ZA200505830B - Use of the cathelicidin LL-37 and derivatives thereof for wound healing - Google Patents
Use of the cathelicidin LL-37 and derivatives thereof for wound healing Download PDFInfo
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- ZA200505830B ZA200505830B ZA200505830A ZA200505830A ZA200505830B ZA 200505830 B ZA200505830 B ZA 200505830B ZA 200505830 A ZA200505830 A ZA 200505830A ZA 200505830 A ZA200505830 A ZA 200505830A ZA 200505830 B ZA200505830 B ZA 200505830B
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
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- Biotechnology (AREA)
- Wood Science & Technology (AREA)
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- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (1)
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| SE0300207A SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | New use and composition |
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| ZA200505830B true ZA200505830B (en) | 2006-04-26 |
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| ZA200505830A ZA200505830B (en) | 2003-01-29 | 2005-07-20 | Use of the cathelicidin LL-37 and derivatives thereof for wound healing |
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| ZA (1) | ZA200505830B (enExample) |
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| US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
| SE0300207D0 (sv) * | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| US7777000B2 (en) * | 2003-03-06 | 2010-08-17 | The Regents Of The University Of California | Anti-viral activity of cathelicidin peptides |
| EP2481287B1 (en) * | 2003-08-01 | 2016-07-20 | Stratatech Corporation | Human skin equivalents expressing exogenous polypeptides |
| ATE529125T1 (de) | 2003-08-07 | 2011-11-15 | Healor Ltd | Pharmazeutische zusammensetzungen und verfahren zur beschleunigung der wundheilung |
| US7776823B2 (en) * | 2003-10-21 | 2010-08-17 | The Regents Of The University Of California | Human cathelicidin antimicrobial peptides |
| SE0401942D0 (sv) * | 2004-07-28 | 2004-07-28 | Lipopeptide Ab | New antimicrobial peptide complexes |
| US7741275B2 (en) | 2004-12-22 | 2010-06-22 | Lipopeptide Ab | Agents and use thereof |
| JP5846711B2 (ja) * | 2005-06-09 | 2016-01-20 | メダ アーベー | 炎症性疾患の治療のための方法及び組成物 |
| US9044438B2 (en) | 2005-06-17 | 2015-06-02 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| US8202835B2 (en) | 2005-06-17 | 2012-06-19 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| EP2452691A3 (en) | 2005-08-29 | 2012-09-05 | HealOr Ltd. | Methods and compositions for prevention of diabetic and aged skin |
| WO2007148078A1 (en) * | 2006-06-20 | 2007-12-27 | Lipopeptide Ab | Use cathelicidin antimicrobial protein (hcap18 ) as anticancer agent |
| US20100273748A1 (en) * | 2006-09-08 | 2010-10-28 | The Regents Of The University Of California | Antimicrobial therapy |
| EP2069377A4 (en) * | 2006-09-27 | 2009-11-11 | Univ California | METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS |
| WO2008103751A2 (en) * | 2007-02-20 | 2008-08-28 | The Regents Of The University Of California | Antimicrobial and anti-inflammatory therapies and compositions |
| US20100178320A1 (en) * | 2007-06-25 | 2010-07-15 | Lipopeptide Ab | New medical products |
| CA2696833A1 (en) * | 2007-07-15 | 2009-01-22 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| KR20130121678A (ko) * | 2007-07-30 | 2013-11-06 | 힐로 리미티드 | 약제학적 조성물 및 관련 방법 |
| US20100310514A1 (en) * | 2009-06-04 | 2010-12-09 | Chi Hin Cho | Anti-Inflammatory Bacteria |
| WO2011046983A2 (en) | 2009-10-12 | 2011-04-21 | Smith Holdings, Llc | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
| AU2010316006B2 (en) * | 2009-11-03 | 2013-09-26 | Lipidor Ab | Composition for promoting wound healing |
| US10279007B2 (en) | 2010-11-15 | 2019-05-07 | Oxygenetix Institute, Inc. | Topical treatment method for healing wounds, disinfecting, covering and concealing the wound until healing occurs |
| WO2012150890A1 (en) * | 2011-05-02 | 2012-11-08 | Lipidor Ab | Antibacterial composition |
| AU2013235692B2 (en) * | 2012-03-20 | 2016-12-08 | Helix Biomedix Inc | Short antimicrobial lipopeptides |
| US8969290B2 (en) | 2012-06-26 | 2015-03-03 | Worcester Polytechnic Institute | Matrix scaffold with antimicrobial activity |
| EP2821077A1 (en) * | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
| WO2015075406A1 (en) | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
| CN103920137B (zh) * | 2014-04-28 | 2016-03-30 | 中国药科大学 | 一种具有抗耐药性革兰阳性细菌作用的药物组合物 |
| WO2015183683A2 (en) * | 2014-05-27 | 2015-12-03 | Indiana University Research And Technology Corporation | Peptide antagonist of ll-37 |
