ZA200504478B - Use of adenosine A2a receptor antagonsits. - Google Patents
Use of adenosine A2a receptor antagonsits. Download PDFInfo
- Publication number
- ZA200504478B ZA200504478B ZA200504478A ZA200504478A ZA200504478B ZA 200504478 B ZA200504478 B ZA 200504478B ZA 200504478 A ZA200504478 A ZA 200504478A ZA 200504478 A ZA200504478 A ZA 200504478A ZA 200504478 B ZA200504478 B ZA 200504478B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- alkoxy
- adenosine
- receptor antagonist
- antipsychotic agent
- Prior art date
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- 108010085277 Adenosine A2A receptor Proteins 0.000 title 1
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- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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Publications (1)
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| ZA200504478A ZA200504478B (en) | 2002-12-19 | 2005-05-31 | Use of adenosine A2a receptor antagonsits. |
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| US (2) | US7414058B2 (fr) |
| EP (3) | EP2269596A3 (fr) |
| JP (3) | JP2006514697A (fr) |
| CN (2) | CN100415217C (fr) |
| AT (1) | ATE490775T1 (fr) |
| AU (2) | AU2003304527B2 (fr) |
| BR (1) | BR0317436A (fr) |
| DE (1) | DE60335294D1 (fr) |
| ES (1) | ES2354875T3 (fr) |
| HK (1) | HK1074585A1 (fr) |
| MX (1) | MXPA05006790A (fr) |
| NO (1) | NO20053509L (fr) |
| NZ (1) | NZ540493A (fr) |
| TW (1) | TWI331036B (fr) |
| WO (1) | WO2005044245A1 (fr) |
| ZA (1) | ZA200504478B (fr) |
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| SK287748B6 (sk) * | 2000-05-26 | 2011-08-04 | Schering Corporation | Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
| DE10053397A1 (de) * | 2000-10-20 | 2002-05-02 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
| DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
| US20060106040A1 (en) * | 2002-12-19 | 2006-05-18 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
| JP2006514697A (ja) * | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニストの使用 |
| CN100503609C (zh) * | 2003-04-23 | 2009-06-24 | 先灵公司 | 2-炔基-及2-链烯基-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]-嘧啶腺苷A2a受体拮抗剂 |
| NZ527142A (en) * | 2003-07-23 | 2006-03-31 | Douglas Pharmaceuticals Ltd | A stable suspension formulation |
| WO2005103055A1 (fr) * | 2004-04-21 | 2005-11-03 | Schering Corporation | Antagonistes du recepteur a2a de l'adenosine a base de pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine |
| US7910613B2 (en) | 2004-09-22 | 2011-03-22 | H. Lundbeck A/S | 2-acylaminothiazole derivatives |
| US8455437B2 (en) * | 2005-02-04 | 2013-06-04 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Method to predict and prevent oxygen-induced inflammatory tissue injury |
| US7674912B2 (en) * | 2005-04-25 | 2010-03-09 | H. Lundbeck A/S | Pro-drugs of N-thiazol-2-yl-benzamide derivatives |
| ATE556712T1 (de) * | 2005-06-07 | 2012-05-15 | Kyowa Hakko Kirin Co Ltd | A2a antagonisten zur behandlung von motorischen störungen |
| WO2007035542A1 (fr) * | 2005-09-19 | 2007-03-29 | Schering Corporation | 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2, 4-triazolo-[1,5-c]-pyrimidine en tant qu'antagonistes du recepteur a2a d'adenosine |
| AR056080A1 (es) * | 2005-09-23 | 2007-09-19 | Schering Corp | 7-[2-[4-(6-fluoro-3-metil-1,2-benciosoxazol-5-il)-1-piperazinil]etil]-2-(1-propinil)-7h-pirazol-[4,3-e]-[1,2,4]-triazol-[1,5-c] -pirimidin-5-amine |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| WO2009111449A1 (fr) | 2008-03-04 | 2009-09-11 | Schering Corporation | Composés 1,2,4-triazolo[4,3-c]pyrimidin-3-one et pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one servant d'antagonistes aux récepteurs a2a de l'adénosine |
| TWI473614B (zh) * | 2008-05-29 | 2015-02-21 | Kyowa Hakko Kirin Co Ltd | Anti-analgesic inhibitors |
| JP5765239B2 (ja) | 2009-03-13 | 2015-08-19 | アドヴィナス・セラピューティックス・リミテッド | 置換縮合ピリミジン化合物 |
| EP2499142B1 (fr) | 2009-11-09 | 2016-09-21 | Advinus Therapeutics Limited | Composés pyrimidine fusionnés substitués, leur préparation et leurs utilisations |
