BRPI0409002A - pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos - Google Patents
pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicosInfo
- Publication number
- BRPI0409002A BRPI0409002A BRPI0409002-0A BRPI0409002A BRPI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A BR PI0409002 A BRPI0409002 A BR PI0409002A
- Authority
- BR
- Brazil
- Prior art keywords
- psychosis
- treatment
- receptor antagonists
- neurological disorders
- substituted pyrazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
"PIRAZóIS 1,3,4-SUBSTITUìDOS PARA USO COMO ANTAGONISTAS RECEPTORES 5H-T NO TRATAMENTO DE PSICOSES E DISTúRBIOS NEUROLóGICOS". A presente invenção refere-se a compostos de fórmula (I) e sais e solvatos dos mesmos, em que X, R¬ 1¬, R¬ 2¬, R¬ 5¬ e Q possuem os significados indicados na reivindicação 1, que são adequados como ligantes de receptores de 5HT; bem como como compostos intermediários de fórmula (IA).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2003115573 DE10315573A1 (de) | 2003-04-05 | 2003-04-05 | Substituierte Pyrazole |
PCT/EP2004/002354 WO2004089910A1 (de) | 2003-04-05 | 2004-03-08 | 1,3,4-substituierte pyrazole als 5-ht rezeptor-antagonisten zur behandlung von psychosen und neurologischen störungen |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0409002A true BRPI0409002A (pt) | 2006-03-28 |
Family
ID=32981074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0409002-0A BRPI0409002A (pt) | 2003-04-05 | 2004-03-08 | pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos |
Country Status (16)
Country | Link |
---|---|
US (1) | US7566709B2 (pt) |
EP (1) | EP1611107B1 (pt) |
JP (1) | JP4740116B2 (pt) |
KR (1) | KR20050119194A (pt) |
CN (1) | CN1768043A (pt) |
AR (1) | AR043838A1 (pt) |
AT (1) | ATE478052T1 (pt) |
AU (1) | AU2004228121B2 (pt) |
BR (1) | BRPI0409002A (pt) |
CA (1) | CA2521202A1 (pt) |
DE (2) | DE10315573A1 (pt) |
ES (1) | ES2349922T3 (pt) |
MX (1) | MXPA05010646A (pt) |
RU (1) | RU2005133990A (pt) |
WO (1) | WO2004089910A1 (pt) |
ZA (1) | ZA200508951B (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
DE10315571A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
DE10315569A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
EP1848428A4 (en) * | 2005-02-18 | 2012-04-18 | Neurogen Corp | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGS |
CN101248049B (zh) * | 2005-06-27 | 2013-08-28 | 埃克塞利希斯专利有限责任公司 | 咪唑类lxr调节剂 |
CA2613522A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
JP2009503103A (ja) | 2005-08-02 | 2009-01-29 | レキシコン・ファーマシューティカルズ・インコーポレーテッド | アリールピリジン及びその使用方法 |
JP2008169191A (ja) * | 2006-02-20 | 2008-07-24 | Eisai R & D Management Co Ltd | 運動ニューロン疾患治療剤 |
CN101679297B (zh) | 2006-12-08 | 2012-01-11 | 埃克塞利希斯股份有限公司 | Lxr和fxr调节剂 |
US8524909B2 (en) * | 2010-02-02 | 2013-09-03 | Hoffmann-La Roche Inc. | Tetrahydro-pyran derivatives |
TW201321367A (zh) * | 2011-10-25 | 2013-06-01 | Du Pont | 經1,3-二芳基取代之雜環殺蟲劑 |
BR112014028375A2 (pt) | 2012-05-16 | 2017-06-27 | Du Pont | composto, composição, método para controlar uma praga e semente |
GB201312800D0 (en) | 2013-07-17 | 2013-08-28 | Heptares Therapeutics Ltd | mGlu5 modulators |
WO2015022293A2 (en) * | 2013-08-12 | 2015-02-19 | Basf Se | 1,3-(het)aryl-substituted pyrazole compounds |
TW201601632A (zh) | 2013-11-20 | 2016-01-16 | 杜邦股份有限公司 | 1-芳基-3-烷基吡唑殺蟲劑 |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
WO2020113094A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
