ZA200508727B - Microwave method for preparing radiolabelled gallium complexes - Google Patents
Microwave method for preparing radiolabelled gallium complexes Download PDFInfo
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- ZA200508727B ZA200508727B ZA200508727A ZA200508727A ZA200508727B ZA 200508727 B ZA200508727 B ZA 200508727B ZA 200508727 A ZA200508727 A ZA 200508727A ZA 200508727 A ZA200508727 A ZA 200508727A ZA 200508727 B ZA200508727 B ZA 200508727B
- Authority
- ZA
- South Africa
- Prior art keywords
- chelating agent
- anion exchanger
- dota
- microwave activation
- radiolabelled
- Prior art date
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
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- 229950003776 protoporphyrin Drugs 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 239000012857 radioactive material Substances 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- RPENMORRBUTCPR-UHFFFAOYSA-M sodium;1-hydroxy-2,5-dioxopyrrolidine-3-sulfonate Chemical compound [Na+].ON1C(=O)CC(S([O-])(=O)=O)C1=O RPENMORRBUTCPR-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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- 230000003068 static effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000007669 thermal treatment Methods 0.000 description 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Nuclear Medicine (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0308408.4A GB0308408D0 (en) | 2003-04-11 | 2003-04-11 | Microwave activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200508727B true ZA200508727B (en) | 2007-09-26 |
Family
ID=9956634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200508727A ZA200508727B (en) | 2003-04-11 | 2005-10-27 | Microwave method for preparing radiolabelled gallium complexes |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8007766B2 (pt) |
| EP (1) | EP1620134B1 (pt) |
| JP (1) | JP4814785B2 (pt) |
| KR (1) | KR101108420B1 (pt) |
| CN (1) | CN1771058B (pt) |
| AT (1) | ATE366122T1 (pt) |
| AU (1) | AU2004228746B2 (pt) |
| BR (1) | BRPI0409101A (pt) |
| CA (1) | CA2520653C (pt) |
| DE (1) | DE602004007371T2 (pt) |
| ES (1) | ES2288255T3 (pt) |
| GB (1) | GB0308408D0 (pt) |
| IL (1) | IL170864A (pt) |
| MX (1) | MXPA05010854A (pt) |
| NO (1) | NO332419B1 (pt) |
| PL (1) | PL1620134T3 (pt) |
| RU (1) | RU2333557C2 (pt) |
| WO (1) | WO2004089425A1 (pt) |
| ZA (1) | ZA200508727B (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101443051A (zh) * | 2005-02-22 | 2009-05-27 | 通用电气健康护理有限公司 | 放射性标记镓复合物、其合成方法及其在恶性肿瘤中egfr表达的pet成像中的应用 |
| CA2625196C (fr) | 2005-10-07 | 2016-04-05 | Guerbet | Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US7586102B2 (en) | 2006-08-14 | 2009-09-08 | Board Of Regents The University Of Texas System | Automated system for formulating radiopharmaceuticals |
| US20100233082A1 (en) * | 2006-08-28 | 2010-09-16 | Bengt Langstrom | 68GA-Labeled Peptide-Based Radiopharmaceuticals |
| WO2008026051A2 (en) * | 2006-08-29 | 2008-03-06 | Ge Healthcare Limited | 68ga-labelling of a free and macromolecule conjugated macrocyclic chelator at ambient temperature |
| JP5088928B2 (ja) * | 2006-11-24 | 2012-12-05 | 新日鐵化学株式会社 | ８−オキシキノリン銅の製造方法 |
| FR2942227B1 (fr) * | 2009-02-13 | 2011-04-15 | Guerbet Sa | Utilisation de tampons pour la complexation de radionucleides |
| GB0922492D0 (en) * | 2009-12-23 | 2010-02-03 | Hammersmith Imanet Ltd | Method for obtaining 68GA |
| ITFI20110180A1 (it) * | 2011-08-12 | 2013-02-13 | Advanced Accelerator Applic S A | Processo per la preparazione di complessi di 68ga. |
| CN102965502A (zh) * | 2011-09-01 | 2013-03-13 | 广西大学 | 一种分离富集镓的固相萃取法 |
| BE1021191B1 (fr) | 2014-08-29 | 2015-10-27 | Anmi S.A. | Kit pour radiomarquage. |
| US11027030B2 (en) | 2014-08-29 | 2021-06-08 | Anmi S.A. | Kit for radiolabelling |
