ZA200508951B - 1, 3, 4-Substituted pyrazoles for use as 5-HT receptor antagonists in the treatment of psychoses and neurological disorders - Google Patents
1, 3, 4-Substituted pyrazoles for use as 5-HT receptor antagonists in the treatment of psychoses and neurological disorders Download PDFInfo
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- ZA200508951B ZA200508951B ZA200508951A ZA200508951A ZA200508951B ZA 200508951 B ZA200508951 B ZA 200508951B ZA 200508951 A ZA200508951 A ZA 200508951A ZA 200508951 A ZA200508951 A ZA 200508951A ZA 200508951 B ZA200508951 B ZA 200508951B
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- 238000011282 treatment Methods 0.000 title claims description 20
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pregnancy & Childbirth (AREA)
- Rheumatology (AREA)
- Gynecology & Obstetrics (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2003115573 DE10315573A1 (de) | 2003-04-05 | 2003-04-05 | Substituierte Pyrazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508951B true ZA200508951B (en) | 2007-03-28 |
Family
ID=32981074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508951A ZA200508951B (en) | 2003-04-05 | 2005-11-04 | 1, 3, 4-Substituted pyrazoles for use as 5-HT receptor antagonists in the treatment of psychoses and neurological disorders |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7566709B2 (zh) |
| EP (1) | EP1611107B1 (zh) |
| JP (1) | JP4740116B2 (zh) |
| KR (1) | KR20050119194A (zh) |
| CN (1) | CN1768043A (zh) |
| AR (1) | AR043838A1 (zh) |
| AT (1) | ATE478052T1 (zh) |
| AU (1) | AU2004228121B2 (zh) |
| BR (1) | BRPI0409002A (zh) |
| CA (1) | CA2521202A1 (zh) |
| DE (2) | DE10315573A1 (zh) |
| ES (1) | ES2349922T3 (zh) |
| MX (1) | MXPA05010646A (zh) |
| RU (1) | RU2005133990A (zh) |
| WO (1) | WO2004089910A1 (zh) |
| ZA (1) | ZA200508951B (zh) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| DE10315571A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| WO2006089076A2 (en) * | 2005-02-18 | 2006-08-24 | Neurogen Corporation | Thiazole amides, imidazole amides and related analogues |
| KR20080028964A (ko) | 2005-06-27 | 2008-04-02 | 엑셀리시스, 인코포레이티드 | 피라졸계 ｌｘｒ 변조제 |
| SG162803A1 (en) * | 2005-06-27 | 2010-07-29 | Exelixis Inc | Imidazole based lxr modulators |
| EP1919895A2 (en) | 2005-08-02 | 2008-05-14 | Lexicon Pharmaceuticals, Inc. | 2-aminoaryl pyridines as protein kinases inhibitors |
| JP2008169191A (ja) * | 2006-02-20 | 2008-07-24 | Eisai R & D Management Co Ltd | 運動ニューロン疾患治療剤 |
| JP5399262B2 (ja) | 2006-12-08 | 2014-01-29 | エグゼリクシス パテント カンパニー エルエルシー | Ｌｘｒおよびｆｘｒのモジュレーター |
| US8524909B2 (en) * | 2010-02-02 | 2013-09-03 | Hoffmann-La Roche Inc. | Tetrahydro-pyran derivatives |
| TW201321367A (zh) * | 2011-10-25 | 2013-06-01 | Du Pont | 經１，３－二芳基取代之雜環殺蟲劑 |
| EP2850074A1 (en) | 2012-05-16 | 2015-03-25 | E. I. Du Pont de Nemours and Company | 1,3-diaryl-substituted heterocyclic pesticides |
| GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
| WO2015022293A2 (en) * | 2013-08-12 | 2015-02-19 | Basf Se | 1,3-(het)aryl-substituted pyrazole compounds |
| TW201601632A (zh) | 2013-11-20 | 2016-01-16 | 杜邦股份有限公司 | １－芳基－３－烷基吡唑殺蟲劑 |
| LT3762368T (lt) | 2018-03-08 | 2022-06-10 | Incyte Corporation | Aminopirazindiolio junginiai, kaip pi3k-γ inhibitoriai |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
| CH518155A (de) * | 1970-08-18 | 1972-01-31 | Schaerer Willy | Verfahren zur Erleichterung des Schleifens schraubenlinienförmiger Nuten, bei einer Serie von unter sich gleichen Werkstücken mit je mindestens einer schraubenlinienförmig eingefrästen Nut und Simuliergerät zur Durchführung des Verfahrens |
| BE793955A (fr) | 1972-01-15 | 1973-07-12 | Merck Patent Gmbh | Arylpiperazines et leur procede de preparation |
