CN105079784B - Cathelicidin ll-37及其衍生物在伤口愈合中的用途 - Google Patents
Cathelicidin ll-37及其衍生物在伤口愈合中的用途 Download PDFInfo
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/0018—Culture media for cell or tissue culture
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| US44496403P | 2003-02-05 | 2003-02-05 | |
| US60/444,964 | 2003-02-05 | ||
| CN2004800032098A CN1744913B (zh) | 2003-01-29 | 2004-01-28 | Cathelicidin ll-37及其衍生物在伤口愈合中的用途 |
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| CN2004800032098A Expired - Fee Related CN1744913B (zh) | 2003-01-29 | 2004-01-28 | Cathelicidin ll-37及其衍生物在伤口愈合中的用途 |
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| CN201010150582A Pending CN101838326A (zh) | 2003-01-29 | 2004-01-28 | Cathelicidin ll-37及其衍生物在伤口愈合中的用途 |
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| US20060258562A1 (en) * | 2000-07-31 | 2006-11-16 | Healor Ltd. | Methods and pharmaceutical compositions for healing wounds |
| SE0300207D0 (sv) * | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
| WO2004098536A2 (en) * | 2003-03-06 | 2004-11-18 | The Regents Of The University Of California | Anti-viral activity of cathelicidin peptides |
| PT3100611T (pt) * | 2003-08-01 | 2018-12-14 | Stratatech Corp | Equivalentes de pele humana que expressam polipéptidos exógenos |
| CA2535029C (en) | 2003-08-07 | 2013-07-16 | Healor Ltd. | Pharmaceutical compositions and methods for accelerating wound healing |
| US7776823B2 (en) * | 2003-10-21 | 2010-08-17 | The Regents Of The University Of California | Human cathelicidin antimicrobial peptides |
| SE0401942D0 (sv) * | 2004-07-28 | 2004-07-28 | Lipopeptide Ab | New antimicrobial peptide complexes |
| WO2006067402A2 (en) * | 2004-12-22 | 2006-06-29 | Lipopeptide Ab | Agents inibiting the cathelin-like protein cap18/ll-37 |
| US20090220583A1 (en) * | 2005-06-09 | 2009-09-03 | Lena Pereswetoff-Morath | Method and composition for treating inflammatory disorders |
| US8202835B2 (en) | 2005-06-17 | 2012-06-19 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| US9044438B2 (en) * | 2005-06-17 | 2015-06-02 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| US8367606B2 (en) | 2005-08-29 | 2013-02-05 | Healor Ltd. | Method and compositions for prevention and treatment of diabetic and aged skin |
| WO2007148078A1 (en) * | 2006-06-20 | 2007-12-27 | Lipopeptide Ab | Use cathelicidin antimicrobial protein (hcap18 ) as anticancer agent |
| WO2008073174A2 (en) * | 2006-09-08 | 2008-06-19 | The Regents Of The University Of California | Antimicrobial therapy |
| EP2069377A4 (en) * | 2006-09-27 | 2009-11-11 | Univ California | METHOD AND COMPOSITIONS FOR THE TREATMENT OF SKIN DISEASES AND SKIN FUNCTIONAL DISORDERS |
| WO2008103751A2 (en) * | 2007-02-20 | 2008-08-28 | The Regents Of The University Of California | Antimicrobial and anti-inflammatory therapies and compositions |
| KR20100049039A (ko) * | 2007-06-25 | 2010-05-11 | 리포펩타이드 아베 | 신규한 의약제 |
| EP2200628A2 (en) * | 2007-07-15 | 2010-06-30 | Yitzchak Hillman | Disease treatment via antimicrobial peptides or their inhibitors |
| NZ582556A (en) * | 2007-07-30 | 2013-02-22 | Healor Ltd | Pharmaceutical composition for treating wounds and related methods |
| US20100310514A1 (en) * | 2009-06-04 | 2010-12-09 | Chi Hin Cho | Anti-Inflammatory Bacteria |
| DK3252068T3 (da) | 2009-10-12 | 2025-08-25 | Larry J Smith | Metoder og sammensætninger til modulering af genekspression ved anvendelse af oligonukleotidbaserede lægemidler administreret in vivo eller in vitro |
| CA2779433A1 (en) * | 2009-11-03 | 2011-05-12 | Lipidor Ab | Composition for promoting wound healing |
| US10279007B2 (en) | 2010-11-15 | 2019-05-07 | Oxygenetix Institute, Inc. | Topical treatment method for healing wounds, disinfecting, covering and concealing the wound until healing occurs |
| WO2012150890A1 (en) * | 2011-05-02 | 2012-11-08 | Lipidor Ab | Antibacterial composition |
| WO2013142088A1 (en) * | 2012-03-20 | 2013-09-26 | Helix Biomedix Inc | Short antimicrobial lipopeptides |
| WO2014004719A2 (en) | 2012-06-26 | 2014-01-03 | Worcester Polytechnic Institute | Matrix scaffold with antimicrobial activity |
| EP2821077A1 (en) * | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
| CN104513293A (zh) * | 2013-09-26 | 2015-04-15 | 深圳信立泰药业股份有限公司 | 一种多肽疫苗的盐及其制备方法和含有该盐的药物制品 |
