ZA200510252B - Pharmaceutically useful salts of carboxylic acid derivates - Google Patents
Pharmaceutically useful salts of carboxylic acid derivates Download PDFInfo
- Publication number
- ZA200510252B ZA200510252B ZA200510252A ZA200510252A ZA200510252B ZA 200510252 B ZA200510252 B ZA 200510252B ZA 200510252 A ZA200510252 A ZA 200510252A ZA 200510252 A ZA200510252 A ZA 200510252A ZA 200510252 B ZA200510252 B ZA 200510252B
- Authority
- ZA
- South Africa
- Prior art keywords
- phenyl
- salt
- ethoxy
- phenylethyl
- amino
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims description 36
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 92
- 239000012453 solvate Substances 0.000 claims description 18
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 16
- DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 claims description 16
- 235000019260 propionic acid Nutrition 0.000 claims description 16
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 6
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical class CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 claims description 5
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- VFYAWARECOZRBD-VWLOTQADSA-N (2s)-2-ethoxy-3-[4-[2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy]phenyl]propanoic acid Chemical compound C=1C=C(C[C@H](OCC)C(O)=O)C=CC=1OCC(=O)N(CCCCCC)CCC1=CC=CC=C1 VFYAWARECOZRBD-VWLOTQADSA-N 0.000 claims description 2
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- IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 description 1
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- 229960004425 sibutramine Drugs 0.000 description 1
- 229960002855 simvastatin Drugs 0.000 description 1
- RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
- 108091008012 small dense LDL Proteins 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
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- AHYHTSYNOHNUSH-HXFGRODQSA-N trandolaprilat Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)C(O)=O)CC1=CC=CC=C1 AHYHTSYNOHNUSH-HXFGRODQSA-N 0.000 description 1
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- IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 description 1
- UQWLOWFDKAFKAP-WXHSDQCUSA-N zofenoprilat Chemical compound C1[C@@H](C(O)=O)N(C(=O)[C@@H](CS)C)C[C@H]1SC1=CC=CC=C1 UQWLOWFDKAFKAP-WXHSDQCUSA-N 0.000 description 1
- 229950001300 zofenoprilat Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314129.8A GB0314129D0 (en) | 2003-06-18 | 2003-06-18 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200510252B true ZA200510252B (en) | 2006-12-27 |
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| ZA200510252A ZA200510252B (en) | 2003-06-18 | 2005-12-15 | Pharmaceutically useful salts of carboxylic acid derivates |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20060142389A1 (zh) |
| EP (1) | EP1638922A1 (zh) |
| JP (1) | JP3822900B1 (zh) |
| KR (1) | KR20060027348A (zh) |
| CN (1) | CN1809529A (zh) |
| AR (1) | AR044801A1 (zh) |
| AU (1) | AU2004247610B2 (zh) |
| BR (1) | BRPI0411525A (zh) |
| CA (1) | CA2528932A1 (zh) |
| CO (1) | CO5650228A2 (zh) |
| GB (1) | GB0314129D0 (zh) |
| IL (1) | IL172167A0 (zh) |
| IS (1) | IS8231A (zh) |
| MX (1) | MXPA05013714A (zh) |
| MY (1) | MY137277A (zh) |
| NO (1) | NO20055922L (zh) |
| RU (1) | RU2005138590A (zh) |
| SA (1) | SA04250169B1 (zh) |
| TW (1) | TW200503677A (zh) |
| UA (1) | UA81807C2 (zh) |
| UY (1) | UY28375A1 (zh) |
| WO (1) | WO2004110984A1 (zh) |
| ZA (1) | ZA200510252B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0314079D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
| SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| SE0104334D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
| GB0229931D0 (en) * | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| DE60319084T2 (de) | 2002-06-20 | 2009-01-29 | Astrazeneca Ab | Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz |
| SE0403072D0 (sv) * | 2004-12-16 | 2004-12-16 | Astrazeneca Ab | Pharmaceutically useful salts of carboxylic acid derivates |
