ZA200504044B - N-arylsufonyl-3-aminoalkoxyindoles - Google Patents
N-arylsufonyl-3-aminoalkoxyindoles Download PDFInfo
- Publication number
- ZA200504044B ZA200504044B ZA200504044A ZA200504044A ZA200504044B ZA 200504044 B ZA200504044 B ZA 200504044B ZA 200504044 A ZA200504044 A ZA 200504044A ZA 200504044 A ZA200504044 A ZA 200504044A ZA 200504044 B ZA200504044 B ZA 200504044B
- Authority
- ZA
- South Africa
- Prior art keywords
- yloxy
- indol
- dimethylamine
- ethyl
- bromo
- Prior art date
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- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 494
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 234
- -1 hydroxy, thio, amino Chemical group 0.000 claims description 102
- 150000001875 compounds Chemical class 0.000 claims description 55
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical group C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 39
- 125000005842 heteroatom Chemical group 0.000 claims description 36
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 32
- 229910052757 nitrogen Inorganic materials 0.000 claims description 30
- 125000000623 heterocyclic group Chemical group 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 239000001257 hydrogen Substances 0.000 claims description 25
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 22
- 125000003545 alkoxy group Chemical group 0.000 claims description 22
- 229910052760 oxygen Inorganic materials 0.000 claims description 22
- 229910052717 sulfur Inorganic materials 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 15
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
- 125000004122 cyclic group Chemical group 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 238000011282 treatment Methods 0.000 claims description 12
- 125000002252 acyl group Chemical group 0.000 claims description 11
- 125000004423 acyloxy group Chemical group 0.000 claims description 11
- 125000003342 alkenyl group Chemical group 0.000 claims description 11
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 11
- 125000004949 alkyl amino carbonyl amino group Chemical group 0.000 claims description 11
- 125000004414 alkyl thio group Chemical group 0.000 claims description 11
- 125000000304 alkynyl group Chemical group 0.000 claims description 11
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 11
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 11
- 125000001691 aryl alkyl amino group Chemical group 0.000 claims description 11
- 125000001769 aryl amino group Chemical group 0.000 claims description 11
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- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 11
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 11
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- 125000006598 aminocarbonylamino group Chemical group 0.000 claims description 10
- 150000001602 bicycloalkyls Chemical group 0.000 claims description 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
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- 125000004986 diarylamino group Chemical group 0.000 claims description 10
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 9
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 9
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- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
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IN883MA2002 | 2002-11-28 |
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ZA200504044A ZA200504044B (en) | 2002-11-28 | 2006-05-19 | N-arylsufonyl-3-aminoalkoxyindoles |
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US (2) | US7507835B2 (el) |
EP (1) | EP1567492B1 (el) |
JP (2) | JP4782425B2 (el) |
KR (1) | KR100776118B1 (el) |
CN (2) | CN102249981A (el) |
AU (1) | AU2003285759B2 (el) |
BR (1) | BRPI0315958B8 (el) |
CA (1) | CA2507505C (el) |
CY (1) | CY1114241T1 (el) |
EA (1) | EA009193B1 (el) |
ES (1) | ES2425143T3 (el) |
MX (1) | MXPA05005700A (el) |
NO (1) | NO331805B1 (el) |