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| US10138282B2 (en) * | 2014-05-27 | 2018-11-27 | Indiana University Research And Technology Corporation | Peptide antagonist of LL-37 |
| CN104984321A (zh) * | 2015-07-24 | 2015-10-21 | 中国药科大学 | 人源抗菌肽ll-37在制备治疗或预防血栓性疾病药物中的应用 |
| CN105859867A (zh) * | 2016-05-30 | 2016-08-17 | 黄石市中心医院 | 一种人源抗菌肽ll-37突变体及其应用 |
| CN106519042A (zh) * | 2016-12-29 | 2017-03-22 | 陕西慧康生物科技有限责任公司 | 人源胶原蛋白与抗菌肽的融合蛋白及其制备方法与编码基因 |
| US20190300575A1 (en) | 2018-03-29 | 2019-10-03 | Deetex, LLC | Lytic peptide biosensor and methods of making and using the same |
| CN108659102B (zh) * | 2018-04-25 | 2021-08-17 | 南方医科大学 | 具有抗菌及抗炎活性的多肽化合物 |
| ES2799098B2 (es) | 2019-06-10 | 2021-12-10 | Univ Madrid Carlos Iii | Aptameros agonistas del receptor fpr2 y usos de los mismos |
| KR102475936B1 (ko) * | 2020-10-15 | 2022-12-09 | 코스맥스 주식회사 | 펩타이드 ll-37을 발현하는 효모를 포함하는 화장료 조성물 |
| PL443243A1 (pl) * | 2022-12-22 | 2024-06-24 | Uniwersytet Warszawski | Nowe peptydy antydrobnoustrojowe |
| CN118895244B (zh) * | 2024-07-23 | 2025-06-20 | 浙江自贸区中航生物科技有限责任公司 | 一种提高nk细胞杀伤活性的多肽及其应用 |
| CN120789277A (zh) * | 2025-09-18 | 2025-10-17 | 山东大学 | 一种基于(1,3)-β-D-葡聚糖合成酶抑制剂的抗真菌药物组合物 |
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| BR9506681A (pt) | 1994-02-04 | 1997-11-18 | Scotia Lipidteknik Ab | Emulsão oleo em água e composição farmacêutica |
| HU221432B (en) | 1994-02-04 | 2002-10-28 | Lipocore Holding Ab | Lipophilic carrier preparations |
| SE9403055L (sv) | 1994-09-13 | 1996-03-14 | Hans G Boman | Nytt humant peptidantibiotikum (fall-39) och dess användning |
| US5654273A (en) * | 1994-09-22 | 1997-08-05 | Children's Medical Center Corporation | Synducin mediated modulation of tissue repair |
| EP0935965A4 (en) * | 1996-04-23 | 2002-01-23 | Toray Industries | SUBSTANCE AGAINST PYLORI |
| SE515982C2 (sv) * | 1998-03-06 | 2001-11-05 | Lipocore Holding Ab | Användning av en olja-i-vatten emulsion som bärare för framställning av en topikal kräm eller lotion |
| US5925534A (en) * | 1998-06-08 | 1999-07-20 | Wako Pure Chemical Industries, Ltd. | Method for measuring LDL-cholesterol |
| AU4013200A (en) * | 1999-03-26 | 2000-10-16 | Beth Israel Deaconess Medical Center | Method for pr-39 peptide regulated stimulation of angiogenesis |
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| JP2004518405A (ja) | 2000-07-27 | 2004-06-24 | アポゲーネ・ゲーエムベーハー・ウント・コー・カーゲー | 組換えタンパク質、細胞、および生物を産生するための体細胞クローニング遺伝子移入 |
| US20020072495A1 (en) * | 2000-09-21 | 2002-06-13 | Oleg Chertov | LL-37 is an immunostimulant |
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| EP1358888A1 (en) * | 2002-02-28 | 2003-11-05 | Robert Bals | The human peptide antibiotic LL-37/hCAP-18 is an inducer of angiogenesis |
| GB0223655D0 (en) * | 2002-10-10 | 2002-11-20 | Mabtech Ab | Method of diagnosis |
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| SE0300207D0 (sv) | 2003-01-29 | 2003-01-29 | Karolinska Innovations Ab | New use and composition |
-
2003
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2004
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- 2004-01-28 JP JP2006502781A patent/JP4750690B2/ja not_active Expired - Fee Related
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| CN1744913A (zh) | 2006-03-08 |
| US20090088382A1 (en) | 2009-04-02 |
| US8506994B2 (en) | 2013-08-13 |
| US20110293707A1 (en) | 2011-12-01 |
| CA2513598C (en) | 2015-04-21 |
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| WO2004067025A1 (en) | 2004-08-12 |
| US9125875B2 (en) | 2015-09-08 |
| PT1589987E (pt) | 2014-05-28 |
| SI1589987T1 (sl) | 2014-07-31 |
| CY1115142T1 (el) | 2016-12-14 |
| US20130287839A1 (en) | 2013-10-31 |
| ES2467090T3 (es) | 2014-06-11 |
| US20150094256A1 (en) | 2015-04-02 |
| CN105079784A (zh) | 2015-11-25 |
| US20070149448A1 (en) | 2007-06-28 |
| US8012933B2 (en) | 2011-09-06 |
| CN101838326A (zh) | 2010-09-22 |
| DK1589987T3 (da) | 2014-05-26 |
| US7452864B2 (en) | 2008-11-18 |
| ZA200505830B (en) | 2006-04-26 |
| JP2006518375A (ja) | 2006-08-10 |
| EP1589987A1 (en) | 2005-11-02 |
| HK1217661A1 (zh) | 2017-01-20 |
| SE0300207D0 (sv) | 2003-01-29 |
| EP1589987B1 (en) | 2014-04-23 |
| CN1744913B (zh) | 2010-05-26 |
| CA2513598A1 (en) | 2004-08-12 |
| JP4750690B2 (ja) | 2011-08-17 |
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