| US8435994B2 (en) | 2009-11-16 | 2013-05-07 | Merck Sharp & Dohme Corp. | Substituted [1,2,4]triazolo[4,3-alpha]quinoxalines as adenosine A2a receptor antagonists |
| US8473582B2 (en) * | 2009-12-16 | 2013-06-25 | International Business Machines Corporation | Disconnected file operations in a scalable multi-node file system cache for a remote cluster file system |
| WO2011101861A1 (fr) | 2010-01-29 | 2011-08-25 | Msn Laboratories Limited | Procédé de préparation d'inhibiteurs de la dpp-iv |
| ES2579949T3 (es) | 2010-02-05 | 2016-08-17 | Heptares Therapeutics Limited | Derivados de 1,2,4-triazin-4-amina |
| CN103261202B (zh) * | 2010-09-24 | 2016-01-20 | 阿迪维纳斯疗法有限公司 | 作为腺苷受体拮抗剂的稠合三环化合物 |
| WO2012066330A1 (fr) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Composés utiles en tant qu'inhibiteurs du récepteur a2a |
| WO2012135084A1 (fr) * | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | Métabolites de 2-(furan-2-yl)-7-(2-(4-(4-(2-méthoxyéthoxy)phényl)pipérazin-1-yl)éthyl)-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine et leur utilité en tant qu'antagonistes du récepteur a2a de l'adénosine |
| WO2014101113A1 (fr) | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution pipérazine présentant des propriétés d'antagoniste d'a2a |
| CN105025899B (zh) * | 2012-12-28 | 2017-08-18 | 默沙东公司 | 具有A2A拮抗剂性质的杂二环取代的‑[1,2,4]三唑并[1,5‑c]喹唑啉‑5‑胺化合物 |
| WO2014101120A1 (fr) * | 2012-12-28 | 2014-07-03 | Merck Sharp & Dohme Corp. | Composés de 7-méthoxy-[1,2,4]triazolo[1,5-c]quinazoline-5-amine à substitution hétérobicyclo présentant des propriétés d'antagoniste d'a2a |
| WO2018013951A1 (fr) * | 2016-07-15 | 2018-01-18 | Northwestern University | Ciblage des récepteurs a2a de l'adénosine pour le traitement de dyskinésies induites par la lévodopa |
| CN110809577A (zh) * | 2017-06-30 | 2020-02-18 | 雷沃医疗有限公司 | 腺苷a2a受体的调节剂 |
| US20200316077A1 (en) | 2017-12-19 | 2020-10-08 | Impetis Biosciences Ltd. | Pharmaceutical composition for the treatment of cancer |
| AU2019205661B2 (en) | 2018-01-04 | 2022-06-30 | Impetis Biosciences Ltd. | Tricyclic compounds, compositions and medicinal applications thereof |
| DE102019116986A1 (de) | 2019-06-24 | 2020-12-24 | Helmholtz-Zentrum Dresden-Rossendorf E. V. | Deuterierte 7-(3-(4-(2-([18F]Fluor)ethoxy)phenyl)propyl)-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amin-Derivate |
| JP2022540583A (ja) * | 2019-07-17 | 2022-09-16 | テオン セラピューティクス，インク． | アデノシンａ２ａ受容体アンタゴニスト及びその使用 |
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| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| ATE208199T1 (de) * | 1993-07-27 | 2001-11-15 | Kyowa Hakko Kogyo Kk | Arzneimittel gegen parkinsonsche krankheit |
| IT1277392B1 (it) * | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| US5933964A (en) * | 1996-07-17 | 1999-08-10 | Wahl Clipper Corporation | Cutter blade for hair clippers |
| AU1251499A (en) | 1997-11-26 | 1999-06-15 | Cerebrus Limited | (-)-mefloquine to block purinergic receptors and to treat movement or neurodegenerative disorders |
| GB9819384D0 (en) * | 1998-09-04 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9915437D0 (en) * | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
| SK287748B6 (sk) * | 2000-05-26 | 2011-08-04 | Schering Corporation | Substituované 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo[1,5- c]pyrimidíny, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB0100624D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical compounds VII |
| MXPA03009185A (es) * | 2001-04-09 | 2004-02-17 | Neurosearch As | Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson. |
| EP1425017A1 (fr) * | 2001-09-13 | 2004-06-09 | Schering Corporation | Combinaison d'un antagoniste du recepteur d'adenosine a2a et d'un antidepresseur ou d'un anxiolytique |
| PE20030477A1 (es) | 2001-10-15 | 2003-06-06 | Schering Corp | ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a |
| US6875772B2 (en) * | 2001-11-30 | 2005-04-05 | Schering Corporation | [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists |
| AR038366A1 (es) | 2001-11-30 | 2005-01-12 | Schering Corp | Compuestos de 1,2,4-triazolo [1,5-c] pirimidinas sustituidas, antagonistas del receptor de adenosina a2a, composiciones farmaceuticas, el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de enfermedades del sistema nervioso central y un kit que comprende combinacion |
| WO2003048165A1 (fr) | 2001-11-30 | 2003-06-12 | Schering Corporation | Antagonistes du recepteur a2a d'adenosine |
| ES2716404T3 (es) | 2002-01-28 | 2019-06-12 | Kyowa Hakko Kogyo Kk | Antagonistas de receptores A2A para su uso en el tratamiento de trastornos del movimiento |
| MXPA05001461A (es) * | 2002-08-30 | 2005-06-03 | Kyowa Hakko Kogyo Kk | Antagonistas del receptor a2a de adenosina para el tratamiento del sindrome de las piernas inquietas o trastornos relacionados. |
| JP2006514697A (ja) * | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニストの使用 |
| CN100503609C (zh) * | 2003-04-23 | 2009-06-24 | 先灵公司 | 2-炔基-及2-链烯基-吡唑并-[4,3-e]-1,2,4-三唑并[1,5-c]-嘧啶腺苷A2a受体拮抗剂 |
-
2003
- 2003-12-17 JP JP2005510511A patent/JP2006514697A/ja not_active Withdrawn
- 2003-12-17 EP EP10186087A patent/EP2269596A3/fr not_active Withdrawn
- 2003-12-17 US US10/738,906 patent/US7414058B2/en not_active Expired - Fee Related
- 2003-12-17 BR BR0317436-0A patent/BR0317436A/pt not_active IP Right Cessation
- 2003-12-17 TW TW092135740A patent/TWI331036B/zh not_active IP Right Cessation
- 2003-12-17 WO PCT/US2003/040456 patent/WO2005044245A1/fr active Application Filing
- 2003-12-17 CN CNB2003801070872A patent/CN100415217C/zh not_active Expired - Fee Related
- 2003-12-17 NZ NZ540493A patent/NZ540493A/en not_active IP Right Cessation
- 2003-12-17 DE DE60335294T patent/DE60335294D1/de not_active Expired - Lifetime
- 2003-12-17 MX MXPA05006790A patent/MXPA05006790A/es active IP Right Grant
- 2003-12-17 AT AT03818838T patent/ATE490775T1/de not_active IP Right Cessation
- 2003-12-17 ES ES03818838T patent/ES2354875T3/es not_active Expired - Lifetime
- 2003-12-17 AU AU2003304527A patent/AU2003304527B2/en not_active Ceased
- 2003-12-17 EP EP10186097A patent/EP2295047A3/fr not_active Withdrawn
- 2003-12-17 EP EP03818838A patent/EP1578409B1/fr not_active Expired - Lifetime
- 2003-12-17 CN CNA2008101361548A patent/CN101310724A/zh active Pending
-
2005
- 2005-05-31 ZA ZA200504478A patent/ZA200504478B/en unknown
- 2005-07-18 NO NO20053509A patent/NO20053509L/no not_active Application Discontinuation
- 2005-09-28 HK HK05108564.4A patent/HK1074585A1/xx not_active IP Right Cessation
-
2008
- 2008-07-29 US US12/181,736 patent/US20090029967A1/en not_active Abandoned
-
2010
- 2010-08-06 JP JP2010177518A patent/JP2011006431A/ja active Pending
- 2010-08-31 AU AU2010214749A patent/AU2010214749B2/en not_active Ceased
-
2013
- 2013-01-29 JP JP2013013961A patent/JP2013136592A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20040138235A1 (en) | 2004-07-15 |
| CN100415217C (zh) | 2008-09-03 |
| AU2003304527B2 (en) | 2010-09-09 |
| TW200505927A (en) | 2005-02-16 |
| US20090029967A1 (en) | 2009-01-29 |
| CN1728990A (zh) | 2006-02-01 |
| EP1578409A1 (fr) | 2005-09-28 |
| CN101310724A (zh) | 2008-11-26 |
| JP2011006431A (ja) | 2011-01-13 |
| NO20053509D0 (no) | 2005-07-18 |
| JP2013136592A (ja) | 2013-07-11 |
| EP1578409B1 (fr) | 2010-12-08 |
| ATE490775T1 (de) | 2010-12-15 |
| NO20053509L (no) | 2005-09-16 |
| JP2006514697A (ja) | 2006-05-11 |
| EP2295047A3 (fr) | 2011-05-18 |
| EP2269596A3 (fr) | 2011-09-14 |
| US7414058B2 (en) | 2008-08-19 |
| NZ540493A (en) | 2008-04-30 |
| EP2295047A2 (fr) | 2011-03-16 |
| AU2003304527A1 (en) | 2005-05-26 |
| MXPA05006790A (es) | 2005-09-08 |
| BR0317436A (pt) | 2005-11-16 |
| AU2010214749A1 (en) | 2010-09-23 |
| WO2005044245A1 (fr) | 2005-05-19 |
| EP2269596A2 (fr) | 2011-01-05 |
| DE60335294D1 (de) | 2011-01-20 |
| HK1074585A1 (en) | 2005-11-18 |
| TWI331036B (en) | 2010-10-01 |
| AU2010214749B2 (en) | 2011-06-09 |
| ES2354875T3 (es) | 2011-03-18 |
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