ZA200508116B - Composition comprising a PDE4 inhibitor and a PDE5 inhibitor - Google Patents
Composition comprising a PDE4 inhibitor and a PDE5 inhibitor Download PDFInfo
- Publication number
- ZA200508116B ZA200508116B ZA200508116A ZA200508116A ZA200508116B ZA 200508116 B ZA200508116 B ZA 200508116B ZA 200508116 A ZA200508116 A ZA 200508116A ZA 200508116 A ZA200508116 A ZA 200508116A ZA 200508116 B ZA200508116 B ZA 200508116B
- Authority
- ZA
- South Africa
- Prior art keywords
- pde4
- pdes
- inhibitor
- phosphodiesterase
- disease
- Prior art date
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Classifications
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| EP03011609 | 2003-05-22 |
Publications (1)
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| ZA200508116B true ZA200508116B (en) | 2007-01-31 |
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| ZA200508116A ZA200508116B (en) | 2003-05-22 | 2005-10-07 | Composition comprising a PDE4 inhibitor and a PDE5 inhibitor |
Country Status (23)
| Country | Link |
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| US (3) | US20060094723A1 (ru) |
| EP (1) | EP1628682B1 (ru) |
| JP (1) | JP2006528229A (ru) |
| KR (1) | KR20060012004A (ru) |
| CN (1) | CN1791429A (ru) |
| AU (1) | AU2004241749B2 (ru) |
| BR (1) | BRPI0410326A (ru) |
| CA (1) | CA2525946C (ru) |
| CO (1) | CO5660275A2 (ru) |
| EA (1) | EA012279B1 (ru) |
| EC (1) | ECSP056173A (ru) |
| GE (1) | GEP20084342B (ru) |
| IL (1) | IL171306A (ru) |
| IS (1) | IS8181A (ru) |
| MA (1) | MA27855A1 (ru) |
| MX (1) | MXPA05012302A (ru) |
| NO (1) | NO333501B1 (ru) |
| NZ (1) | NZ544040A (ru) |
| RS (1) | RS52730B (ru) |
| TN (1) | TNSN05265A1 (ru) |
| UA (1) | UA83041C2 (ru) |
| WO (1) | WO2004103407A2 (ru) |
| ZA (1) | ZA200508116B (ru) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| CA2503290C (en) | 2003-03-10 | 2012-12-04 | Altana Pharma Ag | Novel process for the preparation of roflumilast |
| MXPA06002521A (es) | 2003-09-05 | 2006-06-20 | Altana Pharma Ag | Uso de inhibidores de pde4 para el tratamiento de diabetes mellitus. |
| JP2007536350A (ja) * | 2004-05-10 | 2007-12-13 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺気腫の予防又は治療のためのロフルミラストの使用 |
| WO2006094942A1 (en) * | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| EA015382B1 (ru) * | 2005-03-08 | 2011-08-30 | Никомед Гмбх | Применение рофлумиласта для лечения сахарного диабета типа 2 |
| CA2601250C (en) | 2005-03-16 | 2014-10-28 | Nycomed Gmbh | Taste masked dosage form containing roflumilast |
| DE102005016345A1 (de) * | 2005-04-09 | 2006-10-12 | Bayer Healthcare Ag | Neue Verwendung von 2-Phenyl-substituierten Imidazotriazinon-Derivaten |
| ME01609B (me) * | 2005-04-19 | 2014-09-20 | Takeda Gmbh | Roflumilast za liječenje pulmonarne hipertenzije |
| NL2000291C2 (nl) | 2005-11-10 | 2009-02-17 | Pfizer Prod Inc | 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan. |
| RS53461B (en) | 2006-07-05 | 2014-12-31 | Takeda Gmbh | COMBINATION OF HMG-COA REDUCTASE INHIBITOR OR SIMVASTATIN WITH PHOSPHODIESTERASE 4 INHIBITOR AS A ROFLUMILAST FOR THE TREATMENT OF INFLAMMATORY PULMONARY DISEASES |
| MX2009003673A (es) * | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| WO2010013925A2 (en) * | 2008-07-31 | 2010-02-04 | Dong-A Pharmaceutical. Co., Ltd. | Pharmacological composition for prevention and treatment of respiratory disease containing pyrazolopyrimidinone compound or pharmaceutically acceptable salts thereof |
| JP2014526461A (ja) * | 2011-09-09 | 2014-10-06 | エスケー ケミカルズ カンパニー，リミテッド | Ｐｄｅ５抑制剤を含む皮膚しわ改善用組成物 |
| UA117913C2 (uk) * | 2012-05-31 | 2018-10-25 | Фінекс Фармас'Ютікалс Аг | КАРБОКСАМІД- АБО СУЛЬФОНАМІДЗАМІЩЕНІ ТІАЗОЛИ ТА СПОРІДНЕНІ ПОХІДНІ ЯК МОДУЛЯТОРИ ОРФАНОВОГО ЯДЕРНОГО РЕЦЕПТОРА RORγ |
