ZA200509930B - Tablet comprising fluvastatin and carmellose calcium - Google Patents
Tablet comprising fluvastatin and carmellose calcium Download PDFInfo
- Publication number
- ZA200509930B ZA200509930B ZA200509930A ZA200509930A ZA200509930B ZA 200509930 B ZA200509930 B ZA 200509930B ZA 200509930 A ZA200509930 A ZA 200509930A ZA 200509930 A ZA200509930 A ZA 200509930A ZA 200509930 B ZA200509930 B ZA 200509930B
- Authority
- ZA
- South Africa
- Prior art keywords
- fluvastatin
- tablet
- sodium
- carbonate
- weight
- Prior art date
Links
- 229960003765 fluvastatin Drugs 0.000 title claims abstract description 66
- 229920002134 Carboxymethyl cellulose Polymers 0.000 title claims description 22
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 title claims description 22
- 235000010948 carboxy methyl cellulose Nutrition 0.000 title claims description 22
- 229950008138 carmellose Drugs 0.000 title claims description 22
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 21
- 229910052791 calcium Inorganic materials 0.000 title claims description 21
- 239000011575 calcium Substances 0.000 title claims description 21
- FJLGEFLZQAZZCD-MCBHFWOFSA-N (3R,5S)-fluvastatin Chemical compound C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 FJLGEFLZQAZZCD-MCBHFWOFSA-N 0.000 title abstract description 4
- ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 76
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 28
- 239000003795 chemical substances by application Substances 0.000 claims description 21
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 19
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- 238000000576 coating method Methods 0.000 claims description 18
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- 229960000868 fluvastatin sodium Drugs 0.000 claims description 9
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims description 9
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- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 9
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- NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 claims description 7
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003181349 | 2003-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200509930B true ZA200509930B (en) | 2007-01-31 |
Family
ID=33549526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200509930A ZA200509930B (en) | 2003-06-25 | 2005-12-07 | Tablet comprising fluvastatin and carmellose calcium |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20090117181A1 (zh) |
| EP (1) | EP1641440B1 (zh) |
| KR (1) | KR20060030480A (zh) |
| CN (1) | CN1809342A (zh) |
| AT (1) | ATE471713T1 (zh) |
| AU (1) | AU2004251439B2 (zh) |
| BR (1) | BRPI0411855A (zh) |
| CA (1) | CA2529447A1 (zh) |
| CO (1) | CO5650224A2 (zh) |
| DE (1) | DE602004027808D1 (zh) |
| EC (1) | ECSP056238A (zh) |
| IL (1) | IL172531A0 (zh) |
| IS (1) | IS8249A (zh) |
| MA (1) | MA27889A1 (zh) |
| MX (1) | MXPA05013943A (zh) |
| NO (1) | NO20060261L (zh) |
| NZ (1) | NZ544119A (zh) |
| RU (1) | RU2361582C2 (zh) |
| TN (1) | TNSN05330A1 (zh) |
| WO (1) | WO2005000276A1 (zh) |
| ZA (1) | ZA200509930B (zh) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007100822A2 (en) * | 2006-02-24 | 2007-09-07 | Teva Pharmaceutical Industries Ltd. | Fluvastatin sodium pharmaceutical compositions |
| CN103200930A (zh) * | 2010-10-12 | 2013-07-10 | 拜耳知识产权有限责任公司 | 非淀粉基软咀嚼品 |
| WO2012141160A1 (ja) | 2011-04-12 | 2012-10-18 | 沢井製薬株式会社 | ピタバスタチン含有製剤及びその製造方法 |
| CN102309452B (zh) * | 2011-09-14 | 2013-01-23 | 海南美大制药有限公司 | 氟伐他汀钠脂质体固体制剂 |