| CN104984321A (zh) * | 2015-07-24 | 2015-10-21 | 中国药科大学 | 人源抗菌肽ll-37在制备治疗或预防血栓性疾病药物中的应用 |
| CN105859867A (zh) * | 2016-05-30 | 2016-08-17 | 黄石市中心医院 | 一种人源抗菌肽ll-37突变体及其应用 |
| CN106519042A (zh) * | 2016-12-29 | 2017-03-22 | 陕西慧康生物科技有限责任公司 | 人源胶原蛋白与抗菌肽的融合蛋白及其制备方法与编码基因 |
| US20190300575A1 (en) | 2018-03-29 | 2019-10-03 | Deetex, LLC | Lytic peptide biosensor and methods of making and using the same |
| CN108659102B (zh) * | 2018-04-25 | 2021-08-17 | 南方医科大学 | 具有抗菌及抗炎活性的多肽化合物 |
| ES2799098B2 (es) | 2019-06-10 | 2021-12-10 | Univ Madrid Carlos Iii | Aptameros agonistas del receptor fpr2 y usos de los mismos |
| KR102475936B1 (ko) * | 2020-10-15 | 2022-12-09 | 코스맥스 주식회사 | 펩타이드 ll-37을 발현하는 효모를 포함하는 화장료 조성물 |
| PL443243A1 (pl) * | 2022-12-22 | 2024-06-24 | Uniwersytet Warszawski | Nowe peptydy antydrobnoustrojowe |
| CN118895244B (zh) * | 2024-07-23 | 2025-06-20 | 浙江自贸区中航生物科技有限责任公司 | 一种提高nk细胞杀伤活性的多肽及其应用 |
| CN120789277A (zh) * | 2025-09-18 | 2025-10-17 | 山东大学 | 一种基于(1,3)-β-D-葡聚糖合成酶抑制剂的抗真菌药物组合物 |
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| US5861478A (en) | 1987-07-06 | 1999-01-19 | Helix Biomedix, Inc. | Lytic peptides |
| CA2182576C (en) | 1994-02-04 | 2002-09-17 | Anders Carlsson | Bilayer preparations |
| JP3203359B2 (ja) | 1994-02-04 | 2001-08-27 | リポコーア・ホールディング・アクチエボラーグ | 親油性担体製剤 |
| EE03220B1 (et) | 1994-02-04 | 1999-10-15 | Scotia Lipidteknik Ab | Õli-vees-emulsioon, selle kasutamine ja seda sisaldav farmatseutiline kompositsioon |
| SE9403055L (sv) | 1994-09-13 | 1996-03-14 | Hans G Boman | Nytt humant peptidantibiotikum (fall-39) och dess användning |
| US5654273A (en) * | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
| JP4048565B2 (ja) * | 1996-04-23 | 2008-02-20 | 東レ株式会社 | 「抗ピロリ菌剤」 |
| SE515982C2 (sv) * | 1998-03-06 | 2001-11-05 | Lipocore Holding Ab | Användning av en olja-i-vatten emulsion som bärare för framställning av en topikal kräm eller lotion |
| US5925534A (en) * | 1998-06-08 | 1999-07-20 | Wako Pure Chemical Industries, Ltd. | Method for measuring LDL-cholesterol |
| AU4013200A (en) | 1999-03-26 | 2000-10-16 | Beth Israel Deaconess Medical Center | Method for pr-39 peptide regulated stimulation of angiogenesis |
| EP1301797A2 (en) | 2000-07-17 | 2003-04-16 | Hansa Medical AB | Antimicrobial agent |
| CA2416877C (en) | 2000-07-27 | 2013-03-12 | Apogene Gmbh & Co. Kg | Somatic cloning gene transfer for producing recombinant proteins, cells and organs |
| US20020072495A1 (en) * | 2000-09-21 | 2002-06-13 | Oleg Chertov | LL-37 is an immunostimulant |
| AU2002240137A1 (en) * | 2001-01-30 | 2002-08-12 | University Of Iowa Research Foundation | Antiviral activities of primate theta defensins and mammalian cathelicidins |
| US6835713B2 (en) * | 2001-02-16 | 2004-12-28 | University Of Pittsburgh | Virus derived antimicrobial peptides |
| WO2002095076A2 (en) * | 2001-05-23 | 2002-11-28 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Modified polypeptides having protease-resistance and/or protease-sensitivity |
| EP1358888A1 (en) * | 2002-02-28 | 2003-11-05 | Robert Bals | The human peptide antibiotic LL-37/hCAP-18 is an inducer of angiogenesis |
| GB0223655D0 (en) * | 2002-10-10 | 2002-11-20 | Mabtech Ab | Method of diagnosis |
| NZ540506A (en) | 2002-12-19 | 2008-09-26 | Yitzchak Hillman | Disease treatment via antimicrobial peptide inhibitors |
| SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
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Also Published As
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|---|---|
| CN101838326A (zh) | 2010-09-22 |
| DK1589987T3 (da) | 2014-05-26 |
| EP1589987B1 (en) | 2014-04-23 |
| CA2513598C (en) | 2015-04-21 |
| CN1744913B (zh) | 2010-05-26 |
| CY1115142T1 (el) | 2016-12-14 |
| ES2467090T3 (es) | 2014-06-11 |
| US20150094256A1 (en) | 2015-04-02 |
| US7452864B2 (en) | 2008-11-18 |
| CN105079784B (zh) | 2018-05-18 |
| US9125875B2 (en) | 2015-09-08 |
| PT1589987E (pt) | 2014-05-28 |
| CN105079784A (zh) | 2015-11-25 |
| CN1744913A (zh) | 2006-03-08 |
| WO2004067025A1 (en) | 2004-08-12 |
| SE0300207D0 (sv) | 2003-01-29 |
| JP2006518375A (ja) | 2006-08-10 |
| US20070149448A1 (en) | 2007-06-28 |
| JP4750690B2 (ja) | 2011-08-17 |
| CA2513598A1 (en) | 2004-08-12 |
| SI1589987T1 (sl) | 2014-07-31 |
| US20130287839A1 (en) | 2013-10-31 |
| US20110293707A1 (en) | 2011-12-01 |
| US20090088382A1 (en) | 2009-04-02 |
| US8012933B2 (en) | 2011-09-06 |
| HK1217661A1 (zh) | 2017-01-20 |
| US8936807B2 (en) | 2015-01-20 |
| EP1589987A1 (en) | 2005-11-02 |
| US8506994B2 (en) | 2013-08-13 |
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