CH518155A (de) * | 1970-08-18 | 1972-01-31 | Schaerer Willy | Verfahren zur Erleichterung des Schleifens schraubenlinienförmiger Nuten, bei einer Serie von unter sich gleichen Werkstücken mit je mindestens einer schraubenlinienförmig eingefrästen Nut und Simuliergerät zur Durchführung des Verfahrens |
BE793955A (fr) | 1972-01-15 | 1973-07-12 | Merck Patent Gmbh | Arylpiperazines et leur procede de preparation |
DE2906252A1 (de) | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
US4631343A (en) | 1983-11-07 | 1986-12-23 | Eli Lilly And Company | Cyanopyrazole intermediates |
WO1996033175A1 (en) | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
WO1998031227A1 (en) | 1997-01-21 | 1998-07-23 | Smithkline Beecham Corporation | Novel cannabinoid receptor modulators |
US6150393A (en) * | 1998-12-18 | 2000-11-21 | Arena Pharmaceuticals, Inc. | Small molecule modulators of non-endogenous, constitutively activated human serotonin receptors |
US20010044445A1 (en) | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
US6407238B1 (en) | 1999-10-29 | 2002-06-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Process of making substituted pyrazoles |
ES2202189T3 (es) | 1999-10-29 | 2004-04-01 | Boehringer Ingelheim Pharmaceuticals Inc. | Procedimiento para preparar pirazoles sustituidos. |
ATE286883T1 (de) | 1999-11-05 | 2005-01-15 | Smithkline Beecham Plc | Isochinolin und chinazolinderivate mit kombinierter 5ht1a, 5ht1b und 5ht1d rezeptor aktivität |
WO2002100399A1 (en) | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles useful in the treatment of alzheimer's disease |
DE10149370A1 (de) | 2001-10-06 | 2003-04-10 | Merck Patent Gmbh | Pyrazolderivate |
EP1494664A2 (en) | 2002-04-18 | 2005-01-12 | Pharmacia Corporation | Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease |
US20060148858A1 (en) * | 2002-05-24 | 2006-07-06 | Tsuyoshi Maekawa | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity |
WO2004024705A1 (ja) * | 2002-09-10 | 2004-03-25 | Takeda Pharmaceutical Company Limited | 5員複素環化合物 |
WO2004037248A2 (en) * | 2002-10-24 | 2004-05-06 | Carex Sa | Modulation of peroxisome proliferator activated receptors activity |
DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
DE10315572A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
DE10315569A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
US20070093492A1 (en) | 2004-03-09 | 2007-04-26 | Weir-Torn Jiaang | Pyrrolidine derivatives |
-
2003
- 2003-04-05 DE DE2003115573 patent/DE10315573A1/de not_active Withdrawn
-
2004
- 2004-03-08 RU RU2005133990/04A patent/RU2005133990A/ru not_active Application Discontinuation
- 2004-03-08 DE DE502004011551T patent/DE502004011551D1/de not_active Expired - Lifetime
- 2004-03-08 AU AU2004228121A patent/AU2004228121B2/en not_active Ceased
- 2004-03-08 WO PCT/EP2004/002354 patent/WO2004089910A1/de active Application Filing
- 2004-03-08 US US10/551,998 patent/US7566709B2/en not_active Expired - Fee Related
- 2004-03-08 BR BRPI0409002-0A patent/BRPI0409002A/pt not_active Application Discontinuation
- 2004-03-08 AT AT04718264T patent/ATE478052T1/de active
- 2004-03-08 MX MXPA05010646A patent/MXPA05010646A/es unknown
- 2004-03-08 KR KR1020057018898A patent/KR20050119194A/ko not_active Application Discontinuation
- 2004-03-08 EP EP04718264A patent/EP1611107B1/de not_active Expired - Lifetime
- 2004-03-08 JP JP2006504585A patent/JP4740116B2/ja not_active Expired - Fee Related
- 2004-03-08 CN CNA2004800086295A patent/CN1768043A/zh active Pending
- 2004-03-08 ES ES04718264T patent/ES2349922T3/es not_active Expired - Lifetime