| DE2906252A1 (de) | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4631343A (en) | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
| DE69629364T2 (de) * | 1995-04-20 | 2004-06-09 | G.D. Searle & Co., Chicago | Zyclische amidino mittel als stickstoffoxid-synthase inhibitoren |
| EP0971588B1 (en) | 1997-01-21 | 2004-03-17 | Smithkline Beecham Corporation | Novel cannabinoid receptor modulators |
| US6150393A (en) | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
| US20010044445A1 (en) | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| WO2001032627A1 (en) | 1999-10-29 | 2001-05-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
| US6407238B1 (en) | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
| DE60017446T2 (de) | 1999-11-05 | 2006-03-02 | Smithkline Beecham P.L.C., Brentford | Isochinolin- und Chinazolinderivate mit kombinierter 5-HT1A-, 5-HT1B- und 5-HT1D- Rezeptoraffinität |
| CA2450167A1 (en) | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
| DE10149370A1 (de) | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
| EP1494664A2 (en) | 2002-04-18 | 2005-01-12 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
| WO2003099793A1 (en) | 2002-05-24 | 2003-12-04 | Takeda Pharmaceutical Company Limited | 1,2-azole derivatives with hypoglycemic and hypolipidemic activity |
| AU2003262023A1 (en) * | 2002-09-10 | 2004-04-30 | Takeda Pharmaceutical Company Limited | Five-membered heterocyclic compounds |
| AU2003287965A1 (en) * | 2002-10-24 | 2004-05-13 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
| DE10315572A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| DE10315569A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| US20070093492A1 (en) | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
-
2003
- 2003-04-05 DE DE2003115573 patent/DE10315573A1/de not_active Withdrawn
-
2004
- 2004-03-08 WO PCT/EP2004/002354 patent/WO2004089910A1/de active Application Filing
- 2004-03-08 DE DE502004011551T patent/DE502004011551D1/de not_active Expired - Lifetime
- 2004-03-08 CN CNA2004800086295A patent/CN1768043A/zh active Pending
- 2004-03-08 KR KR1020057018898A patent/KR20050119194A/ko not_active Application Discontinuation
- 2004-03-08 MX MXPA05010646A patent/MXPA05010646A/es unknown
- 2004-03-08 AT AT04718264T patent/ATE478052T1/de active
- 2004-03-08 EP EP04718264A patent/EP1611107B1/de not_active Expired - Lifetime
- 2004-03-08 RU RU2005133990/04A patent/RU2005133990A/ru not_active Application Discontinuation
- 2004-03-08 US US10/551,998 patent/US7566709B2/en not_active Expired - Fee Related
- 2004-03-08 CA CA002521202A patent/CA2521202A1/en not_active Abandoned
- 2004-03-08 ES ES04718264T patent/ES2349922T3/es not_active Expired - Lifetime
- 2004-03-08 AU AU2004228121A patent/AU2004228121B2/en not_active Ceased
- 2004-03-08 BR BRPI0409002-0A patent/BRPI0409002A/pt not_active Application Discontinuation
- 2004-03-08 JP JP2006504585A patent/JP4740116B2/ja not_active Expired - Fee Related
- 2004-04-02 AR ARP040101120A patent/AR043838A1/es unknown
-
2005
- 2005-11-04 ZA ZA200508951A patent/ZA200508951B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006522036A (ja) | 2006-09-28 |
| RU2005133990A (ru) | 2006-03-20 |
| DE10315573A1 (de) | 2004-10-14 |
| US7566709B2 (en) | 2009-07-28 |
| AU2004228121A1 (en) | 2004-10-21 |
| DE502004011551D1 (de) | 2010-09-30 |
| AR043838A1 (es) | 2005-08-17 |
| EP1611107B1 (de) | 2010-08-18 |
| WO2004089910A1 (de) | 2004-10-21 |
| CA2521202A1 (en) | 2004-10-21 |
| JP4740116B2 (ja) | 2011-08-03 |
| CN1768043A (zh) | 2006-05-03 |
| AU2004228121B2 (en) | 2010-11-04 |
| KR20050119194A (ko) | 2005-12-20 |
| ES2349922T3 (es) | 2011-01-13 |
| BRPI0409002A (pt) | 2006-03-28 |
| MXPA05010646A (es) | 2005-12-12 |
| ATE478052T1 (de) | 2010-09-15 |
| EP1611107A1 (de) | 2006-01-04 |
| US20070105871A1 (en) | 2007-05-10 |
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