ZA200503133B - Extended, controlled release pharmaceutical compositions comprising charged polymers - Google Patents
Extended, controlled release pharmaceutical compositions comprising charged polymers Download PDFInfo
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- ZA200503133B ZA200503133B ZA200503133A ZA200503133A ZA200503133B ZA 200503133 B ZA200503133 B ZA 200503133B ZA 200503133 A ZA200503133 A ZA 200503133A ZA 200503133 A ZA200503133 A ZA 200503133A ZA 200503133 B ZA200503133 B ZA 200503133B
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- ZA
- South Africa
- Prior art keywords
- treating agent
- composition
- polymer
- treating
- bioadhesive
- Prior art date
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- 229920000642 polymer Polymers 0.000 title claims description 69
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 14
- 238000013270 controlled release Methods 0.000 title description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 166
- 239000000203 mixture Substances 0.000 claims description 139
- 229920000148 Polycarbophil calcium Polymers 0.000 claims description 30
- 239000000227 bioadhesive Substances 0.000 claims description 30
- 229950005134 polycarbophil Drugs 0.000 claims description 30
- 208000000450 Pelvic Pain Diseases 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 26
- 239000000839 emulsion Substances 0.000 claims description 23
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 21
- -1 acyclorvir Chemical compound 0.000 claims description 20
- 229960004194 lidocaine Drugs 0.000 claims description 20
- 125000002091 cationic group Chemical group 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 206010003119 arrhythmia Diseases 0.000 claims description 15
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 13
- 230000003531 anti-dysrhythmic effect Effects 0.000 claims description 13
- 229920000831 ionic polymer Polymers 0.000 claims description 13
- 238000004519 manufacturing process Methods 0.000 claims description 13
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- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 claims description 12
- 208000000509 infertility Diseases 0.000 claims description 12
- 230000036512 infertility Effects 0.000 claims description 12
- 231100000535 infertility Toxicity 0.000 claims description 12
- 125000000129 anionic group Chemical group 0.000 claims description 11
- 229920006318 anionic polymer Polymers 0.000 claims description 10
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 10
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims description 10
- 230000035587 bioadhesion Effects 0.000 claims description 9
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims description 8
- 239000008139 complexing agent Substances 0.000 claims description 7
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- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 claims description 5
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 claims description 5
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 5
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- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 5
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- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 5
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- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 5
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- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims description 5
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 5
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- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Pregnancy & Childbirth (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/278,912 US20030114394A1 (en) | 2001-10-29 | 2002-10-24 | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US43850103P | 2003-01-08 | 2003-01-08 | |
| PCT/EP2003/004316 WO2004037229A1 (en) | 2002-10-24 | 2003-04-25 | Extended, controlled release pharmaceutical compositions comprising charged polymers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200503133B true ZA200503133B (en) | 2006-12-27 |
Family
ID=32179474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200503133A ZA200503133B (en) | 2002-10-24 | 2005-04-19 | Extended, controlled release pharmaceutical compositions comprising charged polymers |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1556015B1 (ko) |
| JP (1) | JP5204374B2 (ko) |
| KR (1) | KR20050083802A (ko) |
| CN (2) | CN101327326A (ko) |
| AR (1) | AR039464A1 (ko) |
| AU (1) | AU2003233066B2 (ko) |
| BR (1) | BR0315576A (ko) |
| CA (1) | CA2503383C (ko) |
| CO (1) | CO5700711A2 (ko) |
| ES (1) | ES2618300T3 (ko) |
| HR (1) | HRP20050448A2 (ko) |
| MA (1) | MA27493A1 (ko) |
| ME (2) | ME00233B (ko) |
| MX (1) | MXPA05004330A (ko) |
| NO (1) | NO20052480L (ko) |
| NZ (1) | NZ539512A (ko) |
| PE (2) | PE20081613A1 (ko) |
| PL (1) | PL376537A1 (ko) |
| RS (1) | RS20050321A (ko) |
| RU (2) | RU2366410C2 (ko) |