- 2004-03-08 CA CA002521202A patent/CA2521202A1/en not_active Abandoned
- 2004-04-02 AR ARP040101120A patent/AR043838A1/es unknown
-
2005
- 2005-11-04 ZA ZA200508951A patent/ZA200508951B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ATE478052T1 (de) | 2010-09-15 |
CN1768043A (zh) | 2006-05-03 |
ES2349922T3 (es) | 2011-01-13 |
US20070105871A1 (en) | 2007-05-10 |
AU2004228121A1 (en) | 2004-10-21 |
KR20050119194A (ko) | 2005-12-20 |
RU2005133990A (ru) | 2006-03-20 |
JP4740116B2 (ja) | 2011-08-03 |
CA2521202A1 (en) | 2004-10-21 |
US7566709B2 (en) | 2009-07-28 |
EP1611107B1 (de) | 2010-08-18 |
JP2006522036A (ja) | 2006-09-28 |
DE502004011551D1 (de) | 2010-09-30 |
WO2004089910A1 (de) | 2004-10-21 |
AR043838A1 (es) | 2005-08-17 |
EP1611107A1 (de) | 2006-01-04 |
MXPA05010646A (es) | 2005-12-12 |
DE10315573A1 (de) | 2004-10-14 |
AU2004228121B2 (en) | 2010-11-04 |
ZA200508951B (en) | 2007-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0409002A (pt) | pirazóis 1,3,4-substituìdos para uso como antagonistas receptores 5h-t no tratamento de psicoses e distúrbios neurológicos | |
ATE524466T1 (de) | 3-azabicycloä3.3.0üoktanverbindungen | |
BRPI0520812A2 (pt) | método para preparar um composto de quinolina 4-substituìda, e, composto | |
ATE483707T1 (de) | 2-cyclopropylthiazolderivate | |
BRPI0510762A (pt) | derivados de tetraidronaftiridina úteis como ligantes do receptor de histamina h3 | |
CL2004000917A1 (es) | Compuestos derivados de tiazol; procedimiento de preparacion; composicion farmaceutica; y su uso para el tratamiento de enfermedades mediadas por 3-cinasa de dosfatidilnositol tal como enfermedades respiratorias, alergias, artritis reumatoide, osteoa | |
ATE429427T1 (de) | Pyrimidinderivate als orexin-rezeptorantagonisten | |
BRPI0414541A8 (pt) | compostos heterocíclicos fundidos, seu uso, método de preparação de compostos intermediários e método para estudar distúrbios mediados por serotonina | |
NO20083427L (no) | Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse | |
CY1113798T1 (el) | Υποκατεστημενες ενωσεις διαζεπανης ως ανταγωνιστες υποδοχεα ορεξινης | |
ECSP066541A (es) | Nuevos derivados de piridazin-3(2h)-ona | |
ECSP088549A (es) | Nuevos derivados de pirrol fusionado | |
TW200604183A (en) | Triazole compounds and their use as metabotropic glutamate receptor antagonists | |
ECSP099413A (es) | COMPUESTOS A BASE DE 4 - fenil - 6 - (2,2,2 - trifluoro - 1 - feniletoxi)pirimidina Y MÉTODOS PARA SU EMPLEO | |
TNSN07313A1 (en) | Substituted thiophene derivatives as glucagon receptor antagonists, preparation and therapeutic uses | |
BRPI0407976A (pt) | tetrahidroisoquinolinas substituìdas em 2,5 e 2,6 para uso como moduladores de 5-ht6 | |
MX2009005358A (es) | Derivados de 5-sulfanilmetil-pirazolo[1,5-a]pirimidin-7-ol como antagonistas de cxcr2. | |
WO2007108936A3 (en) | N-substituted-azacyclylamines as histamine-3 antagonists | |
WO2008002596A3 (en) | Adenosine a2a receptor antagonists | |
WO2007136668A3 (en) | N-benzoyl-and n-benzylpyrrolidin-3-ylamines as histamine-3 antagonists | |
MX2009005174A (es) | Derivados de 5-sulfanilmetil-[1,2,4]triazol[1,5-a]pirimidin-7-ol como antagonistas de cxcr2. | |
DE602005021150D1 (de) | 3-substituierte pyridinderivate als h3-antagonisten | |
BR122018070508B8 (pt) | derivados de arilamida triazol-substituída e seu uso | |
MX2010002760A (es) | Derivados de isoquinolinilo e isoindolinilo como antagonistas de la histamina-3. | |
WO2008045371A3 (en) | N-substituted-azacyclylamines as histamine-3 antagonists |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |