ZA200503166B - Method of producing recombinant proteins in the mammary gland on non-transgenic mammals - Google Patents
Method of producing recombinant proteins in the mammary gland on non-transgenic mammals Download PDFInfo
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- ZA200503166B ZA200503166B ZA200503166A ZA200503166A ZA200503166B ZA 200503166 B ZA200503166 B ZA 200503166B ZA 200503166 A ZA200503166 A ZA 200503166A ZA 200503166 A ZA200503166 A ZA 200503166A ZA 200503166 B ZA200503166 B ZA 200503166B
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- South Africa
- Prior art keywords
- milk
- mammary gland
- proteins
- adenoviral
- infusion
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/102—Caprine
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
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- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20020235A CU23102A1 (es) | 2002-10-21 | 2002-10-21 | Método para la producción de proteínas recombinantes en la glándula mamaria de mamíferos no transgénicos |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200503166B true ZA200503166B (en) | 2006-10-25 |
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| ZA200503166A ZA200503166B (en) | 2002-10-21 | 2005-04-19 | Method of producing recombinant proteins in the mammary gland on non-transgenic mammals |
Country Status (13)
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| EP (1) | EP1557084A2 (ru) |
| JP (1) | JP2006503560A (ru) |
| KR (1) | KR20050083791A (ru) |
| CN (1) | CN1744814A (ru) |
| AR (1) | AR041644A1 (ru) |
| AU (1) | AU2003273726B8 (ru) |
| BR (1) | BR0315555A (ru) |
| CA (1) | CA2502902A1 (ru) |
| CU (1) | CU23102A1 (ru) |
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| RU (1) | RU2345088C2 (ru) |
| WO (1) | WO2004034780A2 (ru) |
| ZA (1) | ZA200503166B (ru) |
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| CU23576A1 (es) * | 2006-02-28 | 2010-09-30 | Ct Ingenieria Genetica Biotech | Antígenos vacunales quiméricos contra el virus de la influenza aviar |
| CU23544A1 (es) | 2006-02-28 | 2010-06-17 | Ct Ingenieria Genetica Biotech | Antígenos vacunales quiméricos contra el virus de la peste porcina clásica |
| CN1869217B (zh) * | 2006-05-22 | 2013-08-07 | 李青旺 | 以腺病毒为载体乳腺表达生产转基因蛋白药物的方法 |
| KR101033818B1 (ko) * | 2008-06-30 | 2011-05-13 | 조아제약주식회사 | 돼지의 알파에스 1 카제인 유전자, 그 프로모터 및 그의 용도 |
| CA2858825A1 (en) * | 2011-12-19 | 2013-06-27 | Lfb Usa, Inc. | Recombinant human alpha-1-antitrypsin for the treatment of inflammatory disorders |
| CL2014002410A1 (es) * | 2014-09-12 | 2014-11-14 | Univ Concepcion | Método para la producción de proteínas recombinantes en glándula mamaria de mamíferos mediante la transformación del epítelio glandular mamario con vectores adenoasociados. |
| WO2018085967A1 (en) * | 2016-11-08 | 2018-05-17 | Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences | Genetically humanized mammals expressing human serum albumin and uses thereof |
| WO2021013997A1 (en) | 2019-07-25 | 2021-01-28 | Medichem, S.A. | Process for the synthesis of n-alkyl-4-pyridinamines |
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| US5780009A (en) * | 1995-01-20 | 1998-07-14 | Nexia Biotechnologies, Inc. | Direct gene transfer into the ruminant mammary gland |
| AU7719596A (en) * | 1995-11-07 | 1997-05-29 | Baylor College Of Medicine | Adenovirus-mediated production of bioactive proteins by mammalian cells and animals |
| EP0954579A1 (en) * | 1996-06-20 | 1999-11-10 | Merck & Co., Inc. | Gene therapy for obesity |
| WO1999043795A1 (en) * | 1998-02-24 | 1999-09-02 | Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada | Trans-somatics with gene transfer into mammary epithelial cells |
| AU2002228730A1 (en) * | 2000-10-27 | 2002-05-06 | Beth Israel Deaconess Medical Center, Inc. | Mammary secreted protein 36 (msp36) for cancer treatment and diagnosis |
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2002
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2003
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- 2003-10-20 CA CA002502902A patent/CA2502902A1/en not_active Abandoned
- 2003-10-20 KR KR1020057006830A patent/KR20050083791A/ko not_active Application Discontinuation
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- 2003-10-20 WO PCT/CU2003/000011 patent/WO2004034780A2/es active Application Filing
- 2003-10-20 EP EP03757653A patent/EP1557084A2/en not_active Withdrawn
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2005
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Also Published As
| Publication number | Publication date |
|---|---|
| BR0315555A (pt) | 2005-08-23 |
| RU2345088C2 (ru) | 2009-01-27 |
| AR041644A1 (es) | 2005-05-26 |
| MXPA05004295A (es) | 2005-08-03 |
| KR20050083791A (ko) | 2005-08-26 |
| WO2004034780A2 (es) | 2004-04-29 |
| AU2003273726A1 (en) | 2004-05-04 |
| EP1557084A2 (en) | 2005-07-27 |
| CN1744814A (zh) | 2006-03-08 |
| WO2004034780A3 (es) | 2004-05-27 |
| JP2006503560A (ja) | 2006-02-02 |
| RU2005115495A (ru) | 2005-11-20 |
| CA2502902A1 (en) | 2004-04-29 |
| CU23102A1 (es) | 2005-12-20 |
| AU2003273726B8 (en) | 2009-09-03 |
| AU2003273726B2 (en) | 2009-07-09 |
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