ZA200504624B - Shape-retentive hydrogel particle aggregates and their uses - Google Patents

Shape-retentive hydrogel particle aggregates and their uses

Info

Publication number
ZA200504624B
ZA200504624B ZA200504624A ZA200504624A ZA200504624B ZA 200504624 B ZA200504624 B ZA 200504624B ZA 200504624 A ZA200504624 A ZA 200504624A ZA 200504624 A ZA200504624 A ZA 200504624A ZA 200504624 B ZA200504624 B ZA 200504624B
Authority
ZA
South Africa
Prior art keywords
shape
particle aggregates
hydrogel particle
retentive
retentive hydrogel
Prior art date
Application number
ZA200504624A
Other languages
English (en)
Inventor
John John V St
Bill C Ponder
Daniel G Moro
Original Assignee
Access Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Access Pharma Inc filed Critical Access Pharma Inc
Publication of ZA200504624B publication Critical patent/ZA200504624B/xx

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5138Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/20Esters of polyhydric alcohols or phenols, e.g. 2-hydroxyethyl (meth)acrylate or glycerol mono-(meth)acrylate
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04Homopolymers or copolymers of esters
    • C08L33/14Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/25Peptides having up to 20 amino acids in a defined sequence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/44Radioisotopes, radionuclides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04Acids; Metal salts or ammonium salts thereof
    • C08F220/06Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10Esters
    • C08F220/34Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10Esters
    • C08F222/1006Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00Crosslinking
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T442/00Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
    • Y10T442/20Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
    • Y10T442/2525Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
ZA200504624A 2002-11-06 2005-06-06 Shape-retentive hydrogel particle aggregates and their uses ZA200504624B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/289,756 US7351430B2 (en) 2002-11-06 2002-11-06 Shape-retentive hydrogel particle aggregates and their uses

Publications (1)

Publication Number Publication Date
ZA200504624B true ZA200504624B (en) 2007-02-28

Family

ID=32176104

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200504624A ZA200504624B (en) 2002-11-06 2005-06-06 Shape-retentive hydrogel particle aggregates and their uses

Country Status (8)