| TW (1) | TW200406223A (ko) |
| WO (1) | WO2004037229A1 (ko) |
| ZA (1) | ZA200503133B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2007145528A (ru) * | 2005-05-10 | 2009-06-20 | Новартис АГ (CH) | Фармацевтические композиции с модифицированным высвобождением фамцикловира |
| WO2017130208A1 (en) * | 2016-01-29 | 2017-08-03 | Faheem Hyder Pottoo | Triple drug combination for treatment of status epilepticus and/or partial seizures and/or partial seizures with associated neurological disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE151286T1 (de) * | 1983-11-14 | 1997-04-15 | Columbia Lab Inc | Bioadhäsive mittel |
| US5578315A (en) * | 1993-12-01 | 1996-11-26 | Rutgers, The State University Of New Jersey | Mucosal adhesive device for long-acting delivery of pharmaceutical combinations in oral cavity |
| US5667492A (en) * | 1994-10-07 | 1997-09-16 | Columbia Laboratories, Inc. | Use and composition of an anti-sexually transmitted diseases formulation |
| US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
| DE69819748T2 (de) * | 1997-09-12 | 2004-09-30 | Columbia Laboratories (Bermuda) Ltd. | Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen |
| US6624200B2 (en) * | 1998-08-25 | 2003-09-23 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets |
| US6248358B1 (en) * | 1998-08-25 | 2001-06-19 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets and methods of making and using the same |
| UA74168C2 (uk) * | 1999-10-05 | 2005-11-15 | Коламбіа Леборетеріс (Бермуда) Лімітед | Лікування ендометріозу або безпліддя, або покращення плідності та застосування бета-адренергічного агоніста для виробництва лікарського засобу |
-
2002
- 2002-10-28 CN CNA2008100962684A patent/CN101327326A/zh active Pending
-
2003
- 2003-04-24 TW TW092109642A patent/TW200406223A/zh unknown
- 2003-04-25 PL PL376537A patent/PL376537A1/pl not_active Application Discontinuation
- 2003-04-25 WO PCT/EP2003/004316 patent/WO2004037229A1/en active Application Filing
- 2003-04-25 ME MEP-2008-341A patent/ME00233B/me unknown
- 2003-04-25 ME MEP-341/08A patent/MEP34108A/xx unknown
- 2003-04-25 PE PE2008001302A patent/PE20081613A1/es not_active Application Discontinuation
- 2003-04-25 RU RU2005115574/15A patent/RU2366410C2/ru not_active IP Right Cessation
- 2003-04-25 AU AU2003233066A patent/AU2003233066B2/en not_active Ceased
- 2003-04-25 RS YUP-2005/0321A patent/RS20050321A/sr unknown
- 2003-04-25 MX MXPA05004330A patent/MXPA05004330A/es active IP Right Grant
- 2003-04-25 EP EP03727364.6A patent/EP1556015B1/en not_active Expired - Lifetime
- 2003-04-25 KR KR1020057006990A patent/KR20050083802A/ko not_active Application Discontinuation
- 2003-04-25 CN CN038254182A patent/CN1703205B/zh not_active Expired - Fee Related
- 2003-04-25 ES ES03727364.6T patent/ES2618300T3/es not_active Expired - Lifetime
- 2003-04-25 NZ NZ539512A patent/NZ539512A/en not_active IP Right Cessation
- 2003-04-25 CA CA2503383A patent/CA2503383C/en not_active Expired - Fee Related
- 2003-04-25 BR BR0315576-5A patent/BR0315576A/pt not_active Application Discontinuation
- 2003-04-25 PE PE2003000414A patent/PE20040323A1/es not_active Application Discontinuation
- 2003-04-25 JP JP2005501510A patent/JP5204374B2/ja not_active Expired - Fee Related
- 2003-04-28 AR ARP030101458A patent/AR039464A1/es not_active Application Discontinuation
-
2005
- 2005-04-19 ZA ZA200503133A patent/ZA200503133B/en unknown
- 2005-05-17 CO CO05047639A patent/CO5700711A2/es not_active Application Discontinuation
- 2005-05-19 HR HR20050448A patent/HRP20050448A2/hr not_active Application Discontinuation
- 2005-05-20 MA MA28292A patent/MA27493A1/fr unknown
- 2005-05-23 NO NO20052480A patent/NO20052480L/no not_active Application Discontinuation
-
2009
- 2009-04-01 RU RU2009112072/15A patent/RU2009112072A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MA27493A1 (fr) | 2005-08-01 |
| CA2503383C (en) | 2013-03-12 |
| PL376537A1 (pl) | 2006-01-09 |
| JP2006506453A (ja) | 2006-02-23 |
| NO20052480L (no) | 2005-07-25 |
| MEP34108A (en) | 2011-02-10 |
| WO2004037229A1 (en) | 2004-05-06 |
| EP1556015B1 (en) | 2017-02-22 |
| CN101327326A (zh) | 2008-12-24 |
| AU2003233066B2 (en) | 2009-11-19 |
| RU2005115574A (ru) | 2005-10-27 |
| CN1703205B (zh) | 2010-12-01 |
| AU2003233066A1 (en) | 2004-05-13 |
| MXPA05004330A (es) | 2005-08-02 |
| RU2366410C2 (ru) | 2009-09-10 |
| BR0315576A (pt) | 2005-08-30 |
| CO5700711A2 (es) | 2006-11-30 |
| HRP20050448A2 (en) | 2005-12-31 |
| JP5204374B2 (ja) | 2013-06-05 |
| ME00233B (me) | 2011-05-10 |
| PE20040323A1 (es) | 2004-06-10 |
| NO20052480D0 (no) | 2005-05-23 |
| AR039464A1 (es) | 2005-02-23 |
| NZ539512A (en) | 2009-03-31 |
| ES2618300T3 (es) | 2017-06-21 |
| PE20081613A1 (es) | 2008-11-15 |
| CA2503383A1 (en) | 2004-05-06 |
| TW200406223A (en) | 2004-05-01 |
| RS20050321A (en) | 2007-08-03 |
| KR20050083802A (ko) | 2005-08-26 |
| CN1703205A (zh) | 2005-11-30 |
| RU2009112072A (ru) | 2010-10-10 |
| EP1556015A1 (en) | 2005-07-27 |
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