| US8652527B1 (en) * | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| CN104069502B (zh) * | 2013-03-29 | 2018-02-16 | 北京罗诺强施医药技术研发中心有限公司 | 复合骨架材料及其药物组合物 |
| CN104095850B (zh) * | 2013-04-03 | 2019-04-05 | 深圳信立泰药业股份有限公司 | 一种稳定的匹伐他汀钙药物组合物及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4739073A (en) * | 1983-11-04 | 1988-04-19 | Sandoz Pharmaceuticals Corp. | Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof |
| HU217629B (hu) * | 1991-12-12 | 2000-03-28 | Novartis Ag. | Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására |
| GB9703388D0 (en) * | 1997-02-18 | 1997-04-09 | Sandoz Yakuhin K K Tokyo Sykk | Organic compounds |
| AR035016A1 (es) * | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| WO2001058491A1 (fr) * | 2000-02-10 | 2001-08-16 | Takeda Chemical Industries, Ltd. | Medicament comprenant une combinaison |
| US20020025952A1 (en) * | 2000-07-06 | 2002-02-28 | American Home Products Corporation | Combinations of statins, estrogens and estrogenic agents |
| WO2002030400A1 (fr) * | 2000-10-06 | 2002-04-18 | Takeda Chemical Industries, Ltd. | Preparations solides |
-
2004
- 2004-06-24 CN CNA2004800174031A patent/CN1809342A/zh active Pending
- 2004-06-24 MX MXPA05013943A patent/MXPA05013943A/es unknown
- 2004-06-24 US US10/560,940 patent/US20090117181A1/en not_active Abandoned
- 2004-06-24 RU RU2006101889/15A patent/RU2361582C2/ru not_active IP Right Cessation
- 2004-06-24 BR BRPI0411855-3A patent/BRPI0411855A/pt not_active IP Right Cessation
- 2004-06-24 WO PCT/EP2004/006865 patent/WO2005000276A1/en not_active Application Discontinuation
- 2004-06-24 KR KR1020057024682A patent/KR20060030480A/ko not_active Application Discontinuation
- 2004-06-24 DE DE602004027808T patent/DE602004027808D1/de not_active Expired - Fee Related
- 2004-06-24 EP EP04740278A patent/EP1641440B1/en not_active Expired - Lifetime
- 2004-06-24 NZ NZ544119A patent/NZ544119A/en unknown
- 2004-06-24 CA CA002529447A patent/CA2529447A1/en not_active Abandoned
- 2004-06-24 AT AT04740278T patent/ATE471713T1/de not_active IP Right Cessation
- 2004-06-24 AU AU2004251439A patent/AU2004251439B2/en not_active Ceased
-
2005
- 2005-12-07 ZA ZA200509930A patent/ZA200509930B/en unknown
- 2005-12-12 IL IL172531A patent/IL172531A0/en unknown
- 2005-12-19 EC EC2005006238A patent/ECSP056238A/es unknown
- 2005-12-21 MA MA28679A patent/MA27889A1/fr unknown
- 2005-12-23 TN TNP2005000330A patent/TNSN05330A1/en unknown
- 2005-12-27 CO CO05130257A patent/CO5650224A2/es not_active Application Discontinuation
-
2006
- 2006-01-18 NO NO20060261A patent/NO20060261L/no not_active Application Discontinuation
- 2006-01-20 IS IS8249A patent/IS8249A/is unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP056238A (es) | 2006-04-19 |
| RU2006101889A (ru) | 2007-08-10 |
| IL172531A0 (en) | 2006-04-10 |
| US20090117181A1 (en) | 2009-05-07 |
| ATE471713T1 (de) | 2010-07-15 |
| BRPI0411855A (pt) | 2006-08-29 |
| TNSN05330A1 (en) | 2007-07-10 |
| CN1809342A (zh) | 2006-07-26 |
| AU2004251439B2 (en) | 2008-09-11 |
| CO5650224A2 (es) | 2006-06-30 |
| CA2529447A1 (en) | 2005-01-06 |
| MA27889A1 (fr) | 2006-05-02 |
| KR20060030480A (ko) | 2006-04-10 |
| IS8249A (is) | 2006-01-20 |
| RU2361582C2 (ru) | 2009-07-20 |
| NZ544119A (en) | 2008-04-30 |
| EP1641440B1 (en) | 2010-06-23 |
| AU2004251439A1 (en) | 2005-01-06 |
| WO2005000276A1 (en) | 2005-01-06 |
| EP1641440A1 (en) | 2006-04-05 |
| DE602004027808D1 (de) | 2010-08-05 |
| MXPA05013943A (es) | 2006-02-24 |
| NO20060261L (no) | 2006-01-18 |
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