Country Link
US (2) US7351430B2 (de)
EP (2) EP1567132A4 (de)
JP (1) JP2006514705A (de)
AU (1) AU2003295428C1 (de)
CA (1) CA2512033A1 (de)
NZ (1) NZ540571A (de)
WO (1) WO2004043438A1 (de)
ZA (1) ZA200504624B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100349935C (zh) * 2002-02-15 2007-11-21 Zms有限责任公司 用于生物医学应用的聚合方法和材料
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7811605B2 (en) * 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
WO2005089106A2 (en) * 2004-02-27 2005-09-29 Molecular Therapeutics, Inc. Degradable nanoparticles
US8663225B2 (en) 2004-11-12 2014-03-04 Medtronic, Inc. Hydrogel bone void filler
US20060193894A1 (en) * 2005-02-28 2006-08-31 Jen James S Methods for providing biomedical devices with hydrophilic antimicrobial coatings
SI1948259T1 (sl) * 2005-10-26 2017-07-31 Genesis Technologies Limited Acelularni bioabsorbljivi tkivni regeneracijski matriksi, proizvedeni z inkubiranjem acelularnih proizvodov krvi
EP1890147B1 (de) * 2005-11-01 2010-01-27 JSR Corporation Organische Polymerpartikel und Herstellungsverfahren dafür, magnetische Partikel zur Diagnose, Partikel mit einer Carboxylgruppe und Herstellungsverfahren dafür sowie sondengebundene Partikel und Herstellungsverfahren dafür
US7910135B2 (en) * 2006-10-13 2011-03-22 Uluru Inc. Hydrogel wound dressing and biomaterials formed in situ and their uses
US20080228268A1 (en) * 2007-03-15 2008-09-18 Uluru, Inc. Method of Formation of Viscous, Shape Conforming Gels and Their Uses as Medical Prosthesis
JP2011500898A (ja) * 2007-10-10 2011-01-06 ベンズ リサーチ アンド ディベロップメント コーポレーション 高い含水率および安定性を有するヒドロゲル
US20110009520A1 (en) * 2008-03-20 2011-01-13 Figuly Garret D Dimensionally stable, shaped articles comprised of dried, aggregated, water-swellable hydrogel microspheres and method of making same
CA2728891A1 (en) 2008-06-30 2010-01-07 Thomas E. Powell Fillable prosthetic implant with gel-like properties
ES2335958B2 (es) * 2008-08-06 2010-11-02 Universidad De Santiago De Compostela Hidrogeles acrilicos con ciclodextrinas colgantes, su preparacion y su aplicacion como sistemas de liberacion y componentes de lentes de contacto.
JP2012235797A (ja) * 2009-09-18 2012-12-06 Terumo Corp ステント
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
WO2011065987A1 (en) * 2009-11-25 2011-06-03 Healionics Corporation Granules of porous biocompatible materials
WO2011066441A1 (en) * 2009-11-25 2011-06-03 Healionics Corporation Implantable medical devices having microporous surface layers and method for reducing foreign body response to the same
EP3960215B1 (de) 2009-12-15 2024-10-16 Incept, LLC Implantate und biologisch abbaubare bezugsmarkierungen
CN103037911B (zh) 2010-04-08 2015-07-15 矽瑞奥科技公司 具有微孔表面层的植入式医学装置及降低针对所述装置的异物反应的方法
GB201110042D0 (en) * 2011-06-14 2011-07-27 Univ Edinburgh Growth of cells
WO2012176023A1 (en) * 2011-06-23 2012-12-27 Indian Institute Of Technology Kanpur Hydrogel scaffolds for tissue engineering
JP6199883B2 (ja) 2011-12-05 2017-09-20 インセプト・リミテッド・ライアビリティ・カンパニーIncept,Llc 医療用オルガノゲルプロセス及び組成物
US9594188B2 (en) 2011-12-06 2017-03-14 University Of Florida Research Foundation, Inc. UV blocker loaded contact lenses
US9353313B2 (en) 2012-08-09 2016-05-31 Auburn University Microdevices and methods of manufacture
CN104888669A (zh) * 2014-03-05 2015-09-09 中国科学院苏州纳米技术与纳米仿生研究所 一种彩色水凝胶及其制备方法
US10407527B2 (en) * 2015-06-04 2019-09-10 Mcmaster University Charge-shifting polymers for tissue compatible hydrogels
US11532817B2 (en) * 2017-03-24 2022-12-20 Zeon Corporation Binder composition for nonaqueous secondary batteries and slurry composition for nonaqueous secondary batteries
KR102114277B1 (ko) * 2018-08-23 2020-05-22 주식회사 매스컨 고체 화장품 조성물 및 그 제조방법
CN110559470B (zh) * 2019-08-19 2021-02-09 浙江大学 一种水凝胶血管栓塞材料及形状记忆栓塞处理方法
CN114073791B (zh) * 2020-08-21 2022-05-31 中国科学院化学研究所 一种软骨组织工程支架及其制备方法与应用
CN113121036A (zh) * 2021-03-15 2021-07-16 太原理工大学 一种过硫酸盐降解抗生素废水的一体化装置
WO2023108124A1 (en) * 2021-12-09 2023-06-15 Likarda, LLC Hydrogel microparticle-based soft tissue fillers

