ZA200600966B - Antagonistic analogs of GH-RH (2003) - Google Patents

Antagonistic analogs of GH-RH (2003) Download PDF

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Publication number
ZA200600966B
ZA200600966B ZA200600966A ZA200600966A ZA200600966B ZA 200600966 B ZA200600966 B ZA 200600966B ZA 200600966 A ZA200600966 A ZA 200600966A ZA 200600966 A ZA200600966 A ZA 200600966A ZA 200600966 B ZA200600966 B ZA 200600966B
Authority
ZA
South Africa
Prior art keywords
arg
tyr
har
phe
abu
Prior art date
Application number
ZA200600966A
Other languages
English (en)
Inventor
Andrew V Schally
Varga Jozsef
Zarandi Marta
Cai Ren Zhi
Original Assignee
Us Health
Univ Tulane
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Univ Tulane filed Critical Us Health
Publication of ZA200600966B publication Critical patent/ZA200600966B/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/60Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/06Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA200600966A 2003-08-05 2006-02-02 Antagonistic analogs of GH-RH (2003) ZA200600966B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49270603P 2003-08-05 2003-08-05

Publications (1)

Publication Number Publication Date
ZA200600966B true ZA200600966B (en) 2007-05-30

Family

ID=34193144

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200600966A ZA200600966B (en) 2003-08-05 2006-02-02 Antagonistic analogs of GH-RH (2003)

Country Status (19)

Country Link
US (1) US7452865B2 (ja)
EP (1) EP1651662A4 (ja)
JP (1) JP2007526900A (ja)
KR (1) KR20060088875A (ja)
CN (1) CN1871020A (ja)
AR (1) AR049149A1 (ja)
AU (1) AU2004265280A1 (ja)
BR (1) BRPI0413257A (ja)
CA (1) CA2534436A1 (ja)
IL (1) IL173201A0 (ja)
MX (1) MXPA06001369A (ja)
NO (1) NO20061060L (ja)
PL (1) PL380437A1 (ja)
RS (1) RS20060086A (ja)
RU (1) RU2335506C2 (ja)
SG (1) SG136958A1 (ja)
TW (1) TW200517400A (ja)
WO (1) WO2005016953A2 (ja)
ZA (1) ZA200600966B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009108364A2 (en) * 2008-02-27 2009-09-03 Ipsen Pharma S.A.S. Antagonistic analogues of ghrh
AU2009228244A1 (en) * 2008-03-28 2009-10-01 The United States Of America Represented By The United States Department Of Veteran's Affairs Novel N-and C-terminal substituted -antagonistic analogs of human GH-RH
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
US8796216B2 (en) 2008-06-12 2014-08-05 Syntaxin Limited Suppression of neuroendocrine diseases
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
KR101642363B1 (ko) * 2008-06-12 2016-07-25 입센 바이오이노베이션 리미티드 신경내분비계 질환의 억제
US8227421B2 (en) * 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
WO2011153491A2 (en) 2010-06-03 2011-12-08 University Of Miami Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
CN103547591A (zh) 2011-04-21 2014-01-29 瑟瑞技术公司 生长激素释放因子(grf)类似物及其用途
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
EP2866894A4 (en) * 2012-06-27 2016-03-16 Univ Miami COMPOSITION AND METHOD FOR THE TREATMENT OF MORBUS ALZHEIMER
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
EP2935317B1 (en) 2012-12-21 2019-03-27 University of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
AU2020218272A1 (en) 2019-02-08 2021-09-02 United States Government As Represented By The Department Of Veterans Affairs Growth hormone-releasing hormone antagonists and uses thereof
CA3178840A1 (en) 2020-04-27 2021-11-04 The University Of Miami Method of treating an inflammatory disorder
CN114195881B (zh) * 2021-12-16 2022-09-16 浙江湃肽生物股份有限公司 一种制备醋酸舍莫瑞林的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity
US6057422A (en) * 1998-11-25 2000-05-02 The Administrators Of The Tulane Educational Fund Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Also Published As

Publication number Publication date
RU2335506C2 (ru) 2008-10-10
SG136958A1 (en) 2007-11-29
WO2005016953A3 (en) 2006-02-09
EP1651662A4 (en) 2009-07-01
TW200517400A (en) 2005-06-01
US20070042950A1 (en) 2007-02-22
CA2534436A1 (en) 2005-02-24
WO2005016953A2 (en) 2005-02-24
EP1651662A2 (en) 2006-05-03
JP2007526900A (ja) 2007-09-20
KR20060088875A (ko) 2006-08-07
CN1871020A (zh) 2006-11-29
RU2006106701A (ru) 2007-09-20
MXPA06001369A (es) 2007-02-19
AR049149A1 (es) 2006-07-05
PL380437A1 (pl) 2007-01-22
AU2004265280A1 (en) 2005-02-24
NO20061060L (no) 2006-05-03
BRPI0413257A (pt) 2006-10-03
RS20060086A (en) 2008-08-07
US7452865B2 (en) 2008-11-18
IL173201A0 (en) 2006-06-11

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