NZ (1) | NZ540842A (el) |
PT (1) | PT1567492E (el) |
SI (1) | SI1567492T1 (el) |
WO (1) | WO2004048328A2 (el) |
ZA (1) | ZA200504044B (el) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
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AU2003285759B2 (en) * | 2002-11-28 | 2010-01-28 | Suven Life Sciences Limited | N-arylsulfonyl-3-aminoalkoxyindoles |
PT1581538E (pt) * | 2002-12-18 | 2007-05-31 | Suven Life Sciences Ltd | Indolos tetracíclicos substituidos na posição 3 que possuem afinidade pelo receptor de serotonina. |
JP4886522B2 (ja) | 2004-01-02 | 2012-02-29 | スベン ライフ サイエンシズ リミティド | 新規なインデノ[2,1−a]インデンおよびイソインドロ[2,1−A]インドール |
MX2008002018A (es) | 2005-08-12 | 2008-03-27 | Suven Life Sciences Ltd | Derivados de aminoaril sulfonamida como ligandos funcionales del 5-ht6. |
WO2007020654A1 (en) | 2005-08-16 | 2007-02-22 | Suven Life Sciences | An improved process for the preparation of losartan |
KR100724095B1 (ko) * | 2005-10-21 | 2007-06-04 | 한국표준과학연구원 | 정밀 전류, 전압 및 전력 측정장치 |
US8470830B2 (en) | 2007-01-08 | 2013-06-25 | Suven Life Sciences Limited | 5-(heterocyclyl)alkyl-N-(arylsulfonyl)indole compounds and their use as 5-HT6 ligands |
EP1947085A1 (en) * | 2007-01-19 | 2008-07-23 | Laboratorios del Dr. Esteve S.A. | Substituted indole sulfonamide compounds, their preparation and use as medicaments |
ATE513810T1 (de) * | 2007-05-03 | 2011-07-15 | Suven Life Sciences Ltd | Aminoalkoxy-aryl-sulfonamidverbindungen und ihre verwendung als 5-ht6-liganden |
EA017154B1 (ru) * | 2007-10-26 | 2012-10-30 | Сувен Лайф Сайенсиз Лимитед | Аминоарилсульфонамидные соединения и их применение в качестве 5-нтлигандов |
AR072297A1 (es) * | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
EP2149573A1 (en) * | 2008-08-01 | 2010-02-03 | Laboratorios Del. Dr. Esteve, S.A. | Substituted indole sulfonamide compounds their preparation and use as medicaments |
WO2010032257A1 (en) | 2008-09-17 | 2010-03-25 | Suven Life Sciences Limited | Aryl indolyl sulfonamide compounds and their use as 5-ht6 ligands |
EA019496B1 (ru) | 2008-09-17 | 2014-04-30 | Сувен Лайф Сайенсиз Лимитед | Арилсульфонамидные аминосоединения и их применение в качестве лигандов 5-ht |
DK2521714T3 (en) | 2010-01-05 | 2015-10-19 | Suven Life Sciences Ltd | Aromatic sulfone compositions useful in the treatment of central nervous disorders |
JP5659322B2 (ja) * | 2012-12-13 | 2015-01-28 | オリンパスメディカルシステムズ株式会社 | 処置具 |
DE102013013602A1 (de) * | 2013-08-19 | 2015-02-19 | Trützschler GmbH + Co KG Textilmaschinenfabrik | Vorrichtung an einer Karde oder Krempel für Baumwolle, Chemiefasern u. dgl. mit einer drehbaren Abstreifwalze |
JP6454346B2 (ja) | 2013-12-20 | 2019-01-16 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | 芳香族複素環式化合物及び医薬におけるその応用 |
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US723550A (en) * | 1902-09-15 | 1903-03-24 | Eagle Lock Co | Padlock. |
CH481104A (de) | 1967-01-25 | 1969-11-15 | Geigy Ag J R | Verfahren zur Herstellung von neuen Indolderivaten |
US3860609A (en) | 1969-05-27 | 1975-01-14 | Novo Terapeutisk Labor As | 3-aminoalkyloxyindoles |
US3860608A (en) | 1969-05-27 | 1975-01-14 | Novo Terapeutisk Labor As | 3-aminoalkyloxyindoles |
GB1306230A (el) * | 1969-05-27 | 1973-02-07 | ||
ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
ZA815541B (en) | 1980-08-12 | 1983-03-30 | Glaxo Group Ltd | Heterocyclic compounds |
JPS57200362A (en) | 1981-06-05 | 1982-12-08 | Mitsui Toatsu Chem Inc | Preparation of indoxyl |
GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
GB8719167D0 (en) | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
JPH01139564A (ja) * | 1987-08-31 | 1989-06-01 | Terumo Corp | N−置換インドールエステル化合物、その製造法ならびに該化合物を用いた試験組成物および試験具 |
GB8724912D0 (en) | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
GB8819024D0 (en) | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
IL96891A0 (en) | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
CA2042295A1 (fr) | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