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3822089A (en) * 1968-09-25 1974-07-02 Akademie Ved Contact lens blank or replica made from anhydrous, sparingly cross-linked hydrophilic copolymers
CS153762B1 (de) 1969-01-14 1974-03-29
JPS492189B1 (de) * 1970-10-28 1974-01-18
CS163469B1 (de) * 1972-05-22 1975-09-15
US3948841A (en) * 1972-05-22 1976-04-06 Karel Dusek Process for producing transparent gels with improved mechanical and sorption properties from copolymers of 2-hydroxyethyl methacrylate and amides of acrylic or methacrylic acid
US3963685A (en) * 1974-05-13 1976-06-15 Abrahams Robert A Alcohol soluble hydrophilic polymer via aqueous polymerization
JPS5340038A (en) * 1976-09-27 1978-04-12 Japan Exlan Co Ltd Preparation of microhydrogel
US4272518A (en) * 1979-07-10 1981-06-09 Moro Daniel G Plastic wound bandage
GB2100269B (en) * 1981-06-12 1985-06-12 Nat Res Dev Preparation of particulate gels
JPS5911602B2 (ja) * 1982-12-28 1984-03-16 東レ株式会社 診断用微粒子
US4959217A (en) 1986-05-22 1990-09-25 Syntex (U.S.A.) Inc. Delayed/sustained release of macromolecules
AU611244B2 (en) 1987-12-25 1991-06-06 Terumo Kabushiki Kaisha Medical instrument
US5122544A (en) * 1988-05-31 1992-06-16 Nalco Chemical Company Process for producing improved superabsorbent polymer aggregates from fines
US5840293A (en) * 1988-11-16 1998-11-24 Advanced Polymer Systems, Inc. Ionic beads for controlled release and adsorption
US4962133A (en) * 1989-09-05 1990-10-09 Dow Corning Corporation Method of making highly adsorptive copolymers
US5468811A (en) * 1989-11-02 1995-11-21 National Patent Development Corporation Hydrophilic composite polymer articles formed from a settable paste comprising a mixture of hydrophilic polymer and unsaturated monomer
US5045266A (en) * 1989-11-02 1991-09-03 National Patent Development Corporation Process of making a hearing aid earmold in situ
US5266325A (en) * 1990-09-28 1993-11-30 Hydro Med Science Division Of National Patent Development Corp. Preparation of homogeneous hydrogel copolymers
AU651654B2 (en) * 1992-01-14 1994-07-28 Endo Pharmaceuticals Solutions Inc. Manufacture of water-swellable hydrophilic articles and drug delivery devices
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
JP2993801B2 (ja) * 1992-07-09 1999-12-27 株式会社日本触媒 粒子状含水ゲル状重合体および吸水性樹脂の製造方法
WO1998020939A2 (en) * 1996-11-15 1998-05-22 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
HUT77530A (hu) * 1994-05-06 1998-05-28 Pfizer Inc. Azitromicint tartalmazó, szabályozott hatóanyag-felszabadítású dózisformák
US5840338A (en) * 1994-07-18 1998-11-24 Roos; Eric J. Loading of biologically active solutes into polymer gels
US5632774A (en) * 1995-01-17 1997-05-27 Babian; Hamik In-the-shell hydration to make implant filler material and prosthesis employing same
JP3156955B2 (ja) * 1995-07-12 2001-04-16 大日精化工業株式会社 連結されたミクロゲル粒子の製造方法及びそれで処理された物品
AU676971B1 (en) * 1995-08-24 1997-03-27 Dainichiseika Color & Chemicals Mfg. Co. Ltd. Production process of connected microgel particles and articles treated with connected microgel particles
DE19601764A1 (de) * 1996-01-19 1997-07-24 Hoechst Ag Verfahren zur Herstellung hydrophiler, hochquellfähiger Hydrogele
JP2001517494A (ja) * 1997-09-19 2001-10-09 リプロジェネシス・インコーポレーテッド 組織エンジニアリングのための改良されたヒドロゲル
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US6521431B1 (en) * 1999-06-22 2003-02-18 Access Pharmaceuticals, Inc. Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments
JP2002284882A (ja) * 2001-03-27 2002-10-03 Mitsubishi Chemicals Corp 高吸水性ポリマーの製造方法
JP4883844B2 (ja) * 2001-04-05 2012-02-22 住友精化株式会社 カルボキシル基含有重合体粒子
WO2003007782A2 (en) * 2001-06-29 2003-01-30 Medgraft Microtech, Inc. Biodegradable injectable implants and related methods of manufacture and use
WO2003022910A1 (en) * 2001-09-08 2003-03-20 Access Pharmaceuticals, Inc. Synthesis and uses of polymer gel nanoparticle networks
JP2003261777A (ja) * 2002-03-07 2003-09-19 Japan Science & Technology Corp 高圧により形成される分子複合体
US7811605B2 (en) * 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses

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AU2003295428C1 (en) 2009-07-30
EP1567132A4 (de) 2007-03-21
JP2006514705A (ja) 2006-05-11
CA2512033A1 (en) 2004-05-27
NZ540571A (en) 2008-05-30
US7351430B2 (en) 2008-04-01
EP1674086A3 (de) 2007-03-21
AU2003295428A1 (en) 2004-06-03
US20080166409A1 (en) 2008-07-10
EP1674086A2 (de) 2006-06-28
EP1567132A1 (de) 2005-08-31
AU2003295428B2 (en) 2009-02-12
WO2004043438A1 (en) 2004-05-27
US20040086548A1 (en) 2004-05-06

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