| EP3082428A4 (en) | 2013-12-09 | 2017-08-02 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
| EP3165224A1 (en) | 2015-11-09 | 2017-05-10 | Albert-Ludwigs-Universität Freiburg | Use of pde4 inhibitors for the prophylaxis and/or therapy of dyslipoproteinaemia and related disorders |
| US10058545B2 (en) * | 2016-08-09 | 2018-08-28 | Cipla Limited | Method of treating pulmonary arterial hypertension |
| CN107648224A (zh) * | 2017-10-31 | 2018-02-02 | 泰州中国医药城中医药研究院 | 一种治疗和预防心力衰竭药物及其在制药中的应用 |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| CN108976107B (zh) * | 2018-08-23 | 2021-03-23 | 南方医科大学 | 3-芳基-4-烷氧基苄胺衍生物及其制备方法和应用 |
| KR20210095165A (ko) | 2018-11-19 | 2021-07-30 | 프로제너티, 인크. | 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스 |
| CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| WO2021175250A1 (en) * | 2020-03-03 | 2021-09-10 | Aptorum Therapeutics Limited | Compounds and methods for treating diseases and/or conditions caused by coronavirus |
Family Cites Families (14)
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| GB9013750D0 (en) | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
| AU687087B2 (en) | 1993-07-02 | 1998-02-19 | Takeda Gmbh | Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors |
| GB9401090D0 (en) * | 1994-01-21 | 1994-03-16 | Glaxo Lab Sa | Chemical compounds |
| CN1043993C (zh) * | 1994-08-29 | 1999-07-07 | 山之内制药株式会社 | 萘啶衍生物及其医药组合物 |
| US6127363A (en) * | 1997-10-28 | 2000-10-03 | Vivus, Inc. | Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| DE59803108D1 (de) | 1997-11-12 | 2002-03-21 | Bayer Ag | 2-phenyl-substituierte imidazotriazinone als phosphodiesterase inhibitoren |
| US6417190B1 (en) * | 1998-12-17 | 2002-07-09 | Boehringer Ingelheim Pharma Kg | Tricyclic nitrogen heterocycles as PDE IV inhibitors |
| TWI224966B (en) * | 1999-11-02 | 2004-12-11 | Pfizer | Pharmaceutical composition (I) useful for treating or preventing pulmonary hypertension in a patient |
| EE05386B1 (et) * | 2001-02-15 | 2011-02-15 | ALTANA�Pharma�AG | Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim |
| EP1397135B1 (en) * | 2001-05-25 | 2006-12-06 | Boehringer Ingelheim Pharma GmbH & Co.KG | Combination of a pde4 inhibitor and tiotropium or derivative thereof for treating obstructive airways |
| US20030114469A1 (en) * | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
| US20030216407A1 (en) * | 2002-01-31 | 2003-11-20 | Pfizer Inc. | Use of PDE5 inhibitors in the treatment of scarring |
| GB0202254D0 (en) * | 2002-01-31 | 2002-03-20 | Pfizer Ltd | Prevention of scarring |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
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| US20100234382A1 (en) | 2010-09-16 |
| RS20050858A (en) | 2007-12-31 |
| WO2004103407A3 (en) | 2005-02-17 |
| US20060094723A1 (en) | 2006-05-04 |
| CN1791429A (zh) | 2006-06-21 |
| CA2525946C (en) | 2013-01-29 |
| BRPI0410326A (pt) | 2006-05-23 |
| EP1628682A2 (en) | 2006-03-01 |
| IL171306A (en) | 2013-08-29 |
| EP1628682B1 (en) | 2013-09-25 |
| US20120196867A1 (en) | 2012-08-02 |
| AU2004241749A1 (en) | 2004-12-02 |
| CA2525946A1 (en) | 2004-12-02 |
| TNSN05265A1 (en) | 2007-07-10 |
| EA012279B1 (ru) | 2009-08-28 |
| JP2006528229A (ja) | 2006-12-14 |
| MA27855A1 (fr) | 2006-04-03 |
| AU2004241749B2 (en) | 2010-03-25 |
| ECSP056173A (es) | 2006-04-19 |
| WO2004103407A2 (en) | 2004-12-02 |
| NZ544040A (en) | 2009-03-31 |
| EA200501690A1 (ru) | 2006-06-30 |
| CO5660275A2 (es) | 2006-07-31 |
| IS8181A (is) | 2005-12-14 |
| RS52730B (sr) | 2013-08-30 |
| UA83041C2 (ru) | 2008-06-10 |
| NO20055941L (no) | 2005-12-14 |
| GEP20084342B (en) | 2008-03-25 |
| NO333501B1 (no) | 2013-06-24 |
| MXPA05012302A (es) | 2006-01-30 |
| KR20060012004A (ko) | 2006-02-06 |
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