ZA200508086B - Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections - Google Patents
Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infectionsInfo
- Publication number
- ZA200508086B ZA200508086B ZA200508086A ZA200508086A ZA200508086B ZA 200508086 B ZA200508086 B ZA 200508086B ZA 200508086 A ZA200508086 A ZA 200508086A ZA 200508086 A ZA200508086 A ZA 200508086A ZA 200508086 B ZA200508086 B ZA 200508086B
- Authority
- ZA
- South Africa
- Prior art keywords
- polysaccharide
- carrier protein
- protein conjugates
- immunization against
- nosocomial infections
- Prior art date
Links
- 102000014914 Carrier Proteins Human genes 0.000 title 1
- 108010078791 Carrier Proteins Proteins 0.000 title 1
- 206010011409 Cross infection Diseases 0.000 title 1
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45272803P | 2003-03-07 | 2003-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200508086B true ZA200508086B (en) | 2010-04-28 |
Family
ID=32990675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200508086A ZA200508086B (en) | 2003-03-07 | 2005-10-06 | Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
Country Status (12)
Country | Link |
---|---|
US (2) | US9296795B2 (zh) |
EP (1) | EP1601381A2 (zh) |
JP (2) | JP5102487B2 (zh) |
KR (1) | KR20060035581A (zh) |
CN (2) | CN102366630B (zh) |
AU (1) | AU2004220590B2 (zh) |
BR (1) | BRPI0408167B1 (zh) |
CA (1) | CA2517439C (zh) |
MX (1) | MXPA05009351A (zh) |
NZ (1) | NZ561879A (zh) |
WO (1) | WO2004080490A2 (zh) |
ZA (1) | ZA200508086B (zh) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003295520B8 (en) | 2002-11-12 | 2011-05-19 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for Staphylococcal infections |
JP5102487B2 (ja) * | 2003-03-07 | 2012-12-19 | ワイス・ホールディングズ・コーポレイション | 院内感染に対する免疫化のための多糖ブドウ球菌表面付着因子キャリアタンパク質接合体 |
PT2336147E (pt) | 2003-12-17 | 2014-07-16 | Janssen Alzheimer Immunotherap | Conjugados transportadores de péptidos beta imunogénicos e seus processos de produção |
WO2005058940A2 (en) * | 2003-12-17 | 2005-06-30 | Wyeth | Immunogenic peptide carrier conjugates and methods of producing same |
US20080085289A1 (en) * | 2004-09-22 | 2008-04-10 | Cindy Castado | Immunogenic Composition |
FR2884830A1 (fr) | 2005-04-25 | 2006-10-27 | Sanofi Pasteur Sa | Procede de production de souches de staphylococcus aureus surproductrices |
GB0526038D0 (en) * | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
AR060188A1 (es) * | 2006-03-30 | 2008-05-28 | Glaxosmithkline Biolog Sa | Procedimiento de conjugacion |
AU2007233705B2 (en) * | 2006-03-30 | 2010-12-23 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
TWI494124B (zh) * | 2006-03-30 | 2015-08-01 | Glaxosmithkline Biolog Sa | 免疫原組合物 |
FR2899110A1 (fr) * | 2006-03-31 | 2007-10-05 | Sanofi Pasteur Sa | Polysaccharides capsulaires de type 5 et de type 8 des souches surproductrices de staphylococcus aureus |
KR100829257B1 (ko) * | 2006-06-22 | 2008-05-14 | 부경대학교 산학협력단 | 인간 섬유육종세포에서 메트릭스 메탈로프로테이나제-9의발현 및 활성을 억제하는 카복시화 글루코사민 화합물 및이를 함유한 메트릭스 메탈로프로테이나제-9 억제제 |
KR100780868B1 (ko) | 2006-07-10 | 2007-11-30 | 부경대학교 산학협력단 | 항암효과를 나타내는 4급 아미노 글루코사민 화합물 |
GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
CA2697538C (en) * | 2007-08-31 | 2019-02-12 | University Of Chicago | Methods and compositions related to immunizing against staphylococcal lung diseases and conditions |