WO1991018897A1 (en) | 1990-06-07 | 1991-12-12 | The Wellcome Foundation Limited | Therapeutic heterocyclic compounds |
CZ283018B6 (cs) | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
GB9113802D0 (en) | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
GB9210400D0 (en) | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
KR940007001A (ko) | 1992-09-16 | 1994-04-26 | 최승주 | 새로운 n-신나모일-2-메틸-5-메톡시-3-인돌 아세트산 에스테르, 그 제조방법 및 이를 함유하는 약학적 제제 |
IL130169A (en) | 1999-05-27 | 2006-08-20 | Neurim Pharma 1991 | Indole derivatives, and pharmaceutical preparations, skin protection preparations, and cosmetics containing them |
FR2799757B1 (fr) | 1999-10-15 | 2001-12-14 | Adir | Nouveaux derives polycycliques azaindoliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2821843B1 (fr) | 2001-03-12 | 2003-05-09 | Servier Lab | Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
EP1523486B1 (en) * | 2002-06-21 | 2007-11-07 | Suven Life Sciences Limited | Tetracyclic arylsulfonyl indoles having serotonin receptor affinity |
US7521395B2 (en) * | 2002-07-22 | 2009-04-21 | Basf Aktiengesellschaft | Synergistically acting herbicidal mixtures |
AU2003285759B2 (en) * | 2002-11-28 | 2010-01-28 | Suven Life Sciences Limited | N-arylsulfonyl-3-aminoalkoxyindoles |
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2003
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- 2003-11-25 CN CN2011101270926A patent/CN102249981A/zh active Pending
- 2003-11-25 ES ES03778739T patent/ES2425143T3/es not_active Expired - Lifetime
- 2003-11-25 JP JP2004554902A patent/JP4782425B2/ja not_active Expired - Fee Related
- 2003-11-25 EP EP03778739.7A patent/EP1567492B1/en not_active Expired - Lifetime
- 2003-11-25 CA CA2507505A patent/CA2507505C/en not_active Expired - Fee Related
- 2003-11-25 MX MXPA05005700A patent/MXPA05005700A/es active IP Right Grant
- 2003-11-25 NZ NZ540842A patent/NZ540842A/en not_active IP Right Cessation
- 2003-11-25 WO PCT/IN2003/000370 patent/WO2004048328A2/en active Application Filing
- 2003-11-25 BR BRPI0315958A patent/BRPI0315958B8/pt not_active IP Right Cessation
- 2003-11-25 KR KR1020057009253A patent/KR100776118B1/ko active IP Right Grant
- 2003-11-25 PT PT37787397T patent/PT1567492E/pt unknown
- 2003-11-25 CN CNA2003801046430A patent/CN1720227A/zh active Pending
- 2003-11-25 EA EA200500882A patent/EA009193B1/ru not_active IP Right Cessation
- 2003-11-25 US US10/536,592 patent/US7507835B2/en not_active Expired - Fee Related
- 2003-11-25 SI SI200332271T patent/SI1567492T1/sl unknown
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2005
- 2005-06-10 NO NO20052825A patent/NO331805B1/no not_active IP Right Cessation
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2011
- 2011-02-28 JP JP2011043072A patent/JP2011116769A/ja active Pending
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Also Published As
Publication number | Publication date |
---|---|
WO2004048328A3 (en) | 2004-10-28 |
JP2011116769A (ja) | 2011-06-16 |
NO20052825L (no) | 2005-08-25 |
AU2003285759B2 (en) | 2010-01-28 |
CN1720227A (zh) | 2006-01-11 |
CA2507505C (en) | 2011-10-04 |
MXPA05005700A (es) | 2005-08-16 |
EA200500882A1 (ru) | 2005-12-29 |
CN102249981A (zh) | 2011-11-23 |
NO20052825D0 (no) | 2005-06-10 |
US7718690B2 (en) | 2010-05-18 |
NZ540842A (en) | 2008-05-30 |
US20060173193A1 (en) | 2006-08-03 |
EP1567492B1 (en) | 2013-05-22 |
SI1567492T1 (sl) | 2013-07-31 |
AU2003285759A1 (en) | 2004-06-18 |
JP2006511506A (ja) | 2006-04-06 |
CY1114241T1 (el) | 2016-08-31 |
EP1567492A2 (en) | 2005-08-31 |
EA009193B1 (ru) | 2007-12-28 |
KR20050083963A (ko) | 2005-08-26 |
BRPI0315958B8 (pt) | 2021-05-25 |
BRPI0315958B1 (pt) | 2018-06-26 |
WO2004048328A2 (en) | 2004-06-10 |
US7507835B2 (en) | 2009-03-24 |
PT1567492E (pt) | 2013-07-22 |
US20090131507A1 (en) | 2009-05-21 |
ES2425143T3 (es) | 2013-10-11 |
KR100776118B1 (ko) | 2007-11-15 |
JP4782425B2 (ja) | 2011-09-28 |
CA2507505A1 (en) | 2004-06-10 |
NO331805B1 (no) | 2012-04-10 |
BR0315958A (pt) | 2005-09-13 |
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