Cessation
- 2004-09-02 CN CN2004800326655A patent/CN1984926B/zh not_active Expired - Fee Related
- 2004-09-02 AT AT04783331T patent/ATE511829T1/de active
- 2004-09-02 MX MXPA06002119A patent/MXPA06002119A/es active IP Right Grant
- 2004-09-02 ES ES04783331T patent/ES2367784T3/es not_active Expired - Lifetime
- 2004-09-02 US US10/934,707 patent/US7700112B2/en not_active Expired - Fee Related
- 2004-09-02 PL PL04783331T patent/PL1694271T3/pl unknown
- 2004-09-02 PT PT04783331T patent/PT1694271E/pt unknown
- 2004-09-02 EA EA200600526A patent/EA012175B1/ru not_active IP Right Cessation
-
2006
- 2006-03-01 IL IL174037A patent/IL174037A0/en unknown
- 2006-03-30 NO NO20061446A patent/NO20061446L/no not_active Application Discontinuation
-
2007
- 2007-08-30 HK HK07109465.0A patent/HK1101315A1/xx not_active IP Right Cessation
-
2011
- 2011-06-08 HR HR20110430T patent/HRP20110430T1/hr unknown
- 2011-07-19 CY CY20111100704T patent/CY1112439T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE511829T1 (de) | 2011-06-15 |
| CN1984926A (zh) | 2007-06-20 |
| BRPI0413206A (pt) | 2006-10-03 |
| IL174037A0 (en) | 2006-08-01 |
| SI1694271T1 (sl) | 2011-08-31 |
| CY1112439T1 (el) | 2015-12-09 |
| EA012175B1 (ru) | 2009-08-28 |
| UA88879C2 (en) | 2009-12-10 |
| JP2007508245A (ja) | 2007-04-05 |
| PT1694271E (pt) | 2011-07-07 |
| KR101099809B1 (ko) | 2011-12-27 |
| AU2004268683A2 (en) | 2005-03-10 |
| MXPA06002119A (es) | 2006-05-31 |
| DK1694271T3 (da) | 2011-09-12 |
| ES2367784T3 (es) | 2011-11-08 |
| AU2004268683A1 (en) | 2005-03-10 |
| US7700112B2 (en) | 2010-04-20 |
| HRP20110430T1 (hr) | 2011-07-31 |
| EP1694271B1 (en) | 2011-06-08 |
| AU2004268683B2 (en) | 2010-06-24 |
| US20050100989A1 (en) | 2005-05-12 |
| EP1694271A2 (en) | 2006-08-30 |
| WO2005020934A3 (en) | 2007-02-15 |
| WO2005020934A2 (en) | 2005-03-10 |
| KR20070029620A (ko) | 2007-03-14 |
| CN1984926B (zh) | 2012-04-11 |
| EA200600526A1 (ru) | 2007-04-27 |
| JP4653090B2 (ja) | 2011-03-16 |
| HK1101315A1 (en) | 2007-10-12 |
| PL1694271T3 (pl) | 2011-11-30 |
| CA2535522A1 (en) | 2005-03-10 |
| NO20061446L (no) | 2006-03-30 |
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