BRPI0910884A2 (pt) * | 2008-04-16 | 2015-10-06 | Glaxonsmithkline Biolog S A | composição imunogênica, método para tratar ou prevenir infecção ou doença estafilocócicas, e, uso de uma composição imunogênica. |
RU2532911C2 (ru) | 2008-07-21 | 2014-11-20 | Дзе Брихэм Энд Уимен'З Хоспитал, Инк. | Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам |
US8568735B2 (en) * | 2009-06-22 | 2013-10-29 | Wyeth Llc | Immunogenic compositions of Staphylococcus aureus antigens |
MY158231A (en) * | 2009-06-22 | 2016-09-15 | Wyeth Llc | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
EA031447B1 (ru) | 2009-07-15 | 2019-01-31 | Аимм Терапьютикс Б.В. | Антитела, которые связываются с sdr белками, и способы их использования |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
CA2779798C (en) | 2009-09-30 | 2019-03-19 | Novartis Ag | Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides |
AU2010310919B2 (en) | 2009-10-30 | 2015-05-07 | Glaxosmithkline Biologicals S.A. | Purification of Staphylococcus aureus type 5 and type 8 capsular saccharides |
US20130259896A1 (en) | 2010-12-22 | 2013-10-03 | Lakshmi Khandke | Stable Immunogenic Compositions of Staphylococcus Aureus Antigens |
CN102759618A (zh) * | 2012-07-18 | 2012-10-31 | 成都欧林生物科技股份有限公司 | 用ELISA法检测血清中Hib多糖抗体含量的方法 |
US9517274B2 (en) | 2012-08-16 | 2016-12-13 | Pfizer Inc. | Glycoconjugation processes and compositions |
PT3363806T (pt) | 2012-12-20 | 2022-12-16 | Pfizer | Processo de glicoconjugação |
GB201310008D0 (en) | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
PT3010535T (pt) | 2013-06-19 | 2020-07-03 | Integrated Biotherapeutics Inc | Péptidos de toxoide derivados de modulina solúvel em fenol, delta toxina, superantigénios e suas fusões |
AU2014359277B2 (en) | 2013-12-04 | 2017-10-26 | Glaxosmithkline Biologicals S.A. | Prevention of Staphylococcus aureus infections by glycoprotein vaccines synthesized in Escherichia coli |
ES2930318T3 (es) | 2014-02-14 | 2022-12-09 | Pfizer | Conjugados glucoproteicos inmunogénicos |
BE1023004A1 (fr) | 2014-12-10 | 2016-10-31 | Glaxosmithkline Biologicals Sa | Procede de traitement |
IL297740A (en) | 2015-05-04 | 2022-12-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing the conjugates, immunogenic preparations containing conjugates and their uses |
WO2017079681A1 (en) | 2015-11-05 | 2017-05-11 | The Texas A&M University System | Targeting of ligand binding sites in clfa |
CN106084037B (zh) * | 2016-06-08 | 2020-01-07 | 中国人民解放军第二军医大学 | 一种炭疽杆菌荚膜表面三糖缀合物及其制备方法和应用 |
CN106366163A (zh) * | 2016-10-31 | 2017-02-01 | 中国人民解放军第二军医大学 | 一种β‑1,2‑D‑寡聚甘露糖肽‑蛋白缀合物及其制备方法和应用 |
SG11201912601RA (en) | 2017-06-23 | 2020-01-30 | Nosocomial Vaccine Corp | Immunogenic compositions |
WO2019023341A1 (en) | 2017-07-27 | 2019-01-31 | Integrated Biotherapeutics, Inc. | IMMUNOGENIC COMPOSITION COMPRISING A MELTING PEPTIDE DERIVED FROM TOXOIDS OF SUPERANTIGENES |
CN110484773B (zh) * | 2019-09-12 | 2020-06-23 | 江苏沃钛有色金属有限公司 | 一种钛合金基材及其制备方法 |
WO2021219047A1 (zh) | 2020-05-01 | 2021-11-04 | 神州细胞工程有限公司 | 一种增强蛋白/肽抗原免疫原性的方法 |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE454403B (sv) | 1984-05-30 | 1988-05-02 | Alfa Laval Agri Int | Anvendning av ett cellyteprotein med fibronektin-, fibrinogen-, kollagen-, och/eller lamininbindande egenskaper vid framstellning av sarbehandlingsmedel |
US5189015A (en) * | 1984-05-30 | 1993-02-23 | Alfa-Laval Agri International Ab | Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability |
IL78775A (en) | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
US5571514A (en) * | 1987-06-01 | 1996-11-05 | Alfa Laval Ab | Fibronectin binding protein as well as its preparation |
US5320951A (en) * | 1987-06-01 | 1994-06-14 | Hoeoek Magnus | Fibronectin binding protein as well as its preparation |
SE8801894D0 (sv) * | 1988-05-20 | 1988-05-20 | Alfa Laval Agri Int | Fibronektinbindande protein |
SE8901687D0 (sv) * | 1989-05-11 | 1989-05-11 | Alfa Laval Agri Int | Fibronectin binding protein as well as its preparation |
US5730978A (en) * | 1989-09-01 | 1998-03-24 | Fred Hutchinson Cancer Research Center | Inhibition of lymphocyte adherence with α4β1-specific antibodies |
US5440014A (en) * | 1990-08-10 | 1995-08-08 | H+E,Uml/Oo/ K; Magnus | Fibronectin binding peptide |
US5851794A (en) * | 1990-10-22 | 1998-12-22 | Alfa Laval Ab | Collagen binding protein as well as its preparation |
US5980908A (en) * | 1991-12-05 | 1999-11-09 | Alfa Laval Ab | Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment |
US20020173462A1 (en) * | 1992-09-21 | 2002-11-21 | Boden Wastfelt Maria K. | Fibrinogen binding protein |
IL107458A0 (en) * | 1992-11-02 | 1994-02-27 | Gen Hospital Corp | Conjugate vaccine against group b streptococcus |
JP3828145B2 (ja) | 1993-09-22 | 2006-10-04 | ヘンリー エム.ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン | 免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法 |
US5648240A (en) * | 1994-05-24 | 1997-07-15 | Texas A&M University | MHC II analog from Staphylococcus aureus |
US6994855B1 (en) * | 1994-08-22 | 2006-02-07 | The Provost Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | S. aureus fibrinogen binding protein gene |
US6008341A (en) * | 1994-08-22 | 1999-12-28 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | S. aureus fibrinogen binding protein gene |
ATE309271T1 (de) * | 1996-05-16 | 2005-11-15 | Texas A & M Univ Sys | Zusammensetzungen von kollagenbindungsprotein und verfahren zur deren verwendungen |
SE9602496D0 (sv) | 1996-06-20 | 1996-06-20 | Bengt Guss | Method and means for producing a fibrinogen binding protein and its use in biotechnology |
EP1000076A1 (en) | 1997-07-17 | 2000-05-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | HEXADECASACCHARIDE-PROTEIN CONJUGATE VACCINE FOR $i(SHIGELLA DYSENTERIAE) TYPE 1 |
US7252828B2 (en) * | 1998-07-15 | 2007-08-07 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
US6703025B1 (en) * | 1998-08-31 | 2004-03-09 | Inhibitex, Inc. | Multicomponent vaccines |
EP2311944A1 (en) * | 1998-08-31 | 2011-04-20 | The Provost, Fellows and Scholars of the College Of the Holy and Undivided Trinity of Queen Elizabeth near Dublin | Polypeptides and polynucleotides from coagulase-negative staphylococci |
CA2340304C (en) | 1998-08-31 | 2012-12-04 | Inhibitex, Inc. | Multicomponent vaccines |
AU5408099A (en) | 1998-09-01 | 2000-03-21 | John F. Wetling | Electrically treated composition and use thereof |
EP1034792A1 (en) | 1999-03-11 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Intranasal delivery of pneumococcal polysaccharide vaccines |
EP1035137A1 (en) * | 1999-03-12 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Method for the reductive amination of polysaccharides |
CA2365296A1 (en) * | 1999-03-19 | 2000-09-28 | Pierre Michel Desmons | Vaccine |
AU5867100A (en) * | 1999-05-03 | 2000-12-12 | Medarex, Inc. | Human antibodies to staphylococcus aureus |
