ZA200504016B - Genetic constructs and compositions comprising RRE and CTE and uses thereof - Google Patents
Genetic constructs and compositions comprising RRE and CTE and uses thereof Download PDFInfo
- Publication number
- ZA200504016B ZA200504016B ZA200504016A ZA200504016A ZA200504016B ZA 200504016 B ZA200504016 B ZA 200504016B ZA 200504016 A ZA200504016 A ZA 200504016A ZA 200504016 A ZA200504016 A ZA 200504016A ZA 200504016 B ZA200504016 B ZA 200504016B
- Authority
- ZA
- South Africa
- Prior art keywords
- coding sequence
- hiv
- protein
- nucleic acid
- composition
- Prior art date
Links
- 230000002068 genetic effect Effects 0.000 title claims abstract description 50
- 239000000203 mixture Substances 0.000 title claims abstract description 50
- 108091026890 Coding region Proteins 0.000 claims abstract description 146
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 100
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 92
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 64
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 63
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 63
- 241000725303 Human immunodeficiency virus Species 0.000 claims abstract description 61
- 101710172711 Structural protein Proteins 0.000 claims abstract description 49
- 230000002163 immunogen Effects 0.000 claims abstract description 46
- 238000000034 method Methods 0.000 claims abstract description 46
- 108700020121 Human Immunodeficiency Virus-1 rev Proteins 0.000 claims abstract description 34
- 230000028993 immune response Effects 0.000 claims abstract description 14
- 230000001939 inductive effect Effects 0.000 claims abstract description 8
- 239000013612 plasmid Substances 0.000 claims description 11
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- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 108010029697 CD40 Ligand Proteins 0.000 description 1
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- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 1
- 108010048209 Human Immunodeficiency Virus Proteins Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
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- 108091027981 Response element Proteins 0.000 description 1
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- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
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- 239000003114 blood coagulation factor Substances 0.000 description 1
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- 125000002091 cationic group Chemical group 0.000 description 1
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- 238000001415 gene therapy Methods 0.000 description 1
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- 230000003463 hyperproliferative effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
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- 239000002502 liposome Substances 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 230000030147 nuclear export Effects 0.000 description 1
- 108010089520 pol Gene Products Proteins 0.000 description 1
- 230000008488 polyadenylation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001177 retroviral effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
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- 238000001890 transfection Methods 0.000 description 1
- 241001430294 unidentified retrovirus Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42785602P | 2002-11-19 | 2002-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200504016B true ZA200504016B (en) | 2006-08-30 |
Family
ID=32326604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200504016A ZA200504016B (en) | 2002-11-19 | 2005-05-18 | Genetic constructs and compositions comprising RRE and CTE and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7455841B2 (ko) |
| EP (1) | EP1570051B1 (ko) |
| JP (1) | JP2006506094A (ko) |
| KR (1) | KR101159519B1 (ko) |
| CN (1) | CN100379853C (ko) |
| AT (1) | ATE447008T1 (ko) |
| AU (1) | AU2003291086B2 (ko) |
| BR (1) | BR0316722A (ko) |
| CA (1) | CA2506695A1 (ko) |
| CO (1) | CO5650177A2 (ko) |
| DE (1) | DE60329862D1 (ko) |
| IL (1) | IL168614A (ko) |
| MX (1) | MXPA05005329A (ko) |
| NZ (1) | NZ540152A (ko) |
| WO (1) | WO2004045548A2 (ko) |