| GB201814291D0 (en) * | 2018-09-03 | 2018-10-17 | Univ Oslo | Process for the production of gallium radionculides |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2932948C2 (de) * | 1979-08-14 | 1982-11-18 | Stiftung Deutsches Krebsforschungszentrum, 6900 Heidelberg | Verfahren zur Herstellung eines Ionenaustauschers und dessen Verwendung |
| US5029065A (en) | 1986-12-16 | 1991-07-02 | Ciba-Geigy Corporation | Control system for a sample preparation system |
| DE4231622C2 (de) * | 1992-09-22 | 1996-09-05 | Bakelite Ag | Verfahren zur Herstellung von Metallneutralkomplexen mit hoher Koordinationszahl und deren Verwendung |
| EP0683676A4 (en) * | 1993-02-02 | 1998-09-30 | Neorx Corp | BIODISTRIBUTION DIRECTED FROM SMALL MOLECULES. |
| WO1995033757A1 (en) * | 1994-06-03 | 1995-12-14 | Mallinckrodt Medical, Inc. | RAPIDLY CLEARING TECHNETIUM-99m PHOSPHONATE SKELETAL IMAGING AGENTS |
| US6071490A (en) * | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
| AU5079099A (en) * | 1998-05-07 | 1999-11-23 | Research Foundation Of The State University Of New York, The | S3n radionuclide complexes |
| US7011816B2 (en) * | 2001-12-26 | 2006-03-14 | Immunomedics, Inc. | Labeling targeting agents with gallium-68 and gallium-67 |
-
2003
- 2003-04-11 GB GBGB0308408.4A patent/GB0308408D0/en not_active Ceased
-
2004
- 2004-04-08 JP JP2006506106A patent/JP4814785B2/ja not_active Expired - Fee Related
- 2004-04-08 ES ES04726564T patent/ES2288255T3/es not_active Expired - Lifetime
- 2004-04-08 MX MXPA05010854A patent/MXPA05010854A/es active IP Right Grant
- 2004-04-08 WO PCT/GB2004/001550 patent/WO2004089425A1/en active IP Right Grant
- 2004-04-08 EP EP04726564A patent/EP1620134B1/en not_active Expired - Lifetime
- 2004-04-08 US US10/552,134 patent/US8007766B2/en not_active Expired - Fee Related
- 2004-04-08 CA CA2520653A patent/CA2520653C/en not_active Expired - Fee Related
- 2004-04-08 CN CN2004800095951A patent/CN1771058B/zh not_active Expired - Fee Related
- 2004-04-08 RU RU2005130862/06A patent/RU2333557C2/ru not_active IP Right Cessation
- 2004-04-08 AU AU2004228746A patent/AU2004228746B2/en not_active Ceased
- 2004-04-08 KR KR1020057019262A patent/KR101108420B1/ko not_active IP Right Cessation
- 2004-04-08 BR BRPI0409101-9A patent/BRPI0409101A/pt not_active IP Right Cessation
- 2004-04-08 AT AT04726564T patent/ATE366122T1/de not_active IP Right Cessation
- 2004-04-08 PL PL04726564T patent/PL1620134T3/pl unknown
- 2004-04-08 DE DE602004007371T patent/DE602004007371T2/de not_active Expired - Lifetime
-
2005
- 2005-09-14 IL IL170864A patent/IL170864A/en not_active IP Right Cessation
- 2005-10-07 NO NO20054615A patent/NO332419B1/no not_active IP Right Cessation
- 2005-10-27 ZA ZA200508727A patent/ZA200508727B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004007371D1 (de) | 2007-08-16 |
| JP4814785B2 (ja) | 2011-11-16 |
| BRPI0409101A (pt) | 2006-04-04 |
| CN1771058A (zh) | 2006-05-10 |
| IL170864A (en) | 2010-05-31 |
| AU2004228746A1 (en) | 2004-10-21 |
| ES2288255T3 (es) | 2008-01-01 |
| KR101108420B1 (ko) | 2012-01-30 |
| US8007766B2 (en) | 2011-08-30 |
| RU2005130862A (ru) | 2006-05-27 |
| EP1620134A1 (en) | 2006-02-01 |
| KR20060006030A (ko) | 2006-01-18 |
| JP2006522783A (ja) | 2006-10-05 |
| CA2520653A1 (en) | 2004-10-21 |
| CN1771058B (zh) | 2010-05-26 |
| PL1620134T3 (pl) | 2007-11-30 |
| NO20054615L (no) | 2005-10-07 |
| NO332419B1 (no) | 2012-09-17 |
| RU2333557C2 (ru) | 2008-09-10 |
| CA2520653C (en) | 2012-06-05 |
| ATE366122T1 (de) | 2007-07-15 |
| WO2004089425A1 (en) | 2004-10-21 |
| GB0308408D0 (en) | 2003-05-21 |
| MXPA05010854A (es) | 2005-12-14 |
| EP1620134B1 (en) | 2007-07-04 |
| DE602004007371T2 (de) | 2008-03-06 |
| AU2004228746B2 (en) | 2009-11-12 |
| US20070027307A1 (en) | 2007-02-01 |
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