DE19937864C2 (de) * | 1999-08-13 | 2002-10-31 | Rudolf Marx | Werkstück und Verfahren zum Herstellen und zum Verwerten des Werkstückes |
CA2723664A1 (en) * | 2000-03-22 | 2001-09-27 | Solulink, Incorporated | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
GB0007432D0 (en) * | 2000-03-27 | 2000-05-17 | Microbiological Res Authority | Proteins for use as carriers in conjugate vaccines |
EP2332581B1 (en) * | 2001-01-23 | 2015-07-01 | Sanofi Pasteur Inc. | Tri- or tetravalent meningococcal polysaccharide-CRM197 conjugate vaccine |
WO2002102829A2 (en) * | 2001-06-15 | 2002-12-27 | Inhibitex, Inc. | Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus |
CA2351018A1 (en) | 2001-07-09 | 2003-01-09 | Universite De Sherbrooke | Dna vaccine against staphylococcus aureus |
US20030113350A1 (en) * | 2001-09-19 | 2003-06-19 | Fattom Ali I. | Glycoconjugate vaccines for use in immune-compromised populations |
EP1481011A4 (en) | 2002-03-05 | 2007-05-30 | Inhibitex Inc | MONOCLONAL AND POLYCLONAL ANTIBODIES THAT DETECT COAGULASENEGATIVE STAPHYLOKOCKE PROTEINS |
JP5102487B2 (ja) * | 2003-03-07 | 2012-12-19 | ワイス・ホールディングズ・コーポレイション | 院内感染に対する免疫化のための多糖ブドウ球菌表面付着因子キャリアタンパク質接合体 |
US7892563B2 (en) | 2003-05-20 | 2011-02-22 | Wyeth Holdings Corporation | Methods for treatment of severe acute respiratory syndrome (SARS) |
-
2004
- 2004-03-04 JP JP2006509140A patent/JP5102487B2/ja not_active Expired - Fee Related
- 2004-03-04 CN CN201110225310.XA patent/CN102366630B/zh not_active Expired - Fee Related
- 2004-03-04 EP EP04717417A patent/EP1601381A2/en not_active Withdrawn
- 2004-03-04 BR BRPI0408167-6B1A patent/BRPI0408167B1/pt not_active IP Right Cessation
- 2004-03-04 MX MXPA05009351A patent/MXPA05009351A/es active IP Right Grant
- 2004-03-04 CA CA2517439A patent/CA2517439C/en not_active Expired - Fee Related
- 2004-03-04 KR KR1020057016646A patent/KR20060035581A/ko not_active Application Discontinuation
- 2004-03-04 NZ NZ561879A patent/NZ561879A/en not_active IP Right Cessation
- 2004-03-04 CN CN2004800122658A patent/CN1787839B/zh not_active Expired - Fee Related
- 2004-03-04 US US10/548,507 patent/US9296795B2/en active Active
- 2004-03-04 AU AU2004220590A patent/AU2004220590B2/en not_active Ceased
- 2004-03-04 WO PCT/US2004/006661 patent/WO2004080490A2/en active Application Filing
-
2005
- 2005-10-06 ZA ZA200508086A patent/ZA200508086B/xx unknown
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2006
- 2006-11-07 US US11/593,481 patent/US8377451B2/en active Active
-
2011
- 2011-10-18 JP JP2011228995A patent/JP5757841B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2006519870A (ja) | 2006-08-31 |
AU2004220590A1 (en) | 2004-09-23 |
US8377451B2 (en) | 2013-02-19 |
US20070141077A1 (en) | 2007-06-21 |
CN1787839A (zh) | 2006-06-14 |
CA2517439C (en) | 2013-07-23 |
JP5102487B2 (ja) | 2012-12-19 |
BRPI0408167A (pt) | 2006-03-21 |
CN102366630B (zh) | 2015-04-01 |
BRPI0408167B1 (pt) | 2014-10-21 |
WO2004080490A2 (en) | 2004-09-23 |
KR20060035581A (ko) | 2006-04-26 |
EP1601381A2 (en) | 2005-12-07 |
CA2517439A1 (en) | 2004-09-23 |
US9296795B2 (en) | 2016-03-29 |
US20070087014A1 (en) | 2007-04-19 |
AU2004220590B2 (en) | 2010-02-18 |
WO2004080490A3 (en) | 2004-10-28 |
NZ561879A (en) | 2009-05-31 |
CN102366630A (zh) | 2012-03-07 |
JP5757841B2 (ja) | 2015-08-05 |
JP2012051922A (ja) | 2012-03-15 |
MXPA05009351A (es) | 2006-03-08 |
CN1787839B (zh) | 2011-09-28 |
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