| ZA (1) | ZA200504016B (ko) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2008013529A (es) | 2006-04-20 | 2009-01-15 | Janssen Pharmaceutica Nv | Inhibidores de c-fms cinasa. |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| WO2008075911A1 (en) * | 2006-12-20 | 2008-06-26 | Avixgen Inc. | Vector for expressing nc protein of hiv and method for producing nc protein using the same |
| CA2912665C (en) | 2013-05-15 | 2021-03-02 | Robert Kruse | Intracellular translation of circular rna |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US554528A (en) * | 1896-02-11 | John m | ||
| US5604114A (en) * | 1986-05-20 | 1997-02-18 | Dana-Farber Cancer Institute | Cis-acting repression sequences, cis-acting antirepression sequences, vectors, methods of preparation and use |
| US5554528A (en) * | 1987-08-21 | 1996-09-10 | Board Of Revents Of University Of Colorado | Compositions and methods for inhibition of HIV production |
| US5665577A (en) * | 1989-02-06 | 1997-09-09 | Dana-Farber Cancer Institute | Vectors containing HIV packaging sequences, packaging defective HIV vectors, and uses thereof |
| EP0487587A1 (en) | 1989-08-18 | 1992-06-03 | Chiron Corporation | Recombinant retroviruses delivering vector constructs to target cells |
| ATE302854T1 (de) | 1993-01-26 | 2005-09-15 | Univ Pennsylvania | Zusammensetzungen und verfahren zur verabreichung von genetischem material |
| US5981505A (en) * | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US5585263A (en) * | 1994-05-20 | 1996-12-17 | University Of Alabama At Birmingham Research Foundation | Purified retroviral constitutive transport enhancer and its use to facilitate mRNA transport, and to produce recombinant, attenuated HIV |
| US5650309A (en) * | 1995-05-16 | 1997-07-22 | The Regents Of The University Of California | Viral vectors |
| US6057095A (en) * | 1997-07-11 | 2000-05-02 | Medical University Of South Carolina | Screening procedure for inhibitors of HIV Rev function |
| IT1297090B1 (it) * | 1997-12-01 | 1999-08-03 | Barbara Ensoli | Tat di hiv-1 o suoi derivati, da soli od in combinazione, a scopo vaccinale, profilattico e terapeutico, contro l'aids i tumori e le |
-
2003
- 2003-11-19 MX MXPA05005329A patent/MXPA05005329A/es active IP Right Grant
- 2003-11-19 JP JP2004553917A patent/JP2006506094A/ja active Pending
- 2003-11-19 WO PCT/US2003/036924 patent/WO2004045548A2/en active Application Filing
- 2003-11-19 BR BR0316722-4A patent/BR0316722A/pt not_active IP Right Cessation
- 2003-11-19 US US10/535,326 patent/US7455841B2/en active Active
- 2003-11-19 EP EP03783674A patent/EP1570051B1/en not_active Expired - Lifetime
- 2003-11-19 AU AU2003291086A patent/AU2003291086B2/en not_active Ceased
- 2003-11-19 CN CNB2003801089135A patent/CN100379853C/zh not_active Expired - Fee Related
- 2003-11-19 KR KR1020057009084A patent/KR101159519B1/ko not_active IP Right Cessation
- 2003-11-19 DE DE60329862T patent/DE60329862D1/de not_active Expired - Lifetime
- 2003-11-19 CA CA002506695A patent/CA2506695A1/en not_active Abandoned
- 2003-11-19 NZ NZ540152A patent/NZ540152A/en not_active IP Right Cessation
- 2003-11-19 AT AT03783674T patent/ATE447008T1/de not_active IP Right Cessation
-
2005
- 2005-05-16 IL IL168614A patent/IL168614A/en not_active IP Right Cessation
- 2005-05-18 ZA ZA200504016A patent/ZA200504016B/en unknown
- 2005-05-19 CO CO05048670A patent/CO5650177A2/es not_active Application Discontinuation
-
2008
- 2008-11-20 US US12/275,192 patent/US8685407B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006506094A (ja) | 2006-02-23 |
| CA2506695A1 (en) | 2004-06-03 |
| US7455841B2 (en) | 2008-11-25 |
| US20060140978A1 (en) | 2006-06-29 |
| EP1570051B1 (en) | 2009-10-28 |
| DE60329862D1 (de) | 2009-12-10 |
| KR101159519B1 (ko) | 2012-06-25 |
| CO5650177A2 (es) | 2006-06-30 |
| WO2004045548A3 (en) | 2004-09-10 |
| BR0316722A (pt) | 2005-10-18 |
| MXPA05005329A (es) | 2005-08-16 |
| US20090170800A1 (en) | 2009-07-02 |
| CN100379853C (zh) | 2008-04-09 |
| EP1570051A4 (en) | 2006-02-15 |
| NZ540152A (en) | 2008-03-28 |
| WO2004045548A2 (en) | 2004-06-03 |
| CN1738897A (zh) | 2006-02-22 |
| KR20050083919A (ko) | 2005-08-26 |
| AU2003291086B2 (en) | 2009-02-05 |
| EP1570051A2 (en) | 2005-09-07 |
| ATE447008T1 (de) | 2009-11-15 |
| US8685407B2 (en) | 2014-04-01 |
| IL168614A (en) | 2011-03-31 |
| AU2003291086A1 (en) | 2004-06-15 |
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