| WO2007004957A1 (en) * | 2005-07-05 | 2007-01-11 | Astrazeneca Ab | Novel crystalline form |
| AR055073A1 (es) * | 2005-07-11 | 2007-08-01 | Astrazeneca Ab | Agentes terapeuticos |
| CN103717214A (zh) | 2011-06-06 | 2014-04-09 | 阿克比治疗有限公司 | 用于稳定低氧诱导因子-2α作为治疗癌症的方法的化合物和组合物 |
| NO2686520T3 (zh) | 2011-06-06 | 2018-03-17 | ||
| RU2019134558A (ru) | 2013-06-13 | 2020-02-20 | Экебиа Терапьютикс, Инк. | Композиции и способы лечения анемии |
| AU2014348523B2 (en) | 2013-11-15 | 2019-01-03 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| EP3247355A4 (en) | 2015-01-23 | 2018-06-13 | Akebia Therapeutics, Inc. | Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof |
| SG11201707994UA (en) | 2015-04-01 | 2017-10-30 | Akebia Therapeutics Inc | Compositions and methods for treating anemia |
| CN112088155A (zh) | 2018-05-09 | 2020-12-15 | 阿克比治疗有限公司 | 用于制备2-[[5-(3-氯苯基)-3-羟基吡啶-2-羰基]氨基]乙酸的方法 |
| US11524939B2 (en) | 2019-11-13 | 2022-12-13 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0009593A (pt) * | 1999-04-06 | 2002-06-18 | Sankyo Co | Agente melhorador de resistência à insulina, agente hipoglicêmico, agente imunorregulador, inibidor de aldose redutase, inibidor de 5-lipoxigenase, supressor de produção de lipìdios peroxidados, ativador de ppar, antagonista de leucotrienos, promotor de formação hidroxiadipocelular ou antagonista de cálcio, agente preventivo e/ou terapêutico, derivados de ácido carboxìlico, medicamento, composição farmacêutica, e, uso de um composto |
| SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
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2003
- 2003-06-18 GB GBGB0314129.8A patent/GB0314129D0/en not_active Ceased
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2004
- 2004-06-09 TW TW093116585A patent/TW200503677A/zh unknown
- 2004-06-16 EP EP04749009A patent/EP1638922A1/en not_active Withdrawn
- 2004-06-16 BR BRPI0411525-2A patent/BRPI0411525A/pt not_active IP Right Cessation
- 2004-06-16 MY MYPI20042310A patent/MY137277A/en unknown
- 2004-06-16 WO PCT/SE2004/000964 patent/WO2004110984A1/en active Application Filing
- 2004-06-16 UA UAA200511381A patent/UA81807C2/uk unknown
- 2004-06-16 CA CA002528932A patent/CA2528932A1/en not_active Abandoned
- 2004-06-16 JP JP2006517039A patent/JP3822900B1/ja not_active Expired - Fee Related
- 2004-06-16 KR KR1020057024204A patent/KR20060027348A/ko not_active Application Discontinuation
- 2004-06-16 RU RU2005138590/04A patent/RU2005138590A/ru not_active Application Discontinuation
- 2004-06-16 AU AU2004247610A patent/AU2004247610B2/en not_active Expired - Fee Related
- 2004-06-16 US US10/560,657 patent/US20060142389A1/en not_active Abandoned
- 2004-06-16 SA SA04250169A patent/SA04250169B1/ar unknown
- 2004-06-16 MX MXPA05013714A patent/MXPA05013714A/es not_active Application Discontinuation
- 2004-06-16 CN CNA2004800169480A patent/CN1809529A/zh active Pending
- 2004-06-17 AR ARP040102111A patent/AR044801A1/es not_active Application Discontinuation
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2006
- 2006-01-13 IS IS8231A patent/IS8231A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200503677A (en) | 2005-02-01 |
| CA2528932A1 (en) | 2004-12-23 |
| SA04250169B1 (ar) | 2007-08-07 |
| JP2006527766A (ja) | 2006-12-07 |
| RU2005138590A (ru) | 2006-07-27 |
| BRPI0411525A (pt) | 2006-08-01 |
| IL172167A0 (en) | 2009-02-11 |
| KR20060027348A (ko) | 2006-03-27 |
| AR044801A1 (es) | 2005-10-05 |
| MXPA05013714A (es) | 2006-06-27 |
| WO2004110984A1 (en) | 2004-12-23 |
| CN1809529A (zh) | 2006-07-26 |
| US20060142389A1 (en) | 2006-06-29 |
| UA81807C2 (uk) | 2008-02-11 |
| JP3822900B1 (ja) | 2006-09-20 |
| GB0314129D0 (en) | 2003-07-23 |
| MY137277A (en) | 2009-01-30 |
| SA04250169A (ar) | 2005-12-03 |
| UY28375A1 (es) | 2005-01-31 |
| AU2004247610B2 (en) | 2008-04-17 |
| EP1638922A1 (en) | 2006-03-29 |
| IS8231A (is) | 2006-01-13 |
| CO5650228A2 (es) | 2006-06-30 |
| NO20055922L (no) | 2006-01-06 |
| AU2004247610A1 (en) | 2004-12-23 |
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