ZA200507239B - Benzofurane derivatives and use of the same as antidepressants and anxiolytics - Google Patents

Benzofurane derivatives and use of the same as antidepressants and anxiolytics Download PDF

Info

Publication number
ZA200507239B
ZA200507239B ZA200507239A ZA200507239A ZA200507239B ZA 200507239 B ZA200507239 B ZA 200507239B ZA 200507239 A ZA200507239 A ZA 200507239A ZA 200507239 A ZA200507239 A ZA 200507239A ZA 200507239 B ZA200507239 B ZA 200507239B
Authority
ZA
South Africa
Prior art keywords
formula
solvates
denotes
stereoisomers
compounds
Prior art date
Application number
ZA200507239A
Other languages
English (en)
Inventor
Guenther Hoelzemann
Kai Schiemann
Joachim Leibrock
Gerd Bartoszyk
Henning Boetccher
Timo Heinrich
Christoph Van Amsterdam
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200507239B publication Critical patent/ZA200507239B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Anesthesiology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • External Artificial Organs (AREA)
ZA200507239A 2003-02-11 2005-09-08 Benzofurane derivatives and use of the same as antidepressants and anxiolytics ZA200507239B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10305739A DE10305739A1 (de) 2003-02-11 2003-02-11 Benzofuranderivate

Publications (1)

Publication Number Publication Date
ZA200507239B true ZA200507239B (en) 2006-06-28

Family

ID=32730991

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200507239A ZA200507239B (en) 2003-02-11 2005-09-08 Benzofurane derivatives and use of the same as antidepressants and anxiolytics

Country Status (16)

Country Link
US (1) US7262216B2 (es)
EP (1) EP1592687B1 (es)
JP (1) JP4664275B2 (es)
KR (1) KR20050098889A (es)
CN (1) CN1742006A (es)
AT (1) ATE397604T1 (es)
AU (1) AU2004212026B2 (es)
BR (1) BRPI0407360A (es)
CA (1) CA2515541A1 (es)
DE (2) DE10305739A1 (es)
ES (1) ES2304599T3 (es)
MX (1) MXPA05008437A (es)
PL (1) PL377319A1 (es)
RU (1) RU2005128187A (es)
WO (1) WO2004072067A1 (es)
ZA (1) ZA200507239B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008169191A (ja) * 2006-02-20 2008-07-24 Eisai R & D Management Co Ltd 運動ニューロン疾患治療剤
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US10316025B2 (en) 2015-06-03 2019-06-11 Sunshine Lake Pharma Co., Ltd. Substituted piperazine compounds and methods of use and use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US625198A (en) * 1899-05-16 Of same place
DE4333254A1 (de) 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
DE19514567A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Benzofurane
DE19725664A1 (de) * 1997-06-18 1998-12-24 Merck Patent Gmbh 3-Benzylpiperidine
DE19730989A1 (de) * 1997-07-18 1999-01-21 Merck Patent Gmbh Piperazin-Derivate
WO1999051575A1 (en) * 1998-04-08 1999-10-14 American Home Products Corporation N-aryloxyethyl-indoly-alkylamines for the treatment of depression (5-ht1a receptor active agents)
ATE223379T1 (de) * 1998-04-08 2002-09-15 Wyeth Corp N-aryloxyethylaminderivate zur behandlung der depression
TW518218B (en) * 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
AU1502702A (en) * 2000-11-14 2002-05-27 Merck Patent Gmbh Novel uses of combined 5-HT<sub>1A</sub> agonists and serotonin reuptake inhibitors
DE10112151A1 (de) * 2001-03-14 2002-09-19 Merck Patent Gmbh Substituierte Benzofuran-2-carbonsäureamide

Also Published As

Publication number Publication date
DE502004007318D1 (de) 2008-07-17
ES2304599T3 (es) 2008-10-16
MXPA05008437A (es) 2005-10-19
KR20050098889A (ko) 2005-10-12
ATE397604T1 (de) 2008-06-15
BRPI0407360A (pt) 2006-01-10
JP2006517209A (ja) 2006-07-20
CN1742006A (zh) 2006-03-01
CA2515541A1 (en) 2004-08-26
US20060142372A1 (en) 2006-06-29
JP4664275B2 (ja) 2011-04-06
WO2004072067A1 (de) 2004-08-26
DE10305739A1 (de) 2004-08-19
EP1592687A1 (de) 2005-11-09
AU2004212026B2 (en) 2010-07-29
PL377319A1 (pl) 2006-01-23
EP1592687B1 (de) 2008-06-04
AU2004212026A1 (en) 2004-08-26
RU2005128187A (ru) 2006-05-10
US7262216B2 (en) 2007-08-28

Similar Documents

Publication Publication Date Title
ZA200507436B (en) Benzofuran oxyethylamines serving as antidepressant drugs and anxiolytic drugs
JP4740115B2 (ja) 置換ピラゾール
KR20070085916A (ko) 부분 도파민 d2 수용체 효능 및 세로토닌 재흡수 억제가조합된 페닐피페라진 유도체
SK280261B6 (sk) Chrománový derivát, spôsoby jeho výroby a farmaceu
KR20160008191A (ko) 신규한 (시아노-디메틸-메틸)-이속사졸 및 -[1,3,4]티아디아졸
ZA200507239B (en) Benzofurane derivatives and use of the same as antidepressants and anxiolytics
AU2003302361B2 (en) Derivatives of pyridinalkyl-amonoalkyl-1H-indole inhibiting receptors 5-HT and recapture of serotonin which can be used as antidepressant and anxiolitic
IL294674A (en) Pirzol derivative
DE10353657A1 (de) Indolderivate
WO2009128479A1 (ja) イミダゾリン誘導体
KR100832750B1 (ko) N-페닐아마이드 유도체를 함유하는 허혈성 질환의 예방또는 치료용 조성물